SIRPα+ dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes.

abstract：:Dendritic cells (DC) are known to support the activation of natural killer (NK) cells. However, little is known about the role for DC in NK-cell homeostasis. In order to investigate this question, a novel bacterial artificial chromosome transgenic mouse model was generated in which the diphtheria toxin receptor is exp...

journal_title：European journal of immunology

authors： Hochweller K,Striegler J,Hämmerling GJ,Garbi N

更新日期：2008-10-01 00:00:00

abstract：:Prostein is a prostate tissue-specific protein that is uniquely and abundantly expressed in normal and cancerous prostate tissues. Due to this expression profile, we examined the immunogenicity of prostein as a potential vaccine candidate for prostate cancer. To determine the presence of CD8 T cells specific for natur...

journal_title：European journal of immunology

authors： Friedman RS,Spies AG,Kalos M

更新日期：2004-04-01 00:00:00

abstract：:Injection of M-1 (Cmu), G-1 (Cgamma) heterozygous chickens on the day of hatch with anti-IgM-1 antiserum induced allotype suppression from which chickens recovered over a period of approximately 4 months. The suppression of the serum IgM-1 levels was matched by a decrease in the number of splenic and peripheral blood ...

journal_title：European journal of immunology

authors： Ratcliffe MJ,Ivanyi J

更新日期：1981-04-01 00:00:00

abstract：:Although potentially autoreactive T cells are present even in healthy subjects, most individuals do not develop autoimmune disease. It has been well demonstrated that CD4+ CD25+ regulatory T cells play a significant role in controlling the expansion of autoreactive T cells in the periphery. However, some healthy indiv...

journal_title：European journal of immunology

authors： James EA,Kwok WW

更新日期：2007-01-01 00:00:00

abstract：:The effects of vasoactive intestinal peptide (VIP) on human IgA1 and IgA2 production were studied. In unfractionated small resting B cells stimulated with anti-CD40 monoclonal antibody (mAb), VIP induced IgA1 and IgA2 production without affecting the production of IgG1, IgG2, IgG3, IgG4, IgM, or IgE. When small B cell...

journal_title：European journal of immunology

authors： Kimata H,Fujimoto M

更新日期：1994-09-01 00:00:00

abstract：:Recombinant vaccinia viruses (VV)-encoding murine interferon-gamma (IFN-gamma) were constructed and the effect of virus-encoded IFN-gamma on the immune response towards VV in vivo investigated. In athymic nude mice and sublethally irradiated euthymic mice, IFN-gamma expression by VV enabled the mice to recover from th...

journal_title：European journal of immunology

authors： Kohonen-Corish MR,King NJ,Woodhams CE,Ramshaw IA

更新日期：1990-01-01 00:00:00

abstract：:The murine T cell clone D10.G4.1 can be induced to proliferate by monoclonal antibodies (mAb) to the T cell receptor (TcR) or to Thy-1 molecules. When cells were stimulated by anti-TcR mAb, a group of 4 proteins (19-25 kDa) was specifically phosphorylated. This effect was completely mimicked by the Ca2+ ionophore A231...

journal_title：European journal of immunology

authors： Peyron JF,Pont S,Pierres M,Fehlmann M

更新日期：1988-07-01 00:00:00

abstract：:Muramyl peptides are the building blocks of bacterial peptidoglycan, and their biological functions in mammals have been extensively studied. In particular, muramyl peptides trigger inflammation, contribute to host defense against microbial infections, and modulate the adaptive immune response to antigens. These bacte...

journal_title：European journal of immunology

authors： Magalhaes JG,Lee J,Geddes K,Rubino S,Philpott DJ,Girardin SE

更新日期：2011-05-01 00:00:00

abstract：:To study the question when and where self peptides become associated with major histocompatibility complex class II molecules for tolerance induction, we recently developed a system in which the intracellular site(s) of antigen expression could be manipulated using gene cloning techniques. We previously constructed a ...

journal_title：European journal of immunology

authors： Bikoff EK

更新日期：1991-06-01 00:00:00

abstract：:B cell-activating factor belonging to the TNF family (BAFF) and its receptor BAFF-R play critical roles in the maturation and survival of conventional peripheral B cells. However, they appeared to be dispensable for the generation and maintenance of CD5(+) B-1 cells as BAFF(-/-) and BAFF-R(-/-) mice have normal B-1 ce...

journal_title：European journal of immunology

authors： Ng LG,Ng CH,Woehl B,Sutherland AP,Huo J,Xu S,Mackay F,Lam KP

更新日期：2006-07-01 00:00:00

abstract：:The second HLA-DR molecules, which are encoded by loci different from HLA-DRB1 are weakly polymorphic. Predominant alleles such as HLA-DRB3*0101, HLA-DRB4*0101 and HLA-DRB5*0101 are therefore interesting targets to define antigenic peptides with major impact for the entire population. Strikingly, they have been poorly...

