Lymphocyte specificity to protein antigens. III. Capacity of low responder mice to beef cytochrome c to respond to a peptide fragment of the molecule.

abstract：:B cell development is dependent on both direct interactions with stromal cells and their secreted cytokines. The precise mechanisms by which these interactions regulate B cell differentiation are currently unknown. We report here that a novel growth factor thymic stromal-derived lymphopoietin (TSLP) can replace the ac...

journal_title：European journal of immunology

authors： Ray RJ,Furlonger C,Williams DE,Paige CJ

更新日期：1996-01-01 00:00:00

abstract：:Impaired control of chronic pathogen replication may be associated to alterations of NK-cell function. Whether mechanisms underlying this dysfunction involve perturbations of differentiating NK cells is still unknown. We studied an "in vitro" model of differentiation from CD34(+)Lin(-) precursors growing only myelomon...

journal_title：European journal of immunology

authors： Costa P,Sivori S,Bozzano F,Martini I,Moretta A,Moretta L,De Maria A

更新日期：2009-01-01 00:00:00

abstract：:The production of IL-10, a potent immunosuppressive cytokine, must be strictly regulated to ensure a balanced immune response. IFN-γ, a key cytokine in multiple immune processes and pathologies, is known as an inhibitor of IL-10 production by monocytes and macrophages, but also has some regulatory functions. In the pr...

journal_title：European journal of immunology

authors： Imbrechts M,De Samblancx K,Fierens K,Brisse E,Vandenhaute J,Mitera T,Libert C,Smets I,Goris A,Wouters C,Matthys P

更新日期：2018-09-01 00:00:00

abstract：:Human invariant natural killer T (NKT) cell TCRs bind to CD1d via an "invariant" Vα24-Jα18 chain (iNKTα) paired to semi-invariant Vβ11 chains (iNKTβ). Single-amino acid variations at position 93 (p93) of iNKTα, immediately upstream of the "invariant" CDR3α region, have been reported in a substantial proportion of huma...

journal_title：European journal of immunology

authors： Sanderson JP,Waldburger-Hauri K,Garzón D,Matulis G,Mansour S,Pumphrey NJ,Lissin N,Villiger PM,Jakobsen B,Faraldo-Gómez JD,Gadola SD

更新日期：2012-01-01 00:00:00

abstract：:The mechanism of synergistic complement-mediated lysis of rat red cells was investigated using rat monoclonal antibodies against class I RT1Aa antigens. The increased lytic activity when using two antibodies simultaneously is due to the increase in the number of activated C1 molecules on the cell surface and this resu...

journal_title：European journal of immunology

authors： Hughes-Jones NC,Gorick BD,Howard JC

更新日期：1983-08-01 00:00:00

abstract：:Constitutive expression of CD25, the IL-2 receptor alpha-chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in vivo. IL-2 has been implicated in the generation and maintenance of Treg, however, a functional contribution of the IL-2 receptor during suppression is thus far...

journal_title：European journal of immunology

authors： de la Rosa M,Rutz S,Dorninger H,Scheffold A

更新日期：2004-09-01 00:00:00

abstract：:Crosslinking of Fc γ receptor II B (FcγRIIB) and the BCR by immune complexes (IC) can downregulate antigen-specific B-cell responses. Accordingly, FcγRIIB deficiencies have been associated with B-cell hyperactivity in patients with systemic lupus erythematosus and mouse models of lupus. However, we have previously sho...

journal_title：European journal of immunology

authors： Avalos AM,Uccellini MB,Lenert P,Viglianti GA,Marshak-Rothstein A

更新日期：2010-10-01 00:00:00

abstract：:Since signals via CD40 and the B cell receptor are known to synergize to induce B cell activation, we have analyzed the pocket protein/E2F complexes in mouse B lymphocytes following stimulation by anti-IgM, anti-CD40, alone or together. We find that E2F4 and DP1 form the predominant E2F heterodimers in the G0 and G1 p...

journal_title：European journal of immunology

authors： Lam EW,Glassford J,van der Sman J,Banerji L,Pizzey AR,Shaun N,Thomas B,Klaus GG

更新日期：1999-10-01 00:00:00

abstract：:Membrane-bound IgG was found only on old populations of platelets from normal individuals. This IgG could be dissociated from senescent cells by repeatedly heating the cells. Heat-eluted IgG (He-IgG) prepared from senescent red blood cells was capable of binding to either heat-treated old platelets or Vibrio cholerae ...

journal_title：European journal of immunology

authors： Khansari N,Fudenberg HH

更新日期：1983-12-01 00:00:00

abstract：:Despite the presence of tumor-specific effector cells in the circulation of cancer patients, the immune response of the majority of these patients is not sufficient to prevent the growth and spread of their tumors. That tumor cells can be killed in vitro by tumor-reactive cytotoxic T cells is testimony to the fact tha...

