Alternative T cell receptor gene usage induced by self tolerance.

abstract：:The migration of immunocytes within the extracellular matrix (ECM) is influenced by the activation state of the incoming cell and its responses to the presence of chemokines and cytokines. We studied the regulatory role of TGF-beta1 on T cell homing to secondary lymphatic organs, such as the spleen, and chemotaxis wit...

journal_title：European journal of immunology

authors： Franitza S,Kollet O,Brill A,Vaday GG,Petit I,Lapidot T,Alon R,Lider O

更新日期：2002-01-01 00:00:00

abstract：:Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains elusive. By using accurate mass spectrometry and multi-epitope ligand cartography (MELC) we character...

journal_title：European journal of immunology

authors： van Ham M,Teich R,Philipsen L,Niemz J,Amsberg N,Wissing J,Nimtz M,Gröbe L,Kliche S,Thiel N,Klawonn F,Hubo M,Jonuleit H,Reichardt P,Müller AJ,Huehn J,Jänsch L

更新日期：2017-12-01 00:00:00

abstract：:Brain invasion by Borrelia burgdorferi, the agent of Lyme disease, results in an inflammatory and neurodegenerative disorder called neuroborreliosis. In humans, neuroborreliosis has been correlated with enhanced concentration of glial fibrillary acidic protein in the cerebrospinal fluid, a sign of astrogliosis. Rhesus...

journal_title：European journal of immunology

authors： Ramesh G,Alvarez AL,Roberts ED,Dennis VA,Lasater BL,Alvarez X,Philipp MT

更新日期：2003-09-01 00:00:00

abstract：:Intravenous immunoglobulins (IVIgs) efficiently suppress a variety of autoimmune diseases. Over the past few years several potential mechanisms underlying this antiinflammatory activity have become apparent. Among these, terminal sialic acid residues in the sugar moiety of the immunoglobulin G constant fragment have b...

journal_title：European journal of immunology

authors： Schwab I,Seeling M,Biburger M,Aschermann S,Nitschke L,Nimmerjahn F

更新日期：2012-12-01 00:00:00

abstract：:To define activation-specific sequences in human T lymphocytes, a cDNA library was constructed by subtractive hybridization using resting and stimulated peripheral blood lymphocyte pairs. Stimulation of peripheral blood lymphocytes was achieved by triggering with mitogenic anti-CD2 (T11) monoclonal antibodies. Differe...

journal_title：European journal of immunology

authors： Chang HC,Reinherz EL

更新日期：1989-06-01 00:00:00

abstract：:Mouse peritoneal macrophages were charged with IgG molecules in monomeric (mIgG), heat-aggregated (agIgG) or antigen-complexed (acIgG) form. Upon exposure to 37 degrees C, all bound IgG ligand types are redistributed on the cell surface due to the mobilization of their corresponding Fc receptor (FcR). The major findin...

journal_title：European journal of immunology

authors： Sulica A,Gherman M,Medeşan C,Gheţie V,Sjöquist J

更新日期：1979-12-01 00:00:00

abstract：:IL-7 is a major regulator of lymphocyte homeostasis; however, little is known about the mechanisms that regulate IL-7 production. To study Il7 gene regulation in vivo, we generated a novel IL-7-reporter mouse, which allows the non-invasive quantification of Il7 gene activity in live mice and, additionally, the simulta...

journal_title：European journal of immunology

authors： Shalapour S,Deiser K,Sercan O,Tuckermann J,Minnich K,Willimsky G,Blankenstein T,Hämmerling GJ,Arnold B,Schüler T

更新日期：2010-09-01 00:00:00

abstract：:In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed. Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription. We s...

journal_title：European journal of immunology

authors： Sartoris S,Tosi G,De Lerma Barbaro A,Cestari T,Accolla RS

更新日期：1996-10-01 00:00:00

abstract：:Maintenance of peripheral tolerance and inactivation of autoreactive T cells is based on a delicate balance between pro-inflammatory and protective cytokines that is poorly understood. We have here addressed how the local expression of the inflammatory cytokine TNF-alpha can impair peripheral tolerance and lead to aut...

journal_title：European journal of immunology

authors： Skak K,Guerder S,Picarella DE,Brenden N,Flavell RA,Michelsen BK

更新日期：2003-05-01 00:00:00

abstract：:Previously we implicated c-Jun N-terminal kinase (JNK) as an element that is involved in signal integration during co-stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR and CD28. A large portio...

journal_title：European journal of immunology

authors： Avraham A,Jung S,Samuels Y,Seger R,Ben-Neriah Y

更新日期：1998-08-01 00:00:00

abstract：:Ligation of interleukin 2 (IL2) is known to regulate both protein tyrosine and serine/threonine phosphorylation. A family of leukocyte transmembrane proteins whose cytoplasmic domain exhibits intrinsic protein tyrosine phosphatase activity is collectively called CD45 and is identified by a set of common cell surface e...

