Acute rejection of allogeneic hemopoietic progenitors by genetically resistant mice.

abstract：:Disseminated infections by the opportunistic yeast Cryptococcus neoformans are characterized by accumulation in tissues of glucuronoxylomannan (GXM), the major component of the capsular polysaccharide. We investigated binding, uptake, and disposal of GXM by peripheral blood neutrophils and monocytes, and the effect of...

journal_title：European journal of immunology

authors： Monari C,Retini C,Casadevall A,Netski D,Bistoni F,Kozel TR,Vecchiarelli A

更新日期：2003-04-01 00:00:00

abstract：:IL-12 is a potent inducer of IFN-gamma production and drives the development of Th1 cells. Human polarized Th2 cells do not express the signaling beta2-subunit of the IL-12R and, therefore, do not signal in response to IL-12. The question was raised as to what extent the loss of the IL-12Rbeta2 chain in Th2 cells has ...

journal_title：European journal of immunology

authors： Smits HH,van Rietschoten JG,Hilkens CM,Sayilir R,Stiekema F,Kapsenberg ML,Wierenga EA

更新日期：2001-04-01 00:00:00

abstract：:HSP gp96-based vaccines have been trialled in rodent models and, more recently, in humans. Better understanding of gp96's immunomodulatory role will help with the design of more effective strategies for treatment of cancer and infectious diseases. In this study, we monitored the activities of T cells and activation of...

journal_title：European journal of immunology

authors： Liu Z,Li X,Qiu L,Zhang X,Chen L,Cao S,Wang F,Meng S

更新日期：2009-11-01 00:00:00

abstract：:Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, ...

journal_title：European journal of immunology

authors： Ichikawa T,Negishi Y,Shimizu M,Takeshita T,Takahashi H

更新日期：2016-08-01 00:00:00

abstract：:Peptides presented by MHC class I molecules are mostly derived from proteins synthesized by the antigen-presenting cell itself, while peptides presented by MHC class II molecules are predominantly from materials acquired by endocytosis. External antigens can also be presented by MHC class I molecules in a process refe...

journal_title：European journal of immunology

authors： Hari A,Ganguly A,Mu L,Davis SP,Stenner MD,Lam R,Munro F,Namet I,Alghamdi E,Fürstenhaupt T,Dong W,Detampel P,Shen LJ,Amrein MW,Yates RM,Shi Y

更新日期：2015-02-01 00:00:00

abstract：:CD72 has been reported to regulate BCR-mediated signals both positively and negatively. SHP-1 and Grb2 bind, respectively, to ITIM1 and ITIM2 of CD72. We generated transformed B cell lines with an immature phenotype following J2 virus infection of splenocytes from CD72(-/-) and wild-type (Wt) mice. The transformed lin...

journal_title：European journal of immunology

authors： Baba T,Fusaki N,Aoyama A,Li DH,Okamura RM,Parnes JR,Hozumi N

更新日期：2005-05-01 00:00:00

abstract：:Human natural killer (NK) cells can be subdivided into two populations based on the density of cell surface CD56 antigen. The great majority (approximately 90%) of NK cells express CD56 at low levels (the CD56dim phenotype), whereas a small NK cell subset (approximately 10%) exhibits approximately fivefold greater den...

journal_title：European journal of immunology

authors： Baume DM,Robertson MJ,Levine H,Manley TJ,Schow PW,Ritz J

更新日期：1992-01-01 00:00:00

abstract：:Allogeneic bone marrow transplantation in the neonate is an effective way of inducing permanent tolerance to donor tissue. To do the same in the immunocompetent adult requires immunosuppression to counter host-versus-graft alloreactivity. Conditioning with monoclonal antibodies (mAb) to CD4 and CD8 has been sufficient...

journal_title：European journal of immunology

authors： Leong LY,Qin S,Cobbold SP,Waldmann H

更新日期：1992-11-01 00:00:00

abstract：:In vivo, T cells expressing low-affinity TCR predominate in primary, but not in secondary responses, a process referred to as T cell affinity maturation. Using CD4 dependence as a measure of the avidity of the interaction between the allospecific TCR and the alloantigen, we show that a similar process occurs in mixed ...

journal_title：European journal of immunology

authors： van Bergen J,Kooy Y,Koning F

更新日期：2001-02-01 00:00:00

abstract：:NK cells offer a first line of defense against viruses and are considered beneficial to the host during infection. Nevertheless, little is understood regarding the phenotype and function of NK cells in the lung during influenza virus infection. We found that the frequency of NK cells in mouse lung increased during inf...

journal_title：European journal of immunology

authors： Zhou G,Juang SW,Kane KP

更新日期：2013-04-01 00:00:00

abstract：:Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic glycolysis. In this study, we examined whether metabolic reprogramming toward aerobic glycolysis is important for the host response to Mycoba...

