Abstract:
:Mitogens such as pokeweed mitogen, Staphylococcus aureus Cowan I, concanavalin A and phytohemagglutinin and monoclonal anti-CD antibodies were examined for their capacity to induce IgE synthesis by peripheral blood leukocytes obtained from both atopic and nonatopic individuals. While lectins failed to induce IgE synthesis, monoclonal anti-CD3 antibodies were very potent stimuli for the induction of human in vitro IgE synthesis, possibly due to the activation of T cells. Activation via CD4 or CD8 molecules by OKT4 or OKT8 antibodies did not lead to a T cell-dependent modulation of IgE synthesis. PWM acted in synergy with the enhancing effect of anti-CD3 antibodies for IgE synthesis. In vitro IgG production was less affected. These results indicate that activation of T cell via CD3 molecules may be important in the regulation of IgE immune responses in man. Furthermore, the successful induction of IgE synthesis by anti-CD3 antibody in unfractionated peripheral blood leukocytes culture provides a simple model for investigation of human IgE regulatory mechanism in vitro.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Yang XD,De Weck AL,Stadler BMdoi
10.1002/eji.1830180322subject
Has Abstractpub_date
1988-03-01 00:00:00pages
467-71issue
3eissn
0014-2980issn
1521-4141journal_volume
18pub_type
杂志文章abstract::Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate immune inflammatory responses, however, mechanism(s) by which SFAs control inflamma...
journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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更新日期:2004-01-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1987-02-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1976-06-01 00:00:00
abstract::Beside diabetes, non-obese diabetic (NOD) mice develop sporadic lymphoid infiltration of the thyroid gland, mimicking Hashimoto's thyroiditis. We have examined the prevalence of those manifestations in NOD mice, the influence of the major histocompatibility complex (MHC) and the association with autoantibodies. The in...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830271117
更新日期:1997-11-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830081105
更新日期:1978-11-01 00:00:00
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journal_title:European journal of immunology
pub_type: 评论,杂志文章
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更新日期:2015-02-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:European journal of immunology
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更新日期:1996-07-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230207
更新日期:1993-02-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1993-08-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
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更新日期:2010-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
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