Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes.

abstract：:Diacylglycerol kinases (DGKs) play important roles in restraining diacylglycerol (DAG)-mediated signaling. Within the DGK family, the ζ isoform appears to be the most important isoform in T cells for controlling their development and function. DGKζ has been demonstrated to regulate T cell maturation, activation, anerg...

journal_title：European journal of immunology

authors： Xie D,Zhang S,Chen P,Deng W,Pan Y,Xie J,Wang J,Liao B,Sleasman JW,Zhong XP

更新日期：2020-11-01 00:00:00

abstract：:The human IgG3 (b) allotype is associated with a high and the (g) allotype with a low mean serum level of IgG3 which is due to a low frequency of B cell switching in the latter. In the present study, we found a polymorphism in position -73 (C --> A), located in the 4th NF-kappaB site of the germ-line (GL) gamma3 promo...

journal_title：European journal of immunology

authors： Pan Q,Petit-Frére C,Hammarström L

更新日期：2000-08-01 00:00:00

abstract：:The number of patients with severe atopic dermatitis (AD) has been on the rise recently. We are therefore urgently in need of a treatment that can suppress Th2 cell-mediated responses in an Ag-specific fashion. Oligodeoxynucleotides (ODN)containing CpG motifs (CpG ODN) have been highlighted as immunomodulators that re...

journal_title：European journal of immunology

authors： Kootiratrakarn T,Fujimura T,Sano K,Okuyama R,Aiba S,Tagami H,Terui T

更新日期：2005-11-01 00:00:00

abstract：:We report here the identification and characterization of murine CCX-CKR, a high affinity receptor for the murine beta-chemokines SLC/mCCL21, MIP-3beta/mCCL19 and TECK/mCCL25. Unlike most other chemokine receptors, CCX-CKR is unable to mediate Ca(2+) fluxes upon ligand binding when expressed in HEK293 cells. Murine CC...

journal_title：European journal of immunology

authors： Townson JR,Nibbs RJ

更新日期：2002-05-01 00:00:00

abstract：:Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using...

journal_title：European journal of immunology

authors： Schlunck T,Schraut W,Riethmüller G,Ziegler-Heitbrock HW

更新日期：1990-09-01 00:00:00

abstract：:Recent experimental studies have greatly clarified the function of cell surface molecules in the induction and modulation of T cell responses by antigen-presenting cells (APC). However, the differences in ability to stimulate T cells evident for different types and subpopulations of the same APC, such as dendritic cel...

journal_title：European journal of immunology

authors： Brooke GP,Parsons KR,Howard CJ

更新日期：1998-01-01 00:00:00

abstract：:The inbred strain 13 guinea pig expresses at least three isotypes of immunoglobulin (Ig) lambda chain. The proportion of these isotypes in normal Ig can be estimated by isolating a constant (C) region cyanogen bromide peptide from lambda chains and quantitatively analyzing its component tryptic peptides. Anti-phenyltr...

journal_title：European journal of immunology

authors： Brunhouse RF,Cebra JJ

更新日期：1978-12-01 00:00:00

abstract：:Thyroglobulin-binding lymphoid cells were identified in the spleen of Obese strain (DS) chickens by their capacity to form rosettes with thyroglobulin-coated chicken red blood cells. The nature of these cells was studied in inhibition experiments using turkey anti-chicken bursa or thymus cell sera and rabbit antisera ...

journal_title：European journal of immunology

authors： Richter E,Wick G,Schauenstein K

更新日期：1975-08-01 00:00:00

abstract：:Natural killer (NK) cells play an important role in early defense against viral infection. The cytotoxic activity of NK cells is increased by interferon-alpha/beta (IFN-alpha/beta), produced en masse in virally infected cells. However, the mechanism(s) by which IFN-alpha/beta contribute to the NK-cell-mediated antivir...

journal_title：European journal of immunology

authors： Sato K,Hida S,Takayanagi H,Yokochi T,Kayagaki N,Takeda K,Yagita H,Okumura K,Tanaka N,Taniguchi T,Ogasawara K

更新日期：2001-11-01 00:00:00

abstract：:The killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed by memory T cells and NK cells in man and mice. It is frequently used as a cell differentiation marker and members of the cadherin family are ligands for KLRG1. The present study provides new insights into the interaction of mouse KLRG...

journal_title：European journal of immunology

authors： Rosshart S,Hofmann M,Schweier O,Pfaff AK,Yoshimoto K,Takeuchi T,Molnar E,Schamel WW,Pircher H

更新日期：2008-12-01 00:00:00

abstract：:We have investigated perforin and granzyme B expression in graft-infiltrating lymphocytes of patients who underwent heart transplantation. Those proteins are commonly present in the cytoplasmic granules of cytotoxic T lymphocytes and are released upon effector-target cell interaction. From 28 patients 103 endomyocardi...