journal_title：European journal of immunology

authors： Lachmandas E,Beigier-Bompadre M,Cheng SC,Kumar V,van Laarhoven A,Wang X,Ammerdorffer A,Boutens L,de Jong D,Kanneganti TD,Gresnigt MS,Ottenhoff TH,Joosten LA,Stienstra R,Wijmenga C,Kaufmann SH,van Crevel R,Netea MG

更新日期：2016-11-01 00:00:00

abstract：:Human invariant natural killer T (NKT) cell TCRs bind to CD1d via an "invariant" Vα24-Jα18 chain (iNKTα) paired to semi-invariant Vβ11 chains (iNKTβ). Single-amino acid variations at position 93 (p93) of iNKTα, immediately upstream of the "invariant" CDR3α region, have been reported in a substantial proportion of huma...

journal_title：European journal of immunology

authors： Sanderson JP,Waldburger-Hauri K,Garzón D,Matulis G,Mansour S,Pumphrey NJ,Lissin N,Villiger PM,Jakobsen B,Faraldo-Gómez JD,Gadola SD

更新日期：2012-01-01 00:00:00

abstract：:An approach to the preparation of antigen-specific human monoclonal antibodies focuses on mice transgenic for human immunoglobulin gene miniloci; the V gene segments in these miniloci undergo productive rearrangement to yield mouse B cells expressing human immunoglobulin (Ig) chains. The general usefulness of this str...

journal_title：European journal of immunology

authors： Wagner SD,Popov AV,Davies SL,Xian J,Neuberger MS,Brüggemann M

更新日期：1994-11-01 00:00:00

abstract：:NKp46 is a novel triggering receptor expressed by all human NK cells that is involved in natural cytotoxicity. In this study we show that the surface density of NKp46 may vary in different NK cells and that a precise correlation exists between the NKp46 phenotype of NK clones and their natural cytotoxicity against HLA...

journal_title：European journal of immunology

authors： Sivori S,Pende D,Bottino C,Marcenaro E,Pessino A,Biassoni R,Moretta L,Moretta A

更新日期：1999-05-01 00:00:00

abstract：:A human lymphoid cell ine (S95) with surface-located IgG is described. The line was derived from a patient with Hodgkin's disease and is aneuploid. Its characteristics are suggestive of a malignant B lymphocyte derivation, but no ultimate proof of malignancy can be forwarded. The line produces immunoglobulin (IgG) whi...

journal_title：European journal of immunology

authors： Nilsson K,Ghetie V,Sjöquist J

更新日期：1975-08-01 00:00:00

abstract：:In asymptomatic human immunodeficiency virus-1 infection T cells respond normally to allogeneic dendritic cells (DC), but DC show reduced stimulatory capacity. By contrast in HTLV-1 infection no significant changes in allogeneic stimulation were seen but DC-stimulated activity of autologous T cells. In seeking animal ...

journal_title：European journal of immunology

authors： Gabrilovich DI,Roberts MS,Harvey JJ,Botcherby M,Bedford PA,Knight SC

更新日期：1993-11-01 00:00:00

abstract：:T cell receptor (TCR) genes are initially activated in hematopoietic stem cells that have been committed to the T cell lineage during ontogeny. We have established cell lines derived from hematopoietic organs which express truncated TCR delta mRNA (1.3 kbp). In this study, cDNA clones of this mRNA were analyzed to cha...

journal_title：European journal of immunology

authors： Shimamura M,Ohta S

更新日期：1995-06-01 00:00:00

abstract：:The aim of this study was to investigate the effects of IL-17-producing T cells, including Th17 and Tc17 cells, on acute graft-versus-host disease (aGVHD) in patients who had undergone granulocyte colony-stimulating factor (G-CSF)-mobilised peripheral blood progenitor cell (PBPC) and G-CSF-primed bone marrow (G-BM) tr...

journal_title：European journal of immunology

authors： Zhao XY,Xu LL,Lu SY,Huang XJ

更新日期：2011-02-01 00:00:00

abstract：:In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF-β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote the generation and maintenance of mucosal IgA-expressing plasma cells. Here, we demonst...

journal_title：European journal of immunology

authors： Beller A,Kruglov A,Durek P,von Goetze V,Werner K,Heinz GA,Ninnemann J,Lehmann K,Maier R,Hoffmann U,Riedel R,Heiking K,Zimmermann J,Siegmund B,Mashreghi MF,Radbruch A,Chang HD

更新日期：2020-06-01 00:00:00

abstract：:We have investigated the role of TNF-alpha in mast cell-mediated late airway hyperresponsiveness (AHR) using mast cell-deficient WBB6F1-W/W(v) (W/W(v)) mice in a murine model of asthma, which exhibits a biphasic increase in AHR. TNF-alpha levels in the airway and magnitude of late AHR in response to airway allergen ch...

