ICOS regulates the pool of group 2 innate lymphoid cells under homeostatic and inflammatory conditions in mice.

abstract：:Multiple myeloma is a fatal B cell malignancy characterized by the accumulation of plasma cells within the bone marrow. IL-6 is a major survival factor for myeloma cells. Bcl-2 protein family regulates pathways to apoptosis that are activated upon growth factor deprivation. Pro-apoptotic proteins that have only a sing...

journal_title：European journal of immunology

authors： Gomez-Bougie P,Bataille R,Amiot M

更新日期：2004-11-01 00:00:00

abstract：:Activation of the alternative complement pathway by human B cell lymphoma lines is correlated with the presence of Epstein Barr virus (EBV) in the cell genome. EBV-negative B cell lymphoma lines produce little activation of the alternative pathway as measured either by C3 deposition on the cell surface or C3 conversio...

journal_title：European journal of immunology

authors： McConnell I,Klein G,Lint TF,Lachmann PJ

更新日期：1978-07-01 00:00:00

abstract：:B cells from bursa of Fabricius of newly hatched chickens are able to reconstitute the B cell compartment of chemically bursectomized chickens. The resulting B cell chimerism can be detected with monoclonal antibodies against donor B cell alloantigen. Chimeric chickens accept donor-type skin grafts and are unresponsiv...

journal_title：European journal of immunology

authors： Lehtonen L,Vainio O,Veromaa T,Toivanen P

更新日期：1989-03-01 00:00:00

abstract：:The nature of Ig receptors carried by lipopolysaccharide (LPS)-stimulated mouse spleen B cells was analyzed by surface iodination, direct antiserum precipitation and polyacrylamide gel electrophoresis. LPS activation led to a rapid decrease of surface IgD to 20 % and 80 % of the original level on days three and five o...

journal_title：European journal of immunology

authors： Bourgois A,Kitajima K,Hunter IR,Askonas BA

更新日期：1977-03-01 00:00:00

abstract：:The DC-derived chemokine CCL17, a ligand of CCR4, has been shown to promote various inflammatory diseases such as atopic dermatitis, atherosclerosis, and inflammatory bowel disease. Under steady-state conditions, and even after systemic stimulation with LPS, CCL17 is not expressed in resident splenic DCs as opposed to...

journal_title：European journal of immunology

authors： Globisch T,Steiner N,Fülle L,Lukacs-Kornek V,Degrandi D,Dresing P,Alferink J,Lang R,Pfeffer K,Beyer M,Weighardt H,Kurts C,Ulas T,Schultze JL,Förster I

更新日期：2014-02-01 00:00:00

abstract：:Murine splenic T lymphocytes display maximal cellular myc gene (c-myc) expression already 3 h after concanavalin A stimulation and subsequent down-regulation before the onset of DNA synthesis. Stimulation by leucoagglutinin in the presence or absence of interleukin 2 leads to only low initial levels of c-myc-specific ...

journal_title：European journal of immunology

authors： Schneider-Schaulies J,Hünig T,Schimpl A,Wecker E

更新日期：1986-03-01 00:00:00

abstract：:The role of CD8(+) T cells in the development of allergic airway disease is controversial. On the one hand, CD8(+) T cells are known to inhibit the development of airway hyperreactivity (AHR) in murine models of asthma. In humans, IL-10-producing CD8(+) T cells were shown to act as regulatory cells, inhibiting both pr...

journal_title：European journal of immunology

authors： Stock P,Kallinich T,Akbari O,Quarcoo D,Gerhold K,Wahn U,Umetsu DT,Hamelmann E

更新日期：2004-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these cells in its immunopathogenesis. This subset uses an invariant TC...

journal_title：European journal of immunology

authors： Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A

更新日期：2007-02-01 00:00:00

abstract：:The immaturity of the neonatal immune system in mice is associated with defective IFN-gamma production and Th2-biased immune responses. In this study, infants vaccinated at birth with BCG produced similar concentrations of IFN-gamma in response to PPD and showed similar frequencies of IFN-gamma-producing lymphocytes a...

journal_title：European journal of immunology

authors： Vekemans J,Amedei A,Ota MO,D'Elios MM,Goetghebuer T,Ismaili J,Newport MJ,Del Prete G,Goldman M,McAdam KP,Marchant A

更新日期：2001-05-01 00:00:00

abstract：:Ia. W39 is a B cell differentiation antigen whose membrane expression is controlled by the xid gene. In this report we show that, analogous to its B cell expression, Ia. W39 is also present on a subset of Ia+ macrophages, indicating heterogeneity within that cell population. The Ir gene(s) for the antigenic determinan...

