Beta 2-adrenergic stimulation causes detachment of natural killer cells from cultured endothelium.

abstract：:A previously designed isotopic in vivo method for measuring delayed hypersensitivity was used with nonantigenic (or weakly antigenic) phlogogenic substances. A strong reaction was observed in some circumstances, witnessing the fact that the method has a specific and a nonspecific component. The reaction is drastically...

journal_title：European journal of immunology

authors： Sabolović D,Oth D,Bujadoux M

更新日期：1976-06-01 00:00:00

abstract：:The covalent binding reaction of the third component of complement (C3) with rabbit IgG immune aggregates has been studied by enzymic digestion of C3b-IgG adducts. In these adducts C3b was radioactively labeled in the free thiol group generated during activation of the internal thioester of C3. Trypsin digestion of 14...

journal_title：European journal of immunology

authors： Antón LC,Ruiz S,Barrio E,Marqués G,Sánchez A,Vivanco F

更新日期：1994-03-01 00:00:00

abstract：:T lymphocyte subsets expressing either T cell receptor alpha/beta or gamma/delta were selected from human peripheral blood T cells and proliferative responses to molecular mass-fractionated mycobacterial lysates were determined. alpha/beta T cells primarily responded to fractions greater than 30 kDa whereas gamma/delt...

journal_title：European journal of immunology

authors： Pfeffer K,Schoel B,Gulle H,Kaufmann SH,Wagner H

更新日期：1990-05-01 00:00:00

abstract：:In the past 15 years, it became clear that the symbiotic microbiota has an important impact on the development and regulation of the immune system. Consequently, it is incorrect to interpret a phenotype solely as a direct result of the genotype, without considering the impact of the microbiota. In fact, ignorance of t...

journal_title：European journal of immunology

authors： Eberl G,Vieira P

更新日期：2020-06-01 00:00:00

abstract：:The squirrel monkey Saimiri sciureus is one of the World Health Organization recommended experimental models of Plasmodium falciparum blood stage infection. Anti-malaria antibodies developed by this host after a drug-controlled infection play an important part in the acquired protection against the P. falciparum blood...

journal_title：European journal of immunology

authors： Groux H,Perraut R,Garraud O,Poingt JP,Gysin J

更新日期：1990-10-01 00:00:00

abstract：:By comparing the restriction patterns of the DNA from 23 unrelated individuals 16 polymorphisms were defined which allowed us to differentiate between the duplicated copies Op, Ap, Lp and Od, Ad, Ld of the kappa locus (p for the C kappa proximal, d for the distal copy). Some of these duplication-differentiating polymo...

journal_title：European journal of immunology

authors： Pargent W,Schäble KF,Zachau HG

更新日期：1991-08-01 00:00:00

abstract：:In this study, we demonstrated that antibodies reactive with a common beta 1 subunit (CD29) of the VLA family of antigens could synergize with CD3 but not CD2 in inducing CD4 cell proliferation in a serum-free culture system. The extent of activation was similar to that obtained when CD4 cells were cultured with anti-...

journal_title：European journal of immunology

authors： Yamada A,Nojima Y,Sugita K,Dang NH,Schlossman SF,Morimoto C

更新日期：1991-02-01 00:00:00

abstract：:Riboflavin, also known as vitamin B2 , is converted by riboflavin kinase (RFK) into flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential cofactors of dehydrogenases, reductases, and oxidases including the phagocytic NADPH oxidase 2 (Nox2). Riboflavin deficiency is common in young adul...

journal_title：European journal of immunology

authors： Schramm M,Wiegmann K,Schramm S,Gluschko A,Herb M,Utermöhlen O,Krönke M

更新日期：2014-03-01 00:00:00

abstract：:B cells isolated from germinal centers (GC) of immune mice 2-5 days after antigen (Ag) challenge migrate in response to chemotactic signals, whereas GC B cells isolated at other times and resting B cells do not. Since B cells are in direct contact with follicular dendritic cells (FDC) in GC we reasoned that FDC might ...

journal_title：European journal of immunology

authors： Burton GF,Kupp LI,McNalley EC,Tew JG

更新日期：1995-04-01 00:00:00

abstract：:In chickens, the pre-B cell development takes place in a specialized organ, the bursa of Fabricius. In this study, we show that fibronectin can be detected in the bursa at least from the day 15 of embryonic incubation up to 10 weeks of age after which the bursa starts to involute. During the embryonic incubation, fibr...

