cDNA cloning of murine interleukin-HP1: homology with human interleukin 6.

abstract：:Regulatory T cells (Treg) are vital in maintaining the homeostasis of immune reactions. In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity. Thus, we performed in vivo studies using TLR2-/- mice infected with Schistosoma mansoni an...

journal_title：European journal of immunology

authors： Layland LE,Rad R,Wagner H,da Costa CU

更新日期：2007-08-01 00:00:00

abstract：:Multi-component glycopeptide libraries and single glycopeptides were used for immunization of mice with the aim of inducing strong T helper cell responses to the repetitive sequence of MUC1 expressed by human tumor cells. The glycopeptides and glycopeptide libraries were modeled upon the native human MUC1 amino acid v...

journal_title：European journal of immunology

authors： Gad M,Jensen T,Gagne R,Komba S,Daugaard S,Kroman N,Meldal M,Werdelin O

更新日期：2003-06-01 00:00:00

abstract：:Antigen-free (AGF) and germ-free (GF) mice, although essentially free of serum IgG, maintain normal levels of circulating IgM. Using a quantitative immunoblot assay, we have now analyzed the repertoire of serum IgM from AGF, GF, and specific pathogen-free (SPF) BALB/c mice, on large panels of natural antigens from hom...

journal_title：European journal of immunology

authors： Haury M,Sundblad A,Grandien A,Barreau C,Coutinho A,Nobrega A

更新日期：1997-06-01 00:00:00

abstract：:Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...

journal_title：European journal of immunology

authors： Werner-Favre C,Bovia F,Schneider P,Holler N,Barnet M,Kindler V,Tschopp J,Zubler RH

更新日期：2001-01-01 00:00:00

abstract：:Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains elusive. By using accurate mass spectrometry and multi-epitope ligand cartography (MELC) we character...

journal_title：European journal of immunology

authors： van Ham M,Teich R,Philipsen L,Niemz J,Amsberg N,Wissing J,Nimtz M,Gröbe L,Kliche S,Thiel N,Klawonn F,Hubo M,Jonuleit H,Reichardt P,Müller AJ,Huehn J,Jänsch L

更新日期：2017-12-01 00:00:00

abstract：:We studied the capacity of human factor H to promote the secretion of a lymphocyte-activating factor (LAF) by human monocytes cultured under serum-free conditions. Presence of LAF in the culture supernatants was assessed with the mouse thymocyte assay. Highly purified factor H alone had no effect on thymocyte prolifer...

journal_title：European journal of immunology

authors： Iferroudjene D,Schouft MT,Lemercier C,Gilbert D,Fontaine M

更新日期：1991-04-01 00:00:00

abstract：:Cells from the monoclonal B cell lymphoma I.29 expressing surface IgM (mu +) are capable of differentiating in vitro to IgM secretion and of switching to IgA or IgE production in response to lipopolysaccharide (LPS) stimulation. To determine whether a single mu + B cell is capable of undertaking both differentiative p...

journal_title：European journal of immunology

authors： Alberini C,Biassoni R,DeAmbrosis S,Vismara D,Sitia R

更新日期：1987-04-01 00:00:00

abstract：:Vgamma9/Vdelta2+ T cells specifically recognize Mycobacterium tuberculosis in vitro and are precociously recruited in early mycobacterial lesions. Even if gammadelta T cells are only fortuitously detected in granulomas or bronchoalveolar lavages of patients with active pulmonary tuberculosis, a role in shaping the mat...

journal_title：European journal of immunology

authors： Manfredi AA,Heltai S,Rovere P,Sciorati C,Paolucci C,Galati G,Rugarli C,Vaiani R,Clementi E,Ferrarini M

更新日期：1998-06-01 00:00:00

abstract：:DC-based vaccination against Leishmania major induces a parasite-specific Th1 response and long-lasting protective immunity in susceptible mice. Since distinct DC subsets have been proposed to direct the predominant development of either Th1 or Th2 cells, we analyzed the capability of plasmacytoid DC (pDC) to induce p...

journal_title：European journal of immunology

authors： Remer KA,Apetrei C,Schwarz T,Linden C,Moll H

更新日期：2007-09-01 00:00:00

abstract：:Thymic nurse cells, cortical epithelial cells enclosing 20-200 lymphocytes, were prepared from mouse thymus by enzyme digestion and repetitive sedimentation. Individual nurse cells were then isolated free of any exogenous thymocytes by micromanipulation, and the endogeneous thymocytes released from inside the nurse ce...

