High- and low-affinity receptors for murine interleukin 6. Distinct distribution on B and T cells.

abstract：:In the frog Xenopus, MHC class I antigen presentation and processing genes (the immunoproteasome LMP2 and LMP7 and the transporter TAP1 and TAP2) seem to be closely linked in a primordial organization. Two distinct lineages of class Ia and LMP7 loci were previously identified, thus strongly suggesting co-evolution amo...

journal_title：European journal of immunology

authors： Ohta Y,Powis SJ,Lohr RL,Nonaka M,Pasquier LD,Flajnik MF

更新日期：2003-11-01 00:00:00

abstract：:The influence of muramyl dipeptide (N-acetylmuramyl-L-alanyl-D-isoglutamine) on the rejection of mouse skin allografts was investigated. While the 0.1-mg dose administered on days 7, 6, 5 prior to transplantation caused significant prolongation of the graft survival, the 0.5-mg dose administered on days 3, 2, 1 prior ...

journal_title：European journal of immunology

authors： Zídek Z,Capková J,Boubelík M,Masek K

更新日期：1983-10-01 00:00:00

abstract：:For long-term attack on tumor cells in patients with prostate cancer, induction of cytolytic T cells is desirable. Several lineage-specific target proteins are known and algorithms have identified candidate MHC class I-binding peptides, particularly for HLA-A*0201. We have designed tolerance-breaking DNA fusion vaccin...

journal_title：European journal of immunology

authors： Vittes GE,Harden EL,Ottensmeier CH,Rice J,Stevenson FK

更新日期：2011-08-01 00:00:00

abstract：:Strains CBA (M523) (= M523) and CBA differ by a mutation which has been mapped genetically into the K region of the H-2 complex. Similarly, strains B 10.D2 (M504 (= M504) and b 10.D2 differ in a mutation which occurred in the D region. The data presented in this study show that mixed lymphocyte culture in M523 anti-CB...

journal_title：European journal of immunology

authors： Geib RW,Klein J

更新日期：1979-02-01 00:00:00

abstract：:Large granular lymphocyte clones were prepared from normal human mononuclear cells. Seven clones were studied in detail. All had high cytotoxic activity against the natural killer (NK) cell target K562 and all were T11- and DR-positive but T4- and T8-negative: none released migration inhibitory factor, a characteristi...

journal_title：European journal of immunology

authors： Vyakarnam A,Brenner MK,Reittie JE,Houlker CH,Lachmann PJ

更新日期：1985-06-01 00:00:00

abstract：:We analyzed the stimulating capacities of malignant B cells from non-Hodgkin's lymphomas (NHL) to induce an allogeneic response in primary mixed lymphocyte reaction (MLR). T cells purified from a single healthy donor (KS) were used to compare the responses induced by either malignant or hyperplastic cells. Malignant B...

journal_title：European journal of immunology

authors： Plumas J,Chaperot L,Jacob MC,Molens JP,Giroux C,Sotto JJ,Bensa JC

更新日期：1995-12-01 00:00:00

abstract：:The host protective immune response to blood stage malaria infection was studied using Plasmodium chabaudi chabaudi (P.chabaudi) in NIH mice. It has been shown previously that CD4+ cells are critically required for protection against erythrocytic infection. Mice lacking a functional CD4+ cell compartment suffer unremi...

journal_title：European journal of immunology

authors： Taylor-Robinson AW,Phillips RS

更新日期：1994-01-01 00:00:00

abstract：:The potential of synthetic peptides as vaccines is restricted by their frequent lack of immunogenicity. As with haptens, coupling to a carrier protein is usually required to provide T cell help to anti-peptide antibody-producing B cells. In spite of their short length, a few natural or synthetic peptides are immunogen...

journal_title：European journal of immunology

authors： Borras-Cuesta F,Petit-Camurdan A,Fedon Y

更新日期：1987-08-01 00:00:00

abstract：:A monoclonal antibody, B20.1, was generated by fusing spleen cells from a Lou rat immunized with a soluble alpha/beta T cell receptor (TcR; V alpha 2/V beta 2) to mouse myeloma cells. Analysis of a panel of V alpha 2 mRNA-expressing T cell lines, hybridomas and transfectants revealed that the B20.1 antibody was specif...

journal_title：European journal of immunology

authors： Pircher H,Rebaï N,Groettrup M,Grégoire C,Speiser DE,Happ MP,Palmer E,Zinkernagel RM,Hengartner H,Malissen B

更新日期：1992-02-01 00:00:00

abstract：:The monoclonal antibody W6/32.1 recognizes a public determinant on the HLA-A, B and C antigens of all tested human haplotypes. Though the antibody does not bind to normal mouse cells of any H-2 haplotype, it does show an unexpected specificity for the T cell leukemia line MBL-2 from a C57BL/6 mouse. It is shown that t...