journal_title：European journal of immunology

authors： Legler DF,Johnson-Léger C,Wiedle G,Bron C,Imhof BA

更新日期：2004-06-01 00:00:00

abstract：:Invariant NKT cells were stimulated with cholesteryl O-acyl α-glycosides in the context of CD1d. The activated NKT cells have potential to sustain the homeostasis in the body exposed to excess in either Th1- or Th2-immunity. ...

journal_title：European journal of immunology

authors： Shimamura M,Kamijo SI,Illarionov P

更新日期：2019-02-01 00:00:00

abstract：:Several T cell abnormalities have been described in the course of acute Trypanosoma cruzi infection in mice, including severe effects on the thymus. In the present study, looking at the expression of extracellular matrix ligands in the thymus, we observed that deposits of fibronectin and laminin increased progressivel...

journal_title：European journal of immunology

authors： Cotta-de-Almeida V,Bonomo A,Mendes-da-Cruz DA,Riederer I,De Meis J,Lima-Quaresma KR,Vieira-de-Abreu A,Villa-Verde DM,Savino W

更新日期：2003-09-01 00:00:00

abstract：:The migration of monocytes to sites of inflammation is largely determined by their response to chemokines. Although the chemokine specificities and expression patterns of chemokine receptors are well defined, it is still a matter of debate how cells integrate the messages provided by different chemokines that are conc...

journal_title：European journal of immunology

authors： Kuscher K,Danelon G,Paoletti S,Stefano L,Schiraldi M,Petkovic V,Locati M,Gerber BO,Uguccioni M

更新日期：2009-04-01 00:00:00

abstract：:Young (less than 3 months of age) and old (greater than 1 year of age) C.B-17 scid/scid mice were tested for the presence of immunoglobulin in serum and CD3+ T cells in spleen and peritoneal cavity. In all old severe combined immune deficiency (scid) mice tested we found detectable, but very variable levels of serum i...

journal_title：European journal of immunology

authors： Rudolphi A,Spiess S,Conradt P,Claësson MH,Reimann J

更新日期：1991-02-01 00:00:00

abstract：:The influence of Th2 cytokines in tuberculosis has been a matter of dispute. Here we report that IL-4 has a profound regulatory effect on the infection of BALB/c mice with Mycobacterium tuberculosis. Depletion of IL-4 with a neutralizing mAb caused only evanescent reduction of lung infection, but when combined with i....

journal_title：European journal of immunology

authors： Buccheri S,Reljic R,Caccamo N,Ivanyi J,Singh M,Salerno A,Dieli F

更新日期：2007-03-01 00:00:00

abstract：:A comparison of the clonal nature of the immune response to phosphorylcholine (PC) was made in nine different inbred mouse strains. Quantitative idiotypic analysis showed that anti-PC antibodies from each strain were composed of antibodies bearing binding-site idiotypic determinants indistinguishable from two differen...

journal_title：European journal of immunology

authors： Claflin JL

更新日期：1976-10-01 00:00:00

abstract：:By means of a novel technique for identification and isolation of MHC class II-restricted antigen-specific T cells, we describe here in non-transgenic BALB / c mice physiological positive selection of an oligoclonal population of T cells which recognizes both a self MHC-derived peptide (Ialpha52) and a bacterial homol...

journal_title：European journal of immunology

authors： Bonnin D,Prakken B,Samodal R,La Cava A,Carson DA,Albani S

更新日期：1999-12-01 00:00:00

abstract：:Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the sec...

journal_title：European journal of immunology

authors： Müller N,Fischer JC,Yabal M,Haas T,Poeck H,Jost PJ

更新日期：2019-03-01 00:00:00

abstract：:Dendritic cells (DCs) play a key role in regulating innate and adaptive immunity. Our understanding of DC biology has benefited from studies in CD11c.DTR and CD11c.DOG mouse models that use the CD11c promoter to express a diphtheria toxin (DT) receptor transgene to inducibly deplete CD11c(+) cells. Other models to in...

journal_title：European journal of immunology

authors： van Blijswijk J,Schraml BU,Reis e Sousa C

更新日期：2013-01-01 00:00:00

abstract：:Cognate interactions between major histocompatibility complex class II antigen (Ag)-reactive CD4+ T helper (Th) and Ag-presenting B cells induce first the activation of B cells and their subsequent differentiation into Ig-secreting cells (IgSC). The Th cell-associated homodimeric glycoprotein CD28 has been implicated ...