journal_title：European journal of immunology

authors： Palojoki E,Toivanen P,Jalkanen S

更新日期：1993-03-01 00:00:00

abstract：:T helper cell type 2 (Th2) cells when triggered by antibodies to CD3 acquire the capacity to stimulate the polyclonal proliferation of syngeneic, resting B cells. Here, we tested the ability of various monoclonal antibodies (mAb) to block the B cell proliferation-inducing potential of such activated Th2 cells. We demo...

journal_title：European journal of immunology

authors： Lohoff M,Koch A,Röllinghoff M

更新日期：1992-02-01 00:00:00

abstract：:Acute inflammatory activation of macrophages by Toll-like and related receptors is characterized by transient activation of MAPK-, NF-κB- and IRF-mediated signaling pathways and expression of pro-inflammatory genes. This activation state is inherently unstable and often transitions into a state of 'tolerance' characte...

journal_title：European journal of immunology

authors： Ivashkiv LB

更新日期：2011-09-01 00:00:00

abstract：:The IgG2a(b) heavy chain allopeptide determinant gamma2a(b) 436-451 (Kabat numbering) presented by the major histocompatibility complex (MHC) class II molecule I-Ad is recognized by T cells which cross-react with a corneal self antigen and with the UL6 protein of the herpes simplex virus which induce autoimmune kerati...

journal_title：European journal of immunology

authors： Bartnes K,Leon F,Briand JP,Travers PJ,Hannestad K

更新日期：1999-01-01 00:00:00

abstract：:A majority of immunodominant epitopes of mycobacterial antigens are known to be recognized by murine T cells in the context of several H-2 haplotypes. In this study, we established the frequency of T cells able to recognize these peptides promiscuously, i.e. in the context of allogeneic antigen-presenting cells, using...

journal_title：European journal of immunology

authors： Vordermeier HM,Arya A,Harris DP,Moreno C,Ivanyi J

更新日期：1995-10-01 00:00:00

abstract：:Defined tumor-associated antigens (TAA) are attractive targets for anti-tumor immunotherapy. Here, we describe a novel genome-wide approach to identify multiple TAA from any given tumor. A panel of transplantable thymomas was established from an inbred p53-/- mouse strain. The resulting tumors were examined for gene e...

journal_title：European journal of immunology

authors： Mathiassen S,Lauemøller SL,Ruhwald M,Claesson MH,Buus S

更新日期：2001-04-01 00:00:00

abstract：:Mycoplasma arthritidis produces in culture a polyclonal mitogen which is active for murine and human T lymphocytes in the presence of accessory cells (AC). We studied the requirements for processing and presentation by AC of Mycoplasma arthritidis supernatant (MAS) mitogen to human T cells. As inhibitors of AC process...

journal_title：European journal of immunology

authors： Bauer A,Rutenfranz I,Kirchner H

更新日期：1988-12-01 00:00:00

abstract：:Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains elusive. By using accurate mass spectrometry and multi-epitope ligand cartography (MELC) we character...

journal_title：European journal of immunology

authors： van Ham M,Teich R,Philipsen L,Niemz J,Amsberg N,Wissing J,Nimtz M,Gröbe L,Kliche S,Thiel N,Klawonn F,Hubo M,Jonuleit H,Reichardt P,Müller AJ,Huehn J,Jänsch L

更新日期：2017-12-01 00:00:00

abstract：:Expression of activation markers and proliferative status were measured in peripheral CD4+ and CD8+ T cells of various T cell receptor (TCR)-transgenic mice either before or after intentional antigenic stimulation. In the absence of intentional immunization, CD4+ T cells persisted as resting or partially activated and...

journal_title：European journal of immunology

authors： Bruno L,von Boehmer H,Kirberg J

更新日期：1996-12-01 00:00:00

abstract：:T cell receptor (TCR) down-regulation is a consequence of specific receptor engagement and plays an important role in modulating the T cell response. We have investigated the role of protein kinase C (PKC) and protein tyrosine kinases (PTK) in the induction of TCR down-regulation. We report that the mutation of S126 i...

journal_title：European journal of immunology

authors： Salio M,Valitutti S,Lanzavecchia A

更新日期：1997-07-01 00:00:00

abstract：:Genetic control has been studied of the response to the encephalitogenic nonapeptide (NP) determinant of myelin basic protein (BP) in inbred guinea pigs of strains resistant or susceptible to induction of experimental autoimmune encephalomyelitis (EAE). By studying bone marrow-reconstituted animals, we found that susc...

