Degeneracy of T cell receptor recognition of an influenza virus hemagglutinin epitope restricted by HLA-DQ and -DR class II molecules.

abstract：:Good responder (C57/Br/cd) and poor responder (C57BL/10) mice were immunized with mouse thyroid extract in Freund's complete adjuvant. The good responder mice first showed antibody to thyroglobulin on the seventh day while the poor responder animals had slightly lower titers and antibody did not appear until day 12. T...

journal_title：European journal of immunology

authors： Tomazic V,Rose NR

更新日期：1977-01-01 00:00:00

abstract：:Mouse peritoneal macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide produce substantial amounts of nitric oxide (NO), which correlates with the elimination of the intracellular protozoan parasite Leishmania major. Both the production of NO and the leishmanicidal function of the activated ma...

journal_title：European journal of immunology

authors： Li Y,Severn A,Rogers MV,Palmer RM,Moncada S,Liew FY

更新日期：1992-02-01 00:00:00

abstract：:Human CD8(+) T cells are functionally heterogeneous and can be divided into phenotypically and functionally distinct subsets according to CCR7 and CD45RA expression levels. Among these, CCR7(low) CD45RA(low) effector memory CD8(+) T cells (Tem) and CCR7(low) CD45RA(high) CD8(+) T cells, which are designated as Temra a...

journal_title：European journal of immunology

authors： Setoguchi R,Matsui Y,Mouri K

更新日期：2015-03-01 00:00:00

abstract：:Th cells can adopt a number of different phenotypes. We performed microarray-assisted mRNA profiling on antigen-stimulated, TCR transgenic murine splenocytes that were cultured in the presence of cytokines. Transcriptome snapshots of Th cells differentiating into Th1 and Th2 phenotypes were obtained at various time po...

journal_title：European journal of immunology

authors： van den Ham HJ,de Waal L,Zaaraoui-Boutahar F,Bijl M,van Ijcken WF,Osterhaus AD,de Boer RJ,Andeweg AC

更新日期：2013-04-01 00:00:00

abstract：:Naive and central memory CD8 T cells use CCR7 to recirculate through T cell zones of secondary lymphoid organs where they can encounter antigen. Here we describe a subset of human CD8 T cells expressing CXCR5 which enables homing in response to CXCL13 produced within B cell follicles. CXCR5+ CD8 T cells were found in ...

journal_title：European journal of immunology

authors： Quigley MF,Gonzalez VD,Granath A,Andersson J,Sandberg JK

更新日期：2007-12-01 00:00:00

abstract：:Heat-stable antigen (HSA)/mouse CD24 (formerly termed Nectadrin) is a membrane glycoprotein with an unusual structure consisting of a small protein core and extensive glycosylation. It is expressed by hematopoietic cells but not by mature T lymphocytes. HSA on accessory cells is an important costimulatory molecule req...

journal_title：European journal of immunology

authors： Hubbe M,Altevogt P

更新日期：1994-03-01 00:00:00

abstract：:Previous studies have suggested that T-lymphocyte dysfunction might be attributable to nitrative stress induced by reactive nitrogen species (RNS). In this manuscript, we explored this hypothesis and provided a direct demonstration of the inhibitory effects of RNS on human T-cell signaling, activation, and migration. ...

journal_title：European journal of immunology

authors： Kasic T,Colombo P,Soldani C,Wang CM,Miranda E,Roncalli M,Bronte V,Viola A

更新日期：2011-07-01 00:00:00

abstract：:The deposition of immune complexes, followed by activation of complement and/or Fc receptors and generation of chemoattractants, is the most common feature of human glomerulonephritis. Recently we have shown that primary cultured human glomerular mesangial cells (HMC), which are normally negative for IgG Fc receptors,...

journal_title：European journal of immunology

authors： Uciechowski P,Schwarz M,Gessner JE,Schmidt RE,Resch K,Radeke HH

更新日期：1998-09-01 00:00:00

abstract：:The glycosylphosphatidylinositol (GPI)-anchored CD59 protein (human protectin) protects cells against complement-induced lysis, binds to CD2 and also transduces activation signals within T cells. We have further examined the biochemical signals transduced by CD59 and addressed its role in regard to the CD3-mediated si...

journal_title：European journal of immunology

authors： Deckert M,Ticchioni M,Mari B,Mary D,Bernard A

更新日期：1995-07-01 00:00:00

abstract：:Beta1 integrins can provide T cell co-stimulation, but little is known concerning their downstream signaling pathways. We found that Pyk2, a focal adhesion kinase-related tyrosine kinase, is regulated by beta1 integrin signaling in human T cells. Stimulation of Jurkat T cells with the alpha4beta1 integrin ligand VCAM-...

