Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission.

abstract：:The murine X-linked lymphoproliferative disease scurfy is similar to the Wiskott-Aldrich syndrome in humans. Disease in scurfy (sf) mice is mediated by CD4+ T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesion...

journal_title：European journal of immunology

authors： Kanangat S,Blair P,Reddy R,Daheshia M,Godfrey V,Rouse BT,Wilkinson E

更新日期：1996-01-01 00:00:00

abstract：:The most common reason for heart failure in young adults is dilated cardiomyopathy often resulting from myocarditis. Clinical studies and animal models provide evidence that an autoimmune response against heart myosin is the underlying reason for the disease. IL-12 has been suggested to play a key role in development ...

journal_title：European journal of immunology

authors： Sonderegger I,Röhn TA,Kurrer MO,Iezzi G,Zou Y,Kastelein RA,Bachmann MF,Kopf M

更新日期：2006-11-01 00:00:00

abstract：:The antibody response to the synthetic polypeptide, poly(LTyr, LGlu)-poly(DLAla)--poly(LLys), [(T,G)-A--L], injected entrapped in liposomes which served as adjuvant has been analyzed. The liposomes used were composed of phosphatidylcholine, cholesterol, dicetylphosphate and DL alpha-tocopherol (molar ratios as 4:3:0.1...

journal_title：European journal of immunology

authors： Lifshitz R,Gitler C,Mozes E

更新日期：1981-05-01 00:00:00

abstract：:Dendritic cells (DCs) play a key role in regulating innate and adaptive immunity. Our understanding of DC biology has benefited from studies in CD11c.DTR and CD11c.DOG mouse models that use the CD11c promoter to express a diphtheria toxin (DT) receptor transgene to inducibly deplete CD11c(+) cells. Other models to in...

journal_title：European journal of immunology

authors： van Blijswijk J,Schraml BU,Reis e Sousa C

更新日期：2013-01-01 00:00:00

abstract：:The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal regio...

journal_title：European journal of immunology

authors： Schnittger S,Hamann J,Dannenberg C,Fiebig H,Strauss M,Fonatsch C

更新日期：1993-10-01 00:00:00

abstract：:A diabetes-associated peptide in the glutamic acid decarboxylase 65 (GAD65) molecule, p524-543, activates two distinct populations of T cells, which apparently play opposite roles in the development of diabetes in NOD mice. By comparing the fine specificity of these two T cell repertoires using a nested set of truncat...

journal_title：European journal of immunology

authors： Dai YD,Jensen KP,Marrero I,Li N,Quinn A,Sercarz EE

更新日期：2008-04-01 00:00:00

abstract：:Global transcriptional technologies have revolutionised the study of lymphoid cell populations, but human γδ T lymphocytes specific for phosphoantigens remain far less deeply characterised by these methods despite the great therapeutic potential of these cells. Here we analyse the transcriptome of circulating TCRVγ(+)...

journal_title：European journal of immunology

authors： Pont F,Familiades J,Déjean S,Fruchon S,Cendron D,Poupot M,Poupot R,L'faqihi-Olive F,Prade N,Ycart B,Fournié JJ

更新日期：2012-01-01 00:00:00

abstract：:Interleukin-HP1 (HP1) is a murine T cell-derived lymphokine, originally described as a growth factor for B cell hybridomas and plasmacytomas, that was recently shown to stimulate growth and differentiation of normal B and T lymphocytes. Here, we describe a cDNA for HP1 that was isolated from a library prepared using m...

journal_title：European journal of immunology

authors： Van Snick J,Cayphas S,Szikora JP,Renauld JC,Van Roost E,Boon T,Simpson RJ

更新日期：1988-02-01 00:00:00

abstract：:Mercury-induced autoimmune glomerulonephritis in the Brown-Norway (BN) rat is characterized by the successive appearance of linear and granular glomerular IgG deposits. Anti-laminin autoantibodies represent the major part of the anti-glomerular basement membrane (GBM) antibodies produced in this model. Fusions were pe...

journal_title：European journal of immunology

authors： Guéry JC,Druet E,Glotz D,Hirsch F,Mandet C,De Heer E,Druet P

更新日期：1990-01-01 00:00:00

abstract：:C1q, a subcomponent of C1--the first component of complement, is synthesized by macrophages (M phi). Immunofluorescence and immunoperoxidase studies first indicated the presence of C1q on the surface of guinea pig (gp) and human peritoneal M phi (Loos, M., Storz, R., Müller, W. and Lemmel, E. M., Immunobiology 1981. 1...

