A bidirectional regulatory network involving IL 2 and IL 4 in the alternative CD2 pathway of T cell activation.

abstract：:The expression of HLA class II genes is under the control of a transcriptional activator, CIITA, encoded by the AIR-1 locus. Here we show that CIITA inhibits HIV-1 LTR transactivation mediated by Tat. The inhibition occurred when CIITA and Tat were transiently expressed in cells after transfection and, most importantl...

journal_title：European journal of immunology

authors： Accolla RS,Mazza S,De Lerma Barbaro A,De Maria A,Tosi G

更新日期：2002-10-01 00:00:00

abstract：:In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF-β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote the generation and maintenance of mucosal IgA-expressing plasma cells. Here, we demonst...

journal_title：European journal of immunology

authors： Beller A,Kruglov A,Durek P,von Goetze V,Werner K,Heinz GA,Ninnemann J,Lehmann K,Maier R,Hoffmann U,Riedel R,Heiking K,Zimmermann J,Siegmund B,Mashreghi MF,Radbruch A,Chang HD

更新日期：2020-06-01 00:00:00

abstract：:A murine monoclonal IgM antibody recognizes an antigen (Mo3e) found on the surface of human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide and muramyl dipeptide and blocks the monocyte response to migration inhibitory factor (MIF). We utilized Western blot and immu...

journal_title：European journal of immunology

authors： Liu DY,Ree JY,Trochelman RD,Todd RF 3rd

更新日期：1989-04-01 00:00:00

abstract：:Alum has been the only adjuvant licensed for human vaccines for decades and is still widely used, but its mechanism of action remains obscure. Recently, the NLRP3 inflammasome has been linked to the immunostimulatory properties of alum and other particulate adjuvants, although it is disputed to what degree NLRP3 is ge...

journal_title：European journal of immunology

authors： Spreafico R,Ricciardi-Castagnoli P,Mortellaro A

更新日期：2010-03-01 00:00:00

abstract：:The involvement of rheumatoid factor (RF)-secreting cells in normal immune responses was examined by screening hybridomas derived from 129/Sv mice during primary and secondary immune responses against foreign proteins. No RF-secreting cells were detected during primary responses, but up to 10% of the total number of c...

journal_title：European journal of immunology

authors： Van Snick J,Coulie P

更新日期：1983-11-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I molecules present peptides from endogenous proteins. However, in some cases class I-restricted peptides can also derive from exogenous antigens. This MHC class I exogenous presentation could be involved in minor histocompatibility antigen (mHAg)-disparate allograft reject...

journal_title：European journal of immunology

authors： Oukka M,Galou M,Belkaid Y,Tricotet V,Riche N,Reynes M,Kosmatopoulos K

更新日期：1997-12-01 00:00:00

abstract：:Regulatory T cells (Treg) are vital in maintaining the homeostasis of immune reactions. In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity. Thus, we performed in vivo studies using TLR2-/- mice infected with Schistosoma mansoni an...

journal_title：European journal of immunology

authors： Layland LE,Rad R,Wagner H,da Costa CU

更新日期：2007-08-01 00:00:00

abstract：:The magnitude of the output of lymphocytes from Peyer's patches (PP), the morphology of the lymphocytes and their route of exit from PP has been examined in sheep. An extracorporeal perfusion system was used to selectively label a 3-4 m length of the terminal ileum of lambs at 6-10 weeks of age (the mesenteric lymph n...

journal_title：European journal of immunology

authors： Reynolds JD,Pabst R

更新日期：1984-01-01 00:00:00

abstract：:In this study, we investigated whether the phenotype-related differentiation of human 2H4+ (CD45R) naive cells to 2H4- (CDw29) memory CD4 cells corresponded to modulation of interleukin (IL) 2, IL 4, interferon (IFN)-gamma and granulocyte-monocyte colony-stimulating factor (GM-CSF) gene expression, a phenomenon which ...

journal_title：European journal of immunology

authors： Bettens F,Walker C,Gauchat JF,Gauchat D,Wyss T,Pichler WJ

更新日期：1989-09-01 00:00:00

abstract：:In humans and in BALB/c mice, immune responses to the hormone insulin use evolutionarily related VHV (human) and VHIX (murine) gene families. To determine if these structural relationships include regulatory elements, BALB/c mice were pretreated with autologous immunoglobulin G (IgG) monoclonal antibodies (mAb) that r...