journal_title：European journal of immunology

authors： Evan GI,Lennox ES,Alderson T,Croft L

更新日期：1983-02-01 00:00:00

abstract：:Peritoneal mast cells (PMC) and intestinal mucosal mast cells (IMMC) were purified from rats infected with the nematode Nippostrongylus brasiliensis. Overall protein constituents of both mast cell subtypes were analyzed by two-dimensional gel electrophoresis using either nonequilibrium pH gradient electrophoresis (NEP...

journal_title：European journal of immunology

authors： Abe T,Swieter M,Imai T,Hollander ND,Befus AD

更新日期：1990-09-01 00:00:00

abstract：:Immunization leads to the generation of both antibody-forming cells (AFC) and memory B cells which are thought to arise in germinal centers within lymphoid follicles. The findings that the precursors to memory B cells reside in the J11Dlo subpopulation of the spleens in non-immune mice and that this subpopulation is d...

journal_title：European journal of immunology

authors： Linton PJ,Lo D,Lai L,Thorbecke GJ,Klinman NR

更新日期：1992-05-01 00:00:00

abstract：:Cross-linking of surface immunoglobulin (sIg) by antibodies against IgM, IgG and IgD activates B cells and in some circumstances can induce cell proliferation. We studied the potential link between anti-Ig-induced changes in the cytosolic free Ca2+ concentration ([Ca2+]i), inositol phosphate production and the ability...

journal_title：European journal of immunology

authors： Roifman CM,Mills GB,Stewart D,Cheung RK,Grinstein S,Gelfand EW

更新日期：1987-12-01 00:00:00

abstract：:In this study, we investigated whether the phenotype-related differentiation of human 2H4+ (CD45R) naive cells to 2H4- (CDw29) memory CD4 cells corresponded to modulation of interleukin (IL) 2, IL 4, interferon (IFN)-gamma and granulocyte-monocyte colony-stimulating factor (GM-CSF) gene expression, a phenomenon which ...

journal_title：European journal of immunology

authors： Bettens F,Walker C,Gauchat JF,Gauchat D,Wyss T,Pichler WJ

更新日期：1989-09-01 00:00:00

abstract：:Listeria monocytogenes (LM) is a foodborne Gram-positive intracellular pathogen that can cause listeriosis in humans and animals. Although phagocytes are known to be involved in the response to this infection, the role of neutrophils is not entirely clear. Here, we have demonstrated that soon after LM infection, a lar...

journal_title：European journal of immunology

authors： Wang G,Lin A,Han Q,Zhao H,Tian Z,Zhang J

更新日期：2018-09-01 00:00:00

abstract：:As we approach the centenary of Elie Metchnikoff's Nobel Prize (1908), it is opportune to reflect upon the history of macrophage immunobiology, take stock of current knowledge and anticipate questions for the future. Starting from his appreciation of phagocytosis as an important determinant of host defence against inf...

journal_title：European journal of immunology

authors： Gordon S

更新日期：2007-11-01 00:00:00

abstract：:Intravenous immunoglobulins (IVIgs) efficiently suppress a variety of autoimmune diseases. Over the past few years several potential mechanisms underlying this antiinflammatory activity have become apparent. Among these, terminal sialic acid residues in the sugar moiety of the immunoglobulin G constant fragment have b...

journal_title：European journal of immunology

authors： Schwab I,Seeling M,Biburger M,Aschermann S,Nitschke L,Nimmerjahn F

更新日期：2012-12-01 00:00:00

abstract：:The class II transactivator (CIITA) has been referred to as the "master control factor" for the expression of MHC class II (MHCII) genes. As our knowledge on the specificity and function of CIITA grows, it is becoming increasingly evident that this sobriquet is entirely justified. First, despite extensive investigatio...

journal_title：European journal of immunology

authors： LeibundGut-Landmann S,Waldburger JM,Krawczyk M,Otten LA,Suter T,Fontana A,Acha-Orbea H,Reith W

更新日期：2004-06-01 00:00:00

abstract：:Macrophage scavenger receptors are trimeric integral membrane glycoproteins which have been implicated in various macrophage functions including uptake of oxidized lipoprotein and the serum-dependent, divalent cation-independent adhesion of macrophages to tissue culture-treated plastic. In this study we have used a re...

journal_title：European journal of immunology

authors： Hughes DA,Fraser IP,Gordon S

更新日期：1995-02-01 00:00:00

abstract：:Multiple myeloma is a fatal B cell malignancy characterized by the accumulation of plasma cells within the bone marrow. IL-6 is a major survival factor for myeloma cells. Bcl-2 protein family regulates pathways to apoptosis that are activated upon growth factor deprivation. Pro-apoptotic proteins that have only a sing...

