Abstract:
:CBA/J mice immunized with thyroglobulin (Tg) develop an experimental autoimmune thyroiditis (EAT) with lymphocytic infiltration of the thyroid glands, autoantibodies to Tg and occurrence of EAT-specific T cells. When these mice were treated for 4 weeks after immunization with 1 mg/week of a monoclonal antibody (mAb) that neutralizes the activity of interferon-gamma (IFN) a beneficial effect on the onset of EAT was observed. Characteristic features of EAT were significantly reduced, including the lymphocytic infiltrations of the thyroid glands and the serum levels of autoantibodies to Tg. Moreover, in lymphoid organs, mAb to IFN-gamma significantly reduced the percentages of Tg-specific CD8+ cells, labeled by the anti-clonotypic mAb AG7. These Tg-specific T cells seem responsible for thyroid damages and disease development, since EAT was simultaneously abrogated. These results show that IFN-gamma plays an essential role in the pathophysiology of EAT and suggest the possibility to treat autoimmune thyroid diseases with mAb to IFN-gamma or drugs able to antagonize the production and/or the action of this cytokine.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Tang H,Mignon-Godefroy K,Meroni PL,Garotta G,Charreire J,Nicoletti Fdoi
10.1002/eji.1830230143subject
Has Abstractpub_date
1993-01-01 00:00:00pages
275-8issue
1eissn
0014-2980issn
1521-4141journal_volume
23pub_type
杂志文章abstract::LIGHT is a recently identified member of the TNF superfamily that is up-regulated on activated T cells and can cooperate with CD40L to condition DC for the priming of CTL. In this report, we show that an intracellular pool of LIGHT is found selectively in some CD45RA-CD27+CD4+ "central" memory T cells and to a greater...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200324410
更新日期:2003-11-01 00:00:00
abstract::5'-Nucleotidase/CD73 is a key enzyme in the regulation of purinergic signaling, hydrolyzing extracellular AMP to produce adenosine, which is critical in the blood vascular system and in immunosuppression. CD73 is expressed by both blood endothelial cells and lymphatic endothelial cells. Although the role of CD73 on bl...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.201445400
更新日期:2015-02-01 00:00:00
abstract::Secretion of proinflammatory mediators by activated macrophages plays an important role in the immune response to Trypanosoma cruzi. We have previously reported that AgC10, a glycosylphosphatidylinositol-anchored mucin from T. cruzi, inhibits TNF secretion by activated macrophages (de Diego, J., Punzon, C., Duarte, M....
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200324660
更新日期:2004-06-01 00:00:00
abstract::The specificity of the IgM receptor expressed by human T cells cultured in IgM-free media has been investigated. IgM receptors have been detected using a rosette system with ox erythrocytes coated with rabbit antibody (EA(IgM)), and the inhibitory capacity of different IgM fragments in the rosette system has been test...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830060714
更新日期:1976-07-01 00:00:00
abstract::The entry of neutrophils into inflamed tissues is initiated by cell rolling on the blood vessel wall followed by arrest and transendothelial migration. Rolling is mediated by the selectins, while the two subsequent steps require activated beta 2-integrins. We have investigated whether the binding of P-selectin to mous...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199802)28:02<433::AID-IMMU
更新日期:1998-02-01 00:00:00
abstract::APO-1/Fas (CD95) is a transmembrane receptor that transduces apoptotic signals within various cells including T and B cells. The APO-1 gene was found to be defective in lpr mice. In these mice insertion of a retrotransposon gives rise to transcription of an abnormal mRNA and only a fraction of wild-type APO-1 mRNA. It...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830241231
更新日期:1994-12-01 00:00:00
abstract::Helicobacter pylori is a Gram-negative bacterium that causes a variety of gastrointestinal diseases, such as duodenal ulcer and gastric carcinoma. The T cell response against H. pylori is thought to contribute to the pathogenesis of these diseases. Here, we show that mouse-adapted H. pylori is able to polyclonally act...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636676
更新日期:2007-07-01 00:00:00