journal_title：European journal of immunology

authors： Texier C,Pouvelle-Moratille S,Busson M,Charron D,Ménez A,Maillère B

更新日期：2001-06-01 00:00:00

abstract：:T-cell development is a spatially and temporally regulated process, orchestrated by well-defined contributions of transcription factors and cytokines. Here, we identify the noncoding RNA miR-142 as an additional regulatory layer within murine thymocyte development and proliferation. MiR-142 deficiency impairs the expr...

journal_title：European journal of immunology

authors： Mildner A,Chapnik E,Varol D,Aychek T,Lampl N,Rivkin N,Bringmann A,Paul F,Boura-Halfon S,Hayoun YS,Barnett-Itzhaki Z,Amit I,Hornstein E,Jung S

更新日期：2017-07-01 00:00:00

abstract：:The receptor for the inflammatory peptide C3a has scarcely been examined on human cells. This work demonstrates that human tumor-derived basophilic granulocytes express C3a receptors, and presents parts of the hitherto unknown C3a-signal transduction. When incubated with IL-3, these cells specifically liberated histam...

journal_title：European journal of immunology

authors： Kretzschmar T,Jeromin A,Gietz C,Bautsch W,Klos A,Köhl J,Rechkemmer G,Bitter-Suermann D

更新日期：1993-02-01 00:00:00

abstract：:Upon treatment with lipopolysaccharide (LPS), primary B cells proliferate and differentiate into plasma cells with concomitant up-regulation of immunoglobulin (Ig) gene expression. Here we examine the role of the Igkappa 3' enhancer in this process using a kappa3'-enhancer-driven beta-globin reporter gene in transgeni...

journal_title：European journal of immunology

authors： Meyer KB

更新日期：1999-03-01 00:00:00

abstract：:MHC class II tetramers are attractive tools to study antigen-specific CD4(+) T cell responses in various clinical situations in humans. HLA-DRA1*0101/DRB1*0401 MHC class II heterodimers were produced as empty molecules using the Drosophila melanogaster expression system. Peptide binding experiments revealed that these...

journal_title：European journal of immunology

authors： Lemaître F,Viguier M,Cho MS,Fourneau JM,Maillère B,Kourilsky P,Van Endert PM,Ferradini L

更新日期：2004-10-01 00:00:00

abstract：:The outcomes of many diseases differ between women and men, with women experiencing a higher incidence and more severe pathogenesis of autoimmune and some infectious diseases. It has been suggested that this is partially due to activation of plasmacytoid dendritic cells (pDCs), the main producers of interferon (IFN)-α...

journal_title：European journal of immunology

authors： Ziegler SM,Beisel C,Sutter K,Griesbeck M,Hildebrandt H,Hagen SH,Dittmer U,Altfeld M

更新日期：2017-02-01 00:00:00

abstract：:KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myel...

journal_title：European journal of immunology

authors： Lucas M,Daniel L,Tomasello E,Guia S,Horschowski N,Aoki N,Figarella-Branger D,Gomez S,Vivier E

更新日期：2002-09-01 00:00:00

abstract：:Cofilin, an actin-depolymerizing protein, is essential for the functional dynamics of the actin cytoskeleton and for cell viability. In unstimulated human peripheral blood T lymphocytes cofilin is phosphorylated and localized in the cytoplasm. Following co-stimulation through accessory receptors (e.g. CD2 or CD28) - h...

journal_title：European journal of immunology

authors： Ambach A,Saunus J,Konstandin M,Wesselborg S,Meuer SC,Samstag Y

更新日期：2000-12-01 00:00:00

abstract：:The N-terminal amino acid sequence (26 residues) of a delta-chain of a human myeloma (Er I) is homologous with the prototype sequence of the human VHIII subgroup. This indicates that the delta-chain is using for its V region the same pool of V genes as the rest of the immunoglobulin classes. Implications of this findi...

journal_title：European journal of immunology

authors： Milstein CP,Northrop F

更新日期：1976-03-01 00:00:00

abstract：:Both interleukin-7 (IL-7) and IL-7 receptor (R) gene knockout (IL-7-/- and IL-7R-/-) mice were employed in order to directly investigate the importance of the IL-7 and IL-7R signaling pathway for the development of intestinal intraepithelial lymphocytes (IEL). Loss of the IL-7R-specific gene resulted in complete defic...

