A synthetic HIV-1 Tat protein breaches the skin barrier and elicits Tat-neutralizing antibodies and cellular immunity.

abstract：:IgG complexes bind to Fc receptor family members FcgammaRI (CD64), FcgammaRII (CD32) and FcgammaRIII (CD16), activating cell MAPK and PI3K resulting in increased cytokine production from particular leukocytes. The signaling molecules involved in cytokine production after cross-linking CD16 have not been determined in ...

journal_title：European journal of immunology

authors： Kramer PR,Winger V,Reuben J

更新日期：2009-02-01 00:00:00

abstract：:The inflammatory process that underlies allergic diseases such as asthma is characterized by tissue infiltration of eosinophils and T cells. We have used the Stamper-Woodruff frozen-section assay to characterize the receptors involved in adhesion of human peripheral blood T cells to nasal polyp endothelium (NPE) as a ...

journal_title：European journal of immunology

authors： Symon FA,McNulty CA,Wardlaw AJ

更新日期：1999-04-01 00:00:00

abstract：:Constitutive expression of CD25, the IL-2 receptor alpha-chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in vivo. IL-2 has been implicated in the generation and maintenance of Treg, however, a functional contribution of the IL-2 receptor during suppression is thus far...

journal_title：European journal of immunology

authors： de la Rosa M,Rutz S,Dorninger H,Scheffold A

更新日期：2004-09-01 00:00:00

abstract：:Cathelicidins are a family of host defence peptides that are known to selectively alter innate immunity in response to infection and other changes in immune status. A study in this issue of the European Journal of Immunology elucidates a new role for mouse cathelin-related antimicrobial peptide in the adaptive immune ...

journal_title：European journal of immunology

authors： Wuerth K,Hancock RE

更新日期：2011-10-01 00:00:00

abstract：:In humans and in BALB/c mice, immune responses to the hormone insulin use evolutionarily related VHV (human) and VHIX (murine) gene families. To determine if these structural relationships include regulatory elements, BALB/c mice were pretreated with autologous immunoglobulin G (IgG) monoclonal antibodies (mAb) that r...

journal_title：European journal of immunology

authors： Thomas JW

更新日期：1992-09-01 00:00:00

abstract：:gp140 is the Epstein-Barr virus receptor and the C3d receptor (EBVR/C3dR) of human B lymphocytes. Recently, we have shown that cross-linking of EBVR/C3dR on cell surface by polyclonal anti-gp140 induced B cell activation, in presence of T cell factors. Immunoregulatory abnormalities of EBV-induced B cell activation ha...

journal_title：European journal of immunology

authors： Barel M,Kahan A,Charriaut-Marlangue C,Kahan A,Frade R

更新日期：1986-11-01 00:00:00

abstract：:We examined T cell development and T cell repertoire in transgenic mice expressing a single T cell receptor (TCR) alpha chain derived from the H-2Db-lymphocytic choriomeningitis virus (LCMV)-specific cytolytic T lymphocyte (CTL) clone P14. To generate these alpha P14 mice, mice transgenic for the P14 TCR alpha chain w...

journal_title：European journal of immunology

authors： Brändle D,Brduscha-Riem K,Hayday AC,Owen MJ,Hengartner H,Pircher H

更新日期：1995-09-01 00:00:00

abstract：:Here we show that tumor cells (TC) from renal cancers regulate the migratory properties of autologous tumor-infiltrating lymphocytes (TIL), enhancing their ability to invade the extracellular matrix. A similar effect is exerted by human recombinant macrophage chemotactic protein 1 (MCP-1) and IL-8, chemokines known to...

journal_title：European journal of immunology

authors： Ferrero E,Fabbri M,Poggi A,Galati G,Bernasconi S,Zocchi MR

更新日期：1998-08-01 00:00:00

abstract：:The CD4 and CD8 coreceptor molecules on immature thymocytes participate in T cell repertoire selection. To examine more definitively the role of CD4 and CD8 in the negative and positive selection of immature thymocytes, we generated transgenic mice with elevated surface CD4 expression and mated them with mice expressi...

journal_title：European journal of immunology

authors： Van Oers NS,Garvin AM,Davis CB,Forbush KA,Carlow DA,Littman DR,Perlmutter RM,Teh HS

更新日期：1992-03-01 00:00:00

abstract：:Fc gamma receptor I-positive (CD64+) and Fc gamma receptor I-negative (CD64-) monocytes were prepared from highly purified (elutriation-derived) human monocytes by cytofluorograph cell sorting, and a phenotypical and functional dissociation of the isolated CD64+ and CD64- monocyte subsets is demonstrated. Surface anal...