abstract::A generalized Shwartzman reaction was found to occur in non-SPF-NMRI mice given a local injection of S. marcescens lipopolysaccharide (LPS) in the footpad, followed, with an interval of 24 h, by an i.v. injection. The reaction occurred several hours after the second injection. It was characterized by disseminated subc...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830171228
更新日期:1987-12-01 00:00:00
abstract::Peritoneal mast cells (PMC) and intestinal mucosal mast cells (IMMC) were purified from rats infected with the nematode Nippostrongylus brasiliensis. Overall protein constituents of both mast cell subtypes were analyzed by two-dimensional gel electrophoresis using either nonequilibrium pH gradient electrophoresis (NEP...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200911
更新日期:1990-09-01 00:00:00
abstract::Mononuclear phagocytes and lymphocytes can both synthesize cytotoxins which kill certain tumor cell lines and recent evidence suggests that these cytotoxins may be identical. In this study, human monocyte cytotoxin and lymphoblastoid lymphotoxin have been critically compared in terms of specificity, physicochemical ch...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150321
更新日期:1985-03-01 00:00:00
abstract::Interactions between CD8+ T cells and endothelial cells are important in both protective and pathologic immune responses. Endothelial cells regulate the recruitment of CD8+ T cells into tissues, and the activation of CD8+ T cells by antigen presentation and costimulatory signals. PD-L1 and PD-L2 are recently described...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200324270
更新日期:2003-11-01 00:00:00
abstract::The recently discovered B6.C-H-2bm12 (bm12) histocompatibility mutant bears a mutation of the I-A subregion of the H-2b haplotype. We have studied cytotoxic T lymphocytes (CTL) generated in secondary mixed lymphocyte culture (MLC) between the bm12 mutant and the strain of origin C57BL/6 (B6). In both directions, stron...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830110317
更新日期:1981-03-01 00:00:00
abstract::A cell surface lectin found on activated human lymphoid cells has been identified and characterized using membrane glycoprotein micelles as probes. These micelles, which are large, water-soluble aggregates, are composed of glycoproteins isolated from detergent-solubilized membranes of human B lymphoblastoid cell lines...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830120708
更新日期:1982-07-01 00:00:00
abstract::A multiparametric analysis of the resident immune populations in the parotid, submandibular and sublingual salivary glands was done in single-cell suspensions. The incidence of T and B cells and of macrophages was assessed using phenotypic markers in immunofluorescent staining and a functional assay was used to enumer...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160313
更新日期:1986-03-01 00:00:00
abstract::We have investigated the role of TNF-alpha in mast cell-mediated late airway hyperresponsiveness (AHR) using mast cell-deficient WBB6F1-W/W(v) (W/W(v)) mice in a murine model of asthma, which exhibits a biphasic increase in AHR. TNF-alpha levels in the airway and magnitude of late AHR in response to airway allergen ch...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636612
更新日期:2007-04-01 00:00:00
abstract::In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF-β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote the generation and maintenance of mucosal IgA-expressing plasma cells. Here, we demonst...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948474
更新日期:2020-06-01 00:00:00
abstract::The expression of interleukin (IL)-1 beta, IL-6 and their respective receptors has been studied in the rat brain before and up to 24 h after injury. Messenger RNA transcripts of these four genes were detected by in situ hybridization (ISH) in different structures of the intact brain. The distribution was very similar ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221131
更新日期:1992-11-01 00:00:00
abstract::In the present study, we examined whether anti-CD40+IL-4-mediated B cell proliferation and immunoglobulin synthesis is affected by vitamin D (VD) and its low-hypercalcemic analogue EB1089 in Bcells from healthy donors. Analysis of vitamin D receptor (VDR) expression showed that only anti-CD40+IL-4-stimulated, but not ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200212)32:12<3395::AID-IMMU3395>
更新日期:2002-12-01 00:00:00