journal_title：European journal of immunology

authors： Andrews P,Boyd RL,Shortman K

更新日期：1985-10-01 00:00:00

abstract：:Injection of incomplete Freund's adjuvant (IFA) into the footpads of BALB/c mice induced an acute inflammation. Draining popliteal lymph nodes showed major histocompatibility complex (MHC) class II-restricted proliferation when challenged in vitro with recombinant Mycobacterium bovis 65-kDa heat shock protein (hsp65)....

journal_title：European journal of immunology

authors： Anderton SM,van der Zee R,Goodacre JA

更新日期：1993-01-01 00:00:00

abstract：:Human tonsils contain B cells capable of spontaneous and high-rate immunoglobulin (Ig) secretion in vitro. These cells are in vivo induced mature B cells, and, as such, they provide and adequate model for studying tonsil B cell differentiation. The present report analyzes the effect of a variety of factors on purified...

journal_title：European journal of immunology

authors： Rodríguez C,Roldán E,Navas G,Brieva JA

更新日期：1993-05-01 00:00:00

abstract：:Immune enhancement is desirable in situations where decreased immunity results in increased morbidity. We investigated whether blocking the surface inhibitory receptor PD-1 and/or p38 MAP kinase could enhance the proliferation of the effector memory CD8(+) T-cell subset that re-expresses CD45RA (EMRA) and exhibits cha...

journal_title：European journal of immunology

authors： Henson SM,Macaulay R,Riddell NE,Nunn CJ,Akbar AN

更新日期：2015-05-01 00:00:00

abstract：:Antigen stimulation induces specific CD4 T cells to change from a resting phenotype (CD45RC+) to a "memory" phenotype (CD45RC-), an isoform switch that is reversible and regulated by persisting antigen. We show here that CD4 T cells responsible for mediating allograft rejection undergo a similar CD45RC+ to CD45RC- swi...

journal_title：European journal of immunology

authors： Yang CP,Bell EB

更新日期：1999-07-01 00:00:00

abstract：:The recently discovered B6.C-H-2bm12 (bm12) histocompatibility mutant bears a mutation of the I-A subregion of the H-2b haplotype. We have studied cytotoxic T lymphocytes (CTL) generated in secondary mixed lymphocyte culture (MLC) between the bm12 mutant and the strain of origin C57BL/6 (B6). In both directions, stron...

journal_title：European journal of immunology

authors： de Waal LP,Melief CJ,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:T cell receptor (TCR) genes are initially activated in hematopoietic stem cells that have been committed to the T cell lineage during ontogeny. We have established cell lines derived from hematopoietic organs which express truncated TCR delta mRNA (1.3 kbp). In this study, cDNA clones of this mRNA were analyzed to cha...

journal_title：European journal of immunology

authors： Shimamura M,Ohta S

更新日期：1995-06-01 00:00:00

abstract：:Anti-immunoglobulin antibodies (anti-Ig) provoke the rapid breakdown of phosphatidylinositol bisphosphate (PIP2), elevation of cytoplasmic Ca2+ levels ([Ca2+]i) and activation of protein kinase C (PKC) in B lymphocytes. Tumor-promoting phorbol esters, like phorbol myristate acetate, also activate PKC, but inhibit anti...

journal_title：European journal of immunology

authors： Bijsterbosch MK,Klaus GG

更新日期：1987-01-01 00:00:00

abstract：:An expanding spectrum of acute and chronic non-infectious inflammatory diseases is uniquely responsive to IL-1β neutralization. IL-1β-mediated diseases are often called "auto-inflammatory" and the dominant finding is the release of the active form of IL-1β driven by endogenous molecules acting on the monocyte/macropha...

journal_title：European journal of immunology

authors： Dinarello CA

更新日期：2011-05-01 00:00:00

abstract：:Cells present in the polyoma virus-induced murine ascites tumor SEYF-a showed the capacity to fix soluble immune complexes of ovalbumin anti-ovalbumin. The fixation could be inhibited by preincubating the cells with antisera directed against H-2 antigens and with syngeneic anti-tumor antibodies. The latter did not rea...

journal_title：European journal of immunology

authors： Braslawsky GR,Serban D,Witz IP

更新日期：1976-08-01 00:00:00

abstract：:Colony-stimulating factors are required for survival proliferation, differentiation and functional activation of granulocytes, macrophages and their precursor cells. In the present report, however, we demonstrate antiproliferative activity of recombinant human (rh) granulocyte-macrophage colony-stimulating factor (GM-...

journal_title：European journal of immunology

authors： Lindemann A,Riedel D,Oster W,Mertelsmann R,Herrmann F

更新日期：1988-03-01 00:00:00

abstract：:Chemokine receptor CXCR6 mediates the chemotaxis and adhesion of leukocytes to soluble and membrane-anchored forms of CXCL16, and is an HIV-1 co-receptor. Here, we describe the effects of mutation of acidic extracellular CXCR6 residues on receptor function. Although most CXCR6 mutants examined were expressed at levels...