journal_title：European journal of immunology

authors： Ben-Nun A,Otmy H,Cohen IR

更新日期：1981-04-01 00:00:00

abstract：:Human antibodies against HIV-1 have been sought to study neutralization events on the molecular level, and for possible use in passive immune intervention. The development of phage display techniques has opened the possibility of rapidly generating human monoclonal antibodies with desired specificities. We and others ...

journal_title：European journal of immunology

authors： Samuelsson A,Yari F,Hinkula J,Ersoy O,Norrby E,Persson MA

更新日期：1996-12-01 00:00:00

abstract：:The potential of synthetic peptides as vaccines is restricted by their frequent lack of immunogenicity. As with haptens, coupling to a carrier protein is usually required to provide T cell help to anti-peptide antibody-producing B cells. In spite of their short length, a few natural or synthetic peptides are immunogen...

journal_title：European journal of immunology

authors： Borras-Cuesta F,Petit-Camurdan A,Fedon Y

更新日期：1987-08-01 00:00:00

abstract：:The conditions under which tumor necrosis factor-alpha (TNF) induces apoptosis in primary microvascular endothelial cells (MVEC) were investigated. In the absence of sensitizing agents, TNF induced apoptosis after 3 days of incubation in confluent MVEC. In contrast, upon addition of the transcriptional inhibitor actin...

journal_title：European journal of immunology

authors： Lucas R,Garcia I,Donati YR,Hribar M,Mandriota SJ,Giroud C,Buurman WA,Fransen L,Suter PM,Nunez G,Pepper MS,Grau GE

更新日期：1998-11-01 00:00:00

abstract：:The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal, emergency hematopoiesis, and acute myeloid leukemia initiation and maintenan...

journal_title：European journal of immunology

authors： Jackson JT,O'Donnell K,Light A,Goh W,Huntington ND,Tarlinton DM,McCormack MP

更新日期：2020-07-01 00:00:00

abstract：:Majority of HIV-2-infected individuals meet the criteria of long-term non-progressors. This has been linked to superior qualitative HIV-2-specific cellular immune responses that correlate with viral control. However, it is unknown whether this is due to frequent targeting of immunodominant Gag epitopes in HIV-2 than H...

journal_title：European journal of immunology

authors： Ondondo BO,Rowland-Jones SL,Dorrell L,Peterson K,Cotten M,Whittle H,Jaye A

更新日期：2008-12-01 00:00:00

abstract：:Regulatory T cells (Treg) provide protection from autoimmune disease, graft-versus-host disease, transplant rejection and overwhelming tissue destruction during infections. Conversely, high Treg numbers enable cancer cells to evade the host immune response. Thus, Treg are seen as an important tool to manipulate the im...

journal_title：European journal of immunology

authors： Banham AH,Powrie FM,Suri-Payer E

更新日期：2006-11-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine kinase and is crucial for cellular energy homeostasis. The exact role of AMPK during memory CD8(+) T-cell differentiation, a process that changes from the metabolically active state of effector T cells to one of quiescence in memory cells is...

journal_title：European journal of immunology

authors： Araki K,Ahmed R

更新日期：2013-04-01 00:00:00

abstract：:The thymus provides the microenvironment in which thymocytes develop into mature T cells, and interactions with thymic stromal cells are thought to provide the necessary signals for thymocyte maturation. Recognition of self-MHC by T cells is a basic requirement for mature T-cell functions, and those thymocytes that do...

journal_title：European journal of immunology

authors： Szondy Z,Garabuczi É,Tóth K,Kiss B,Köröskényi K

更新日期：2012-07-01 00:00:00

abstract：:The causative agents of Lyme disease, Borrelia burgdorferi s.s., B. garinii, and B. afzelii, differ in their susceptibility to complement-mediated lysis. This phenomenon apparently depends on the expression of proteins termed complement regulator-acquiring surface proteins (CRASP) and their binding to the inhibitory p...

journal_title：European journal of immunology

authors： Kraiczy P,Hellwage J,Skerka C,Kirschfink M,Brade V,Zipfel PF,Wallich R

更新日期：2003-03-01 00:00:00

abstract：:Cyclosporin A (CsA), an immunosuppressive drug which completely suppresses the humoral response to thymus-dependent antigens, does not affect the generation of T helper (Th) cells during an in vitro stimulation of murine spleen cells with sheep red blood cells. The appearance of Th cells depends on time and their deve...

journal_title：European journal of immunology

authors： Motta I,Colle JH,Shidani B,Truffa-Bachi P

更新日期：1991-03-01 00:00:00