journal_title：European journal of immunology

authors： Kaul M,Loos M

更新日期：1993-09-01 00:00:00

abstract：:Carbon monoxide (CO) treatment improves pathogenic outcome of autoimmune diseases by promoting tolerance. However, the mechanism behind this protective tolerance is not yet defined. Here, we show in a transgenic mouse model for autoimmune diabetes that ex vivo gaseous CO (gCO)-treated DCs loaded with pancreatic β-cell...

journal_title：European journal of immunology

authors： Simon T,Pogu S,Tardif V,Rigaud K,Rémy S,Piaggio E,Bach JM,Anegon I,Blancou P

更新日期：2013-01-01 00:00:00

abstract：:We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the alternative pathway (AP) of complement activation might play a role in retinal inflamma...

journal_title：European journal of immunology

authors： Chen M,Muckersie E,Luo C,Forrester JV,Xu H

更新日期：2010-10-01 00:00:00

abstract：:A gene-encoding ligand for deletion of T cells bearing TcRV beta 6 and V beta 8.1 cosegregates a new mammary tumor provirus locus, Mtv-50 in NC mice. The sequence of the open reading frame (ORF) in the 3' long terminal repeat (LTR) of Mtv-50 was strikingly similar to those of Mtv-7, Mtv-43 and exogenous mouse mammary ...

journal_title：European journal of immunology

authors： Niimi N,Wajjwalku W,Ando Y,Tomida S,Takeuchi M,Ueda M,Kaneda T,Yoshikai Y

更新日期：1994-02-01 00:00:00

abstract：:At least two subsets of CD4+ T helper cell lymphocytes termed Th1 and Th2 exist in the mouse and probably in humans. They are characterized by the secretion of different lymphokines and by their functional behavior. Dysregulated expansion of one or the other subset may be one reason for the development of certain dise...

journal_title：European journal of immunology

authors： Germann T,Gately MK,Schoenhaut DS,Lohoff M,Mattner F,Fischer S,Jin SC,Schmitt E,Rüde E

更新日期：1993-08-01 00:00:00

abstract：:Mouse peritoneal macrophages were charged with IgG molecules in monomeric (mIgG), heat-aggregated (agIgG) or antigen-complexed (acIgG) form. Upon exposure to 37 degrees C, all bound IgG ligand types are redistributed on the cell surface due to the mobilization of their corresponding Fc receptor (FcR). The major findin...

journal_title：European journal of immunology

authors： Sulica A,Gherman M,Medeşan C,Gheţie V,Sjöquist J

更新日期：1979-12-01 00:00:00

abstract：:We show that IL-13 in the presence of TNF-alpha effected an equal or greater antiviral activity against a dual-tropic HIV-1 (R5X4) in macrophages. A temporary or continued exposure of macrophages to both cytokines significantly decreased the infection and replication of R5X4 HIV-1(89.6) (median, 128-fold, n = 9, p = 0...

journal_title：European journal of immunology

authors： Bailer RT,Lee B,Montaner LJ

更新日期：2000-05-01 00:00:00

abstract：:TCR- but not CD2-triggered IL-2 production is p56(lck) dependent. To test the hypothesis that p59(fyn), a second src-family protein tyrosine kinase (PTK) expressed in T lymphocytes, might be an essential upstream component of the CD2 signaling pathway, we generated human (h) CD2 transgenic (tg) fyn(+/+) and fyn(-/-) m...

journal_title：European journal of immunology

authors： Fukai I,Hussey RE,Sunder-Plassmann R,Reinherz EL

更新日期：2000-12-01 00:00:00

abstract：:Radiolabeled protein A from Staphylococcus aureus (SpA) injected i.v. into mice and rabbits forms a soluble [(IgG)2-(SpA)1]2 complex (Mr = 684 000) which is identical in composition to that formed by SpA in vitro with an equivalent amount or an excess of IgG. A soluble rabbit IgG-SpA complex injected into a mice or ra...

journal_title：European journal of immunology

authors： Dima S,Medeşan C,Moţa G,Moraru I,Sjöquist J,Gheţie V

更新日期：1983-08-01 00:00:00

abstract：:The IgG2a(b) heavy chain allopeptide determinant gamma2a(b) 436-451 (Kabat numbering) presented by the major histocompatibility complex (MHC) class II molecule I-Ad is recognized by T cells which cross-react with a corneal self antigen and with the UL6 protein of the herpes simplex virus which induce autoimmune kerati...

journal_title：European journal of immunology

authors： Bartnes K,Leon F,Briand JP,Travers PJ,Hannestad K

更新日期：1999-01-01 00:00:00

abstract：:The transcription factor c-Maf is critical for IL-4 production and the development of Th2 cells, which promote humoral immunity and protect against extracellular parasites. Yet, little else is known of c-Maf function in CD4 cells. Here, we identify a novel role for c-Maf in regulating susceptibility to apoptosis. Over...

