Spontaneous and ligand-induced endocytosis of CD23 (Fc epsilon receptor II) from the surface of B lymphocytes generates a 16-kDa intracellular fragment.

abstract：:R24 is a monoclonal antibody directed against the cell surface ganglioside GD3. It can detect GD3 on the surface of a subset of T lymphocytes and can stimulate proliferation and secretion of cytokines in vitro. In the present report, we examined the effects of the R24 antibody upon antigen-specific T cell response, em...

journal_title：European journal of immunology

authors： Boussiotis VA,Pardo NA,Collins H,Houghton A,Ritz J,Nadler LM,Soiffer RJ

更新日期：1996-09-01 00:00:00

abstract：:To elucidate the mechanism of autoimmune disease in neonatally thymectomized (NTX) mice, we have investigated the responsiveness of the self-reactive T cells which have not undergone clonal deletion in such animals. Consistent with a recent report (Yuuki et al., Eur. J. Immunol. 1990. 20: 1475), T cells bearing V beta...

journal_title：European journal of immunology

authors： Iwasaki A,Yoshikai Y,Yuuki H,Takimoto H,Nomoto K

更新日期：1991-03-01 00:00:00

abstract：:In an effort to derive monoclonal antibodies (mAb) which can induce production of macrophage-activating factor (MAF) by cloned murine cytolytic T lymphocyte (CTL) lines, we have fused spleen cells from a rat immunized with a CTL clone with the nonsecreting mouse myeloma X63-Ag8.653. Three mAb (designated I-22, III-5 a...

journal_title：European journal of immunology

authors： MacDonald HR,Bron C,Rousseaux M,Horvath C,Cerottini JC

更新日期：1985-05-01 00:00:00

abstract：:Using a culture system which supports primary T cell proliferative responses to various antigens we have detected mouse red blood cell (RBC)-reactive T cells in lymphoid tissues from untreated mice. The release of significant amounts of interleukin 2 (IL2) indicates that T helper (or helper/inducer) cells are activate...

journal_title：European journal of immunology

authors： Hooper DC,Taylor RB

更新日期：1987-06-01 00:00:00

abstract：:Spleen cells from BALB/c mice primed with keyhole limpet hemocyanin (KLH), were stimulated with heat-killed vaccine of rough Pneumococcus pneumoniae R36A (Pn) and/or phosphorylcholine (PC)-coupled KLH to induce an anti-PC response in vitro. The response to PC-KLH was found to be T-dependent while it is T-independent t...

journal_title：European journal of immunology

authors： Quintáns J,Cosenza H

更新日期：1976-06-01 00:00:00

abstract：:The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

journal_title：European journal of immunology

authors： Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

更新日期：2006-08-01 00:00:00

abstract：:In June 2009, the National Institute of Allergy and Infectious Diseases (NIAID), Division of Allergy, Immunology and Transplantation (DAIT), sponsored a workshop entitled Mast Cells in Innate and Adaptive Immunity. International experts in mast cell biology discussed recent advances in the field and future areas of re...

journal_title：European journal of immunology

authors： Palker TJ,Dong G,Leitner WW

更新日期：2010-01-01 00:00:00

abstract：:New Zealand Black (NZB) mice spontaneously develop an autoimmune hemolytic anemia together with a markedly increased production of polyclonal antibodies. The spontaneous generation of anti-mouse red blood cells (MRBC), anti-bromelain-treated MRBC (BrMRBC) and anti-DNA autoantibodies was compared to the polyclonal anti...

journal_title：European journal of immunology

authors： Reininger L,Shibata T,Schurmans S,Merino R,Fossati L,Lacour M,Izui S

更新日期：1990-11-01 00:00:00

abstract：:The delivery of T-cell help to B cells is antigen-specific, MHC-restricted, and CD40L (CD154) dependent. It has been thought that when a T cell recognizes an antigen-presenting B cell, CD40L expressed on the T-cell surface engages with CD40 on the surface of B cells as long as the cells remain conjugated. By adding fl...

journal_title：European journal of immunology

authors： Gardell JL,Parker DC

更新日期：2017-01-01 00:00:00

abstract：:In the lymphoid tissues, adaptive immune responses are initiated by the interaction of interdigitating dendritic cells (IDC) with naive T cells. To understand this interplay better, we used mature Langerhans cells (mLC), migrating from human epidermis, as the correlate of IDC ex vivo to evaluate the different effects ...

journal_title：European journal of immunology

authors： Ludewig B,Graf D,Gelderblom HR,Becker Y,Kroczek RA,Pauli G

更新日期：1995-07-01 00:00:00

abstract：:P-glycoprotein (P-gly) is the transmembrane efflux pump responsible for multidrug resistance in tumor cells. The activity of P-gly in mature peripheral lymphocytes is lineage specific, with CD8+ T cells and natural killer (NK) cells expressing high levels as compared to CD4+ T cells and B cells. We have now investigat...

