Abstract:
:A small dose of the IgG1 fraction of anti-idiotypic antibody (aId1) raised in guinea pigs against a strain A/J antibody specific for streptococcal Group A carbohydrate sensitizes A/J mice against Group A streptococci. This is opposed to the previously established suppressive function of anti-idiotypic antibody of the IgG2 class (aId2). Correspondingly, aId1 but not aId2 is eliminated from the circulation in the way typical of an immunogenic molecule. However, the stimulatory component in the IgG1 fraction is not necessarily itself IgG1 antibody. Sensitization occurs in both B and helper T lymphocytes and is specific for Group A streptococci. In the B cell compartment sensitization is restricted to precursor cells expressing the idiotype. The concomitant activation of T helper cells therefore suggests that these cells make use of receptors with a similar or identical idiotype. Efficient sensitization by aId1 of both T and B cells is also demonstrated in strain C57L/J mice which upon immunization with Group A streptococci express a partially cross-reacting idiotype as a minor component. When such animals were primed with aId1, essentially all of the anti-carbohydrate antibody carried the partially cross-reacting idiotype.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Eichmann K,Rajewsky Kdoi
10.1002/eji.1830051002keywords:
subject
Has Abstractpub_date
1975-10-01 00:00:00pages
661-6issue
10eissn
0014-2980issn
1521-4141journal_volume
5pub_type
杂志文章abstract::Rabbit kappa light (L) chain allotypes are controlled by the allelic genes b4, b5, b6, b9 and a recently described allele b4v. The product of the b4v gene differs from that of b4 by at least two amino acid substitutions in the constant region. A serologic distinction between the b4 and b4v allotyes has now been detect...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830090107
更新日期:1979-01-01 00:00:00
abstract::In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional cytokeleton. We show that CD82 signaling induces long-lasting adhesion, spreading and development of membrane extensions, involving actin polymerization. Addition of various co-stimuli (phorbol ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199812)28:12<4332::AID-IMM
更新日期:1998-12-01 00:00:00
abstract::Chemokines are proinflammatory mediators that regulate leukocyte trafficking at different steps of the leukocyte recruitment cascade. Studies using new imaging approaches and new mouse models are giving new insights into the role of chemokines in neutrophil migration at sites of inflammation. Conventional rolling and ...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201142231
更新日期:2012-02-01 00:00:00
abstract::We have investigated perforin and granzyme B expression in graft-infiltrating lymphocytes of patients who underwent heart transplantation. Those proteins are commonly present in the cytoplasmic granules of cytotoxic T lymphocytes and are released upon effector-target cell interaction. From 28 patients 103 endomyocardi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830240136
更新日期:1994-01-01 00:00:00
abstract::Human interdigitating dendritic cells (IDC) were isolated from tonsils based on their CD40+ lineage-negative expression in situ. Isolated IDC displayed a phenotypic profile similar to that of IDC in tonsils and spleen in situ, characterized by high-level expression of major histocompatibility complex class II, the co-...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270531
更新日期:1997-05-01 00:00:00
abstract::cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270327
更新日期:1997-03-01 00:00:00
abstract::Lipoproteins or lipopeptides (LP) are bacterial cell wall components detected by the innate immune system. For LP, it has been shown that TLR2 is the essential receptor in cellular activation. However, molecular mechanisms of LP recognition are not yet clear. We used a FLAG-labeled derivative of the synthetic lipopept...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425336
更新日期:2005-03-01 00:00:00
abstract::The MHC class Ib molecule H2-M3 presents N-formylated peptides from the N terminus of proteins encoded by the mitochondrial genome to CTL. A panel of CTL specific for a peptide derived from a mitochondrial protein, either COI or ND1, was used to determine the optimal peptide length for sensitizing antigen-deficient ta...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199811)28:11<3773::AID-IMM
更新日期:1998-11-01 00:00:00
abstract::Changes in the epigenetic landscape of immune cells are a crucial component of gene activation during the induction of inflammatory responses, therefore it has been hypothesized that epigenetic modulation could be employed to restore homeostasis in inflammatory scenarios. Fungal pathogens cause a large burden of morbi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201848081
更新日期:2019-11-01 00:00:00
abstract::Cure of leishmaniasis requires a type 1 immune response characterized by IFN-gamma production. Leishmania major infection leads to a type 2 response suppressing cure of susceptible BALB/c mice, and L. major causes an exacerbated type 2 response in mouse strains with a gene knockout (KO) such that they lack IL-12p40 (I...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200212)32:12<3556::AID-IMMU3556>
更新日期:2002-12-01 00:00:00
abstract::Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays an important role in regulating the local inflammatory immune response, but regulatory mechanisms of this cytokine have not been fully elucidated. Here, we demonstrate that IL-10 deficiency renders LPS treatment ineffective in regulating the expression...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141733
更新日期:2012-06-01 00:00:00
abstract::T cell stimulation of B cell proliferation during T-B collaboration requires membrane-bound stimulatory ligands, such as CD40 ligand and the secretion of soluble cytokines, such as IL-4. Nevertheless, it remains unclear whether T cell contact is required to provoke each consecutive B cell division, or whether B cells ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200104)31:4<1150::aid-immu1150>3
更新日期:2001-04-01 00:00:00