journal_title：European journal of immunology

authors： Huber BT,Rosenwasser LJ

更新日期：1982-01-01 00:00:00

abstract：:The recent discovery of IL-17-producing CD4(+) Th subset significantly revised the Th1/Th2 dichotomy model proposed by Mosmann and Coffman almost two decades ago. Th17 cells are involved in the pathogenesis of many human autoimmune diseases. Th17 cells, their developmental pathways and their effector functions, theref...

journal_title：European journal of immunology

authors： Ouyang W,Filvaroff E,Hu Y,Grogan J

更新日期：2009-03-01 00:00:00

abstract：:The glycoprotein CD8 is believed to play an important role in the maturation and function of MHC class I-restricted T lymphocytes. CD8 has been proposed to function as a co-receptor of the TcR to participate in signal transduction, possibly through its cytoplasmic domain that binds to protein tyrosine kinase p56lck. A...

journal_title：European journal of immunology

authors： Fung-Leung WP,Louie MC,Limmer A,Ohashi PS,Ngo K,Chen L,Kawai K,Lacy E,Loh DY,Mak TW

更新日期：1993-11-01 00:00:00

abstract：:Vaccine efficacy largely depends upon DC targeting and activation. The most potent TLR soluble ligands induce diffuse DC activation, which may be associated with marked pro-inflammatory responses and possibly adverse effects. This raises the concern that effective vaccine adjuvants may similarly rely on widespread DC ...

journal_title：European journal of immunology

authors： Kamath AT,Valenti MP,Rochat AF,Agger EM,Lingnau K,von Gabain A,Andersen P,Lambert PH,Siegrist CA

更新日期：2008-05-01 00:00:00

abstract：:Rabbit anti-SII pneumococcal polysaccharide IgG antibody was cross-linked by dithiobis (succinimidyl propionate). The IgG dimers were visualized by electronmicroscopy and resembled two Y-shaped structures connected in random orientations. The three arms of the Y's were of equal length. The six globular domains of the ...

journal_title：European journal of immunology

authors： Tschopp J,Villiger W,Lustig A,Jaton JC,Engel J

更新日期：1980-07-01 00:00:00

abstract：:The study of the immunology of schistosomiasis has allowed a clear understanding of the basic mechanisms of resistance, emphasizing the important role played by cellular and humoral factors. Whereas the production of polyclonal or monoclonal antibodies and the precise inventory of immune effector mechanisms in the rat...

journal_title：European journal of immunology

authors： Auriault C,Damonneville M,Joseph M,Capron M,Verwaerde C,Billaut P,Capron A

更新日期：1985-12-01 00:00:00

abstract：:In this study, we have analyzed the in vivo dynamics of the interaction between polyclonal Foxp3(+) Treg cells, effector T (Teff) cells, and DCs in order to further our understanding of the mechanisms of Treg cell-mediated suppression. Cotransfer of polyclonal activated Treg cells into healthy mice attenuated the ind...

journal_title：European journal of immunology

authors： Davidson TS,Shevach EM

更新日期：2011-10-01 00:00:00

abstract：:An inhibitor of the cytotoxic functions (ICF) mediated by human immunodeficiency virus (HIV)- or HLA-specific cytotoxic T lymphocytes, natural killer and lymphokine-activated killer (LAK) cells is secreted by CD8+CD57+ T lymphocytes, a subset expanded during infection with HIV and after bone marrow transplantation. We...

journal_title：European journal of immunology

authors： Sadat-Sowti B,Debré P,Mollet L,Quint L,Hadida F,Leblond V,Bismuth G,Autran B

更新日期：1994-11-01 00:00:00

abstract：:The present study was designed to elucidate the role of Valpha14(+) NKT cells in the host defense against pulmonary infection with Streptococcus pneumoniae using Jalpha281 gene-disrupted mice (Jalpha281KO mice) that lacked this lymphocyte subset. In these mice, pneumococcal infection was severely exacerbated, as shown...

journal_title：European journal of immunology

authors： Kawakami K,Yamamoto N,Kinjo Y,Miyagi K,Nakasone C,Uezu K,Kinjo T,Nakayama T,Taniguchi M,Saito A

更新日期：2003-12-01 00:00:00

abstract：:In vivo, T cells expressing low-affinity TCR predominate in primary, but not in secondary responses, a process referred to as T cell affinity maturation. Using CD4 dependence as a measure of the avidity of the interaction between the allospecific TCR and the alloantigen, we show that a similar process occurs in mixed ...