journal_title：European journal of immunology

authors： MacDonald HR,Bommhardt U,Cerottini JC

更新日期：1995-05-01 00:00:00

abstract：:Peritoneal macrophages from C57BL/6 mice process antigens from bacteria or coated on polystyrene beads for presentation by major histocompatibility complex (MHC) class I molecules. To investigate this antigen processing pathway, peritoneal macrophages from homozygous TAP1-/- mice, which lack the transporter associated...

journal_title：European journal of immunology

authors： Wick MJ,Pfeifer JD

更新日期：1996-11-01 00:00:00

abstract：:Maintenance of peripheral tolerance and inactivation of autoreactive T cells is based on a delicate balance between pro-inflammatory and protective cytokines that is poorly understood. We have here addressed how the local expression of the inflammatory cytokine TNF-alpha can impair peripheral tolerance and lead to aut...

journal_title：European journal of immunology

authors： Skak K,Guerder S,Picarella DE,Brenden N,Flavell RA,Michelsen BK

更新日期：2003-05-01 00:00:00

abstract：:We have determined the cell cycle position of individual mouse leukemia L 1210 cells by cytophotometric and autoradiographic techniques and simultaneously determined the amount of histocompatibility antigens expressed on the surface of individual cells by quantitative immunofluorescence. Interferon treatment of L 1210...

journal_title：European journal of immunology

authors： Killander D,Lindahl P,Lundin L,Leary P,Gresser I

更新日期：1976-01-01 00:00:00

abstract：:Analysis of mice transgenic for immunoglobulin genes should allow definition of the cis-acting DNA sequences required to target somatic mutation to antibody V genes. We have looked for mutations in a chimeric kappa transgene encoding a V region specific for the hapten 2-phenyloxazolone (phOx) linked to a rat C kappa g...

journal_title：European journal of immunology

authors： Sharpe MJ,Neuberger M,Pannell R,Surani MA,Milstein C

更新日期：1990-06-01 00:00:00

abstract：:Exosomes from APC are nano-vesicles that can induce antigen-specific T cell responses and are presently explored as therapeutic tools in different clinical settings. Investigations of the capacity of exosomes to stimulate T cells in vitro have mostly been performed on T cell hybridomas, clones or lines. Whether exosom...

journal_title：European journal of immunology

authors： Admyre C,Johansson SM,Paulie S,Gabrielsson S

更新日期：2006-07-01 00:00:00

abstract：:It has long been recognized that T cells in the cerebrospinal fluid (CSF) and other inflammatory compartments cannot be stimulated by mitogen and the reason for this has remained unknown. This question was investigated using mononuclear cells (MNC) isolated from the CSF of subjects with multiple sclerosis and other in...

journal_title：European journal of immunology

authors： Chofflon M,González V,Weiner HL,Hafler DA

更新日期：1989-10-01 00:00:00

abstract：:Lymphocyte infiltration to pancreatic islets is associated to chemoattraction, as are other inflammatory autoimmune processes. We examined whether development of insulitis and diabetes depends on chemoattraction of lymphocytes via the CCR5 chemokine receptor. In non-obese diabetic (NOD) mice, a substantial fraction of...

journal_title：European journal of immunology

authors： Carvalho-Pinto C,García MI,Gómez L,Ballesteros A,Zaballos A,Flores JM,Mellado M,Rodríguez-Frade JM,Balomenos D,Martínez-A C

更新日期：2004-02-01 00:00:00

abstract：:The expression of IgG Fc receptor (FcR) molecules was examined on Ly-1+ B cells and B cells tumors. FcR molecules were found on a representative Ly-1+ B cell lymphoma of the pre-B and as well as of the mature cell B phenotypes. The expression of the FcR did not change on these cells during their differentiation to B c...

journal_title：European journal of immunology

authors： Dexter CM,Corley RB

更新日期：1987-06-01 00:00:00

abstract：:Lymph node cells derived from A.TH or A.TL mice primed with beef cytochrome c show striking patterns of reactivity when assayed in vitro for antigen-induced T cell proliferation. Whereas cells from A.TH mice respond specifically to beef cytochrome c or peptides composed of amino acids 1-65 and 81-104, cells from A.TL ...

journal_title：European journal of immunology

authors： Corradin G,Chiller JM

更新日期：1981-02-01 00:00:00

abstract：:Two subpopulations of human T lymphocytes expressing different antigen receptors, alpha/beta and gamma/delta, emigrate into inflamed tissues in distinctive patterns. We compared the transmigration of alpha/beta and gamma/delta T cells to C-C and C-X-C chemokines using an in vitro transendothelial chemotaxis assay. The...