abstract::The functional half-life, a measure of the persistence of lymphocytes in an antigen-free environment, has been estimated and found to be about 7 days for virgin 2,4,6-trinitrophenyl (TNP)-reactive mouse B cells, and 2--3 times longer for TNP-primed B cells. Using allotype-congenic mice, lymph node cells were transferr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830060908
更新日期:1976-09-01 00:00:00
abstract::Macrophages provide a first line of defense against bacterial infection by engulfing and killing invading bacteria, but intracellular bacteria such as Listeria monocytogenes (LM) can survive in macrophages by various mechanisms of evasion. Complement receptor of the immunoglobulin (CRIg), a C3b receptor, binds to C3b ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201242997
更新日期:2013-03-01 00:00:00
abstract::Naïve phenotype (NP) T cells spontaneously initiate homeostatic proliferation (HP) as T-cell output is reduced because of physiologic thymic involution with age. However, the effects of sustained HP on overall immune function are poorly understood. We demonstrated that the NP CD8+ T cell population in adult thymectomi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747431
更新日期:2018-10-01 00:00:00
abstract::Transgenic mice in which mouse interleukin (IL)-7 cDNA is expressed under the control of the mouse major histocompatibility complex (MHC) class II (E alpha) promoter develop a lymphoproliferative disease characterized by the early polyclonal expansion of T cells followed in many cases by the development of lymphomas o...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260105
更新日期:1996-01-01 00:00:00
abstract::The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210518
更新日期:1991-05-01 00:00:00
abstract::IL-18 is involved in the pathogenesis of atopic dermatitis, psoriasis, and allergic contact dermatitis. CXCL9, CXCL10, and CXCL11 recruit type 1 T cells, and the production of these chemokines by keratinocytes is enhanced in these dermatoses. We examined the in vitro effects of IL-18 on IFN-gamma-induced CXCL9, CXCL10...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636420
更新日期:2007-02-01 00:00:00
abstract::To determine the molecular mechanisms of T cell stimulation by staphylococcal enterotoxin A (SEA), we examined the expression of T cell receptor (TcR) V beta on the T cells from four strains of mice stimulated in vitro with SEA, using flow cytometric analysis for the number of T cells bearing V beta 3, V beta 6, V bet...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200323
更新日期:1990-03-01 00:00:00
abstract::Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimul...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210816
更新日期:1991-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260722
更新日期:1996-07-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830161020
更新日期:1986-10-01 00:00:00
abstract::The murine T cell response to heterologous insulins provides a good model system for studying the mechanism of immune response (Ir)-gene function, since insulin is a small, chemically well-defined molecule. H-2b mice respond predominantly to A chain loop determinants of beef insulin, presented by the I-A epitope Ia. W...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830141208
更新日期:1984-12-01 00:00:00
abstract::Bacterial antigens recognized by CD8(+) T cells in the context of MHC class I are thought to play a crucial role in protection against pathogenic intracellular bacteria. Here, we demonstrate the induction of HLA-A*0201-restricted CD8(+) T cell responses against six new high-affinity HLA-A*0201-binding CTL epitopes, en...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200112)31:12<3602::aid-immu3602>
更新日期:2001-12-01 00:00:00
abstract::It has long been recognized that T cells in the cerebrospinal fluid (CSF) and other inflammatory compartments cannot be stimulated by mitogen and the reason for this has remained unknown. This question was investigated using mononuclear cells (MNC) isolated from the CSF of subjects with multiple sclerosis and other in...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191005
更新日期:1989-10-01 00:00:00
abstract::In order to characterize the murine anti-human xenogeneic mixed lymphocyte reactions (MLR), we studied T cell proliferative responses against various human lymphoid cells by immunization of mice either with cellular or purified HLA-DR antigens. Data presented here indicated that small amounts of soluble HLA-DR antigen...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830171103
更新日期:1987-11-01 00:00:00
abstract::The T cell receptor is a molecular complex compriSed of a clonally-restricted heterodimer (Ti) responsible for specific antigen recognition and a set of invariant CD3 peptides termed gamma, delta, epsilon, zeta and eta. The latter are believed to be involved in transmembrane signaling events given that monoclonal anti...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190525
更新日期:1989-05-01 00:00:00
abstract::CD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high-level expression of FOXP3 (FOXP3high) is sufficient to confer suppressive activity to normal non-Treg. Here, we showed for the first time that vascular...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200939887
更新日期:2010-01-01 00:00:00
abstract::Mice carrying the H-2b and H-2s haplotypes are genetically nonresponsive to hen egg-white lysozyme (HEL). Analysis of the anti-HEL response patterns of F1, F2 and backcross progeny showed that responsiveness was dominant and H-2 linked. From plaque-forming cell and serum assays in intra-H-2 recombinant mice, it was es...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830100513
更新日期:1980-05-01 00:00:00
abstract::We identified the presence in the Aleutian skate, Bathyraja aleutica, of two classes of immunoglobulins (Ig), a high molecular weight Ig analogous to mammalian IgM and a low molecular weight Ig, similarly to the spiny rasp skate, Raja kenojei, (Kobayashi, K. et al., Mol. Immunol. 1984. 21: 397), using an immunological...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150916
更新日期:1985-09-01 00:00:00