Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant.

abstract：:A commonly held postulate regarding the etiology of rheumatoid arthritis (RA) is that of antigenic mimicry. Recent interest has focused on the mycobacterial 65-kDa heat-shock protein (hsp) as a putative causal agent. The 65-kDa hsp has over 40% sequence homology with the human hsp 60, and elevated synovial T cell resp...

journal_title：European journal of immunology

authors： Quayle AJ,Wilson KB,Li SG,Kjeldsen-Kragh J,Oftung F,Shinnick T,Sioud M,Førre O,Capra JD,Natvig JB

更新日期：1992-05-01 00:00:00

abstract：:H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level o...

journal_title：European journal of immunology

authors： von Boehmer H,Fathman CG,Haas W

更新日期：1977-07-01 00:00:00

abstract：:Immunizations via the i.n. and intravaginal (ivag) routes effectively generate strong genital tract antibody-mediated immunity. To what extent the same is true for T-cell responses is incompletely known. Therefore, we set out to investigate optimal conditions for stimulation of genital tract CD4(+) T-cell responses, ...

journal_title：European journal of immunology

authors： Marks E,Helgeby A,Andersson JO,Schön K,Lycke NY

更新日期：2011-09-01 00:00:00

abstract：:Naive and memory CD4 T cells differ in cell surface phenotype, function, activation requirements, and modes of regulation. To investigate the molecular bases for the dichotomies between naive and memory CD4 T cells and to understand how the T cell receptor (TCR) directs diverse functional outcomes, we investigated pro...

journal_title：European journal of immunology

authors： Farber DL,Acuto O,Bottomly K

更新日期：1997-08-01 00:00:00

abstract：:P-glycoprotein (P-gly) is the transmembrane efflux pump responsible for multidrug resistance in tumor cells. The activity of P-gly in mature peripheral lymphocytes is lineage specific, with CD8+ T cells and natural killer (NK) cells expressing high levels as compared to CD4+ T cells and B cells. We have now investigat...

journal_title：European journal of immunology

authors： MacDonald HR,Bommhardt U,Cerottini JC

更新日期：1995-05-01 00:00:00

abstract：:Natural resistance to hemopoietic allograft results in functional elimination of the graft from the host within 24 to 48 h. The resistance is specific and is directed to the cell surface target structures of an unidentified nature. These determinants are controlled by the major histocompatibility complex-linked hemopo...

journal_title：European journal of immunology

authors： Shimamura K,Kaminsky SG,Nakamura I

更新日期：1989-07-01 00:00:00

abstract：:The proliferative state of functionally defined populations of size-separated pre-B cells was investigated. The results presented here support the hypothesis that pre-B cells are in the G2 phase when stable membrane IgM is first expressed. Small resting precursor cells significantly adhere to nylon wool columns, unlik...

journal_title：European journal of immunology

authors： Deslauriers-Boisvert N,Mercier G,Lafleur L

更新日期：1982-04-01 00:00:00

abstract：:Autoantigenic epitope mapping represents a critical issue in autoimmune diseases. The islet tyrosine phosphatase-like protein IA-2/ICA512bdc is a major autoantigen in type 1 diabetes (IDDM), but the epitopes responsible for autoantibody binding have been only partially defined. The aim of our study was to identify ICA...

journal_title：European journal of immunology

authors： Farilla L,Tiberti C,Luzzago A,Yu L,Eisenbarth GS,Cortese R,Dotta F,Di Mario U

更新日期：2002-05-01 00:00:00

abstract：:KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myel...

journal_title：European journal of immunology

authors： Lucas M,Daniel L,Tomasello E,Guia S,Horschowski N,Aoki N,Figarella-Branger D,Gomez S,Vivier E

更新日期：2002-09-01 00:00:00

abstract：:In this work the suppressive activity of splenic T cells from young and aged BALB/c mice infected with Trypanosoma cruzi were compared and correlated with the development of autoimmune myocarditis. The T cells from young adult BALB/c mice with acute T. cruzi infection exhibit suppressor activity when added to full all...

journal_title：European journal of immunology

authors： Cardillo F,Falcão RP,Rossi MA,Mengel J

更新日期：1993-10-01 00:00:00

abstract：:Among 15 anti-DNA antibody-producing hybridomas derived from a single NZB X NZW F1 mouse, an IgM and an IgG were shown to use the same VH gene of the Q52 family. Using a combination of two primers both consisting of a mixture of oligonucleotides (one complementary to the 5' end of VH segment and one to the 3' end of V...