journal_title：European journal of immunology

authors： Legros-Maïda S,Soulié A,Benvenuti C,Wargnier A,Vallée N,Berthou C,Guillet J,Sasportes M,Sigaux N

更新日期：1994-01-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (ALCAM; CD166) is a member of the immunoglobulin gene superfamily (IgSF) which is expressed by activated leukocytes and thymic epithelial cells and is a ligand for the lymphocyte antigen CD6. Herein, we report on the isolation and characterization of cDNA clones encoding mous...

journal_title：European journal of immunology

authors： Bowen MA,Bajorath J,D'Egidio M,Whitney GS,Palmer D,Kobarg J,Starling GC,Siadak AW,Aruffo A

更新日期：1997-06-01 00:00:00

abstract：:Patients undergoing allogeneic bone marrow transplantation offer a unique system to analyze NK cell development in vivo. We analyzed NK cells from 23 such patients to assess the acquisition of activating receptors. Four patients displayed an immature NK cell surface phenotype at engraftment, as their cells were CD16(-...

journal_title：European journal of immunology

authors： Vitale C,Chiossone L,Morreale G,Lanino E,Cottalasso F,Moretti S,Dini G,Moretta L,Mingari MC

更新日期：2004-02-01 00:00:00

abstract：:The adoptive transfer of CD4(+)CD25(+) natural regulatory T cells (Treg) is a promising strategy for the treatment of autoimmune diseases and the prevention of alloresponses after transplantation. Clinical trials exploring this strategy require efficient in vitro expansion of this rare cell population. Protocols devel...

journal_title：European journal of immunology

authors： Hoffmann P,Boeld TJ,Eder R,Huehn J,Floess S,Wieczorek G,Olek S,Dietmaier W,Andreesen R,Edinger M

更新日期：2009-04-01 00:00:00

abstract：:Ikaros is a transcriptional regulator whose function is essential for B cell development. It is expressed in the hematopoietic stem cell (HSC) through the mature B cell stage. Using genetically engineered mice in which the endogenous Ikaros gene is disrupted, it has been shown that a lack of Ikaros leads to a block in...

journal_title：European journal of immunology

authors： Wojcik H,Griffiths E,Staggs S,Hagman J,Winandy S

更新日期：2007-04-01 00:00:00

abstract：:To understand further the roles that negative regulatory signals may play in B cell immune responses, we compared three inhibitors of B cell proliferation: cross-linking CD19 with monoclonal antibody (mAb), signaling through Fc receptors by intact anti-mu mAb, and transforming growth factor-beta (TGF-beta). Each agent...

journal_title：European journal of immunology

authors： Barrett TB,Shu GL,Draves KE,Pezzutto A,Clark EA

更新日期：1990-05-01 00:00:00

abstract：:F liver protein occurs in serum at low concentration, and therefore induces tolerance of self only in T cells. T cells which mature in cultured thymus lobes in the absence of this protein become reactive towards it but can be prevented from doing so by exposure to the protein while in culture. The threshold of toleran...

journal_title：European journal of immunology

authors： Robertson K,Simon K,Schneider S,Timms E,Mitchison A

更新日期：1992-01-01 00:00:00

abstract：:The pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) have been shown to be primary mediators in the pathogenesis of chronic inflammatory joint diseases. However, the relative contributions of these molecules to the development and progression of disease is not known. In the present study...

journal_title：European journal of immunology

authors： Probert L,Plows D,Kontogeorgos G,Kollias G

更新日期：1995-06-01 00:00:00

abstract：:Dendritic cells (DC) were cultured from mouse bone marrow (BM) progenitors in low concentrations of granulocyte-macrophage colony-stimulating factor (GM-CSF) (GM(lo) DC) by two different protocols. The phenotype and functional properties of these GM(lo) DC were compared to those of standard BM-DC cultures generated in...

journal_title：European journal of immunology

authors： Lutz MB,Suri RM,Niimi M,Ogilvie AL,Kukutsch NA,Rössner S,Schuler G,Austyn JM

更新日期：2000-07-01 00:00:00

abstract：:In the present study, we sought evidence for a surface nucleosome receptor in the fibroblastic cell line CV-1, and questioned whether anti-double-stranded (ds) DNA and/or anti-histone autoantibodies could recognize and influence the fate of cell surface-bound nucleosomes. 125I-labeled mononucleosomes were shown to bin...

journal_title：European journal of immunology

authors： Koutouzov S,Cabrespines A,Amoura Z,Chabre H,Lotton C,Bach JF

更新日期：1996-02-01 00:00:00

abstract：:IL-12 is an important immunomodulatory cytokine that induces tyrosine phosphorylation and activation of the signal transducer and activator of transcription (STAT)4. IL-12 induces sustained activation and nuclear translocation of STAT4 and this regulatory process is coupled to both tyrosine and serine phosphorylation ...

