Abstract:
:Development of Th1 and Th2 effector lymphocytes is driven primarily by IL-12 or IL-4, but is also influenced by the strength of antigenic stimulation. However, the mechanism by which TCR signaling contributes to T cell polarization remains elusive. We show that in the presence of IL-12 a short TCR stimulation can lead to efficient Th1 polarization and IL-12 exerts its effect when present during, as well as after, TCR signaling. In contrast, Th2 polarization requires a prolonged TCR stimulation and IL-4 is effective only when present during the period of TCR triggering. The simultaneous stimulation by TCR and IL-4 is required to induce demethylation of IL-4 and IL-13 genes that accompanies the stochastic generation of Th2 cells producing either or both cytokines. Thus, the duration of TCR stimulation represents a crucial parameter that influences the response to polarizing cytokines and the acquisition of T cell effector functions.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Iezzi G,Scotet E,Scheidegger D,Lanzavecchia Adoi
10.1002/(SICI)1521-4141(199912)29:12<4092::AID-IMMkeywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
4092-101issue
12eissn
0014-2980issn
1521-4141journal_volume
29pub_type
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