Abstract:
:Mice carrying the nude mutation (nu/nu) lack a functioning thymus and do not contain detectable levels of immunocompetent T cells. We now report that nu/nu mice to have lymphocytes which can be activated in vivo by heterologous erythrocytes and a Lyt-1 T cell-derived factor (interleukin 2) to generate T helper cells. Thus, a lymphokine is described which is able to restore in vivo T helper cell immunocompetence of nu/nu mice. The data may suggest that nu/nu mice contain a low number of T lymphocytes influenced by the cystic remnant of the nu/nu thymus anlage. Alternatively, the data imply that interleukin 2 circumvents the requirement of a thymus during ontogeny of T lymphocytes.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Stötter H,Rüde E,Wagner Hdoi
10.1002/eji.1830100912subject
Has Abstractpub_date
1980-09-01 00:00:00pages
719-22issue
9eissn
0014-2980issn
1521-4141journal_volume
10pub_type
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