journal_title：European journal of immunology

authors： Athié-M V,Flotow H,Hilyard KL,Cantrell DA

更新日期：2000-05-01 00:00:00

abstract：:Anti-immunoglobulin antibodies (anti-Ig) provoke the rapid breakdown of phosphatidylinositol bisphosphate (PIP2), elevation of cytoplasmic Ca2+ levels ([Ca2+]i) and activation of protein kinase C (PKC) in B lymphocytes. Tumor-promoting phorbol esters, like phorbol myristate acetate, also activate PKC, but inhibit anti...

journal_title：European journal of immunology

authors： Bijsterbosch MK,Klaus GG

更新日期：1987-01-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal hematopoietic stem-cell malignancy characterized by the presence of the chimeric BCR-ABL oncoprotein with deregulated tyrosine-kinase (TK) activity. Although conventional T cells are acknowledged as important players in the control of CML, a possible modification of invariant...

journal_title：European journal of immunology

authors： Rossignol A,Levescot A,Jacomet F,Robin A,Basbous S,Giraud C,Roy L,Guilhot F,Turhan AG,Barra A,Herbelin A,Gombert JM

更新日期：2012-07-01 00:00:00

abstract：:The binding of antigen to the multicomponent T cell antigen receptor (TcR)-CD3 complex leads to the activation of several signal transduction pathways which result in T lymphocyte proliferation and lymphokine secretion by molecular mechanisms and catalytic molecules as yet poorly defined. One of the earliest events th...

journal_title：European journal of immunology

authors： Gassmann M,Guttinger M,Amrein KE,Burn P

更新日期：1992-01-01 00:00:00

abstract：:Ia. W39 is a B cell differentiation antigen whose membrane expression is controlled by the xid gene. In this report we show that, analogous to its B cell expression, Ia. W39 is also present on a subset of Ia+ macrophages, indicating heterogeneity within that cell population. The Ir gene(s) for the antigenic determinan...

journal_title：European journal of immunology

authors： Huber BT,Rosenwasser LJ

更新日期：1982-01-01 00:00:00

abstract：:Normal BALB/c spleen cells incubated for 2 days with Streptococcus pneumoniae R 36 a (Pn) vaccine in vitro acquired the specific ability to inhibit the T-independent anti-Pn response of fresh lymphocytes. The activated suppressor cells were susceptible to cytotoxic treatment with mouse anti-theta serum plus complement...

journal_title：European journal of immunology

authors： Cerny J,Caulfield MJ,Siat M

更新日期：1980-09-01 00:00:00

abstract：:In this study, we have analyzed the in vivo dynamics of the interaction between polyclonal Foxp3(+) Treg cells, effector T (Teff) cells, and DCs in order to further our understanding of the mechanisms of Treg cell-mediated suppression. Cotransfer of polyclonal activated Treg cells into healthy mice attenuated the ind...

journal_title：European journal of immunology

authors： Davidson TS,Shevach EM

更新日期：2011-10-01 00:00:00

abstract：:Osteopontin (OPN) and CD44 have been implicated in the development of autoimmune diseases, including arthritis and multiple sclerosis, as well as chronic inflammatory diseases, such as atherosclerosis and colitis. To investigate their roles in autoimmune myocarditis induced by immunization with heart alpha-myosin (MyH...

journal_title：European journal of immunology

authors： Abel B,Kurrer M,Shamshiev A,Marty RR,Eriksson U,Günthert U,Kopf M

更新日期：2006-02-01 00:00:00

abstract：:A large panel of T cell clones (TCC) specific for the recombinant form of Poa pratensis allergen (rKBG7.2 or Poa p9) were established from the peripheral blood of grass pollen-sensitive donor in the absence or presence of recombinant interferon-alpha (IFN-alpha) in bulk culture and their pattern of cytokine secretion,...

journal_title：European journal of immunology

authors： Parronchi P,Mohapatra S,Sampognaro S,Giannarini L,Wahn U,Chong P,Mohapatra S,Maggi E,Renz H,Romagnani S

更新日期：1996-03-01 00:00:00

abstract：:T cell recognition of self antigens is a key event in the pathogenesis of autoimmune diseases. To date, the initial events that trigger autoreactive T cells are unknown. The "molecular mimicry" hypothesis predicts that during an infection T cells that recognize both a microbial antigen and a related self peptide becom...

journal_title：European journal of immunology

authors： Maier B,Molinger M,Cope AP,Fugger L,Schneider-Mergener J,Sønderstrup G,Kamradt T,Kramer A

更新日期：2000-02-01 00:00:00