A new method of radioiodine labeling of polyanionic macromolecules for radioimmunoassay.

abstract：:The pathways leading to activation of mucosal lamina propria (LP) T cells differ from those of peripheral T cells. LP T cells exhibit enhanced IFN-gamma secretion when activated through the CD2 pathway. This study demonstrates CD2 signaling is followed by activation of STAT proteins in both peripheral blood mononuclea...

journal_title：European journal of immunology

authors： Gonsky R,Deem RL,Young HA,Targan SR

更新日期：2003-05-01 00:00:00

abstract：:A cDNA coding for the human interleukin 1 receptor antagonist protein (IL 1Ra) was used to clone the corresponding murine cDNA. The nucleotide sequence of the open reading frame coding for the processed form of mIL 1Ra predicted a 152-residue protein that was 77% identical to human IL 1Ra. The cellular and tissue dist...

journal_title：European journal of immunology

authors： Shuck ME,Eessalu TE,Tracey DE,Bienkowski MJ

更新日期：1991-11-01 00:00:00

abstract：:Cooperation between B cells specific for an antigen exposed on a viral structure and T helper (Th) cells specific for an internal antigen, as demonstrated with influenza, hepatitis B and rabies viruses, has been termed intrastructural help. Th cells specific for internal proteins of HIV, which are much less mutated th...

journal_title：European journal of immunology

authors： Manca F,Fenoglio D,Valle MT,Li Pira G,Kunkl A,Balderas RS,Baccala RG,Kono DH,Ferraris A,Saverino D

更新日期：1995-05-01 00:00:00

abstract：:Th17 cells are defined by their capacity to produce IL-17, and are important mediators of inflammation and autoimmunity. Human Th17 cells express high levels of the retinoic acid-related orphan receptor variant 2 (RORC2), but it is currently unclear whether expression of this transcription factor alone is sufficient t...

journal_title：European journal of immunology

authors： Crome SQ,Wang AY,Kang CY,Levings MK

更新日期：2009-06-01 00:00:00

abstract：:gp140 is the Epstein-Barr virus receptor and the C3d receptor (EBVR/C3dR) of human B lymphocytes. Recently, we have shown that cross-linking of EBVR/C3dR on cell surface by polyclonal anti-gp140 induced B cell activation, in presence of T cell factors. Immunoregulatory abnormalities of EBV-induced B cell activation ha...

journal_title：European journal of immunology

authors： Barel M,Kahan A,Charriaut-Marlangue C,Kahan A,Frade R

更新日期：1986-11-01 00:00:00

abstract：:Macrophage-chemotactic factor (MChF)-producing T cell hybridomas were established. These hybridomas produced MChF upon the specific antigenic stimulation with phosphorylcholine (PC)-conjugated protein in the presence of I-Ed-positive antigen-presenting cells. The hybridomas also secreted MChF after co-culture with con...

journal_title：European journal of immunology

authors： Harita S,Sugimura K,Watanabe T

更新日期：1984-08-01 00:00:00

abstract：:Mycoplasma arthritidis produces an as yet undefined soluble molecule (MAS) that has a potent mitogenic effect on T cells of several species. We have used cloned human cytotoxic and proliferative T lymphocytes to dissect the molecular mechanism of T cell activation by this mitogen. Reactivity to MAS is clonally express...

journal_title：European journal of immunology

authors： Matthes M,Schrezenmeier H,Homfeld J,Fleischer S,Malissen B,Kirchner H,Fleischer B

更新日期：1988-11-01 00:00:00

abstract：:The squirrel monkey Saimiri sciureus is one of the World Health Organization recommended experimental models of Plasmodium falciparum blood stage infection. Anti-malaria antibodies developed by this host after a drug-controlled infection play an important part in the acquired protection against the P. falciparum blood...

journal_title：European journal of immunology

authors： Groux H,Perraut R,Garraud O,Poingt JP,Gysin J

更新日期：1990-10-01 00:00:00

abstract：:It is widely accepted that females have superior immune responses than males, but the ways by which sex hormones may enhance T cell responses are still poorly understood. In the present study, we analyzed the effect of estrogens on CD4 T cell activation and differentiation after immunization with exogenous antigens. W...

journal_title：European journal of immunology

authors： Maret A,Coudert JD,Garidou L,Foucras G,Gourdy P,Krust A,Dupont S,Chambon P,Druet P,Bayard F,Guéry JC

