Dual regulation of BCR-mediated growth inhibition signaling by CD72.

abstract：:Riboflavin, also known as vitamin B2 , is converted by riboflavin kinase (RFK) into flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential cofactors of dehydrogenases, reductases, and oxidases including the phagocytic NADPH oxidase 2 (Nox2). Riboflavin deficiency is common in young adul...

journal_title：European journal of immunology

authors： Schramm M,Wiegmann K,Schramm S,Gluschko A,Herb M,Utermöhlen O,Krönke M

更新日期：2014-03-01 00:00:00

abstract：:Exosomes are nanovesicles produced constitutively and inducibly by several types of cells. They are generated as intraluminal vesicles of multivesicular bodies and express MHC and several endosomal/lysosomal proteins. In spite of their potential role in cellular immunity, the regulatory mechanisms of exosome productio...

journal_title：European journal of immunology

authors： Arita S,Baba E,Shibata Y,Niiro H,Shimoda S,Isobe T,Kusaba H,Nakano S,Harada M

更新日期：2008-05-01 00:00:00

abstract：:The tight-skin (Tsk/+) mutant mouse, a putative murine model of scleroderma, is characterized primarily by the excessive deposition of collagen and other extracellular matrix molecules in the dermis, and also by a developmentally acquired defect in pulmonary architecture. Passive transfer experiments have suggested an...

journal_title：European journal of immunology

authors： Ong C,Wong C,Roberts CR,Teh HS,Jirik FR

更新日期：1998-09-01 00:00:00

abstract：:The immunosuppressive drugs FK506 and rapamycin bind to a family of intracellular proteins termed FK506-binding proteins (FKBP). FK506 and rapamycin inhibit lymphocyte-activation pathways by forming complexes with an FKBP; subsequently, the drug/FKBP complexes interact with target molecules involved in signal transduc...

journal_title：European journal of immunology

authors： Fruman DA,Wood MA,Gjertson CK,Katz HR,Burakoff SJ,Bierer BE

更新日期：1995-02-01 00:00:00

abstract：:Several studies in human patients and in laboratory animals have revealed a correlation between serum interleukin (IL)-6 levels and outcome in clinical sepsis and in related animal models, respectively. In the present study, two monoclonal antibodies were used to investigate the contribution of IL-6 in the lethal acti...

journal_title：European journal of immunology

authors： Libert C,Vink A,Coulie P,Brouckaert P,Everaerdt B,Van Snick J,Fiers W

更新日期：1992-10-01 00:00:00

abstract：:The turnover of mature and immature B cells defined by a range of cell surface markers was investigated by feeding normal or bcl-2-transgenic (bcl-2-Tg) mice 5'-bromo-2-deoxyuridine (BrdUrd) for up to 6 weeks. In peripheral lymphoid tissue, B cells accumulated BrdUrd with a 50% labeling time of 4.3 weeks and a pattern...

journal_title：European journal of immunology

authors： Fulcher DA,Basten A

更新日期：1997-05-01 00:00:00

abstract：:The autoimmune disease systemic lupus erythematosus is characterized by loss of tolerance to nuclear Ags and a heightened inflammatory environment, which together result in end organ damage. Lyn-deficient mice, a model of systemic lupus erythematosus, lack an inhibitor of B-cell and myeloid cell activation. This resul...

journal_title：European journal of immunology

authors： Gutierrez T,Mayeux JM,Ortega SB,Karandikar NJ,Li QZ,Rakheja D,Zhou XJ,Satterthwaite AB

更新日期：2013-02-01 00:00:00

abstract：:Mice carrying the nude mutation (nu/nu) lack a functioning thymus and do not contain detectable levels of immunocompetent T cells. We now report that nu/nu mice to have lymphocytes which can be activated in vivo by heterologous erythrocytes and a Lyt-1 T cell-derived factor (interleukin 2) to generate T helper cells. ...

journal_title：European journal of immunology

authors： Stötter H,Rüde E,Wagner H

更新日期：1980-09-01 00:00:00

abstract：:We have studied the kinetics of the antigen induced response of naive and memory CD8 T cells expressing a transgenic T cell receptor (TCR) specific for the glycoprotein peptide amino acid 33-41 (GP33) of the lymphocytic choriomeningitis virus (LCMV). Memory T cells were generated in vivo by adoptive transfer of LCMV T...

journal_title：European journal of immunology

authors： Zimmermann C,Prévost-Blondel A,Blaser C,Pircher H

更新日期：1999-01-01 00:00:00

abstract：:The TNF member LIGHT also known as TL4 or TNFSF14) can play a major role in cancer control via its two receptors; it induces tumor cell death through lymphotoxin-beta receptor (LT-betaR) and ligation to the herpes virus entry mediator (HVEM) amplifies the immune response. By studying the effect of LIGHT in the transcr...

