FcγRIIB regulation of BCR/TLR-dependent autoreactive B-cell responses.

abstract：:Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains elusive. By using accurate mass spectrometry and multi-epitope ligand cartography (MELC) we character...

journal_title：European journal of immunology

authors： van Ham M,Teich R,Philipsen L,Niemz J,Amsberg N,Wissing J,Nimtz M,Gröbe L,Kliche S,Thiel N,Klawonn F,Hubo M,Jonuleit H,Reichardt P,Müller AJ,Huehn J,Jänsch L

更新日期：2017-12-01 00:00:00

abstract：:Human herpesvirus 6B (HHV-6B) is a ubiquitous pathogen with frequent reactivation observed in immunocompromised patients such as BM transplant (BMT) recipients. Adoptive immunotherapy is a promising therapeutic avenue for the treatment of opportunistic infections, including herpesviruses. While T-cell immunotherapy ca...

journal_title：European journal of immunology

authors： Iampietro M,Morissette G,Gravel A,Dubuc I,Rousseau M,Hasan A,O'Reilly RJ,Flamand L

更新日期：2014-12-01 00:00:00

abstract：:The phosphodiesterase inhibitor oxpentifylline (OXP) has a number of potentially important immunomodulatory actions which include a selective inhibition of the Th1 subset of CD4+ cells in vitro and inhibition of tumor necrosis factor (TNF)-alpha mRNA transcription. In vivo, it has a dramatic protective effect against ...

journal_title：European journal of immunology

authors： Kiely PD,Gillespie KM,Oliveira DB

更新日期：1995-10-01 00:00:00

abstract：:The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation cap...

journal_title：European journal of immunology

authors： Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

更新日期：2016-01-01 00:00:00

abstract：:NK cells play important roles in immune surveillance against malignancy and virus-infected cells. NK cell functions are affected in patients infected with HIV-1; however, whether there is direct interaction between NK cells and HIV-1 remains controversial. In this study the expression of CD4, an important receptor for...

journal_title：European journal of immunology

authors： Harada H,Goto Y,Ohno T,Suzu S,Okada S

更新日期：2007-08-01 00:00:00

abstract：:Recombinant vaccinia viruses (VV)-encoding murine interferon-gamma (IFN-gamma) were constructed and the effect of virus-encoded IFN-gamma on the immune response towards VV in vivo investigated. In athymic nude mice and sublethally irradiated euthymic mice, IFN-gamma expression by VV enabled the mice to recover from th...

journal_title：European journal of immunology

authors： Kohonen-Corish MR,King NJ,Woodhams CE,Ramshaw IA

更新日期：1990-01-01 00:00:00

abstract：:IL-12, IL-23, and IL-27, which are produced by APC, modulate innate and adaptive immunities. Human beta-defensin-2 (hBD-2) produced by epidermal keratinocytes promotes cutaneous antimicrobial defense and inflammation. We examined the in vitro effects of IL-12, IL-23, and IL-27 on hBD-2 production in human keratinocyte...

journal_title：European journal of immunology

authors： Kanda N,Watanabe S

更新日期：2008-05-01 00:00:00

abstract：:Amount and affinity of anti-beta-D-galactosidase-activating antibodies (AAb) were studied in two lines of mice obtained by selective breeding for antibody response to heterologous erythrocytes. These lines, referred to as high (H) and low (L) lines, differ also in their responses to many antigens. Concerning AAb amoun...

journal_title：European journal of immunology

authors： Conway de Macario E,Heumann AM,Macario AJ,Biozzi G

更新日期：1979-03-01 00:00:00

abstract：:An important aspect of clinical immunity to malaria is the ability to down-regulate inflammatory responses, once parasitaemia is under control, in order to avoid immune-mediated pathology. The role of classical (CD4(+)CD25(+)CD127(lo/-)FOXP3(+)) Treg in this process, however, remains controversial. Thus, we have chara...

journal_title：European journal of immunology

authors： Finney OC,Nwakanma D,Conway DJ,Walther M,Riley EM

更新日期：2009-05-01 00:00:00

abstract：:Antigen-free (AGF) and germ-free (GF) mice, although essentially free of serum IgG, maintain normal levels of circulating IgM. Using a quantitative immunoblot assay, we have now analyzed the repertoire of serum IgM from AGF, GF, and specific pathogen-free (SPF) BALB/c mice, on large panels of natural antigens from hom...

journal_title：European journal of immunology

authors： Haury M,Sundblad A,Grandien A,Barreau C,Coutinho A,Nobrega A

更新日期：1997-06-01 00:00:00

abstract：:Regulatory T cells (Treg) are vital in maintaining the homeostasis of immune reactions. In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity. Thus, we performed in vivo studies using TLR2-/- mice infected with Schistosoma mansoni an...