journal_title：European journal of immunology

authors： Kim YS,Ko HM,Kang NI,Song CH,Zhang X,Chung WC,Kim JH,Choi IH,Park YM,Kim GY,Im SY,Lee HK

更新日期：2007-04-01 00:00:00

abstract：:Local graft-vs.-host reaction (GVHR) was induced in rats by injecting parental cells into young F1 recipients. As a consequence of antigenic stimulation in the course of developing GVHR in the responding lymph nodes, the number of interleukin 2-receptor (IL 2R)-bearing T cells increased from less than 1% up to 10% of ...

journal_title：European journal of immunology

authors： Volk HD,Brocke S,Osawa H,Diamantstein T

更新日期：1986-10-01 00:00:00

abstract：:NK cells are important for the control of vaccinia virus (VV) in vivo. Recent studies have shown that multiple pathways are required for effective activation of NK cells. These include both TLR-dependent and -independent pathways, as well as the NKG2D activating receptor that recognizes host stress-induced NKG2D ligan...

journal_title：European journal of immunology

authors： Brandstadter JD,Huang X,Yang Y

更新日期：2014-09-01 00:00:00

abstract：:Chemokines are proinflammatory mediators that regulate leukocyte trafficking at different steps of the leukocyte recruitment cascade. Studies using new imaging approaches and new mouse models are giving new insights into the role of chemokines in neutrophil migration at sites of inflammation. Conventional rolling and ...

journal_title：European journal of immunology

authors： Sanz MJ,Kubes P

更新日期：2012-02-01 00:00:00

abstract：:Autoantibodies in the form of immune complexes are known to be crucial mediators in initiating inflammation in a variety of autoimmune diseases. This has been well documented in the anti-collagen II antibody-induced arthritis animal model for a long time now. Recently, in the K/B x N mouse model (the F1 of the TCR-tra...

journal_title：European journal of immunology

authors： Solomon S,Rajasekaran N,Jeisy-Walder E,Snapper SB,Illges H

更新日期：2005-10-01 00:00:00

abstract：:The pathogenesis of the decline of CD4 lymphocyte counts accompanying the typical course of HIV-1 infection is not completely defined and might be related to a differential susceptibility of naive and memory cells to HIV-1 exposure. Here, we examined the effects induced by heat-inactivated HIV-1 virions on these lymph...

journal_title：European journal of immunology

authors： Masci AM,Paz FL,Borriello A,Cassano S,Della Pietra V,Stoiber H,Matarese G,Della Ragione F,Zappacosta S,Racioppi L

更新日期：1999-06-01 00:00:00

abstract：:Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils. ...

journal_title：European journal of immunology

authors： Samadi N,Polak D,Kitzmüller C,Steinberger P,Zlabinger GJ,Jahn-Schmid B,Bohle B

更新日期：2019-09-01 00:00:00

abstract：:In the thymus, in order to become MHC-restricted self-tolerant T cells, developing thymocytes need to interact with cortical and medullary thymic epithelial cells (TECs). Although the presence of a common bipotent progenitor for these functionally and structurally distinct epithelial subsets has been clearly establish...

journal_title：European journal of immunology

authors： Peterson P,Laan M

更新日期：2013-03-01 00:00:00

abstract：:The purpose of this study was to obtain additional information on the mechanism by which interferon-gamma (IFN-gamma) is able to regulate gene expression in macrophages. The expression of the genes for class II histocompatibility I-A beta, tumor necrosis factor (TNF) and complement component C3 was assayed after treat...

journal_title：European journal of immunology

authors： Celada A,Klemsz MJ,Maki RA

更新日期：1989-06-01 00:00:00

abstract：:Rabbit kappa light (L) chain allotypes are controlled by the allelic genes b4, b5, b6, b9 and a recently described allele b4v. The product of the b4v gene differs from that of b4 by at least two amino acid substitutions in the constant region. A serologic distinction between the b4 and b4v allotyes has now been detect...

journal_title：European journal of immunology

authors： Smith LJ,Sogh JA,Kindt TJ,Mandy WJ

更新日期：1979-01-01 00:00:00

abstract：:Dendritic cells (DC) play the dual task of initiating cellular immunity against potentially harmful foreign antigens (Ag), while maintaining immunological tolerance to self-Ag and environmental Ag. As an approach to induce Ag-specific suppression, we and others introduced CD95 ligand (L) cDNA into DC. The resulting "k...

journal_title：European journal of immunology

authors： Kusuhara M,Matsue K,Edelbaum D,Loftus J,Takashima A,Matsue H

更新日期：2002-04-01 00:00:00