Abstract:
:Murine cytolytic T cell lines have been analyzed for the expression of two surface glycoproteins called T145 and T130. T145, known to be expressed by activated cytolytic T cells, is also expressed by such lines, but T130, which has been described by a universal T cell marker, is not. Our results suggest a structural relationship between T145 and T130. Vicia villosa lectin, which binds selectively to T145 of activated T cells and which is cytotoxic for cytolytic T cell lines, has been used to select lectin-resistant mutants from these lines. Five independent lectin-resistant mutants have been obtained. All of them are cytolytically active, bind up to 100-fold less lectin than the parental lines, but still express T145 or a closely related glycoprotein.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Conzelmann A,Pink R,Acuto O,Mach JP,Dolivo S,Nabholz Mdoi
10.1002/eji.1830101111subject
Has Abstractpub_date
1980-11-01 00:00:00pages
860-8issue
11eissn
0014-2980issn
1521-4141journal_volume
10pub_type
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