journal_title：European journal of immunology

authors： Damle NK,Linsley PS,Ledbetter JA

更新日期：1991-05-01 00:00:00

abstract：:We have developed a quantitative assay for the measurement of class I assembly induced by peptide. We have applied this assay to H-2Db, Kb and HLA-A2.1 with a panel of 49 overlapping peptides derived from HIV-1 gag protein. We find that the effects of peptide on assembly form a continuous distribution. By defining pos...

journal_title：European journal of immunology

authors： Elvin J,Cerundolo V,Elliott T,Townsend A

更新日期：1991-09-01 00:00:00

abstract：:Autoantibodies in the form of immune complexes are known to be crucial mediators in initiating inflammation in a variety of autoimmune diseases. This has been well documented in the anti-collagen II antibody-induced arthritis animal model for a long time now. Recently, in the K/B x N mouse model (the F1 of the TCR-tra...

journal_title：European journal of immunology

authors： Solomon S,Rajasekaran N,Jeisy-Walder E,Snapper SB,Illges H

更新日期：2005-10-01 00:00:00

abstract：:LL-37, derived from human cathelicidin, stimulates immune responses in neutrophils. Although FPR2 and P2X7 were proposed as LL-37 receptors, we have shown that among 21 neutrophil receptors only CXCR2 was down-regulated by LL-37. LL-37 functions similarly to CXCR2-specific chemokines CXCL1 and CXCL7 in terms of recept...

journal_title：European journal of immunology

authors： Zhang Z,Cherryholmes G,Chang F,Rose DM,Schraufstatter I,Shively JE

更新日期：2009-11-01 00:00:00

abstract：:Proliferation of BCL1 cells, generally used for the measurement of murine interleukin (IL)5, is shown to be strongly suppressed by interferon (IFN)-gamma. This effect can be abrogated by the addition of anti-IFN-gamma antibodies. Thus, the IL5 activity of culture supernatants derived from T cells simultaneously produc...

journal_title：European journal of immunology

authors： Lohoff M,Sommer F,Röllinghoff M

更新日期：1989-07-01 00:00:00

abstract：:A commonly held postulate regarding the etiology of rheumatoid arthritis (RA) is that of antigenic mimicry. Recent interest has focused on the mycobacterial 65-kDa heat-shock protein (hsp) as a putative causal agent. The 65-kDa hsp has over 40% sequence homology with the human hsp 60, and elevated synovial T cell resp...

journal_title：European journal of immunology

authors： Quayle AJ,Wilson KB,Li SG,Kjeldsen-Kragh J,Oftung F,Shinnick T,Sioud M,Førre O,Capra JD,Natvig JB

更新日期：1992-05-01 00:00:00

abstract：:R24 is a monoclonal antibody directed against the cell surface ganglioside GD3. It can detect GD3 on the surface of a subset of T lymphocytes and can stimulate proliferation and secretion of cytokines in vitro. In the present report, we examined the effects of the R24 antibody upon antigen-specific T cell response, em...

journal_title：European journal of immunology

authors： Boussiotis VA,Pardo NA,Collins H,Houghton A,Ritz J,Nadler LM,Soiffer RJ

更新日期：1996-09-01 00:00:00

abstract：:The cytokine IL-7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL-7 receptor alpha-deficient mice. We demonstrate that the IL-7 receptor becomes progressively more important with age. B lymphopoiesis takes place...

journal_title：European journal of immunology

authors： Erlandsson L,Licence S,Gaspal F,Bell S,Lane P,Corcoran AE,Mårtensson IL

更新日期：2004-12-01 00:00:00

abstract：:Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using...

journal_title：European journal of immunology

authors： Schlunck T,Schraut W,Riethmüller G,Ziegler-Heitbrock HW

更新日期：1990-09-01 00:00:00

abstract：:We recently reported that parenteral injection of malaria palmitoyl-tailed peptides without adjuvant efficiently induces B, Th and CTL responses. We now show that intranasal (IN) or sub-lingual (SL) delivery of such lipopeptides induces strong systemic immune responses, as demonstrated by specific Th cell responses fr...

journal_title：European journal of immunology

authors： BenMohamed L,Belkaid Y,Loing E,Brahimi K,Gras-Masse H,Druilhe P

更新日期：2002-08-01 00:00:00

abstract：:Polyclonal differentiation of unprimed B cells into IgM-producing cells induced by lipopolysaccharide (LPS) or T cell-derived lymphokine B151-TRF2 has been shown to contain a process of I-A-restricted B-B cell interaction, so that the B cell responses are inhibited by monoclonal antibodies (mAb) specific for I-A molec...

journal_title：European journal of immunology

authors： Takahama Y,Ono S,Ishihara K,Muramatsu M,Hamaoka T

更新日期：1989-12-01 00:00:00