Abstract:
:A previously designed isotopic in vivo method for measuring delayed hypersensitivity was used with nonantigenic (or weakly antigenic) phlogogenic substances. A strong reaction was observed in some circumstances, witnessing the fact that the method has a specific and a nonspecific component. The reaction is drastically augmented by a mild whole-body irradiation of the reacting animals. In the case of the studied substances (carbon, oil and bentonite) the reaction is bound by polymorphonuclear neutrophils (PMN), but it was found to be independent of the number of circulating PMN in the blood.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Sabolović D,Oth D,Bujadoux Mdoi
10.1002/eji.1830060606subject
Has Abstractpub_date
1976-06-01 00:00:00pages
406-9issue
6eissn
0014-2980issn
1521-4141journal_volume
6pub_type
杂志文章abstract::The transcription factor c-Maf is critical for IL-4 production and the development of Th2 cells, which promote humoral immunity and protect against extracellular parasites. Yet, little else is known of c-Maf function in CD4 cells. Here, we identify a novel role for c-Maf in regulating susceptibility to apoptosis. Over...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636979
更新日期:2007-10-01 00:00:00
abstract::By immunizing Lewis rats with myelin basic protein (MBP) peptide variants derived from the major encephalitogenic epitope of guinea pig (MBP(68-88) and then isolating encephalitogenic T cells from these animals, we demonstrated that the variant peptides do not elicit the same encephalitogenic T cell subsets as those i...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250631
更新日期:1995-06-01 00:00:00
abstract::During the course of many human autoimmune diseases, antibodies which recognize negatively charged epitopes on self antigens are detected. Trypanosoma cruzi, an intracellular protozoan parasite capable of infecting a wide variety of vertebrates, is the cause of Chagas disease in humans. Infection with the parasite fre...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221204
更新日期:1992-12-01 00:00:00
abstract::Cytokine-induced memory-like (CIML) NK cells are endowed with the capacity to mediate enhanced effector functions upon cytokine or activating receptor restimulation for several weeks following short-term preactivation with IL-12, IL-15, and IL-18. Promising results from a first-in-human clinical trial highlighted the ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201847931
更新日期:2019-08-01 00:00:00
abstract::T cells from human peripheral blood were enriched in T4+ cells by lysis of T8+ cells with the monoclonal antibody OKT8 plus complement. The T4+ subset was separated into 4 fractions differing in avidity for the lectin Helix pomatia A hemagglutinin (HP). The fractions were studied for their capacity to help autologous ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830141108
更新日期:1984-11-01 00:00:00
abstract::Leukocyte adhesion deficiency (LAD) is a recessive autosomal disease characterized by life-threatening recurrent bacterial infections, by defective functions of leukocytes and by deficient membrane expression of leukocyte adhesion glycoproteins. These proteins, LFA-1, Mac-1 and p150,95, are alpha 1/beta 1 heterodimers...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830181016
更新日期:1988-10-01 00:00:00
abstract::To study allelic exclusion of TcR genes we analyzed two types (I and II) of TcR beta transgenic mice. T cells derived from both types of mice contained similar amounts of transgenic RNA transcripts; however, surface expression of the transgenic beta chain was drastically reduced in type II compared to type I. In type ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200227
更新日期:1990-02-01 00:00:00
abstract::The inflammatory process that underlies allergic diseases such as asthma is characterized by tissue infiltration of eosinophils and T cells. We have used the Stamper-Woodruff frozen-section assay to characterize the receptors involved in adhesion of human peripheral blood T cells to nasal polyp endothelium (NPE) as a ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199904)29:04<1324::AID-IMM
更新日期:1999-04-01 00:00:00
abstract::Graft-versus-host disease (GVHD) caused by donor T cells attacking recipient tissues is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (alloSCT). Studies have shown that effector memory T (T(EM) ) cells do not cause GVHD but are capable of immune functions post-tr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141678
更新日期:2011-09-01 00:00:00
abstract::Amount and affinity of anti-beta-D-galactosidase-activating antibodies (AAb) were studied in two lines of mice obtained by selective breeding for antibody response to heterologous erythrocytes. These lines, referred to as high (H) and low (L) lines, differ also in their responses to many antigens. Concerning AAb amoun...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830090312
更新日期:1979-03-01 00:00:00
abstract::The immaturity of the neonatal immune system in mice is associated with defective IFN-gamma production and Th2-biased immune responses. In this study, infants vaccinated at birth with BCG produced similar concentrations of IFN-gamma in response to PPD and showed similar frequencies of IFN-gamma-producing lymphocytes a...