journal_title：European journal of immunology

authors： Petit SJ,Chayen NE,Pease JE

更新日期：2008-08-01 00:00:00

abstract：:A small dose of the IgG1 fraction of anti-idiotypic antibody (aId1) raised in guinea pigs against a strain A/J antibody specific for streptococcal Group A carbohydrate sensitizes A/J mice against Group A streptococci. This is opposed to the previously established suppressive function of anti-idiotypic antibody of the ...

journal_title：European journal of immunology

authors： Eichmann K,Rajewsky K

更新日期：1975-10-01 00:00:00

abstract：:Two cloned murine helper T lymphocyte (HTL) lines were used to investigate the immunoregulatory properties of highly purified interleukin 2 (IL2). The clone, designated J6.19, secretes lymphokines, including IL2, and proliferates when stimulated with ovalbumin in the presence of I-Ak-bearing spleen cells, while the al...

journal_title：European journal of immunology

authors： Otten G,Wilde DB,Prystowsky MB,Olshan JS,Rabin H,Henderson LE,Fitch FW

更新日期：1986-03-01 00:00:00

abstract：:In the lung, dendritic cells (DC) are key antigen-presenting cells capable of triggering specific cellular responses to inhaled pathogens, and thus, they may be important in the initiation of an early response to mycobacterial infections. The ability of DC to enhance antigen presentation to naive T cells within the lu...

journal_title：European journal of immunology

authors： Demangel C,Bean AG,Martin E,Feng CG,Kamath AT,Britton WJ

更新日期：1999-06-01 00:00:00

abstract：:Twenty-seven B cell hybridomas derived from spleen cells of nonimmunized, 6-day-old BALB/c mice and previously characterized serologically were screened for VH-gene expression: hybridomas expressing the two most D-proximal VH-gene families, 7183 and QUPC 52 were over-represented in this sample. Strikingly, clones sero...

journal_title：European journal of immunology

authors： Holmberg D

更新日期：1987-03-01 00:00:00

abstract：:The binding of antigen to the multicomponent T cell antigen receptor (TcR)-CD3 complex leads to the activation of several signal transduction pathways which result in T lymphocyte proliferation and lymphokine secretion by molecular mechanisms and catalytic molecules as yet poorly defined. One of the earliest events th...

journal_title：European journal of immunology

authors： Gassmann M,Guttinger M,Amrein KE,Burn P

更新日期：1992-01-01 00:00:00

abstract：:Th1 and Th2 cells, which produce distinct sets of cytokines, differentially express several chemokine receptors that may regulate their tissue-specific localization. Although the expression pattern and regulation of chemokines are likely to play a critical role in many immunopathological processes, they remain largely...

journal_title：European journal of immunology

authors： Iellem A,Colantonio L,Bhakta S,Sozzani S,Mantovani A,Sinigaglia F,D'Ambrosio D

更新日期：2000-04-01 00:00:00

abstract：:The DC-derived chemokine CCL17, a ligand of CCR4, has been shown to promote various inflammatory diseases such as atopic dermatitis, atherosclerosis, and inflammatory bowel disease. Under steady-state conditions, and even after systemic stimulation with LPS, CCL17 is not expressed in resident splenic DCs as opposed to...

journal_title：European journal of immunology

authors： Globisch T,Steiner N,Fülle L,Lukacs-Kornek V,Degrandi D,Dresing P,Alferink J,Lang R,Pfeffer K,Beyer M,Weighardt H,Kurts C,Ulas T,Schultze JL,Förster I

更新日期：2014-02-01 00:00:00

abstract：:Activation-induced deaminase (AID) is the master regulator of class switch recombination (CSR) and somatic hypermutation (SHM), but the mechanisms regulating AID function are obscure. The differential pattern of switch plasmid activity in three IgM(+)/AID(+) and two IgG(+)/AID(+) B cell lines prompted an analysis of g...

journal_title：European journal of immunology

authors： Bhattacharya P,Grigera F,Rogozin IB,McCarty T,Morse HC 3rd,Kenter AL

更新日期：2008-01-01 00:00:00

abstract：:Recent studies have suggested that T cell memory for recall antigens resides in clones of primed T cells with a short inter-mitotic half-life. In humans such cells express an isoform of the leukocyte common antigen termed CD45RO. Nevertheless, little is known of the fate of these primed T cells after initial activatio...

journal_title：European journal of immunology

authors： Salmon M,Pilling D,Borthwick NJ,Viner N,Janossy G,Bacon PA,Akbar AN

更新日期：1994-04-01 00:00:00