Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody.

abstract：:Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...

journal_title：European journal of immunology

authors： Sasaki T,Kanaseki T,Shionoya Y,Tokita S,Miyamoto S,Saka E,Kochin V,Takasawa A,Hirohashi Y,Tamura Y,Miyazaki A,Torigoe T,Hiratsuka H,Sato N

更新日期：2016-04-01 00:00:00

abstract：:CD59 is a 18-20-kDa membrane glycoprotein that inhibits formation of the membrane attack complex of complement (C) on homologous cells. In the present study we analyzed the expression and function of CD59 on human endothelial cells. Immunohistochemical analysis of renal cortex demonstrated a predominant expression of ...

journal_title：European journal of immunology

authors： Brooimans RA,Van der Ark AA,Tomita M,Van Es LA,Daha MR

更新日期：1992-03-01 00:00:00

abstract：:Naive and memory CD4 T cells differ in cell surface phenotype, function, activation requirements, and modes of regulation. To investigate the molecular bases for the dichotomies between naive and memory CD4 T cells and to understand how the T cell receptor (TCR) directs diverse functional outcomes, we investigated pro...

journal_title：European journal of immunology

authors： Farber DL,Acuto O,Bottomly K

更新日期：1997-08-01 00:00:00

abstract：:CBA/J mice immunized with thyroglobulin (Tg) develop an experimental autoimmune thyroiditis (EAT) with lymphocytic infiltration of the thyroid glands, autoantibodies to Tg and occurrence of EAT-specific T cells. When these mice were treated for 4 weeks after immunization with 1 mg/week of a monoclonal antibody (mAb) t...

journal_title：European journal of immunology

authors： Tang H,Mignon-Godefroy K,Meroni PL,Garotta G,Charreire J,Nicoletti F

更新日期：1993-01-01 00:00:00

abstract：:While the nasal mucosa is a potentially useful site for human immunization, toxin-based nasal adjuvants are generally unsafe and less effective in humans. Safe mucosal adjuvants that activate protective immunity via mucosal administration are highly dependent on barrier antigen sampling by epithelial and DCs. Here, we...

journal_title：European journal of immunology

authors： Makidon PE,Belyakov IM,Blanco LP,Janczak KW,Landers J,Bielinska AU,Groom JV 2nd,Baker JR Jr

更新日期：2012-08-01 00:00:00

abstract：:Previous studies have suggested that T-lymphocyte dysfunction might be attributable to nitrative stress induced by reactive nitrogen species (RNS). In this manuscript, we explored this hypothesis and provided a direct demonstration of the inhibitory effects of RNS on human T-cell signaling, activation, and migration. ...

journal_title：European journal of immunology

authors： Kasic T,Colombo P,Soldani C,Wang CM,Miranda E,Roncalli M,Bronte V,Viola A

更新日期：2011-07-01 00:00:00

abstract：:Adoptive T-cell therapy (ATCT) can result in tumor rejection, yet the behavior and fate of the introduced T cells remain unclear. We developed a novel bioluminescence mouse model, which enabled highly sensitive detection of T-cell signals at the single-cell level. Transferred T cells preferentially accumulated within ...

journal_title：European journal of immunology

authors： Charo J,Perez C,Buschow C,Jukica A,Czeh M,Blankenstein T

更新日期：2011-11-01 00:00:00

abstract：:Human T cells expressing Vgamma9Ndelta2-encoded TCR recognize several nonpeptide phosphoantigens in the absence of major histocompatibility complex restriction. As these cells respond differentially to increasing concentrations of structurally related phosphoantigens, such ligands constitute agonists of different stre...

journal_title：European journal of immunology

authors： Sireci G,Espinosa E,Di Sano C,Dieli F,Fournié JJ,Salerno A

更新日期：2001-05-01 00:00:00

abstract：:T cell receptor (TCR) genes are initially activated in hematopoietic stem cells that have been committed to the T cell lineage during ontogeny. We have established cell lines derived from hematopoietic organs which express truncated TCR delta mRNA (1.3 kbp). In this study, cDNA clones of this mRNA were analyzed to cha...

journal_title：European journal of immunology

authors： Shimamura M,Ohta S

更新日期：1995-06-01 00:00:00

abstract：:IgG complexes bind to Fc receptor family members FcgammaRI (CD64), FcgammaRII (CD32) and FcgammaRIII (CD16), activating cell MAPK and PI3K resulting in increased cytokine production from particular leukocytes. The signaling molecules involved in cytokine production after cross-linking CD16 have not been determined in ...