journal_title：European journal of immunology

authors： van Seventer GA,Mullen MM,van Seventer JM

更新日期：1998-11-01 00:00:00

abstract：:The interaction between TCR and peptide-MHC is well described in terms of the recognition of the peptide, but the recognition of the MHC is less well understood. At issue is whether particular V gene products may have higher affinity for some MHC over others and to what extent the bound peptide influences V gene selec...

journal_title：European journal of immunology

authors： Battaglia M,Gorski J

更新日期：2002-08-01 00:00:00

abstract：:Macrophage-chemotactic factor (MChF)-producing T cell hybridomas were established. These hybridomas produced MChF upon the specific antigenic stimulation with phosphorylcholine (PC)-conjugated protein in the presence of I-Ed-positive antigen-presenting cells. The hybridomas also secreted MChF after co-culture with con...

journal_title：European journal of immunology

authors： Harita S,Sugimura K,Watanabe T

更新日期：1984-08-01 00:00:00

abstract：:Human papillomavirus (HPV) infections account for more than 50% of infection-linked cancers in women worldwide. The immune system controls, at least partially, viral infection and around 90% of HPV-infected women clear the virus within two years. However, it remains unclear which immune cells are implicated in this pr...

journal_title：European journal of immunology

authors： Renoux VM,Bisig B,Langers I,Dortu E,Clémenceau B,Thiry M,Deroanne C,Colige A,Boniver J,Delvenne P,Jacobs N

更新日期：2011-11-01 00:00:00

abstract：:We have investigated the effects of intravenous immunoglobulin (IVIg), a therapeutic preparation of normal human polyspecific IgG, on the synthesis and release of cytokines by peripheral blood monocytes. IVIg was found to selectively induce gene transcription and secretion of interleukin-1 receptor antagonist (IL-1ra)...

journal_title：European journal of immunology

authors： Ruiz de Souza V,Carreno MP,Kaveri SV,Ledur A,Sadeghi H,Cavaillon JM,Kazatchkine MD,Haeffner-Cavaillon N

更新日期：1995-05-01 00:00:00

abstract：:The migration of monocytes to sites of inflammation is largely determined by their response to chemokines. Although the chemokine specificities and expression patterns of chemokine receptors are well defined, it is still a matter of debate how cells integrate the messages provided by different chemokines that are conc...

journal_title：European journal of immunology

authors： Kuscher K,Danelon G,Paoletti S,Stefano L,Schiraldi M,Petkovic V,Locati M,Gerber BO,Uguccioni M

更新日期：2009-04-01 00:00:00

abstract：:Mice carrying the nude mutation (nu/nu) lack a functioning thymus and do not contain detectable levels of immunocompetent T cells. We now report that nu/nu mice to have lymphocytes which can be activated in vivo by heterologous erythrocytes and a Lyt-1 T cell-derived factor (interleukin 2) to generate T helper cells. ...

journal_title：European journal of immunology

authors： Stötter H,Rüde E,Wagner H

更新日期：1980-09-01 00:00:00

abstract：:The structure of immunological synapses formed between murine naive T cells and mature dendritic cells has been subjected to a quantitative analysis. Immunofluorescence images of synapses formed in the absence of antigen show a diffuse synaptic accumulation of CD3 and LFA-1. In electron microscopy, these antigen-free ...

journal_title：European journal of immunology

authors： Brossard C,Feuillet V,Schmitt A,Randriamampita C,Romao M,Raposo G,Trautmann A

更新日期：2005-06-01 00:00:00

abstract：:Sporozoite surface protein 2 has been identified as a target of malaria vaccines designed to produce protective CD8+ cytotoxic T lymphocytes (CTL) because mice immunized with mastocytoma cells expressing a fragment of Plasmodium yoelii sporozoite surface protein 2 (PySSP2) are protected against malaria by an immune re...

journal_title：European journal of immunology

authors： Wizel B,Rogers WO,Houghten RA,Lanar DE,Tine JA,Hoffman SL

更新日期：1994-07-01 00:00:00

abstract：:In the lymphoid tissues, adaptive immune responses are initiated by the interaction of interdigitating dendritic cells (IDC) with naive T cells. To understand this interplay better, we used mature Langerhans cells (mLC), migrating from human epidermis, as the correlate of IDC ex vivo to evaluate the different effects ...

journal_title：European journal of immunology

authors： Ludewig B,Graf D,Gelderblom HR,Becker Y,Kroczek RA,Pauli G

更新日期：1995-07-01 00:00:00

abstract：:The development and the differentiation of CD8(+) T cells are dependent on IL-15. Here, we have studied the source and mechanism of how IL-15 modulates CD8(+) T cell-mediated Th1 immune responses by employing two delayed-type hypersensitivity (DTH) models. IL-15-deficient (IL-15(-/-)) mice or mice treated with soluble...

