Genetic differences in the T cell receptor alleles of LEW rats and their encephalomyelitis-resistant derivative, LER, and their impact on the inheritance of EAE resistance.

abstract：:Previous studies have shown that IL-10 inhibits the accessory cell functions required for production of IFN-gamma by T cells and NK cells. Our results show that although IL-10 did not induce the production of IFN-gamma by NK cells, it did enhance the ability of IL-18 to stimulate NK cell production of IFN-gamma. In ad...

journal_title：European journal of immunology

authors： Cai G,Kastelein RA,Hunter CA

更新日期：1999-09-01 00:00:00

abstract：:Myeloid dendritic cells (DC) and macrophages evolve from a common precursor. However, factors controlling monocyte differentiation toward DC or macrophages are poorly defined. We report that the surface density of the GM-CSF receptor (GM-CSFR) alpha subunit in human peripheral blood monocytes varies among donors. Alth...

journal_title：European journal of immunology

authors： Conti L,Cardone M,Varano B,Puddu P,Belardelli F,Gessani S

更新日期：2008-03-01 00:00:00

abstract：:T and B cells continually migrate around the body by recirculating between blood and lymph via lymphoid tissues. This is an important way of fostering the cell-cell interactions required for the initiation of an immune response. Data from previous studies of T and B cell recirculation, based on relatively complex appr...

journal_title：European journal of immunology

authors： Reynolds JD,Chin W,Shmoorkoff J

更新日期：1988-06-01 00:00:00

abstract：:Muramyl peptides are the building blocks of bacterial peptidoglycan, and their biological functions in mammals have been extensively studied. In particular, muramyl peptides trigger inflammation, contribute to host defense against microbial infections, and modulate the adaptive immune response to antigens. These bacte...

journal_title：European journal of immunology

authors： Magalhaes JG,Lee J,Geddes K,Rubino S,Philpott DJ,Girardin SE

更新日期：2011-05-01 00:00:00

abstract：:Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, ...

journal_title：European journal of immunology

authors： Ichikawa T,Negishi Y,Shimizu M,Takeshita T,Takahashi H

更新日期：2016-08-01 00:00:00

abstract：:The CBA/N mouse carries the X-linked immunodeficiency xid, resulting in defective B cell development. B cells from these animals cannot mount antibody responses to type 2 T-independent antigens, and do not synthesize DNA when stimulated with anti-immunoglobulin (Ig) antibodies which are mitogenic for normal B cells. T...

journal_title：European journal of immunology

authors： Hasbold J,Klaus GG

更新日期：1994-01-01 00:00:00

abstract：:Interleukin-15 (IL-15) is an inflammatory cytokine whose role in autoimmune diseases has not been fully elucidated. Th17 cells have been shown to play critical roles in experimental autoimmune encephalomyelitis (EAE) models. In this study, we demonstrate that blockade of IL-15 signaling by TMβ-1 mAb treatment aggravat...

journal_title：European journal of immunology

authors： Yu P,Bamford RN,Waldmann TA

更新日期：2014-11-01 00:00:00

abstract：:With the aid of a specific rabbit antibody preparation to purified monoclonal murine IgE, two plaque-forming cell (PFC) assays have been developed for the detection and enumeration of mouse IgE-secreting cells. The first assay, utilizing protein A-coated sheep red cells (protein A-SRC), detected antibody-secreting cel...

journal_title：European journal of immunology

authors： Rector ES,Lang GM,Carter BG,Kelly KA,Bundesen PG,Böttcher I,Sehon AH

更新日期：1980-12-01 00:00:00

abstract：:Rodents are significantly less sensitive to enterotoxin-induced shock, and are thus not valid human disease models. Here, we describe a mouse strain carrying the human CD4 and human major histocompatibility complex (MHC) class II (DQ6) transgenes in an endogenous CD4- and CD8-deficient background. T lymphocytes from t...

journal_title：European journal of immunology

authors： Yeung RS,Penninger JM,Kündig T,Khoo W,Ohashi PS,Kroemer G,Mak TW

更新日期：1996-05-01 00:00:00

abstract：:NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...

journal_title：European journal of immunology

authors： Campos PC,Gomes MTR,Marinho FAV,Guimarães ES,de Moura Lodi Cruz MGF,Oliveira SC

更新日期：2019-07-01 00:00:00

abstract：:Systemic lupus erythematosus is characterized by the presence of high titers of autoantibodies reacting with various components of the U1 small nuclear ribonucleoprotein particle (snRNP). It has been suggested that these antibodies are produced by an antigen-driven mechanism under the dependence of antigen-specific T ...