更新日期：2003-02-01 00:00:00

abstract：:Stem cell factor (SCF) is encoded at the Sl locus of the mouse and is the ligand for the c-kit receptor. Recombinant rat SCF164 (rrSCF164) induces proliferation and promotes maturation of mouse mast cells in vitro and in vivo and can also induce c-kit receptor-dependent mouse mast cell degranulation. We now report tha...

journal_title：European journal of immunology

authors： Tsai M,Tam SY,Galli SJ

更新日期：1993-04-01 00:00:00

abstract：:The cytotoxic response of cell sorter-purified small Lyt-2+ splenic cytotoxic lymphocyte precursors from 10 individual C57BL/6 mice to mutant class I H-2Kbm1 or H-2Dbm14 allodeterminants was analyzed under limiting dilution conditions. The cytotoxic activity of anti-bm1-specific or anti-bm14-specific cytotoxic T lymph...

journal_title：European journal of immunology

authors： Reimann J,Bellan A

更新日期：1986-12-01 00:00:00

abstract：:The importance of human herpesvirus 6 (HHV-6) species as human pathogens is increasingly appreciated. However, we do not understand how infection is controlled in healthy virus carriers, and why control fails in patients with disease. Other persistent viruses are under continuous surveillance by antigen-specific T cel...

journal_title：European journal of immunology

authors： Martin LK,Schub A,Dillinger S,Moosmann A

更新日期：2012-11-01 00:00:00

abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

journal_title：European journal of immunology

authors： Yamada T,Hitomi Y,Satake M,Oikawa T

更新日期：1995-09-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE) is an animal model for the human disease, multiple sclerosis. The LEW rat strain is very susceptible to induction of EAE, whereas the closely related, major histocompatibility complex (MHC)-identical, inbred strain LER is resistant. In this report, the two rat strains have...

journal_title：European journal of immunology

authors： Blankenhorn EP,Stranford SA,Smith PD,Hickey WF

更新日期：1991-09-01 00:00:00

abstract：:The spleen is anatomically and functionally divided into two compartments: the red pulp, where particles are effectively removed from the blood, and the white pulp, where specific immune responses are generated. Here the isolation of white pulp from red pulp is described, allowing a detailed analysis of the cellular c...

journal_title：European journal of immunology

authors： Nolte MA,Hoen EN,van Stijn A,Kraal G,Mebius RE

更新日期：2000-02-01 00:00:00

abstract：:Missing-self-reactivity can be mimicked by blocking self-specific inhibitory receptors on NK cells, leading to increased rejection of syngeneic tumor cells. Using a mouse model, we investigated whether Ab-mediated blocking of inhibitory receptors, to a degree where NK cells rejected syngeneic tumor cells, would still ...

journal_title：European journal of immunology

authors： Vahlne G,Lindholm K,Meier A,Wickström S,Lakshmikanth T,Brennan F,Wilken M,Nielsen R,Romagné F,Wagtmann NR,Kärre K,Johansson MH

更新日期：2010-03-01 00:00:00

abstract：:Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...

journal_title：European journal of immunology

authors： Mommert M,Perret M,Hockin M,Viel S,Belot A,Richard JC,Mezidi M,Fassier JB,Javouhey E,ANTOINE Study Group.,COVID-SER Study Group.,COVID-HCL Study Group.,Hemmert A,Mallet F,Trouillet-Assant S,Brengel-Pesce K

更新日期：2020-12-12 00:00:00

abstract：:Cell ablation is a valuable complement to mutagenesis for experimentally defining specific cell functions in physiology and pathophysiology in small animal models. One of the most popular ablation strategies involves transgenic expression of a primate diphtheria toxin receptor (DTR) on murine cells that are otherwise ...

journal_title：European journal of immunology

authors： Ruedl C,Jung S

更新日期：2018-07-01 00:00:00

abstract：:Muramyl peptides are the building blocks of bacterial peptidoglycan, and their biological functions in mammals have been extensively studied. In particular, muramyl peptides trigger inflammation, contribute to host defense against microbial infections, and modulate the adaptive immune response to antigens. These bacte...

journal_title：European journal of immunology

authors： Magalhaes JG,Lee J,Geddes K,Rubino S,Philpott DJ,Girardin SE

更新日期：2011-05-01 00:00:00

abstract：:The contribution of the costimulatory molecules B7-1 and B7-2 to the in vivo differentiation of Th cells remains controversial. The infection of resistant and susceptible strains of mice with the parasite Leishmania major provides a well-established model for studying in vivo differentiation of CD4+ T cells. We have i...

journal_title：European journal of immunology

authors： Brown JA,Greenwald RJ,Scott S,Schweitzer AN,Satoskar AR,Chung C,Schopf LR,van der Woude D,Sypek JP,Sharpe AH

