Presence of T 145 on cytolytic T cell lines and their lectin-resistant mutants.

Abstract:

:Murine cytolytic T cell lines have been analyzed for the expression of two surface glycoproteins called T145 and T130. T145, known to be expressed by activated cytolytic T cells, is also expressed by such lines, but T130, which has been described by a universal T cell marker, is not. Our results suggest a structural relationship between T145 and T130. Vicia villosa lectin, which binds selectively to T145 of activated T cells and which is cytotoxic for cytolytic T cell lines, has been used to select lectin-resistant mutants from these lines. Five independent lectin-resistant mutants have been obtained. All of them are cytolytically active, bind up to 100-fold less lectin than the parental lines, but still express T145 or a closely related glycoprotein.

journal_name

Eur J Immunol

authors

Conzelmann A,Pink R,Acuto O,Mach JP,Dolivo S,Nabholz M

doi

10.1002/eji.1830101111

subject

Has Abstract

pub_date

1980-11-01 00:00:00

pages

860-8

issue

11

eissn

0014-2980

issn

1521-4141

journal_volume

10

pub_type

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