journal_title：European journal of immunology

authors： Valentine MA,Widmer MB,Ledbetter JA,Pinault F,Voice R,Clark EA,Gallis B,Brautigan DL

更新日期：1991-04-01 00:00:00

abstract：:Regulatory T cells (Treg) provide protection from autoimmune disease, graft-versus-host disease, transplant rejection and overwhelming tissue destruction during infections. Conversely, high Treg numbers enable cancer cells to evade the host immune response. Thus, Treg are seen as an important tool to manipulate the im...

journal_title：European journal of immunology

authors： Banham AH,Powrie FM,Suri-Payer E

更新日期：2006-11-01 00:00:00

abstract：:The conditions under which tumor necrosis factor-alpha (TNF) induces apoptosis in primary microvascular endothelial cells (MVEC) were investigated. In the absence of sensitizing agents, TNF induced apoptosis after 3 days of incubation in confluent MVEC. In contrast, upon addition of the transcriptional inhibitor actin...

journal_title：European journal of immunology

authors： Lucas R,Garcia I,Donati YR,Hribar M,Mandriota SJ,Giroud C,Buurman WA,Fransen L,Suter PM,Nunez G,Pepper MS,Grau GE

更新日期：1998-11-01 00:00:00

abstract：:The receptor for the inflammatory peptide C3a has scarcely been examined on human cells. This work demonstrates that human tumor-derived basophilic granulocytes express C3a receptors, and presents parts of the hitherto unknown C3a-signal transduction. When incubated with IL-3, these cells specifically liberated histam...

journal_title：European journal of immunology

authors： Kretzschmar T,Jeromin A,Gietz C,Bautsch W,Klos A,Köhl J,Rechkemmer G,Bitter-Suermann D

更新日期：1993-02-01 00:00:00

abstract：:gp140 is the Epstein-Barr virus receptor and the C3d receptor (EBVR/C3dR) of human B lymphocytes. Recently, we have shown that cross-linking of EBVR/C3dR on cell surface by polyclonal anti-gp140 induced B cell activation, in presence of T cell factors. Immunoregulatory abnormalities of EBV-induced B cell activation ha...

journal_title：European journal of immunology

authors： Barel M,Kahan A,Charriaut-Marlangue C,Kahan A,Frade R

更新日期：1986-11-01 00:00:00

abstract：:Expression of the high-affinity receptor for IgE (FcεRI) provides mast cells with the ability to react in a proinflammatory manner to antigens (Ags). In particular, the immediate secretion of preformed mediators from secretory lysosomes (degranulation) is typical for FcεRI-mediated mast cell activation. In addition to...

journal_title：European journal of immunology

authors： Huber M

更新日期：2013-07-01 00:00:00

abstract：:A novel surface molecule, Tp90, is described which appears to be involved in an antigen-independent pathway of human T lymphocyte activation. The Tp90 molecule was identified by a monoclonal antibody (mAb), MX20, obtained from a fusion using spleen cells of a mouse immunized with cells from two T cell leukemia lines, ...

journal_title：European journal of immunology

authors： Carrel S,Salvi S,Giuffrè L,Isler P,Cerottini JC

更新日期：1987-06-01 00:00:00

abstract：:Several T cell abnormalities have been described in the course of acute Trypanosoma cruzi infection in mice, including severe effects on the thymus. In the present study, looking at the expression of extracellular matrix ligands in the thymus, we observed that deposits of fibronectin and laminin increased progressivel...

journal_title：European journal of immunology

authors： Cotta-de-Almeida V,Bonomo A,Mendes-da-Cruz DA,Riederer I,De Meis J,Lima-Quaresma KR,Vieira-de-Abreu A,Villa-Verde DM,Savino W

更新日期：2003-09-01 00:00:00

abstract：:Analysis of mice transgenic for immunoglobulin genes should allow definition of the cis-acting DNA sequences required to target somatic mutation to antibody V genes. We have looked for mutations in a chimeric kappa transgene encoding a V region specific for the hapten 2-phenyloxazolone (phOx) linked to a rat C kappa g...

journal_title：European journal of immunology

authors： Sharpe MJ,Neuberger M,Pannell R,Surani MA,Milstein C

更新日期：1990-06-01 00:00:00

abstract：:High BDCA3 expression is associated with a specific human IFN-λ-producing dendritic cell (DC) subset. However, BDCA3 has also been detected on other DC subsets. Thus far, development and function of BDCA3 expression on DCs remains poorly understood. Human Langerhans cells (LCs) and interstitial DCs (intDCs) can be gen...