journal_title：European journal of immunology

authors： Grage-Griebenow E,Lorenzen D,Fetting R,Flad HD,Ernst M

更新日期：1993-12-01 00:00:00

abstract：:The zinc-finger transcription factor GATA3 serves as a master regulator of T-helper-2 (Th2) differentiation by inducing expression of the Th2 cytokines IL-4, IL-5 and IL-13 and by suppressing Th1 development. Here, we investigated how GATA3 affects Th17 differentiation, using transgenic mice with enforced GATA3 expres...

journal_title：European journal of immunology

authors： van Hamburg JP,de Bruijn MJ,Ribeiro de Almeida C,van Zwam M,van Meurs M,de Haas E,Boon L,Samsom JN,Hendriks RW

更新日期：2008-09-01 00:00:00

abstract：:The causative agents of Lyme disease, Borrelia burgdorferi s.s., B. garinii, and B. afzelii, differ in their susceptibility to complement-mediated lysis. This phenomenon apparently depends on the expression of proteins termed complement regulator-acquiring surface proteins (CRASP) and their binding to the inhibitory p...

journal_title：European journal of immunology

authors： Kraiczy P,Hellwage J,Skerka C,Kirschfink M,Brade V,Zipfel PF,Wallich R

更新日期：2003-03-01 00:00:00

abstract：:The influence of muramyl dipeptide (N-acetylmuramyl-L-alanyl-D-isoglutamine) on the rejection of mouse skin allografts was investigated. While the 0.1-mg dose administered on days 7, 6, 5 prior to transplantation caused significant prolongation of the graft survival, the 0.5-mg dose administered on days 3, 2, 1 prior ...

journal_title：European journal of immunology

authors： Zídek Z,Capková J,Boubelík M,Masek K

更新日期：1983-10-01 00:00:00

abstract：:Antigen-specific human T lymphocytes were selected by adsorption of peripheral blood mononuclear cells on monolayers of antigen-treated autologous monocytes. The enriched cell populations were propagated in interleukin 2-containing medium for 60-80 days. Their activity was tested by a proliferative response against th...

journal_title：European journal of immunology

authors： Barak V,Fuks Z,Galilli N,Treves AJ

更新日期：1983-11-01 00:00:00

abstract：:The functional half-life, a measure of the persistence of lymphocytes in an antigen-free environment, has been estimated and found to be about 7 days for virgin 2,4,6-trinitrophenyl (TNP)-reactive mouse B cells, and 2--3 times longer for TNP-primed B cells. Using allotype-congenic mice, lymph node cells were transferr...

journal_title：European journal of immunology

authors： Elson CJ,Jablonska KF,Taylor RB

更新日期：1976-09-01 00:00:00

abstract：:We have investigated the role of TNF-alpha in mast cell-mediated late airway hyperresponsiveness (AHR) using mast cell-deficient WBB6F1-W/W(v) (W/W(v)) mice in a murine model of asthma, which exhibits a biphasic increase in AHR. TNF-alpha levels in the airway and magnitude of late AHR in response to airway allergen ch...

journal_title：European journal of immunology

authors： Kim YS,Ko HM,Kang NI,Song CH,Zhang X,Chung WC,Kim JH,Choi IH,Park YM,Kim GY,Im SY,Lee HK

更新日期：2007-04-01 00:00:00

abstract：:Humanized BALB/c mice (termed trimera mice) conditioned by lethal total body irradiation and bone marrow transplantation from SCID mice have been described to support rapid engraftment of human peripheral blood mononuclear cells (PBMC) and the induction of strong B and T cell responses after immunization in vivo. More...

journal_title：European journal of immunology

authors： Böcher WO,Dekel B,Schwerin W,Geissler M,Hoffmann S,Rohwer A,Arditti F,Cooper A,Bernhard H,Berrebi A,Rose-John S,Shaul Y,Galle PR,Löhr HF,Reisner Y

更新日期：2001-07-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants worldwide. The immunological factors responsible for RSV susceptibility in infants are poorly understood. Here, we used the BALB/c mouse model of neonatal RSV infection to study the mechanisms leading to severe disease upon reexposure to the viru...

journal_title：European journal of immunology

authors： Remot A,Descamps D,Jouneau L,Laubreton D,Dubuquoy C,Bouet S,Lecardonnel J,Rebours E,Petit-Camurdan A,Riffault S

更新日期：2016-04-01 00:00:00

abstract：:IL-23, a proximal regulator of IL-17, may be a major driving force in the induction of autoimmune inflammation. We have used a model of subdiabetogenic treatment with multiple low doses of streptozotocin (MLD-STZ; 4 x 40 mg/kg body weight) in male C57BL/6 mice to study the effect of IL-23 on immune-mediated beta cell ...