journal_title：European journal of immunology

authors： Pasero C,Barbarat B,Just-Landi S,Bernard A,Aurran-Schleinitz T,Rey J,Eldering E,Truneh A,Costello RT,Olive D

更新日期：2009-09-01 00:00:00

abstract：:The thymic architecture is normally compartmentalized into a central medulla surrounded by a peripheral cortical region. We investigated how compartmentalization of the thymic stroma is regulated using T cell receptor (TCR)-transgenic mouse models. Our studies show that the signals generated by TCR/peptide/major histo...

journal_title：European journal of immunology

authors： Brabb T,Huseby ES,Morgan TM,Sant'Angelo DB,Kirchner J,Farr AG,Goverman J

更新日期：1997-01-01 00:00:00

abstract：:Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains elusive. By using accurate mass spectrometry and multi-epitope ligand cartography (MELC) we character...

journal_title：European journal of immunology

authors： van Ham M,Teich R,Philipsen L,Niemz J,Amsberg N,Wissing J,Nimtz M,Gröbe L,Kliche S,Thiel N,Klawonn F,Hubo M,Jonuleit H,Reichardt P,Müller AJ,Huehn J,Jänsch L

更新日期：2017-12-01 00:00:00

abstract：:Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...

journal_title：European journal of immunology

authors： Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ

更新日期：2009-01-01 00:00:00

abstract：:Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process. However, Tfr-cell function in the GC is not well understood. Here, we define Tfr cells as a C...

journal_title：European journal of immunology

authors： Wu H,Chen Y,Liu H,Xu LL,Teuscher P,Wang S,Lu S,Dent AL

更新日期：2016-05-01 00:00:00

abstract：:Monocytes differentiate into dendritic cells (DC) in response to GM-CSF combined with other cytokines including IL-4 and IL-15. Here, we show that IL15-DC are efficient in priming naive CD8+ T cells to differentiate into melanoma antigen-specific cytotoxic T lymphocytes (CTL). While both melanoma peptide-pulsed IL15-D...

journal_title：European journal of immunology

authors： Dubsky P,Saito H,Leogier M,Dantin C,Connolly JE,Banchereau J,Palucka AK

更新日期：2007-06-01 00:00:00

abstract：:A method is described for radiolabeling polyanionic macromolecules by the formation of an electrostatic complex with a radioiodinated tyramine conjugated DEAE-dextran. Data is presented on the use of this technique for the detection and quantitation of immunospecific binding of polynitrophenylated proteins, deoxyribon...

journal_title：European journal of immunology

authors： Little JR,Blanke TJ,Little KD

更新日期：1976-06-01 00:00:00

abstract：:In the frog Xenopus, MHC class I antigen presentation and processing genes (the immunoproteasome LMP2 and LMP7 and the transporter TAP1 and TAP2) seem to be closely linked in a primordial organization. Two distinct lineages of class Ia and LMP7 loci were previously identified, thus strongly suggesting co-evolution amo...

journal_title：European journal of immunology

authors： Ohta Y,Powis SJ,Lohr RL,Nonaka M,Pasquier LD,Flajnik MF

更新日期：2003-11-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE) is an animal model for the human disease, multiple sclerosis. The LEW rat strain is very susceptible to induction of EAE, whereas the closely related, major histocompatibility complex (MHC)-identical, inbred strain LER is resistant. In this report, the two rat strains have...

journal_title：European journal of immunology

authors： Blankenhorn EP,Stranford SA,Smith PD,Hickey WF

更新日期：1991-09-01 00:00:00

abstract：:The human IgG3 (b) allotype is associated with a high and the (g) allotype with a low mean serum level of IgG3 which is due to a low frequency of B cell switching in the latter. In the present study, we found a polymorphism in position -73 (C --> A), located in the 4th NF-kappaB site of the germ-line (GL) gamma3 promo...

journal_title：European journal of immunology

authors： Pan Q,Petit-Frére C,Hammarström L

更新日期：2000-08-01 00:00:00

abstract：:The monoclonal antibody OKT3 can induce T suppressor cells of the in vitro antibody response when used at concentrations as low as 10 ng/ml and in cultures containing as few as 4% OKT3-pretreated T cells. These suppressor cells are radioresistant, cyclosporin sensitive and belong to the T4 as well as the T8 subpopulat...

