Heterogeneity of rat encephalitogenic T cells elicited by variants of the myelin basic protein (68-86) peptide.

Abstract:

:By immunizing Lewis rats with myelin basic protein (MBP) peptide variants derived from the major encephalitogenic epitope of guinea pig (MBP(68-88) and then isolating encephalitogenic T cells from these animals, we demonstrated that the variant peptides do not elicit the same encephalitogenic T cell subsets as those induced by the wild-type peptide or by intact MBP. Rather, the pathogenic T cells differed in clonal composition as reflected by their heterogeneous responses to a panel of variant peptides and by their T cell receptor usage. Thus, molecules mimicking the MBP(68-88) autoantigen can elicit pathogenic T cell subsets without necessarily cross-reacting with T cells specific for the original autoantigen. This suggests that a more clonally diverse group of pathogenic T cells might be involved in EAE than has been apparent from studies with intact MBP or its unaltered peptides.

journal_name

Eur J Immunol

authors

Sun D,Coleclough C,Hu XZ

doi

10.1002/eji.1830250631

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

1687-92

issue

6

eissn

0014-2980

issn

1521-4141

journal_volume

25

pub_type

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