journal_title：European journal of immunology

authors： van Bergen J,Kooy Y,Koning F

更新日期：2001-02-01 00:00:00

abstract：:The T cell repertoire of BALB/c mice contains clones capable of recognizing p-azobenzenearsonate (ABA)-tyrosine (Tyr) in association with both I-A and I-E-encoded class II molecules. Immunization of BALB/c animals with ABA-GAT (terpolymer of L-Glu60-L-Ala30-L-Tyr10) or ABA-GLT (terpolymer of L-Glu51-L-Lys34-L-Tyr15) i...

journal_title：European journal of immunology

authors： Trannoy E,Regnier D,Campbell H,Seman M

更新日期：1985-12-01 00:00:00

abstract：:Interleukin-5 (IL-5) plays a critical role in the pathogenesis of eosinophil-associated allergic disorders, such as asthma. IL-5 may also play a major role in the development of eosinophilia-associated lymphoproliferative disorders caused by human T lymphotropic virus type I (HTLV-I). In this study, we have investigat...

journal_title：European journal of immunology

authors： Li-Weber M,Giaisi M,Krammer PH

更新日期：2001-12-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is a cytokine which, among other properties, is a principle mediator of inflammation and septic shock. It acts upon target cells by binding to specific cell surface receptors. A10G10 is a murine monoclonal antibody which recognizes human TNF and neutralizes its activity. A rabbit polyclonal...

journal_title：European journal of immunology

authors： Galloway CJ,Madanat MS,Sarr T,Espevik T,Dumas ML,Mitra G,Ranges GE

更新日期：1992-11-01 00:00:00

abstract：:Spleen cells from chickens injected with sheep erythrocytes (SE) intravenously 2 to 14 days prior to culture were found to give faster and higher plaque-forming cell responses upon addition of antigen on day 2 rather than on day 0 of culture. Cell mixture experiments showed that this was due to the induction of suppre...

journal_title：European journal of immunology

authors： Chi DS,Grebenau MD,Thorbecke GJ

更新日期：1980-03-01 00:00:00

abstract：:A murine monoclonal IgM antibody recognizes an antigen (Mo3e) found on the surface of human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide and muramyl dipeptide and blocks the monocyte response to migration inhibitory factor (MIF). We utilized Western blot and immu...

journal_title：European journal of immunology

authors： Liu DY,Ree JY,Trochelman RD,Todd RF 3rd

更新日期：1989-04-01 00:00:00

abstract：:The stimulatory as well as the inhibitory capacity of alloantisera has been investigated with respect to rat mast cell functions. Alloantibody against alloantigens coded for by the major histocompatibility (H-1) gene region promoted histamine release from purified LEW mast cells. This process was found to be complemen...

journal_title：European journal of immunology

authors： Mossmann H,Lauer W,Vortisch U,Gunther E,Bazin H,Hammer DK

更新日期：1976-08-01 00:00:00

abstract：:We identified the presence in the Aleutian skate, Bathyraja aleutica, of two classes of immunoglobulins (Ig), a high molecular weight Ig analogous to mammalian IgM and a low molecular weight Ig, similarly to the spiny rasp skate, Raja kenojei, (Kobayashi, K. et al., Mol. Immunol. 1984. 21: 397), using an immunological...

journal_title：European journal of immunology

authors： Kobayashi K,Tomonaga S,Teshima K,Kajii T

更新日期：1985-09-01 00:00:00

abstract：:The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no d...

journal_title：European journal of immunology

authors： Abromson-Leeman S,Laning J,Cantor H,Dorf ME

更新日期：1988-01-01 00:00:00

abstract：:Three molecular forms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1ra type II (IL-1ra3), have no leader sequence, thus ...

journal_title：European journal of immunology

authors： Muzio M,Polentarutti N,Facchetti F,Peri G,Doni A,Sironi M,Transidico P,Salmona M,Introna M,Mantovani A

更新日期：1999-03-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a membrane glycoprotein first identified on rat mucosal type mast cells (line RBL-2H3) and known to inhibit the Fc epsilon RI-mediated secretory response. In its extracellular domain, an amino acid stretch homologous to the carbohydrate binding domain of calcium-depe...

journal_title：European journal of immunology

authors： Binsack R,Pecht I

更新日期：1997-10-01 00:00:00

abstract：:The cell surface molecule CD44, thought to be a cell surface receptor for hyaluronic acid, is expressed by thymocytes and peripheral T cells. Following T cell activation with mitogens or antigens, surface expression of CD44 increases. This increase in CD44 cell surface expression has been used as a means of identifyin...

journal_title：European journal of immunology

authors： Haegel H,Ceredig R

更新日期：1991-06-01 00:00:00