journal_title：European journal of immunology

authors： Taki S,Hirose S,Kinoshita K,Nishimura H,Shimamura T,Hamuro J,Shirai T

更新日期：1992-04-01 00:00:00

abstract：:Using a model of 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity (CHS) we found that, as compared with wild-type mice, IL-15 receptor alpha chain (IL-15Ralpha)-deficient mice showed significantly less ear swelling. This decreased response was associated with diminished expression of CCL5/RANTES and CXCL10...

journal_title：European journal of immunology

authors： Chen JP,Liao NS,Lai SL,Hsu L,Mao WY,Ku MC,Liao F

更新日期：2005-03-01 00:00:00

abstract：:Oxidant stress can initiate or enhance inflammatory responses during tissue injury, possibly through activation of redox-sensitive chemokines. Because the transcription factor Nrf2 (NF-E2-related factor 2) is responsive to oxidative stress, and induces expression of cytoprotective and antioxidant genes that attenuate ...

journal_title：European journal of immunology

authors： Zhang X,Chen X,Song H,Chen HZ,Rovin BH

更新日期：2005-11-01 00:00:00

abstract：:Class I molecules, encoded by diverse alleles at several loci of the major histocompatibility complex (MHC) are assembled in the endoplasmic reticulum (ER) from heavy chain, beta2 microglobulin and peptide in association with accessory proteins of the peptide loading complex. We show here, that mutations in the alpha2...

journal_title：European journal of immunology

authors： Beissbarth T,Sun J,Kavathas PB,Ortmann B

更新日期：2000-04-01 00:00:00

abstract：:One of the clear paradoxes in tumor immunology is the fact that cross-presentation of cell-associated tumor antigens to CD8(+) T cells is efficient, yet CTL generation is weak, and tumors continue to grow. We examined, for the first time whether this may be due to alterations in the phenotype or function of cross-pres...

journal_title：European journal of immunology

authors： McDonnell AM,Prosser AC,van Bruggen I,Robinson BW,Currie AJ

更新日期：2010-06-01 00:00:00

abstract：:The murine monoclonal antibody F23.1 reacts with an allotypic determinant on the beta chain of the T cell receptor expressed by approximately 20% of T helper and cytotoxic T lymphocytes of most common mouse strains. This IgG2a antibody, either in soluble form or covalently coupled to Sepharose beads, can activate rest...

journal_title：European journal of immunology

authors： Staerz UD,Bevan MJ

更新日期：1986-03-01 00:00:00

abstract：:B cells from bursa of Fabricius of newly hatched chickens are able to reconstitute the B cell compartment of chemically bursectomized chickens. The resulting B cell chimerism can be detected with monoclonal antibodies against donor B cell alloantigen. Chimeric chickens accept donor-type skin grafts and are unresponsiv...

journal_title：European journal of immunology

authors： Lehtonen L,Vainio O,Veromaa T,Toivanen P

更新日期：1989-03-01 00:00:00

abstract：:Adenosine triphosphate has previously been shown to induce semi-mature human monocyte-derived dendritic cells (DC). These are characterized by the up-regulation of co-stimulatory molecules, the inhibition of IL-12 and the up-regulation of some genes involved in immune tolerance, such as thrombospondin-1 and indoleamin...

journal_title：European journal of immunology

authors： Ben Addi A,Lefort A,Hua X,Libert F,Communi D,Ledent C,Macours P,Tilley SL,Boeynaems JM,Robaye B

更新日期：2008-06-01 00:00:00

abstract：:The mechanisms responsible for the down-modulation of the activation of separated CD4(+) or CD8(+) human T cell blasts were studied using cells obtained from healthy donors. In the presence of IL-2, human CD8(+) T cell blasts were more sensitive than CD4(+) T cell blasts to regulation by APO2 ligand/TNF-related apopto...

journal_title：European journal of immunology

authors： Bosque A,Pardo J,Martínez-Lorenzo MJ,Lasierra P,Larrad L,Marzo I,Naval J,Anel A

更新日期：2005-06-01 00:00:00

abstract：:The progression of experimental allergic encephalomyelitis (EAE) in certain mouse strains has been reported to involve a broadening of the response to myelin antigens, apparently resulting from priming to endogenous determinants of the myelin sheath. The phenomenon has been termed determinant spread. Interest in this ...

journal_title：European journal of immunology

authors： Takács K,Chandler P,Altmann DM

更新日期：1997-11-01 00:00:00

abstract：:To identify environmental stimuli that induce dendritic cell (DC) maturation, we exposed human monocyte-derived immature DC to apoptotic or necrotic cells and measured the levels of expression of costimulatory molecules and cytokine production. While most necrotic or apoptotic cells did not have any effect, some induc...