journal_title：European journal of immunology

authors： Layland LE,Rad R,Wagner H,da Costa CU

更新日期：2007-08-01 00:00:00

abstract：:Normal immunosuppressive protein, prepared from human plasma by DEAE-cellulose chromatography, inhibits DNA synthesis in human cell lines of lymphocytes of both T and B origin. It also inhibits [3H]thymidine incorporation in mouse cell lines. Normal immunosuppressive protein was able to inhibit the proliferation of th...

journal_title：European journal of immunology

authors： Nelken D,Ovadia H,Hanna N

更新日期：1979-02-01 00:00:00

abstract：:The HIV-1 Tat protein plays a critical role in the pathogenesis of HIV and has been considered as a candidate vaccine antigen. In an effort to design a non-invasive vaccination strategy against HIV-1 that stimulates the induction of systemic and mucosal immune responses, we studied the transcutaneous delivery of a syn...

journal_title：European journal of immunology

authors： Partidos CD,Moreau E,Chaloin O,Tunis M,Briand JP,Desgranges C,Muller S

更新日期：2004-12-01 00:00:00

abstract：:CSF1R (colony stimulating factor 1 receptor) is the main receptor for CSF1 and has crucial roles in regulating myelopoeisis. CSF1R can be proteolytically released from the cell surface by ADAM17 (A disintegrin and metalloprotease 17). Here, we identified CSF1R as a major substrate of ADAM17 in an unbiased degradomics ...

journal_title：European journal of immunology

authors： Qing X,Rogers L,Mortha A,Lavin Y,Redecha P,Issuree PD,Maretzky T,Merad M,McIlwain D,Mak TW,Overall CM,Blobel CP,Salmon JE

更新日期：2016-12-01 00:00:00

abstract：:The role of TGF-beta1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-beta1 has a profound inhibitory effect on naive CD4+ T cell undergoing differentiation...

journal_title：European journal of immunology

authors： Lúdvíksson BR,Seegers D,Resnick AS,Strober W

更新日期：2000-07-01 00:00:00

abstract：:Activated monocyte-macrophages have been implicated in tumor angiogenesis via their capacity to produce many potent angiogenic factors. However, the mechanisms leading to production of these angiogenic factors in macrophages remain to be elucidated. In this study, we demonstrated by use of a mouse Matrigel implantatio...

journal_title：European journal of immunology

authors： Seo KH,Ko HM,Choi JH,Jung HH,Chun YH,Choi IW,Lee HK,Im SY

更新日期：2004-08-01 00:00:00

abstract：:B cells isolated from germinal centers (GC) of immune mice 2-5 days after antigen (Ag) challenge migrate in response to chemotactic signals, whereas GC B cells isolated at other times and resting B cells do not. Since B cells are in direct contact with follicular dendritic cells (FDC) in GC we reasoned that FDC might ...

journal_title：European journal of immunology

authors： Burton GF,Kupp LI,McNalley EC,Tew JG

更新日期：1995-04-01 00:00:00

abstract：:P-glycoprotein (P-gly) is the transmembrane efflux pump responsible for multidrug resistance in tumor cells. The activity of P-gly in mature peripheral lymphocytes is lineage specific, with CD8+ T cells and natural killer (NK) cells expressing high levels as compared to CD4+ T cells and B cells. We have now investigat...

journal_title：European journal of immunology

authors： MacDonald HR,Bommhardt U,Cerottini JC

更新日期：1995-05-01 00:00:00

abstract：:Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...

journal_title：European journal of immunology

authors： Reininger L,Spertini F,Shibata T,Jaton JC,Izui S

更新日期：1989-11-01 00:00:00

abstract：:We recently reported that differentiation of CD8(+) T cells from the naïve to the effector state involves the upregulation of glucose-dependent metabolism. Glucose deprivation or inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) selectively inhibited production of IFN-gamma but not of IL-2. To determine a more glob...

journal_title：European journal of immunology

authors： Cham CM,Driessens G,O'Keefe JP,Gajewski TF

更新日期：2008-09-01 00:00:00

abstract：:Toll-like receptors (TLRs) are innate immune receptors that respond to both exogenous and endogenous stimuli and are suggested to contribute to the perpetuation of chronic inflammation associated with rheumatoid arthritis (RA). In particular, the endosomal TLRs 3, 7, 8, and 9 have more recently been postulated to be o...

