Abstract:
:The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal region in mouse, termed the NK gene complex. The human homologue of this complex is likely to reside on chromosome 12 near the PRP locus (12p13.2). By analyzing T cell hybrids, the CD69 gene was previously mapped to human chromosome 12. Here we report the regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, suggesting that CD69 belongs to one linkage group together with different cell surface molecules on NK cells.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Schnittger S,Hamann J,Dannenberg C,Fiebig H,Strauss M,Fonatsch Cdoi
10.1002/eji.1830231051subject
Has Abstractpub_date
1993-10-01 00:00:00pages
2711-3issue
10eissn
0014-2980issn
1521-4141journal_volume
23pub_type
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章,评审
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journal_title:European journal of immunology
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doi:10.1002/eji.1830251108
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journal_title:European journal of immunology
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doi:10.1002/eji.1830200724
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
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doi:10.1002/eji.1830210413
更新日期:1991-04-01 00:00:00
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doi:10.1002/eji.1830140110
更新日期:1984-01-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250927
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270317
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journal_title:European journal of immunology
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更新日期:1989-06-01 00:00:00
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journal_title:European journal of immunology
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更新日期:1986-05-01 00:00:00
abstract::The recent discovery of IL-17-producing CD4(+) Th subset significantly revised the Th1/Th2 dichotomy model proposed by Mosmann and Coffman almost two decades ago. Th17 cells are involved in the pathogenesis of many human autoimmune diseases. Th17 cells, their developmental pathways and their effector functions, theref...
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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更新日期:1993-08-01 00:00:00