journal_title：European journal of immunology

authors： Kramer PR,Winger V,Reuben J

更新日期：2009-02-01 00:00:00

abstract：:In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed. Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription. We s...

journal_title：European journal of immunology

authors： Sartoris S,Tosi G,De Lerma Barbaro A,Cestari T,Accolla RS

更新日期：1996-10-01 00:00:00

abstract：:Many lymphocytes are produced in the intestinal mucosa, especially in the Peyer's patches. These newly formed lymphoid cells leave the gut wall, undergo further maturation and many reach the lamina propria of the intestinal mucosa where they function as effector and regulator cells of the intestinal immune response. H...

journal_title：European journal of immunology

authors： Rothkötter HJ,Hriesik C,Pabst R

更新日期：1995-03-01 00:00:00

abstract：:Subcutaneous immunization with hen egg-white lysozyme (HEL) in complete Freund's adjuvant induces, both in antibody responder and nonresponder mice, a classical delayed-type hypersensitivity (DTH) reaction evaluated as footpad swelling. This response can be specifically transferred to naive recipients by Lyt-1+2- T ce...

journal_title：European journal of immunology

authors： Colizzi V,Doria G,Adorini L

更新日期：1984-09-01 00:00:00

abstract：:Human herpesvirus 6B (HHV-6B) is a ubiquitous pathogen with frequent reactivation observed in immunocompromised patients such as BM transplant (BMT) recipients. Adoptive immunotherapy is a promising therapeutic avenue for the treatment of opportunistic infections, including herpesviruses. While T-cell immunotherapy ca...

journal_title：European journal of immunology

authors： Iampietro M,Morissette G,Gravel A,Dubuc I,Rousseau M,Hasan A,O'Reilly RJ,Flamand L

更新日期：2014-12-01 00:00:00

abstract：:The interaction between TCR and peptide-MHC is well described in terms of the recognition of the peptide, but the recognition of the MHC is less well understood. At issue is whether particular V gene products may have higher affinity for some MHC over others and to what extent the bound peptide influences V gene selec...

journal_title：European journal of immunology

authors： Battaglia M,Gorski J

更新日期：2002-08-01 00:00:00

abstract：:Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might...

journal_title：European journal of immunology

authors： Zurn AD,Fulpius BW

更新日期：1977-08-01 00:00:00

abstract：:Allogeneic bone marrow transplantation in the neonate is an effective way of inducing permanent tolerance to donor tissue. To do the same in the immunocompetent adult requires immunosuppression to counter host-versus-graft alloreactivity. Conditioning with monoclonal antibodies (mAb) to CD4 and CD8 has been sufficient...

journal_title：European journal of immunology

authors： Leong LY,Qin S,Cobbold SP,Waldmann H

更新日期：1992-11-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein which is one of the ligands for the leukocyte function-associated antigen (LFA-1). It is involved in leukocyte adhesion to endothelial cells as well as in immune functions requiring cell-cell contact. The quantitative expression of ICAM-1 in various cell types can be either induce...

journal_title：European journal of immunology

authors： Geissler D,Gaggl S,Möst J,Greil R,Herold M,Dietrich M

更新日期：1990-12-01 00:00:00

abstract：:Significant variability in efficacy of live Mycobacterium bovis BCG as a tuberculosis vaccine is observed globally. Effects of pre-vaccination sensitisation to non-tuberculous environmental mycobacteria (Env) are suspected to underlie this phenomenon, but the mechanisms remain unclear. We postulated that it could be d...

journal_title：European journal of immunology

authors： Ho P,Zhang L,Wei X,Seah GT

更新日期：2009-07-01 00:00:00

abstract：:The liver and activation-regulated chemokine (LARC), also termed MIP-3alpha and Exodus, is a novel human CC chemokine with a selective chemotactic activity for lymphocytes and dendritic cells. Here we describe genomic and cDNA clones encoding the murine orthologue of LARC (mLARC). The gene consists of four exons and t...

journal_title：European journal of immunology

authors： Tanaka Y,Imai T,Baba M,Ishikawa I,Uehira M,Nomiyama H,Yoshie O

更新日期：1999-02-01 00:00:00

abstract：:The functional immunoglobulin (Ig) genes of B lymphocytes undergo somatic mutations during immune responses. These mutations modify the antigen binding site of the immunoglobulins, thereby enhancing the average affinity of the antibodies produced. The molecular mechanism underlying these B cell hypermutations remains ...