journal_title：European journal of immunology

authors： Roth SJ,Diacovo TG,Brenner MB,Rosat JP,Buccola J,Morita CT,Springer TA

更新日期：1998-01-01 00:00:00

abstract：:Leishmaniasis is currently classified as category 1 disease, i.e. emerging and uncontrolled. Since the importance of persistent infection for maintaining an effective long-lasting protective response is controversial, the present study asks whether immunisation with non-persistent parasites leads to protection against...

journal_title：European journal of immunology

authors： Kedzierski L,Curtis JM,Doherty PC,Handman E,Kedzierska K

更新日期：2008-11-01 00:00:00

abstract：:T cell recognition of self antigens is a key event in the pathogenesis of autoimmune diseases. To date, the initial events that trigger autoreactive T cells are unknown. The "molecular mimicry" hypothesis predicts that during an infection T cells that recognize both a microbial antigen and a related self peptide becom...

journal_title：European journal of immunology

authors： Maier B,Molinger M,Cope AP,Fugger L,Schneider-Mergener J,Sønderstrup G,Kamradt T,Kramer A

更新日期：2000-02-01 00:00:00

abstract：:A murine monoclonal IgM antibody recognizes an antigen (Mo3e) found on the surface of human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide and muramyl dipeptide and blocks the monocyte response to migration inhibitory factor (MIF). We utilized Western blot and immu...

journal_title：European journal of immunology

authors： Liu DY,Ree JY,Trochelman RD,Todd RF 3rd

更新日期：1989-04-01 00:00:00

abstract：:Unexpected fetal loss is one of the common complications of pregnancy; however, the pathogenesis of many miscarriages, particularly those not associated with infections, is unknown. We previously found that activated DEC-205+ dendritic cells (DCs) and NK1.1+ invariant natural killer T (iNKT) cells are recruited into t...

journal_title：European journal of immunology

authors： Negishi Y,Ichikawa T,Takeshita T,Takahashi H

更新日期：2018-06-01 00:00:00

abstract：:The specificity and efficiency of endogenous peptides in the HLA class I binding have been investigated by the use of a simple procedure that is based on the serological detection of the folding of HLA class I alpha chains that is induced by the binding to specific peptides in the presence of beta 2 microglobulin. HLA...

journal_title：European journal of immunology

authors： Tanigaki N

更新日期：1992-08-01 00:00:00

abstract：:The early mechanisms by which DNA-dependent immunization occurs remain poorly understood. We determined whether intradermal injection of a cytomegalovirus (CMV) promoter-driven plasmid encoding hen egg lysozyme (pCMV:HEL) induced sensitization against the encoded protein, and whether cutaneous dendritic cells (DC) wer...

journal_title：European journal of immunology

authors： Bouloc A,Walker P,Grivel JC,Vogel JC,Katz SI

更新日期：1999-02-01 00:00:00

abstract：:Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic glycolysis. In this study, we examined whether metabolic reprogramming toward aerobic glycolysis is important for the host response to Mycoba...

journal_title：European journal of immunology

authors： Lachmandas E,Beigier-Bompadre M,Cheng SC,Kumar V,van Laarhoven A,Wang X,Ammerdorffer A,Boutens L,de Jong D,Kanneganti TD,Gresnigt MS,Ottenhoff TH,Joosten LA,Stienstra R,Wijmenga C,Kaufmann SH,van Crevel R,Netea MG

更新日期：2016-11-01 00:00:00

abstract：:Activated monocyte-macrophages have been implicated in tumor angiogenesis via their capacity to produce many potent angiogenic factors. However, the mechanisms leading to production of these angiogenic factors in macrophages remain to be elucidated. In this study, we demonstrated by use of a mouse Matrigel implantatio...

journal_title：European journal of immunology

authors： Seo KH,Ko HM,Choi JH,Jung HH,Chun YH,Choi IW,Lee HK,Im SY

更新日期：2004-08-01 00:00:00

abstract：:Carbon monoxide (CO) treatment improves pathogenic outcome of autoimmune diseases by promoting tolerance. However, the mechanism behind this protective tolerance is not yet defined. Here, we show in a transgenic mouse model for autoimmune diabetes that ex vivo gaseous CO (gCO)-treated DCs loaded with pancreatic β-cell...

journal_title：European journal of immunology

authors： Simon T,Pogu S,Tardif V,Rigaud K,Rémy S,Piaggio E,Bach JM,Anegon I,Blancou P

更新日期：2013-01-01 00:00:00