journal_title：European journal of immunology

authors： Salio M,Cerundolo V,Lanzavecchia A

更新日期：2000-02-01 00:00:00

abstract：:The transition from fully developed CD4+CD8- single-positive (SP) thymocytes into fully mature recirculating peripheral T cells is both poorly understood with regard to the expression of restricted isoforms (CD45R) of the leukocyte common antigen and in terms of T cell function. The present investigation monitored the...

journal_title：European journal of immunology

authors： Yang CP,Bell EB

更新日期：1992-09-01 00:00:00

abstract：:Autophagy is an intracellular degradation system that plays an important role in T-cell survival. However, the precise mechanism linking autophagy and cell death in primary human T cells is unclear because methods for monitoring autophagy in small numbers of primary human cells remain controversial. We established a n...

journal_title：European journal of immunology

authors： Watanabe R,Fujii H,Shirai T,Saito S,Ishii T,Harigae H

更新日期：2014-08-01 00:00:00

abstract：:Natural antibodies (Ab) reacting with self antigens have been shown to be present in all individuals. These autoantibodies (auto-Ab) can be either pathogenic or non-pathogenic. Auto-Ab reacting with the alpha-subunit of the high-affinity receptor for IgE (FcepsilonRIalpha) have been implicated in the pathogenesis of a...

journal_title：European journal of immunology

authors： Horn MP,Gerster T,Ochensberger B,Derer T,Kricek F,Jouvin MH,Kinet JP,Tschernig T,Vogel M,Stadler BM,Miescher SM

更新日期：1999-04-01 00:00:00

abstract：:Leukocyte adhesion deficiency (LAD) is a recessive autosomal disease characterized by life-threatening recurrent bacterial infections, by defective functions of leukocytes and by deficient membrane expression of leukocyte adhesion glycoproteins. These proteins, LFA-1, Mac-1 and p150,95, are alpha 1/beta 1 heterodimers...

journal_title：European journal of immunology

authors： Dimanche-Boitrel MT,Guyot A,De Saint-Basile G,Fischer A,Griscelli C,Lisowska-Grospierre B

更新日期：1988-10-01 00:00:00

abstract：:CD59 is a 18-20-kDa membrane glycoprotein that inhibits formation of the membrane attack complex of complement (C) on homologous cells. In the present study we analyzed the expression and function of CD59 on human endothelial cells. Immunohistochemical analysis of renal cortex demonstrated a predominant expression of ...

journal_title：European journal of immunology

authors： Brooimans RA,Van der Ark AA,Tomita M,Van Es LA,Daha MR

更新日期：1992-03-01 00:00:00

abstract：:T cell-depleted B cells from a patient with LFA-1 deficiency were tested in costimulation assays for responsiveness to recombinant human IL4 (BSF-1) and purified low molecular weight B cell growth factor (BCGFlow). In both cases the response of LFA-1-deficient B cells was comparable with normal controls. Monoclonal an...

journal_title：European journal of immunology

authors： Shields JG,Smith SH,Strobel S,Levinsky RJ,Defrance T,De Vries J,Banchereau J,Callard RE

更新日期：1988-02-01 00:00:00

abstract：:Btk is a member of the Tec family of protein tyrosine kinases expressed in B cells. It is stimulated following cross-linking of the B cell receptor which leads to the autophosphorylation of a specific residue in the SH3 domain, Y223. Previous work using Btk-derived fusion proteins has shown that the Btk SH3 domain bin...

journal_title：European journal of immunology

authors： Morrogh LM,Hinshelwood S,Costello P,Cory GO,Kinnon C

更新日期：1999-07-01 00:00:00

abstract：:It has been reported that, following the initial expression of the T cell receptor (TcR) alpha/beta, newly generated thymocytes pass through a developmental window characterized by ineffective coupling between the alpha/beta and CD3 components resulting in resistance to deletion (negative selection). However, we now p...

journal_title：European journal of immunology

authors： Jenkinson EJ,Kingston R,Owen JJ

更新日期：1990-11-01 00:00:00

abstract：:The expression and action of Fas/Fas ligand (FasL) in multiple sclerosis has been postulated as a major pathway leading to inflammatory demyelination. To formally test this hypothesis, C57BL/6-lpr and -gld mice, which due to gene mutation express Fas and FasL in an inactive form, were immunized with myelin oligodendro...

journal_title：European journal of immunology

authors： Malipiero U,Frei K,Spanaus KS,Agresti C,Lassmann H,Hahne M,Tschopp J,Eugster HP,Fontana A

更新日期：1997-12-01 00:00:00