journal_title：European journal of immunology

authors： Thomas JW

更新日期：1992-09-01 00:00:00

abstract：:The problem of the structural relationship between suppressive IgG-binding factor and low-affinity receptors for the Fc portion of IgG (Fc gamma RII) has not yet been solved. In the present work we have isolated a recombinant soluble Fc gamma RII containing only the two external domains of Fc gamma RII, and analyzed i...

journal_title：European journal of immunology

authors： Varin N,Sautès C,Galinha A,Even J,Hogarth PM,Fridman WH

更新日期：1989-12-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...

journal_title：European journal of immunology

authors： Zheng LM,Ojcius DM,Young JD

更新日期：1993-09-01 00:00:00

abstract：:Antigen-specific immunotherapy is an attractive strategy for cancer control. In the context of antiviral vaccines, adenoviral vectors have emerged as a favorable means for immunization. Therefore, we chose a strategy combining use of these vectors with another successful approach, namely linkage of the vaccine antigen...

journal_title：European journal of immunology

authors： Sorensen MR,Holst PJ,Pircher H,Christensen JP,Thomsen AR

更新日期：2009-10-01 00:00:00

abstract：:The variable region nucleotide sequences of seven (five IgM and two IgG) anti-histone monoclonal antibodies from a single MRL/Mp-lpr/lpr mouse have been determined. These antibodies are not clonally related and used diverse V, D and J genes. However, six of the seven antibodies have VH segments encoded by genes from t...

journal_title：European journal of immunology

authors： Monestier M

更新日期：1991-07-01 00:00:00

abstract：:In viral meningitis the inflammatory response involves activated T cells and monocytes which are recruited into the subarachnoid space. To identify the chemotactic signals attracting the cells to the site of infection in the meninges, we measured the levels of two CXC chemokines, interferon-gamma (IFN-gamma) inducible...

journal_title：European journal of immunology

authors： Lahrtz F,Piali L,Nadal D,Pfister HW,Spanaus KS,Baggiolini M,Fontana A

更新日期：1997-10-01 00:00:00

abstract：:Interleukin-31 (IL-31) is a Th2 cell-derived cytokine that has been closely linked to pruritic skin inflammation. More recently, enhanced IL-31 serum levels have also been observed in patients with allergic rhinitis and allergic asthma. Therefore, the main aim of this study was to unravel the contribution of IL-31 to ...

journal_title：European journal of immunology

authors： Neuper T,Neureiter D,Sarajlic M,Strandt H,Bauer R,Schwarz H,Suchanek P,Korotchenko E,Dillon SR,Hammerl P,Stoecklinger A,Weiss R,Horejs-Hoeck J

更新日期：2020-07-10 00:00:00

abstract：:In the lung, dendritic cells (DC) are key antigen-presenting cells capable of triggering specific cellular responses to inhaled pathogens, and thus, they may be important in the initiation of an early response to mycobacterial infections. The ability of DC to enhance antigen presentation to naive T cells within the lu...

journal_title：European journal of immunology

authors： Demangel C,Bean AG,Martin E,Feng CG,Kamath AT,Britton WJ

更新日期：1999-06-01 00:00:00

abstract：:Type I IFN are cytokines which play a central role in host resistance to viral or microbial infections and are important components linking innate and adaptive immunity. We and others have previously demonstrated that the production of IFN-beta by DC following bacterial infections or TLR triggering influences, in an a...

journal_title：European journal of immunology

authors： Remoli ME,Gafa V,Giacomini E,Severa M,Lande R,Coccia EM

更新日期：2007-12-01 00:00:00

abstract：:The early mechanisms by which DNA-dependent immunization occurs remain poorly understood. We determined whether intradermal injection of a cytomegalovirus (CMV) promoter-driven plasmid encoding hen egg lysozyme (pCMV:HEL) induced sensitization against the encoded protein, and whether cutaneous dendritic cells (DC) wer...

journal_title：European journal of immunology

authors： Bouloc A,Walker P,Grivel JC,Vogel JC,Katz SI

更新日期：1999-02-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine kinase and is crucial for cellular energy homeostasis. The exact role of AMPK during memory CD8(+) T-cell differentiation, a process that changes from the metabolically active state of effector T cells to one of quiescence in memory cells is...

journal_title：European journal of immunology

authors： Araki K,Ahmed R

更新日期：2013-04-01 00:00:00

abstract：:T90/44 is a cell surface antigen which is present on human T cells of the helper and cytotoxic subsets and which binds the 9.3 monoclonal antibody (9.3 mAb). It is expressed in the form of 90-kDa disulfide-bonded dimers of a 44-kDa polypeptide and of free 44-kDa subunits. The function of T90/44 was investigated in a s...