journal_title：European journal of immunology

authors： Mensah-Brown EP,Shahin A,Al-Shamisi M,Wei X,Lukic ML

更新日期：2006-01-01 00:00:00

abstract：:Restriction fragment length polymorphism has been compared between the Igh loci of C57BL/6 and MOLF/EI (Mus musculus molossinus) mice utilizing probes which detect the C gamma 2b gene and genes from nine VH-gene families. Distinct restriction site patterns were found for the CH genes and for VH families PC7183, Q52 an...

journal_title：European journal of immunology

authors： Blankenstein T,Krawinkel U

更新日期：1987-09-01 00:00:00

abstract：:The immunoglobulin lambda light chain system displays a limited diversity in inbred mice. Indeed, the lambda locus is organized in two recombination units: V lambda 2-V lambda x-J lambda 2-C lambda 2-psi J lambda 4-psi C lambda 4, which can produce either lambda 2(V2) or lambda 2(Vx) chains; and V lambda 1-J lambda 3-...

journal_title：European journal of immunology

authors： Boudinot P,Drapier AM,Cazenave PA,Sanchez P

更新日期：1994-09-01 00:00:00

abstract：:Once generated during an infection, memory CD8+ T cells can provide long-lasting protection against reinfection with an intracellular pathogen, but the longevity of this defense depends on the ability of these pathogen-specific memory cells to be maintained. It is generally believed that the bone marrow plays an impor...

journal_title：European journal of immunology

authors： Nolte MA,Goedhart M,Geginat J

更新日期：2017-11-01 00:00:00

abstract：:Antigen-independent adhesion of CD4+ T lymphocytes to Epstein-Barr virus (EBV)-transformed B cells is mediated by CD2/lymphocyte function-associated antigen (LFA)-3 and LFA-1/intracellular adhesion molecule (ICAM)-1. Although some anti-CD4 antibodies block the antigen-independent adhesion of CD4+ T lymphocytes, the CD...

journal_title：European journal of immunology

authors： Mazerolles F,Amblard F,Lumbroso C,Lecomte O,Van de Moortele PF,Barbat C,Piatier-Tonneau D,Auffray C,Fischer A

更新日期：1990-03-01 00:00:00

abstract：:Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...

journal_title：European journal of immunology

authors： Horgan KJ,Tanaka Y,Luce GE,van Seventer GA,Nutman TB,Shaw S

更新日期：1994-05-01 00:00:00

abstract：:Plasma cells secreting IgG, M, and A abound in the synovium of patients with rheumatoid arthritis, yet their immunoglobulin repertoire and clonal relationship remain to be elucidated. Locally synthesized immunoglobulins probably contribute to the chronic joint inflammatory processes which are characteristic of these p...

journal_title：European journal of immunology

authors： Williams DG,Taylor PC

更新日期：1997-02-01 00:00:00

abstract：:The costimulatory receptor OX40 is expressed on activated T cells and regulates T-cell responses. Here, we show the efficacy and mechanism of action of an OX40 blocking antibody using the chronic house dust mite (HDM) mouse model of lung inflammation and in vitro HDM stimulation of cells from HDM allergic human donors...

journal_title：European journal of immunology

authors： Burrows KE,Dumont C,Thompson CL,Catley MC,Dixon KL,Marshall D

更新日期：2015-04-01 00:00:00

abstract：:The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). We previously showed that binding of A39R to Plexin C1 induces local rearrangement of the actin cytoskeleton and inhibits integrin-mediated adhesion, leading to cell ret...

journal_title：European journal of immunology

authors： Walzer T,Galibert L,De Smedt T

更新日期：2005-02-01 00:00:00

abstract：:The properties of human lymphocyte fractions isolated either by sheep red cell(E) rosetting or by fluorescence-activated cell sorting after staining with UCHT1 monoclonal anti-T cell antibody have been compared. Two populations of E+ cells with very different phenotype and function have been identified. E+/UCHT1+ cell...

journal_title：European journal of immunology

authors： Beverley PC,Callard RE

更新日期：1981-04-01 00:00:00

abstract：:B cell development is dependent on both direct interactions with stromal cells and their secreted cytokines. The precise mechanisms by which these interactions regulate B cell differentiation are currently unknown. We report here that a novel growth factor thymic stromal-derived lymphopoietin (TSLP) can replace the ac...

journal_title：European journal of immunology

authors： Ray RJ,Furlonger C,Williams DE,Paige CJ

更新日期：1996-01-01 00:00:00

abstract：:Among 15 anti-DNA antibody-producing hybridomas derived from a single NZB X NZW F1 mouse, an IgM and an IgG were shown to use the same VH gene of the Q52 family. Using a combination of two primers both consisting of a mixture of oligonucleotides (one complementary to the 5' end of VH segment and one to the 3' end of V...

journal_title：European journal of immunology

authors： Taki S,Hirose S,Kinoshita K,Nishimura H,Shimamura T,Hamuro J,Shirai T

更新日期：1992-04-01 00:00:00