journal_title：European journal of immunology

authors： Fujihashi K,McGhee JR,Yamamoto M,Peschon JJ,Kiyono H

更新日期：1997-09-01 00:00:00

abstract：:We have studied the kinetics of the antigen induced response of naive and memory CD8 T cells expressing a transgenic T cell receptor (TCR) specific for the glycoprotein peptide amino acid 33-41 (GP33) of the lymphocytic choriomeningitis virus (LCMV). Memory T cells were generated in vivo by adoptive transfer of LCMV T...

journal_title：European journal of immunology

authors： Zimmermann C,Prévost-Blondel A,Blaser C,Pircher H

更新日期：1999-01-01 00:00:00

abstract：:We show that, in vitro, the response of thymocytes to certain stimuli, and their survival largely depend on the nature of the culture environment, i.e. whether thymocytes are stimulated within intact thymus lobes or in cell suspension. Exposure of isolated thymocytes to 12-O-tetra-decanoylphorbol 13-acetate (TPA)+iono...

journal_title：European journal of immunology

authors： Moore NC,Jenkinson EJ,Owen JJ

更新日期：1992-10-01 00:00:00

abstract：:The thymic architecture is normally compartmentalized into a central medulla surrounded by a peripheral cortical region. We investigated how compartmentalization of the thymic stroma is regulated using T cell receptor (TCR)-transgenic mouse models. Our studies show that the signals generated by TCR/peptide/major histo...

journal_title：European journal of immunology

authors： Brabb T,Huseby ES,Morgan TM,Sant'Angelo DB,Kirchner J,Farr AG,Goverman J

更新日期：1997-01-01 00:00:00

abstract：:Soluble anti-immunoglobulin (Ig) antibodies have been generally found to inhibit Ig secretion in B cells, via largely unknown mechanisms. To investigate this phenomenon further a two-step culture system was used in which B cells are primed for 24-72 h with various soluble monoclonal or polyclonal anti-Ig antibodies: a...

journal_title：European journal of immunology

authors： Phillips C,Klaus GG

更新日期：1992-06-01 00:00:00

abstract：:Leishmania-induced macrophage (Mphi) dysfunctions have been correlated with altered signaling events. Recent findings from our laboratory suggest that modulation of host protein tyrosine phosphatase (PTP) following Leishmania infection could lead to these Mphi defects. To address this issue, Mphi PTP activity and IFN-...

journal_title：European journal of immunology

authors： Blanchette J,Racette N,Faure R,Siminovitch KA,Olivier M

更新日期：1999-11-01 00:00:00

abstract：:Intrathymic deletion of immature thymocytes that express self-reactive TCR specificities is essential in the generation of self tolerance. Medullary thymic epithelial cells (mTEC) expressing the transcriptional regulator Aire play a key role in this process by regulating expression of tissue-restricted antigens to ens...

journal_title：European journal of immunology

authors： White AJ,Withers DR,Parnell SM,Scott HS,Finke D,Lane PJ,Jenkinson EJ,Anderson G

更新日期：2008-04-01 00:00:00

abstract：:A diabetes-associated peptide in the glutamic acid decarboxylase 65 (GAD65) molecule, p524-543, activates two distinct populations of T cells, which apparently play opposite roles in the development of diabetes in NOD mice. By comparing the fine specificity of these two T cell repertoires using a nested set of truncat...

journal_title：European journal of immunology

authors： Dai YD,Jensen KP,Marrero I,Li N,Quinn A,Sercarz EE

更新日期：2008-04-01 00:00:00

abstract：:In hematopoietic stem cell transplantation (HSCT), when no HLA full-matched donor is available, alternative donors could include one HLA-mismatched donor. Recently, the low expressed HLA-C alleles have been identified as permissive mismatches for the best donor choice. Concerning HLA-A, the degree of variability of ex...

journal_title：European journal of immunology

authors： René C,Lozano C,Villalba M,Eliaou JF

更新日期：2015-12-01 00:00:00

abstract：:Rabbit antibodies to Atlantic cod (Gadus morhua L.) immunoglobulin were affinity purified and used to screen cDNA libraries from spleen and head kidney mRNA. cDNA clones for both the secretory and membrane-bound heavy (H) chain were isolated, the nucleotide and deduced amino acid sequences of which are reported here. ...

journal_title：European journal of immunology

authors： Bengtén E,Leanderson T,Pilström L

更新日期：1991-12-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent inducer of interleukin 1 (IL 1) synthesis and release, and of tumor necrosis factor (TNF) secretion. Many signals can enhance the LPS-induced production of these cytokines. We have previously observed that addition of low amounts of normal human serum to the culture medium enhances...

journal_title：European journal of immunology

authors： Cavaillon JM,Fitting C,Haeffner-Cavaillon N

更新日期：1990-02-01 00:00:00