journal_title：European journal of immunology

authors： Delfraissy JF,Wallon C,Boué F,Vazquez A,Galanaud P

更新日期：1985-05-01 00:00:00

abstract：:Tumor-specific helper T cell activity was detected in the spleens of tumor-bearing mice using a sensitive, simple and reproducible in vitro assay based on those previously described for soluble hapten-carrier antigens. Helper activity disappears when the tumor is large. This is coincident with the appearance of two di...

journal_title：European journal of immunology

authors： Howie S,McBride WH

更新日期：1982-08-01 00:00:00

abstract：:Caspases are essential mediators of cytokine release and apoptosis. Additionally, caspase activity is required for the proliferation of naive T lymphocytes. It remained unclear how proliferating cells are able to cope with the pro-apoptotic activity especially of effector caspases-3 and -7. Possible reasons might incl...

journal_title：European journal of immunology

authors： Paulsen M,Ussat S,Jakob M,Scherer G,Lepenies I,Schütze S,Kabelitz D,Adam-Klages S

更新日期：2008-07-01 00:00:00

abstract：:The CD45RO phenotype of peripheral blood CD4+ and CD8+ lymphocytes were determined in physically active males (n = 171) and females (n = 70) ranging in age from 15-68 years. Direct immunofluorescence and dual color flow cytometry was performed for analysis. Absolute cell numbers (r = 0.473) and percentages of CD4+ CD4...

journal_title：European journal of immunology

authors： Gabriel H,Schmitt B,Kindermann W

更新日期：1993-10-01 00:00:00

abstract：:The early mechanisms by which DNA-dependent immunization occurs remain poorly understood. We determined whether intradermal injection of a cytomegalovirus (CMV) promoter-driven plasmid encoding hen egg lysozyme (pCMV:HEL) induced sensitization against the encoded protein, and whether cutaneous dendritic cells (DC) wer...

journal_title：European journal of immunology

authors： Bouloc A,Walker P,Grivel JC,Vogel JC,Katz SI

更新日期：1999-02-01 00:00:00

abstract：:A human lymphoid cell ine (S95) with surface-located IgG is described. The line was derived from a patient with Hodgkin's disease and is aneuploid. Its characteristics are suggestive of a malignant B lymphocyte derivation, but no ultimate proof of malignancy can be forwarded. The line produces immunoglobulin (IgG) whi...

journal_title：European journal of immunology

authors： Nilsson K,Ghetie V,Sjöquist J

更新日期：1975-08-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have revolutionized the search for genetic influences on complex disorders, such as primary biliary cirrhosis (PBC). Recent GWAS have identified many disease-associated genetic variants. These, overall, highlighted the remarkable contribution of key immunological pathways in PBC ...

journal_title：European journal of immunology

authors： Carbone M,Lleo A,Sandford RN,Invernizzi P

更新日期：2014-04-01 00:00:00

abstract：:Tissue macrophages and their precursors-the blood monocytes-respond rapidly to a bacterial infection with the release of inflammatory mediators. These mediators are involved in the recruitment of phagocytic cells, principally neutrophils, from the blood to the site of infection. To initiate this process macrophages an...

journal_title：European journal of immunology

authors： Jack RS,Grunwald U,Stelter F,Workalemahu G,Schütt C

更新日期：1995-05-01 00:00:00

abstract：:We examined T cell development and T cell repertoire in transgenic mice expressing a single T cell receptor (TCR) alpha chain derived from the H-2Db-lymphocytic choriomeningitis virus (LCMV)-specific cytolytic T lymphocyte (CTL) clone P14. To generate these alpha P14 mice, mice transgenic for the P14 TCR alpha chain w...

journal_title：European journal of immunology

authors： Brändle D,Brduscha-Riem K,Hayday AC,Owen MJ,Hengartner H,Pircher H

更新日期：1995-09-01 00:00:00

abstract：:Antigens in the form of immune complexes are retained on the membranes of follicular dendritic cells (FDC) for long periods of time. To examine how immune complexes reach germinal centers, where FDC are located, we injected mice with anti-2,4-dinitrophenyl (DNP) antibodies complexed to DNP-myoglobin-coated gold partic...

journal_title：European journal of immunology

authors： Heinen E,Braun M,Coulie PG,Van Snick J,Moeremans M,Cormann N,Kinet-Denoël C,Simar LJ

更新日期：1986-02-01 00:00:00

abstract：:Lymphocyte proliferation in response to monocytes pulsed with an antigenic extract of Candida albicans was measured in vitro and the effects of modifying major histocompatibility complex (MHC) class II antigen expression at the surface of the antigen-presenting cells was investigated. The study shows that no simple co...

journal_title：European journal of immunology

authors： Rhodes J,Ivanyi J,Cozens P

更新日期：1986-04-01 00:00:00