journal_title：European journal of immunology

authors： van der Aa E,van de Laar L,Janssen HL,van Montfoort N,Woltman AM

更新日期：2015-05-01 00:00:00

abstract：:Significant variability in efficacy of live Mycobacterium bovis BCG as a tuberculosis vaccine is observed globally. Effects of pre-vaccination sensitisation to non-tuberculous environmental mycobacteria (Env) are suspected to underlie this phenomenon, but the mechanisms remain unclear. We postulated that it could be d...

journal_title：European journal of immunology

authors： Ho P,Zhang L,Wei X,Seah GT

更新日期：2009-07-01 00:00:00

abstract：:The binding of antigen to the multicomponent T cell antigen receptor (TcR)-CD3 complex leads to the activation of several signal transduction pathways which result in T lymphocyte proliferation and lymphokine secretion by molecular mechanisms and catalytic molecules as yet poorly defined. One of the earliest events th...

journal_title：European journal of immunology

authors： Gassmann M,Guttinger M,Amrein KE,Burn P

更新日期：1992-01-01 00:00:00

abstract：:Several studies in human patients and in laboratory animals have revealed a correlation between serum interleukin (IL)-6 levels and outcome in clinical sepsis and in related animal models, respectively. In the present study, two monoclonal antibodies were used to investigate the contribution of IL-6 in the lethal acti...

journal_title：European journal of immunology

authors： Libert C,Vink A,Coulie P,Brouckaert P,Everaerdt B,Van Snick J,Fiers W

更新日期：1992-10-01 00:00:00

abstract：:Leishmaniases are a major international public health problem, and macrophages are crucial for host resistance to this parasite. To determine if phosphatase and tensin homologue deleted on chromosome ten (Pten), a negative regulator of the PI3K pathway, plays a role in macrophage-mediated resistance to Leishmania, we ...

journal_title：European journal of immunology

authors： Kuroda S,Nishio M,Sasaki T,Horie Y,Kawahara K,Sasaki M,Natsui M,Matozaki T,Tezuka H,Ohteki T,Förster I,Mak TW,Nakano T,Suzuki A

更新日期：2008-05-01 00:00:00

abstract：:IFN-gamma plays a crucial role in the defense against infection with Candida albicans. Since IL-18 and IL-12 are strong stimuli of IFN-gamma production, we investigated whether endogenous IL-18 and IL-12 are involved in the host defense during disseminated candidiasis. IL-18 knockout (IL-18-/-) mice, but not IL-12-/- ...

journal_title：European journal of immunology

authors： Netea MG,Vonk AG,van den Hoven M,Verschueren I,Joosten LA,van Krieken JH,van den Berg WB,Van der Meer JW,Kullberg BJ

更新日期：2003-12-01 00:00:00

abstract：:High-dose infusion of IgG (IVIG) is used to treat autoimmune and inflammatory diseases, including Kawasaki disease (KD). Although the immunomodulatory effects of IVIG on blood cells such as macrophages have been well studied, its effects on tissue cells remain unclear. Here, we show that high-dose IgG specifically and...

journal_title：European journal of immunology

authors： Matsuda A,Morita H,Unno H,Saito H,Matsumoto K,Hirao Y,Munechika K,Abe J

更新日期：2012-08-01 00:00:00

abstract：:B cell development is dependent on both direct interactions with stromal cells and their secreted cytokines. The precise mechanisms by which these interactions regulate B cell differentiation are currently unknown. We report here that a novel growth factor thymic stromal-derived lymphopoietin (TSLP) can replace the ac...

journal_title：European journal of immunology

authors： Ray RJ,Furlonger C,Williams DE,Paige CJ

更新日期：1996-01-01 00:00:00

abstract：:In this study we have examined the role of small numbers of adherent cells in the stimulation of highly purified resting T lymphocytes by cross-linked monoclonal anti-CD3 antibodies (T3). T cells were obtained by 3 cycles of purification, using adherence to plastic surface, nylon wool column separation and rosetting w...

journal_title：European journal of immunology

authors： Heumann D,Vischer TL

更新日期：1987-11-01 00:00:00

abstract：:It has been shown previously that three different H-2-associated genes control the resistance to viremia and leukemia in Moloney virus-infected mice: Rmv. 1, mapping to the I-A or less probably K regions; Rmv. 2, mapping to the I-C, S or G regions and Rmv. 3, mapping to the D or T regions. Experiments have been perfo...

journal_title：European journal of immunology

authors： Debré P,Boyer B,Gisselbrecht S,Bismuth A,Lévy JP

更新日期：1980-12-01 00:00:00

abstract：:Interphotoreceptor retinoid-binding protein (IRBP) is an immunologically privileged retinal antigen that can elicit experimental autoimmune uveitis (EAU). The nature and extent of tolerance to immunologically privileged self antigens is poorly understood. To investigate whether transgenic expression of IRBP extraocula...

journal_title：European journal of immunology

authors： Xu H,Wawrousek EF,Redmond TM,Nickerson JM,Wiggert B,Chan CC,Caspi RR

更新日期：2000-01-01 00:00:00