journal_title：European journal of immunology

authors： Gomez-Bougie P,Bataille R,Amiot M

更新日期：2004-11-01 00:00:00

abstract：:MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88(-/-) mice. We found an increased susceptibility to VSV in myd88(-/...

journal_title：European journal of immunology

authors： Lang KS,Navarini AA,Recher M,Lang PA,Heikenwalder M,Stecher B,Bergthaler A,Odermatt B,Akira S,Honda K,Hengartner H,Zinkernagel RM

更新日期：2007-09-01 00:00:00

abstract：:Histological techniques were used to identify antigen-presenting cells (APC) in adoptively transferred diabetes in NOD mice and Ins-HA transgenic mice, and in spontaneously diabetic NOD mice. In adoptively transferred disease, CD4+ T cells and F4/80+ macrophages dominated early infiltrates. By contrast, in spontaneous...

journal_title：European journal of immunology

authors： Lo D,Reilly CR,Scott B,Liblau R,McDevitt HO,Burkly LC

更新日期：1993-07-01 00:00:00

abstract：:Rabbit anti-SII pneumococcal polysaccharide IgG antibody was cross-linked by dithiobis (succinimidyl propionate). The IgG dimers were visualized by electronmicroscopy and resembled two Y-shaped structures connected in random orientations. The three arms of the Y's were of equal length. The six globular domains of the ...

journal_title：European journal of immunology

authors： Tschopp J,Villiger W,Lustig A,Jaton JC,Engel J

更新日期：1980-07-01 00:00:00

abstract：:A novel surface molecule, Tp90, is described which appears to be involved in an antigen-independent pathway of human T lymphocyte activation. The Tp90 molecule was identified by a monoclonal antibody (mAb), MX20, obtained from a fusion using spleen cells of a mouse immunized with cells from two T cell leukemia lines, ...

journal_title：European journal of immunology

authors： Carrel S,Salvi S,Giuffrè L,Isler P,Cerottini JC

更新日期：1987-06-01 00:00:00

abstract：:Previously, we have shown that the intravenous (i.v.) injection of allogeneic lymphocytes across an H-2 class I-mutant disparity leads to specific skin allograft tolerance caused by irradiation-sensitive donor T cells, which function as veto cells. In the present study, we show that the i.v. injection of H-2 class II-...

journal_title：European journal of immunology

authors： van Twuyver E,Kast WM,Mooijaart RJ,Melief CJ,De Waal LP

更新日期：1990-02-01 00:00:00

abstract：:The expression and action of Fas/Fas ligand (FasL) in multiple sclerosis has been postulated as a major pathway leading to inflammatory demyelination. To formally test this hypothesis, C57BL/6-lpr and -gld mice, which due to gene mutation express Fas and FasL in an inactive form, were immunized with myelin oligodendro...

journal_title：European journal of immunology

authors： Malipiero U,Frei K,Spanaus KS,Agresti C,Lassmann H,Hahne M,Tschopp J,Eugster HP,Fontana A

更新日期：1997-12-01 00:00:00

abstract：:A single T cell clone can be activated by many different peptides in the context of a particular HLA molecule. To quantify the number of peptides that can be recognized by a CD4(+) T cell clone, we screened a one-bead-one-peptide synthetic peptide library and a protein database for peptides that stimulate an HLA-DR3-r...

journal_title：European journal of immunology

authors： Hiemstra HS,van Veelen PA,Willemen SJ,Benckhuijsen WE,Geluk A,de Vries RR,Roep BO,Drijfhout JW

更新日期：1999-08-01 00:00:00

abstract：:Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...

journal_title：European journal of immunology

authors： Sasaki T,Kanaseki T,Shionoya Y,Tokita S,Miyamoto S,Saka E,Kochin V,Takasawa A,Hirohashi Y,Tamura Y,Miyazaki A,Torigoe T,Hiratsuka H,Sato N

更新日期：2016-04-01 00:00:00

abstract：:Although anti-inflammatory properties of glucocorticoids (GC) are well documented, their activity in allergic diseases is still controversial. Recently, it has been reported that GC can increase, both in vivo and in vitro, the polyclonal production of total IgE. In this study we investigated the effects of GC on the a...

journal_title：European journal of immunology

authors： Akdis CA,Blesken T,Akdis M,Alkan SS,Heusser CH,Blaser K

更新日期：1997-09-01 00:00:00

abstract：:Activation of naive T cells is tightly controlled and depends on cognate interactions with professional antigen-presenting cells. We analyzed dependency on secondary lymphoid tissues for the activation of naive and memory CD4(+) and CD8(+) T cells following primary and secondary Listeria monocytogenes infection, respe...

journal_title：European journal of immunology

authors： Kursar M,Jänner N,Pfeffer K,Brinkmann V,Kaufmann SH,Mittrücker HW

更新日期：2008-01-01 00:00:00