journal_title:European journal of immunology
pub_type: 临床试验,杂志文章
doi:10.1002/1521-4141(200105)31:5<1531::AID-IMMU1531>3
更新日期:2001-05-01 00:00:00
abstract::Local graft-vs.-host reaction (GVHR) was induced in rats by injecting parental cells into young F1 recipients. As a consequence of antigenic stimulation in the course of developing GVHR in the responding lymph nodes, the number of interleukin 2-receptor (IL 2R)-bearing T cells increased from less than 1% up to 10% of ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830161020
更新日期:1986-10-01 00:00:00
abstract::H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level o...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830070708
更新日期:1977-07-01 00:00:00
abstract::It has been reported that the 45-kDa low-affinity Fc epsilon receptor (Fc epsilon RII) on B cells is cleaved spontaneously from the cell surface to release soluble fragments. This study demonstrates an additional fate of the Fc epsilon RII. 125I-labeled CD23+ B cells were cultured for 24 h at 37 degrees C. After lysis...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220634
更新日期:1992-06-01 00:00:00
abstract::Murine cytolytic T cell lines have been analyzed for the expression of two surface glycoproteins called T145 and T130. T145, known to be expressed by activated cytolytic T cells, is also expressed by such lines, but T130, which has been described by a universal T cell marker, is not. Our results suggest a structural r...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830101111
更新日期:1980-11-01 00:00:00
abstract::The thymic architecture is normally compartmentalized into a central medulla surrounded by a peripheral cortical region. We investigated how compartmentalization of the thymic stroma is regulated using T cell receptor (TCR)-transgenic mouse models. Our studies show that the signals generated by TCR/peptide/major histo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270121
更新日期:1997-01-01 00:00:00
abstract::We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) breaks tolerance induction. The objective of this study was to determine whether GM-CSF breaks established inhalation tolerance. To induce tolerance, BALB/c mice were exposed to aerosolized ovalbumin (OVA) for 10 consecutive days. A co...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425012
更新日期:2004-09-01 00:00:00
abstract::To determine the molecular mechanisms of T cell stimulation by staphylococcal enterotoxin A (SEA), we examined the expression of T cell receptor (TcR) V beta on the T cells from four strains of mice stimulated in vitro with SEA, using flow cytometric analysis for the number of T cells bearing V beta 3, V beta 6, V bet...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200323
更新日期:1990-03-01 00:00:00
abstract::Mast cells are widely distributed in tissues, particularly near surfaces exposed to the environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE and specific Ag and many other stimuli, including products derived from either pathogens or the host during innate immune responses. Althoug...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201040559
更新日期:2010-07-01 00:00:00
abstract::Naive and memory CD4 T cells differ in cell surface phenotype, function, activation requirements, and modes of regulation. To investigate the molecular bases for the dichotomies between naive and memory CD4 T cells and to understand how the T cell receptor (TCR) directs diverse functional outcomes, we investigated pro...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270838
更新日期:1997-08-01 00:00:00
abstract::Indirect immunofluorescence performed with 2 polyclonal and 4 monoclonal antibodies directed against human beta 2-microglobulin (beta 2m) revealed the presence of a beta 2m-like determinant on the membrane of a subpopulation of earthworm leukocytes classified as weakly adherent acidophils. Two out of the 4 monoclonal ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830131216
更新日期:1983-12-01 00:00:00
abstract::Protein kinase C (PKC) has been implicated in the signaling of a number of cellular responses including activation of T cells. In the present report we have evaluated the effect of increased cAMP levels on PKC activation after stimulation of two distinct receptor systems on normal human T cells. PKC substrate phosphor...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190622
更新日期:1989-06-01 00:00:00
abstract::Rabbit anti-SII pneumococcal polysaccharide IgG antibody was cross-linked by dithiobis (succinimidyl propionate). The IgG dimers were visualized by electronmicroscopy and resembled two Y-shaped structures connected in random orientations. The three arms of the Y's were of equal length. The six globular domains of the ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830100709
更新日期:1980-07-01 00:00:00
abstract::For homeostasis, T cells integrate non-cognate TCR-dependent and -independent signals to survive and weakly proliferate. In contrast to antigen-specific, stable, and long-lived contacts, signaling in short-lived homeostatic interactions depends upon the coordination of ongoing T-cell migration on the surface of DC and...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040575
更新日期:2010-10-01 00:00:00
abstract::During their development, B and T lymphocytes are thought to undergo several cycles of chromatin remodeling at their antigen receptor loci that serve to regulate access of a common V(D)J recombinase to particular gene segments. We used germ-line transcription and susceptibility to DNasel as markers to examine tissue a...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199812)28:12<4228::AID-IMM
更新日期:1998-12-01 00:00:00
abstract::Interleukin-18 (IL-18) is not only a co-stimulus for the induction of interferon-gamma but also has direct proinflammatory effects by inducing tumor necrosis factor-alpha (TNF-alpha), IL-1, IL-8 and IL-6. However, the cascade of events leading to induction of cytokines by IL-18 is unclear. The aim of the present study...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200010)30:10<3057::AID-IMMU3057>
更新日期:2000-10-01 00:00:00
abstract::T-cell homeostasis preserves the numbers, the diversity and functional competence of different T-cell subsets that are required for adaptive immunity. Naïve CD4(+) T (TN ) cells are maintained in the periphery via the common γ-chain family cytokine IL-7 and weak antigenic signals. However, it is not clear how memory C...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201444701
更新日期:2014-10-01 00:00:00
abstract::By means of a novel technique for identification and isolation of MHC class II-restricted antigen-specific T cells, we describe here in non-transgenic BALB / c mice physiological positive selection of an oligoclonal population of T cells which recognizes both a self MHC-derived peptide (Ialpha52) and a bacterial homol...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199912)29:12<3826::AID-IMM
更新日期:1999-12-01 00:00:00
abstract::Human T cell clones (TCC) are antigen-presenting cells (APC) able to present peptides and superantigens (SAg) and to process and present intact proteins. TCC express major histocompatibility complex (MHC) class II antigens and molecules involved in the accessory signal delivery, such as B7.1 and B7.2/B70. Notwithstand...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260411
更新日期:1996-04-01 00:00:00
abstract::There is limited insight into the mechanisms involved in the counterregulation of TLR. Given the important role of TLR3/TIR domain-containing adaptor-inducing IFN-β (TRIF)-dependent signalling in innate immunity, novel insights into its modulation is of significance in the context of many physiological and pathologica...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040547
更新日期:2010-11-01 00:00:00