Abstract:
:cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per haploid genome. A unique feature of the Xenopus TCRB constant region is the lack of N-linked carbohydrate glycosylation sites. The recombination signal sequences suggest that the mechanism of rearrangements are identical to those of mammals. The locus is inherited in a diploid manner despite the pseudotetraploidy of the Xenopus laevis and X. gilli used in this study.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Chretien I,Marcuz A,Fellah J,Charlemagne J,Du Pasquier Ldoi
10.1002/eji.1830270327subject
Has Abstractpub_date
1997-03-01 00:00:00pages
763-71issue
3eissn
0014-2980issn
1521-4141journal_volume
27pub_type
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