Abstract:
:Mononuclear phagocytes and lymphocytes can both synthesize cytotoxins which kill certain tumor cell lines and recent evidence suggests that these cytotoxins may be identical. In this study, human monocyte cytotoxin and lymphoblastoid lymphotoxin have been critically compared in terms of specificity, physicochemical characteristics and antigenicity. Despite their similar pattern of reactivity with a panel of cell lines, lymphotoxin was less readily adsorbed than monocyte cytotoxin by tumor cells. The cytotoxins could also be distinguished by their behavior on high performance liquid chromatography and by the failure of antibody to monocyte cytotoxin to react with lymphotoxin.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Matthews Ndoi
10.1002/eji.1830150321subject
Has Abstractpub_date
1985-03-01 00:00:00pages
311-3issue
3eissn
0014-2980issn
1521-4141journal_volume
15pub_type
杂志文章abstract::GTPase immune-associated proteins (Gimap) genes encode evolutionarily conserved GTP-binding proteins that are preferentially expressed in immune cells. Specific members have been shown to be involved in lymphocyte development, or are associated with inflammatory and autoimmune diseases. However, the function of these ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201344375
更新日期:2014-02-01 00:00:00
abstract::We have developed a long-term culture system using the murine bone marrow stromal cells MS-5 to support the growth of progenitor B cells with CD34-, CD10+, CD19+, and cytoplasmic mu chain (C mu)-negative surface phenotype from human CD34+ cells purified from umbilical cord blood (CB). When 10(3) CD34+ cells/well were ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199803)28:03<855::AID-IMMU
更新日期:1998-03-01 00:00:00
abstract::Macrophages are becoming increasingly recognized as key cellular players in intestinal immune homeostasis. However, differentiating between macrophages and dendritic cells (DCs) is often difficult, and finding a specific phenotypic signature for intestinal macrophage identification has remained elusive. In this issue ...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.201243061
更新日期:2012-12-01 00:00:00
abstract::Intravenous immunoglobulins (IVIgs) efficiently suppress a variety of autoimmune diseases. Over the past few years several potential mechanisms underlying this antiinflammatory activity have become apparent. Among these, terminal sialic acid residues in the sugar moiety of the immunoglobulin G constant fragment have b...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201242710
更新日期:2012-12-01 00:00:00
abstract::Neutrophils express pattern recognition receptors (PRRs) and regulate immune responses via PRR-dependent cytokine production. An emerging theme is that neutrophil PRRs often exhibit cell type-specific adaptations in their signalling pathways. This prompted us to examine inflammasome signalling by the PRR NLRP3 in muri...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201545943
更新日期:2016-04-01 00:00:00
abstract::Pulmonary mucosal immune response is critical for preventing opportunistic Aspergillus fumigatus infections. Although fungus-specific CD4+ T cells in blood are described to reflect the actual host-pathogen interaction status, little is known about Aspergillus-specific pulmonary T-cell responses. Here, we exploit the d...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948524
更新日期:2020-11-01 00:00:00
abstract::Although many B lymphocytes contain two completely rearranged immunoglobulin (Ig) heavy (H) chain genes, only one of the alleles specifies a protein product. This phenomenon is termed allelic exclusion and is controlled in part by the membrane portion of Ig H chains. We have identified a mature B cell line derived fro...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210110
更新日期:1991-01-01 00:00:00
abstract::Group 2 innate lymphoid cells (ILC2s) are innate effectors playing an important role in the defense against helminthic infections and in the pathogenesis of allergic inflammation. Cytokines have been identified as the major stimuli driving ILC2 activation and expansion. Conversely, it is unclear whether costimulatory ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201545635
更新日期:2015-10-01 00:00:00
abstract::Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type 2 immune response. Upon allergen exposure, group 2 innate lymphoid cells (ILC2s) can be rapidly activated and represent an early innate source of IL-5 and IL-13. Here, we used a house dust mite (HDM)-driven asthma mouse model to stud...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201546119
更新日期:2016-06-01 00:00:00
abstract::Studies of chronic viral infections have highlighted the phenotypic and functional heterogeneity of antigen-specific T cells and suggested that polyfunctional T cells that secrete multiple cytokines and are able to proliferate on encounter with antigen are more likely than single cytokine secretors to represent correl...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.201040731
更新日期:2010-08-01 00:00:00
abstract::All leukocytes express the cell surface glycoprotein CD45, which has intrinsic intracellular protein tyrosine phosphatase activity. CD45 is known to play a regulatory role in activation-induced signaling in lymphocytes; however, little is known of its role in non-lymphoid leukocytes. Therefore, we examined the potenti...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199905)29:05<1467::AID-IMM
更新日期:1999-05-01 00:00:00
abstract::The cell surface molecule CD44, thought to be a cell surface receptor for hyaluronic acid, is expressed by thymocytes and peripheral T cells. Following T cell activation with mitogens or antigens, surface expression of CD44 increases. This increase in CD44 cell surface expression has been used as a means of identifyin...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210632
更新日期:1991-06-01 00:00:00
abstract::Fc gamma receptor I-positive (CD64+) and Fc gamma receptor I-negative (CD64-) monocytes were prepared from highly purified (elutriation-derived) human monocytes by cytofluorograph cell sorting, and a phenotypical and functional dissociation of the isolated CD64+ and CD64- monocyte subsets is demonstrated. Surface anal...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231213