journal_title：European journal of immunology

authors： Wu H,Pelkonen E,Knuutila S,Kaartinen M

更新日期：1995-12-01 00:00:00

abstract：:The immune system relies on homeostatic mechanisms in order to adapt to the changing requirements encountered during steady-state existence and activation by antigen. For T cells, this involves maintenance of a diverse repertoire of naïve cells, rapid elimination of effector cells after pathogen clearance, and long-te...

journal_title：European journal of immunology

authors： Boyman O,Létourneau S,Krieg C,Sprent J

更新日期：2009-08-01 00:00:00

abstract：:Interferon (IFN) was detected upon co-culture of cloned Sendai virus (SV)-specific T lymphocyte with SV-presenting syngeneic stimulator cells. The antiviral activity was defined as IFN-alpha, beta. The T cell clones, upon contact with antigen-presenting stimulator cells, stimulated adherent cells present in the stimul...

journal_title：European journal of immunology

authors： Ertl HC,Brown EG,Finberg RW

更新日期：1982-12-01 00:00:00

abstract：:The role of complement receptors on the localization of T and B cells in the spleen of mice was studied using short-term homing experiments in cobra venom factor (CoF)-treated animals. The localization ratio of B and T cells in the spleen of CoF-treated mice decreased significantly compared to control recipients. No c...

journal_title：European journal of immunology

authors： Kraal G,Van Hoogstraten I,Klerx JP,Van Dijk H

更新日期：1985-07-01 00:00:00

abstract：:For long-term attack on tumor cells in patients with prostate cancer, induction of cytolytic T cells is desirable. Several lineage-specific target proteins are known and algorithms have identified candidate MHC class I-binding peptides, particularly for HLA-A*0201. We have designed tolerance-breaking DNA fusion vaccin...

journal_title：European journal of immunology

authors： Vittes GE,Harden EL,Ottensmeier CH,Rice J,Stevenson FK

更新日期：2011-08-01 00:00:00

abstract：:Bone marrow (BM) stromal cells are important in the development and maintenance of cells of the immune system. Using single cell RNA sequencing, we here explore the functional and phenotypic heterogeneity of individual transcriptomes of 1167 murine BM mesenchymal stromal cells. These cells exhibit a tremendous heterog...

journal_title：European journal of immunology

authors： Addo RK,Heinrich F,Heinz GA,Schulz D,Sercan-Alp Ö,Lehmann K,Tran CL,Bardua M,Matz M,Löhning M,Hauser AE,Kruglov A,Chang HD,Durek P,Radbruch A,Mashreghi MF

更新日期：2019-09-01 00:00:00

abstract：:A mouse T cell hybrid specific for pigeon cytochrome c in the context of I-Ek responds by secreting interleukin 2 when co-cultured with the native antigen and the B cell lymphoma, LK-35.2, or naive splenic B cells as antigen-presenting cells (APC). Cytochromes c and their corresponding C-terminal fragments which are n...

journal_title：European journal of immunology

authors： Lakey EK,Margoliash E,Flouret G,Pierce SK

更新日期：1986-07-01 00:00:00

abstract：:MS and EAE are T cell-driven autoimmune diseases of the CNS where IL-17-producing Th17 cells promote damage and are pathogenic. Conversely, tolerogenic DCs induce Treg cells and suppress Th17 cells. Chloroquine (CQ) suppresses EAE through the modulation of DCs by unknown mechanisms. Here, we show that STAT 1 is necess...

journal_title：European journal of immunology

authors： Thome R,Bonfanti AP,Rasouli J,Mari ER,Zhang GX,Rostami A,Verinaud L

更新日期：2018-07-01 00:00:00

abstract：:Activation of invariant natural killer T (iNKT) cells by treatment with their α-galactosyl ceramide ligand provides therapeutic benefits in several immune inflammatory settings. Given the artificial nature of this stimulation, the natural regulatory functions of iNKT remain uncertain. Addressing this issue in a mouse ...

journal_title：European journal of immunology

authors： Bourgeois EA,Levescot A,Diem S,Chauvineau A,Bergès H,Milpied P,Lehuen A,Damotte D,Gombert JM,Schneider E,Girard JP,Gourdy P,Herbelin A

更新日期：2011-02-01 00:00:00

abstract：:In this study two newly developed monoclonal antibodies, ED5 and ED6, are described, which specifically recognize nonlymphoid cells in B cell follicles of spleen and lymph nodes. Enzyme and immunocytochemical techniques demonstrated that ED5 and ED6 stain two different types of reticulum cells. The staining patterns w...

journal_title：European journal of immunology

authors： Jeurissen SH,Dijkstra CD

更新日期：1986-05-01 00:00:00