Abstract:
:The potential of synthetic peptides as vaccines is restricted by their frequent lack of immunogenicity. As with haptens, coupling to a carrier protein is usually required to provide T cell help to anti-peptide antibody-producing B cells. In spite of their short length, a few natural or synthetic peptides are immunogenic: they all include both a determinant recognized by B cells and a proven or putative determinant recognized by T cells. We speculated that it should be possible to induce immunogenicity in peptide haptens by the inclusion of a well characterized determinant recognized by T cells. We thus synthesized two peptides, corresponding to different regions of the major protein VP6 of bovine rotavirus, co-linearly linked to a peptide of influenza virus hemagglutinin which had been shown to induce T helper cells in BALB/c mice. Both peptides induced anti-rotavirus antibodies and were more immunogenic than the corresponding bovine serum albumin-conjugated peptides.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Borras-Cuesta F,Petit-Camurdan A,Fedon Ydoi
10.1002/eji.1830170820subject
Has Abstractpub_date
1987-08-01 00:00:00pages
1213-5issue
8eissn
0014-2980issn
1521-4141journal_volume
17pub_type
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journal_title:European journal of immunology
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