更新日期:1993-12-01 00:00:00
abstract::Natural killer (NK) cells play an important role in early defense against viral infection. The cytotoxic activity of NK cells is increased by interferon-alpha/beta (IFN-alpha/beta), produced en masse in virally infected cells. However, the mechanism(s) by which IFN-alpha/beta contribute to the NK-cell-mediated antivir...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200111)31:11<3138::aid-immu3138>
更新日期:2001-11-01 00:00:00
abstract::Lymphotoxin (LT)alpha in combination with LTbeta forms membrane-bound heterotrimeric complexes with a crucial function in lymph node (LN) organogenesis and correct morphogenesis of secondary lymphoid tissue. To study the role of membrane LT (mLT) in lymphoid tissue organogenesis we generated an LTbeta-deficient mouse ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200207)32:7<1993::AID-IMMU1993>3
更新日期:2002-07-01 00:00:00
abstract::Plasmid cassette-transfer vectors pBHuC chi and pBHuC gamma l have been designed which enable the construction of recombinant baculoviruses directing the co-expression of complete immunoglobulin in insect cells. We describe the application of these vectors for the expression of a human/mouse chimeric monoclonal antibo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250731
更新日期:1995-07-01 00:00:00
abstract::Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cytotoxic CD127+ CD94- , ILC1s, ILC2s, ILC3s, and LTi cells. Here, we identify a previously unrecognized subset within the CD127+ ILC population, characterized by the expression of the cytotoxic marker CD94. These CD94+ I...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.202048696
更新日期:2020-12-09 00:00:00
abstract::The murine X-linked lymphoproliferative disease scurfy is similar to the Wiskott-Aldrich syndrome in humans. Disease in scurfy (sf) mice is mediated by CD4+ T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesion...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260125
更新日期:1996-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these cells in its immunopathogenesis. This subset uses an invariant TC...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636695
更新日期:2007-02-01 00:00:00
abstract::Peroxisome proliferator-activated receptor gamma (PPARgamma ), a member of the nuclear receptor superfamily, has recently been described as a modulator of macrophage functions and as an inhibitor of T cell proliferation. Here, we investigated the role of PPARgamma in dendritic cells (DC), the most potent antigen-prese...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(2001010)31:10<2857::aid-immu2857
更新日期:2001-10-01 00:00:00
abstract::Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains elusive. By using accurate mass spectrometry and multi-epitope ligand cartography (MELC) we character...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747041
更新日期:2017-12-01 00:00:00
abstract::The lone CX3C chemokine, fractalkine (FK), is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. We now show that FK is associated with dendritic cells (DC) in epidermis and lymphoid organs. In normal human skin, dual-color fl...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199908)29:08<2551::AID-IMM
更新日期:1999-08-01 00:00:00
abstract::A detailed restriction map of a 430-kb contig comprising the single Ckappa, the 5 Jkappa and the adjoining 22 Vkappa gene segments is presented. The first 12 Vkappa genes following the JkappaCkappa region belong to the Vkappa21 family, the subsequent ones to the closely related families Vkappa8 and Vkappal 9/ 28. Prev...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199805)28:05<1458::AID-IMM
更新日期:1998-05-01 00:00:00
abstract::The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal regio...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231051
更新日期:1993-10-01 00:00:00
abstract::CBA/J mice immunized with thyroglobulin (Tg) develop an experimental autoimmune thyroiditis (EAT) with lymphocytic infiltration of the thyroid glands, autoantibodies to Tg and occurrence of EAT-specific T cells. When these mice were treated for 4 weeks after immunization with 1 mg/week of a monoclonal antibody (mAb) t...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230143
更新日期:1993-01-01 00:00:00
abstract::The capacity of human peripheral blood lymphocytes (PBL) to bind antigen-IgG antibody (EA(IgG)) and antigen-IgM antibody (EA(IgM)) complexes was investigated using a rosette technique with ox erythrocytes coated with rabbit IgG or IgM antibody. It was found that while EA(IgG)-rosette-forming cells (RFC) were detected ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830050812
更新日期:1975-08-01 00:00:00
abstract::Peritoneal mast cells (PMC) and intestinal mucosal mast cells (IMMC) were purified from rats infected with the nematode Nippostrongylus brasiliensis. Overall protein constituents of both mast cell subtypes were analyzed by two-dimensional gel electrophoresis using either nonequilibrium pH gradient electrophoresis (NEP...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200911
更新日期:1990-09-01 00:00:00
abstract::Gradual depletion of CD4+ T cells is a typical characteristic of pathogenic SIV infection. Intriguingly, we find a spontaneous CD4+ T-cell homeostasis in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection. ...
journal_title:European journal of immunology
pub_type: 信件
doi:10.1002/eji.201747284
更新日期:2018-02-01 00:00:00
abstract::By immunizing Lewis rats with myelin basic protein (MBP) peptide variants derived from the major encephalitogenic epitope of guinea pig (MBP(68-88) and then isolating encephalitogenic T cells from these animals, we demonstrated that the variant peptides do not elicit the same encephalitogenic T cell subsets as those i...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250631
更新日期:1995-06-01 00:00:00
abstract::The progression of experimental allergic encephalomyelitis (EAE) in certain mouse strains has been reported to involve a broadening of the response to myelin antigens, apparently resulting from priming to endogenous determinants of the myelin sheath. The phenomenon has been termed determinant spread. Interest in this ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830271127
更新日期:1997-11-01 00:00:00