abstract::It was previously observed that MOPC-315EL, a subline of the BALB/c myeloma tumor MOPC-315, varies in its ability to interact with primary anti-H-2d cytotoxic thymus-derived lymphocytes (CTL) while remaining invariant in its expression of cell surface antigens recognized by anti-H-2d sera. This paper demonstrates (a) ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830080907
更新日期:1978-09-01 00:00:00
abstract::B cells in rabbit preferentially utilize the 3'-most VH gene, VH1, in VDJ genes. To determine whether the preferential utilization of VH1 results from preferential rearrangement, we examined VH gene usage in nonproductive VDJ gene rearrangements, genes that would not be influenced by antigen selection. Since nonproduc...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250927
更新日期:1995-09-01 00:00:00
abstract::Activation of the alternative complement pathway by human B cell lymphoma lines is correlated with the presence of Epstein Barr virus (EBV) in the cell genome. EBV-negative B cell lymphoma lines produce little activation of the alternative pathway as measured either by C3 deposition on the cell surface or C3 conversio...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830080702
更新日期:1978-07-01 00:00:00
abstract::Anti-HLA alloantisera inhibit mixed lymphocyte responses in which normal lymphocytes are used as stimulator cells. These same antisera are unable to inhibit lymphocyte proliferative responses stimulated by lymphoblastoid cells from cultured lymphoid cell lines. They also fail to inhibit either the generation of cytoto...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830060402
更新日期:1976-04-01 00:00:00
abstract::Although originally described in tumor-bearing hosts, myeloid-derived suppressor cells (MDSC) have been detected under numerous pathological situations that cause enhanced demand of myeloid cells. Thus, MDSC might be part of a conserved response to different endogenous and exogenous stress signals, including inflammat...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.200939892
更新日期:2009-10-01 00:00:00
abstract::Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and p...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830261008
更新日期:1996-10-01 00:00:00
abstract::Mutations of forkhead box p3 (FOXP3), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The relevance of other periphe...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040909
更新日期:2011-04-01 00:00:00
abstract::PA28alpha/beta is a regulatory complex of the 20S proteasome which consists of two IFN-gamma inducible subunits. Both subunits, alpha and beta, contribute equally to the formation of hexa- or heptameric rings which can associate with the 20S proteasome. Previously, we have shown that overexpression of the PA28alpha su...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200012)30:12<3672::AID-IMMU3672>
更新日期:2000-12-01 00:00:00
abstract::Tumor necrosis factor (TNF) is a cytokine which, among other properties, is a principle mediator of inflammation and septic shock. It acts upon target cells by binding to specific cell surface receptors. A10G10 is a murine monoclonal antibody which recognizes human TNF and neutralizes its activity. A rabbit polyclonal...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221143
更新日期:1992-11-01 00:00:00
abstract::Gradual depletion of CD4+ T cells is a typical characteristic of pathogenic SIV infection. Intriguingly, we find a spontaneous CD4+ T-cell homeostasis in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection. ...
journal_title:European journal of immunology
pub_type: 信件
doi:10.1002/eji.201747284
更新日期:2018-02-01 00:00:00
abstract::This study was performed as a means to examine the effects of environment and stem cell origin on the molding of T cell receptor gene rearrangements during T cell development. Lethally irradiated adult mice were first reconstituted with (C57BL/6 x DBA/2)F1 stem cells, which derived either from a fetal liver or adult b...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830211208
更新日期:1991-12-01 00:00:00
abstract::Our understanding of the biology of human natural killer (NK) cells has significantly advanced in recent years upon identification of a family of NK cell-expressed genes that encode killer cell inhibitory receptors (KIR). Individual KIR can selectively bind various HLA class I allotypes and consequently transduce inhi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199802)28:02<599::AID-IMMU
更新日期:1998-02-01 00:00:00