journal_title：European journal of immunology

authors： Rückert R,Brandt K,Bulanova E,Mirghomizadeh F,Paus R,Bulfone-Paus S

更新日期：2003-12-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are innate effectors playing an important role in the defense against helminthic infections and in the pathogenesis of allergic inflammation. Cytokines have been identified as the major stimuli driving ILC2 activation and expansion. Conversely, it is unclear whether costimulatory ...

journal_title：European journal of immunology

authors： Paclik D,Stehle C,Lahmann A,Hutloff A,Romagnani C

更新日期：2015-10-01 00:00:00

abstract：:Splenic T cells were primed, after removal of alloreactive cells, to beef insulin on allogeneic antigen-presenting cells (APC). The fine specificity of in vitro secondary response was tested in combinations H-2b (responder) T cell-H-2k (nonresponder) APC, and vice versa, using separated chains of beef and pork insulin...

journal_title：European journal of immunology

authors： Ishii N,Klein J,Nagy ZA

更新日期：1983-08-01 00:00:00

abstract：:The effector function of activated CD4(+) T cells and secretion of cytokines are important in the establishment of productive immune responses and tolerance. We identified expression by CD4(+) T cells of Notch receptors and ligands and enhanced Notch signaling upon activation. Notch1 expression was up regulated and co...

journal_title：European journal of immunology

authors： Benson RA,Adamson K,Corsin-Jimenez M,Marley JV,Wahl KA,Lamb JR,Howie SE

更新日期：2005-03-01 00:00:00

abstract：:Glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) is a synthetic adjuvant TLR4 agonist that promotes potent poly-functional T(H)1 responses. Different TLR4 agonists may preferentially signal via MyD88 or TIR-domain-containing adapter inducing IFN-beta (TRIF) to exert adjuvant effects; however, the contribution of...

journal_title：European journal of immunology

authors： Orr MT,Duthie MS,Windish HP,Lucas EA,Guderian JA,Hudson TE,Shaverdian N,O'Donnell J,Desbien AL,Reed SG,Coler RN

更新日期：2013-09-01 00:00:00

abstract：:This study was performed to investigate whether gamma delta T cells could also be divided into subsets, identified by a cytokine profile, as described for alpha beta T helper (Th) cell subsets. Cytokine production was studied in 22 gamma delta T cell clones obtained from the synovial fluid and peripheral blood of one ...

journal_title：European journal of immunology

authors： Chomarat P,Kjeldsen-Kragh J,Quayle AJ,Natvig JB,Miossec P

更新日期：1994-09-01 00:00:00

abstract：:T cell activation and cytokine secretion are important mediators of inflammation in allergic asthma. The costimulatory pathway CD28/CD80/CD86 has been shown to play an important role in T cell activation in allergic asthma, but less is known about the effect of other costimulatory molecules in allergy. The costimulato...

journal_title：European journal of immunology

authors： Arestides RS,He H,Westlake RM,Chen AI,Sharpe AH,Perkins DL,Finn PW

更新日期：2002-10-01 00:00:00

abstract：:The role of monocytes, B cells, and adherent and nonadherent T cells in the response of purified protein derivative of tuberculin (PPD) as measured by [3H]thymidine uptake in vitro has been explored. The response to PPD was found to be highly dependent on monocytes, to approximately the same extent as previously found...

journal_title：European journal of immunology

authors： Arala-Chaves MP,Porto MT,Hope L,Fudenberg HH

更新日期：1979-04-01 00:00:00

abstract：:TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the pro-inflammatory complement peptide C5a (C5aR/CD88), and regulation of TLR-induced pro-inflammatory responses by C5aR, suggesting crosstalk between TLRs and C5aR. However,...

journal_title：European journal of immunology

authors： Raby AC,Holst B,Davies J,Colmont C,Laumonnier Y,Coles B,Shah S,Hall J,Topley N,Köhl J,Morgan BP,Labéta MO

更新日期：2011-09-01 00:00:00

abstract：:A considerable fraction of T cells express two distinct T cell receptors (TCR), mainly due to expression of two TCR alpha chains. It has been suggested that such dual-TCR cells could have a role in autoimmunity. However, as such cells express less of each TCR, they could be less sensitive to their physiological ligand...

journal_title：European journal of immunology

authors： Blichfeldt E,Munthe LA,Røtnes JS,Bogen B

更新日期：1996-12-01 00:00:00

abstract：:Germinal center (GC) B cells undergo proliferation, somatic hypermutation and isotype switching in the course of differentiation into plasma cells to produce high-affinity antibodies. To understand the molecular mechanism regulating the expansion of memory B cells and the termination of expansion by differentiation in...

journal_title：European journal of immunology

authors： Choe J,Choi YS

更新日期：1998-02-01 00:00:00