更新日期：2002-06-01 00:00:00

abstract：:The recently discovered B6.C-H-2bm12 (bm12) histocompatibility mutant bears a mutation of the I-A subregion of the H-2b haplotype. We have studied cytotoxic T lymphocytes (CTL) generated in secondary mixed lymphocyte culture (MLC) between the bm12 mutant and the strain of origin C57BL/6 (B6). In both directions, stron...

journal_title：European journal of immunology

authors： de Waal LP,Melief CJ,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:HLA class II association with insulin-dependent diabetes mellitus (IDDM) is well established but is still difficult to map to a particular locus. Polymorphism of the genes coding for transporter associated with antigen processing (TAP1 and TAP2), and located in the HLA class II region, was studied in 167 IDDM patients...

journal_title：European journal of immunology

authors： Caillat-Zucman S,Bertin E,Timsit J,Boitard C,Assan R,Bach JF

更新日期：1993-08-01 00:00:00

abstract：:Macrophages can be stimulated to produce a relatively large amount of nitric oxide, which is an important component in macrophage-mediated defense mechanisms and regulation of T cell activities. It has been known that T helper (Th) cell activation requires intimate physical interaction between T helper cells and macro...

journal_title：European journal of immunology

authors： Tian L,Noelle RJ,Lawrence DA

更新日期：1995-01-01 00:00:00

abstract：:In rheumatoid arthritis (RA), T cells in the inflamed joint are considered to play a crucial role in the pathogenesis. However, despite the fact that synovial T cells have an activated memory phenotype, they are functionally suppressed upon combined CD3 and CD28 stimulation. Here, we analyzed the contribution of both ...

journal_title：European journal of immunology

authors： Maurice MM,van der Voort EA,Leow A,Levarht N,Breedveld FC,Verweij CL

更新日期：1998-05-01 00:00:00

abstract：:Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin...

journal_title：European journal of immunology

authors： Feng ZY,Louis J,Kindler V,Pedrazzini T,Eliason JF,Behin R,Vassalli P

更新日期：1988-08-01 00:00:00

abstract：:The functional relevance of CD2-mediated signal transduction in triggering T cell receptor/CD3-independent natural killer cell cytotoxicity was investigated by introducing wild-type CD2 or signaling-deficient CD2 with truncated cytoplasmic region into a murine natural killer-like large granular lymphocyte clone lackin...

journal_title：European journal of immunology

authors： Nakamura T,Takahashi K,Koyanagi M,Yagita H,Okumura K

更新日期：1991-03-01 00:00:00

abstract：:Vitamin A deficiency is known to be accompanied with immune deficiency and susceptibility to a wide range of infectious diseases. Experimental evidence suggests that the active metabolites of vitamin A that mediate its effects on the immune system are the retinoic acids (RA), which are ligands for the nuclear RA recep...

journal_title：European journal of immunology

authors： Kiss I,Rühl R,Szegezdi E,Fritzsche B,Tóth B,Pongrácz J,Perlmann T,Fésüs L,Szondy Z

更新日期：2008-01-01 00:00:00

abstract：:Activation-induced deaminase (AID) is the master regulator of class switch recombination (CSR) and somatic hypermutation (SHM), but the mechanisms regulating AID function are obscure. The differential pattern of switch plasmid activity in three IgM(+)/AID(+) and two IgG(+)/AID(+) B cell lines prompted an analysis of g...

journal_title：European journal of immunology

authors： Bhattacharya P,Grigera F,Rogozin IB,McCarty T,Morse HC 3rd,Kenter AL

更新日期：2008-01-01 00:00:00

abstract：:The interaction of KB-V1, a multidrug resistant (MDR) variant of the KB-3-1 human oral carcinoma, with human complement was investigated. KB-V1 cells were found to be more sensitive than KB-3-1 cells to complement-mediated lysis. Detailed analysis of the capacity of KB cells to activate human complement demonstrated t...

journal_title：European journal of immunology

authors： Bomstein Y,Fishelson Z

更新日期：1997-09-01 00:00:00

abstract：:Expression of the complement-regulatory proteins (CRP) CD46, CD55 and CD59 represents a strategy used by tumor cells to evade complement-dependent cell cytoxicity stimulated by monoclonal antibodies. We have isolated two single-chain variable fragments (scFv) to CD55 and CD59 from a human phage-display library and fro...

journal_title：European journal of immunology

authors： Ziller F,Macor P,Bulla R,Sblattero D,Marzari R,Tedesco F

更新日期：2005-07-01 00:00:00