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CD8alpha+ DC are not the sole subset cross-presenting cell-associated tumor antigens from a solid tumor.

Abstract：

:One of the clear paradoxes in tumor immunology is the fact that cross-presentation of cell-associated tumor antigens to CD8(+) T cells is efficient, yet CTL generation is weak, and tumors continue to grow. We examined, for the first time whether this may be due to alterations in the phenotype or function of cross-presenting DC using a solid tumor model expressing a membrane bound neo-antigen (hemagglutinin, HA). Tumor antigen was constitutively cross-presented in the tumor-draining LN throughout tumor progression by CD11c(+) DC. Further analysis revealed that both CD8alpha(+) and CD8alpha(-) DC subsets, but not plasmacytoid DC, were effective at cross-presenting HA tumor antigen. The proportions of DC subsets in the tumor-draining LN were equivalent to those seen in the LN of naïve mice; however, a significant increase in the expression of the potential inhibitory B7 molecule, B7-DC, was noted and appeared to be restricted to the CD8alpha(-) DC subset. Therefore LN resident CD8alpha(+) DC are not the sole DC subset capable of cross-presenting cell-associated tumor antigens. Migratory tumor DC subsets with altered co-stimulatory receptor expression may contribute to induction and regulation of tumor-specific responses.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

McDonnell AM,Prosser AC,van Bruggen I,Robinson BW,Currie AJ

doi

10.1002/eji.200940153

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

1617-27

issue

6

eissn

0014-2980

issn

1521-4141

journal_volume

40

pub_type

杂志文章

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