journal_title：European journal of immunology

authors： Lesslauer W,Koning F,Ottenhoff T,Giphart M,Goulmy E,van Rood JJ

更新日期：1986-10-01 00:00:00

abstract：:For long-term attack on tumor cells in patients with prostate cancer, induction of cytolytic T cells is desirable. Several lineage-specific target proteins are known and algorithms have identified candidate MHC class I-binding peptides, particularly for HLA-A*0201. We have designed tolerance-breaking DNA fusion vaccin...

journal_title：European journal of immunology

authors： Vittes GE,Harden EL,Ottensmeier CH,Rice J,Stevenson FK

更新日期：2011-08-01 00:00:00

abstract：:Monoclonal antibodies MRC-OX6 and MRC-OX3 were used to define biosynthetically inter-related subsets of I-A-equivalent class II molecules from Lewis rat spleen cells. MRC-OX6 was shown to recognize specifically multiple forms of the class II molecule arising along its maturation pathway from the origin of polypeptide ...

journal_title：European journal of immunology

authors： Reske K,Weitzel R

更新日期：1985-12-01 00:00:00

abstract：:Aging is accompanied by altered immunity, resulting in a variable state of poorly understood immunodeficiency. While both the numbers and the functionality of naïve T cells are decreased by aging, the impact of these changes upon immune defense against bacterial pathogens in vivo remains understudied. Using a model of...

journal_title：European journal of immunology

authors： Smithey MJ,Renkema KR,Rudd BD,Nikolich-Žugich J

更新日期：2011-05-01 00:00:00

abstract：:By combining velocity and linear density fractionations as well as target cell rosetting techniques we have isolated and morphologically identified the human effector cell type responsible for spontaneous, trypsin-augmentable cytotoxicity against chicken red cells and human myeloma cell line targets. This cell is a la...

journal_title：European journal of immunology

authors： Saksela E,Häyry P,Andersson LC

更新日期：1977-11-01 00:00:00

abstract：:The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent activator of invariant natural killer T (iNKT) cells and has been shown to be an effective agent against cancer, infections and autoimmune diseases. The effectiveness of alpha-GalCer and its alkyl chain analogues depends on efficient loading and presen...

journal_title：European journal of immunology

authors： Denkberg G,Stronge VS,Zahavi E,Pittoni P,Oren R,Shepherd D,Salio M,McCarthy C,Illarionov PA,van der Merwe A,Besra GS,Dellabona P,Casorati G,Cerundolo V,Reiter Y

更新日期：2008-03-01 00:00:00

abstract：:T lymphocytes can be activated and induced to proliferate through stimulation of the CD2 glycoprotein with functional combinations of CD2 antibodies. However, this mechanism of signal transduction via CD2 is still not fully understood. We have investigated which molecules on the T cell surface preferentially associate...

journal_title：European journal of immunology

authors： Castro MA,Tavares PA,Almeida MS,Nunes RJ,Wright MD,Mason D,Moreira A,Carmo AM

更新日期：2002-05-01 00:00:00

abstract：:The distribution of the murine receptor for interleukin (IL) 6 was examined on a variety of cells. Binding sites for IL 6 were found on many cell lines including fibroblasts and bone marrow-derived macrophages. The highest density of binding sites was found on B cell hybridomas and plasmacytomas, irrespective of their...

journal_title：European journal of immunology

authors： Coulie PG,Stevens M,Van Snick J

更新日期：1989-11-01 00:00:00

abstract：:The cell surface molecule CD44, thought to be a cell surface receptor for hyaluronic acid, is expressed by thymocytes and peripheral T cells. Following T cell activation with mitogens or antigens, surface expression of CD44 increases. This increase in CD44 cell surface expression has been used as a means of identifyin...

journal_title：European journal of immunology

authors： Haegel H,Ceredig R

更新日期：1991-06-01 00:00:00

abstract：:We show that latently gammaherpesvirus-infected B cells are present in the thymus. This could result in a functional T-cell tolerance against certain viral epitopes. It is conceivable that also antigens from other viruses or pathogens may be conveyed to the thymus for their immune evasion. ...

journal_title：European journal of immunology

authors： Yamano T,Steinert M,Steer B,Klein L,Hammerschmidt W,Adler H

更新日期：2019-02-01 00:00:00