journal_title：European journal of immunology

authors： Peng S,Lalani S,Leavenworth JW,Ho IC,Pauza ME

更新日期：2007-10-01 00:00:00

abstract：:The CD4+ T cell response is of critical importance in determining the fate of many viral infections. Clearance of HCV has a strong association with the MHC class II antigen HLA-DR11 suggesting a key role for CD4+ T cells. We used an epitope-prediction program to identify multiple novel HLA-DR11-restricted epitopes der...

journal_title：European journal of immunology

authors： Godkin A,Jeanguet N,Thursz M,Openshaw P,Thomas H

更新日期：2001-05-01 00:00:00

abstract：:The major histocompatibility complex (MHC)-encoded transporter associated with antigen processing (TAP) delivers cytosolic peptides to the lumen of the endoplasmic reticulum (ER) for presentation by MHC class I molecules. For the rat, it has been demonstrated that TAP polymorphism results in the selection of different...

journal_title：European journal of immunology

authors： Obst R,Armandola EA,Nijenhuis M,Momburg F,Hämmerling GJ

更新日期：1995-08-01 00:00:00

abstract：:Immunotherapies that augment antitumor T cells have had recent success for treating patients with cancer. Here we examined whether tumor-specific CD4(+) T cells enhance CD8(+) T-cell adoptive immunotherapy in a lymphopenic environment. Our model employed physiological doses of tyrosinase-related protein 1-specific CD4...

journal_title：European journal of immunology

authors： Church SE,Jensen SM,Antony PA,Restifo NP,Fox BA

更新日期：2014-01-01 00:00:00

abstract：:Defined tumor-associated antigens (TAA) are attractive targets for anti-tumor immunotherapy. Here, we describe a novel genome-wide approach to identify multiple TAA from any given tumor. A panel of transplantable thymomas was established from an inbred p53-/- mouse strain. The resulting tumors were examined for gene e...

journal_title：European journal of immunology

authors： Mathiassen S,Lauemøller SL,Ruhwald M,Claesson MH,Buus S

更新日期：2001-04-01 00:00:00

abstract：:Rabbit antibodies to Atlantic cod (Gadus morhua L.) immunoglobulin were affinity purified and used to screen cDNA libraries from spleen and head kidney mRNA. cDNA clones for both the secretory and membrane-bound heavy (H) chain were isolated, the nucleotide and deduced amino acid sequences of which are reported here. ...

journal_title：European journal of immunology

authors： Bengtén E,Leanderson T,Pilström L

更新日期：1991-12-01 00:00:00

abstract：:DNase II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. Macrophages in DNase II-deficient mice accumulate undigested DNA and constitutively produce IFN-beta as well as TNF-alpha. The IFN-beta causes severe anemia in the DNase II(-/-) embryos, which die...

journal_title：European journal of immunology

authors： Okabe Y,Kawane K,Nagata S

更新日期：2008-11-01 00:00:00

abstract：:IL-23, a proximal regulator of IL-17, may be a major driving force in the induction of autoimmune inflammation. We have used a model of subdiabetogenic treatment with multiple low doses of streptozotocin (MLD-STZ; 4 x 40 mg/kg body weight) in male C57BL/6 mice to study the effect of IL-23 on immune-mediated beta cell ...

journal_title：European journal of immunology

authors： Mensah-Brown EP,Shahin A,Al-Shamisi M,Wei X,Lukic ML

更新日期：2006-01-01 00:00:00

abstract：:Injection of M-1 (Cmu), G-1 (Cgamma) heterozygous chickens on the day of hatch with anti-IgM-1 antiserum induced allotype suppression from which chickens recovered over a period of approximately 4 months. The suppression of the serum IgM-1 levels was matched by a decrease in the number of splenic and peripheral blood ...

journal_title：European journal of immunology

authors： Ratcliffe MJ,Ivanyi J

更新日期：1981-04-01 00:00:00

abstract：:A cDNA coding for the human interleukin 1 receptor antagonist protein (IL 1Ra) was used to clone the corresponding murine cDNA. The nucleotide sequence of the open reading frame coding for the processed form of mIL 1Ra predicted a 152-residue protein that was 77% identical to human IL 1Ra. The cellular and tissue dist...

journal_title：European journal of immunology

authors： Shuck ME,Eessalu TE,Tracey DE,Bienkowski MJ

更新日期：1991-11-01 00:00:00

abstract：:The activation requirements for antigen-dependent proliferation of CD4+ T cells are well documented, while the events leading to the inactivation phase are poorly understood. Here, we tested the hypothesis that the lymphocyte-activation gene 3 (LAG-3), a second major histocompatibility complex (MHC) class II ligand, p...

journal_title：European journal of immunology

authors： Huard B,Tournier M,Hercend T,Triebel F,Faure F

更新日期：1994-12-01 00:00:00