Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes.

Abstract:

:Previously we implicated c-Jun N-terminal kinase (JNK) as an element that is involved in signal integration during co-stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR and CD28. A large portion of this input is probably integrated at the level of the Rho-family protein CDC42 which, here, activates SEK1 and JNK to the level reached by TCR and CD28 stimulation. We have identified another putative SEK/ JNK pathway regulator, PKCtheta, which in contrast to CDC42, activates SEK and JNK maximally only in conjunction with a calcium signal delivered through calcineurin. Signals originating at the TCR and CD28 may travel down the JNK pathway via PKCtheta, calcineurin, CDC42, MEKK1 and SEK1.

journal_name

Eur J Immunol

authors

Avraham A,Jung S,Samuels Y,Seger R,Ben-Neriah Y

doi

10.1002/(SICI)1521-4141(199808)28:08<2320::AID-IMM

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

2320-30

issue

8

eissn

0014-2980

issn

1521-4141

pii

10.1002/(SICI)1521-4141(199808)28:08<2320::AID-IMM

journal_volume

28

pub_type

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