journal_title：European journal of immunology

authors： Sacre S,Lo A,Gregory B,Stephens M,Chamberlain G,Stott P,Brennan F

更新日期：2016-03-01 00:00:00

abstract：:Thapsigargin (TG), which inhibits endoplasmic reticulum-dependent Ca(2 +)-ATPase and thereby increases cytosolic Ca(2 +), has been reported to cause apoptosis in T lymphocytes another cell types. In this study, we investigated the molecular mechanisms that are involved in the apoptosis induced by TG in T cell hybridom...

journal_title：European journal of immunology

authors： Liu W,Youn HD,Liu JO

更新日期：2001-06-01 00:00:00

abstract：:Prostein is a prostate tissue-specific protein that is uniquely and abundantly expressed in normal and cancerous prostate tissues. Due to this expression profile, we examined the immunogenicity of prostein as a potential vaccine candidate for prostate cancer. To determine the presence of CD8 T cells specific for natur...

journal_title：European journal of immunology

authors： Friedman RS,Spies AG,Kalos M

更新日期：2004-04-01 00:00:00

abstract：:The effects of vasoactive intestinal peptide (VIP) on human IgA1 and IgA2 production were studied. In unfractionated small resting B cells stimulated with anti-CD40 monoclonal antibody (mAb), VIP induced IgA1 and IgA2 production without affecting the production of IgG1, IgG2, IgG3, IgG4, IgM, or IgE. When small B cell...

journal_title：European journal of immunology

authors： Kimata H,Fujimoto M

更新日期：1994-09-01 00:00:00

abstract：:The immune system relies on homeostatic mechanisms in order to adapt to the changing requirements encountered during steady-state existence and activation by antigen. For T cells, this involves maintenance of a diverse repertoire of naïve cells, rapid elimination of effector cells after pathogen clearance, and long-te...

journal_title：European journal of immunology

authors： Boyman O,Létourneau S,Krieg C,Sprent J

更新日期：2009-08-01 00:00:00

abstract：:We used 5-(and 6-) carboxyfluorescein diacetate succinimidyl ester labeled TCR-transgenic CD4(+) T cells to investigate the contribution of B7 costimulation to T cell activation and clonal expansion. B7 costimulation was blocked with the fusion protein cytotoxic T lymphocyte-associated antigen-4 (CTLA-4)-Ig, which pre...

journal_title：European journal of immunology

authors： Lumsden JM,Prasad SJ,Peach RJ,Ronchese F

更新日期：2003-08-01 00:00:00

abstract：:To investigate the effect of HIV-specific CD8(+) T cells on viral plasma load and disease progression, we enumerated HLA-A2-, B8- and B57-restricted CD8(+) T cells directed against several HIV epitopes in a total of 54 patients by the use of tetrameric HLA-peptide complexes. In patients with high CD4(+) T cell numbers...

journal_title：European journal of immunology

authors： Kostense S,Ogg GS,Manting EH,Gillespie G,Joling J,Vandenberghe K,Veenhof EZ,van Baarle D,Jurriaans S,Klein MR,Miedema F

更新日期：2001-03-01 00:00:00

abstract：:Peptides associated with HLA-B35 commonly have a proline or occasionally a serine residue in the P2 anchor position of the peptide, with a tyrosine at the C terminus. Based on this motif, we identified an octamer epitope from influenza A matrix protein which is presented by HLA-B35. The requirements for MHC binding an...

journal_title：European journal of immunology

authors： Dong T,Boyd D,Rosenberg W,Alp N,Takiguchi M,McMichael A,Rowland-Jones S

更新日期：1996-02-01 00:00:00

abstract：:Mice carrying the H-2b and H-2s haplotypes are genetically nonresponsive to hen egg-white lysozyme (HEL). Analysis of the anti-HEL response patterns of F1, F2 and backcross progeny showed that responsiveness was dominant and H-2 linked. From plaque-forming cell and serum assays in intra-H-2 recombinant mice, it was es...

journal_title：European journal of immunology

authors： Hill SW,Kipp DE,Melchers I,Frelinger JA,Sercarz EE

更新日期：1980-05-01 00:00:00

abstract：:Leukocyte adhesion deficiency (LAD) is a recessive autosomal disease characterized by life-threatening recurrent bacterial infections, by defective functions of leukocytes and by deficient membrane expression of leukocyte adhesion glycoproteins. These proteins, LFA-1, Mac-1 and p150,95, are alpha 1/beta 1 heterodimers...

journal_title：European journal of immunology

authors： Dimanche-Boitrel MT,Guyot A,De Saint-Basile G,Fischer A,Griscelli C,Lisowska-Grospierre B

更新日期：1988-10-01 00:00:00