journal_title：European journal of immunology

authors： Monneaux F,Briand JP,Muller S

更新日期：2000-08-01 00:00:00

abstract：:The lectin leucoagglutinin has been used to induce reactivity to interleukin 2 (IL2) in unseparated spleen cells and in highly purified Lyt-2+ lymph node T cells. Recombinant human IL2 and various other IL2-containing preparations, including concanavalin A-induced spleen cell supernatant, were compared for their capac...

journal_title：European journal of immunology

authors： Vohr HW,Hünig T

更新日期：1985-04-01 00:00:00

abstract：:Synthetic peptides encoding protective pathogen-derived epitopes represent--in principle--an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to be...

journal_title：European journal of immunology

authors： Overstreet MG,Freyberger H,Cockburn IA,Chen YC,Tse SW,Zavala F

更新日期：2010-01-01 00:00:00

abstract：:Normal human peripheral blood lymphocytes were shown to activate complement in normal human serum (NHS). This activation led to C3 fixation on the cell membrane, which in turn was visualized by fluorescence. The reaction occurred in the absence of detectable amounts of antibodies, since an agammaglobulinemic patient's...

journal_title：European journal of immunology

authors： Gutiérrez C,Vega J,Kreisler M

更新日期：1979-01-01 00:00:00

abstract：:Chemokine receptor CXCR6 mediates the chemotaxis and adhesion of leukocytes to soluble and membrane-anchored forms of CXCL16, and is an HIV-1 co-receptor. Here, we describe the effects of mutation of acidic extracellular CXCR6 residues on receptor function. Although most CXCR6 mutants examined were expressed at levels...

journal_title：European journal of immunology

authors： Petit SJ,Chayen NE,Pease JE

更新日期：2008-08-01 00:00:00

abstract：:Dendritic cells expanded from mouse bone marrow (BMDC) with granulocyte/macrophage-colony-stimulating factor have potent T cell-stimulatory properties both in vitro and in vivo. This has been well documented for major histocompatibility complex (MHC) class II-restricted responses, and more recently using peptide-loade...

journal_title：European journal of immunology

authors： Norbury CC,Chambers BJ,Prescott AR,Ljunggren HG,Watts C

更新日期：1997-01-01 00:00:00

abstract：:The MOPC460 idiotype is expressed in mice with the IghCa allotypic haplotype after anti-2,4-dinitrophenyl (DNP) immunization. We have previously shown that two monoclonal syngeneic anti-idiotypic antibodies (IDM 92-13 and IDM 41-27) define two distinct idiotopes (the 460.92 and the 460.41) on the M460 idiotype. The cu...

journal_title：European journal of immunology

authors： Sanchez P,Juy D,Cazenave PA

更新日期：1983-12-01 00:00:00

abstract：:Mast cells are widely distributed in tissues, particularly near surfaces exposed to the environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE and specific Ag and many other stimuli, including products derived from either pathogens or the host during innate immune responses. Althoug...

journal_title：European journal of immunology

authors： Galli SJ,Tsai M

更新日期：2010-07-01 00:00:00

abstract：:Viruses encode immune evasion mechanisms to survive in the immunocompetent host. Chemokines mediate the migration of immune cells and their critical role in immunity is emphasized by the numerous virus-encoded strategies to modulate their activity. Evidence published in this issue of the European Journal of Immunology...

journal_title：European journal of immunology

authors： Alcami A

更新日期：2007-04-01 00:00:00

abstract：:Using a model of 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity (CHS) we found that, as compared with wild-type mice, IL-15 receptor alpha chain (IL-15Ralpha)-deficient mice showed significantly less ear swelling. This decreased response was associated with diminished expression of CCL5/RANTES and CXCL10...

journal_title：European journal of immunology

authors： Chen JP,Liao NS,Lai SL,Hsu L,Mao WY,Ku MC,Liao F

更新日期：2005-03-01 00:00:00

abstract：:Based upon the success of using polyclonal, Epstein-Barr virus (EBV)-specific CTL lines for the prophylaxis and treatment of patients with post-transplant lymphoproliferative disease (PTLPD), there is now considerable incentive to develop CTL directed against the sub-dominant EBV antigens EBNA1, LMP1 and LMP2, which a...

journal_title：European journal of immunology

authors： Su Z,Peluso MV,Raffegerst SH,Schendel DJ,Roskrow MA

更新日期：2001-03-01 00:00:00

abstract：:Surviving an infection requires the generation of an immune response that controls the invading pathogen while limiting collateral damage to self tissues that may result from an exuberant immune response. Various populations of regulatory cells, including Foxp3+ Treg, have been shown to play a central role in the esta...

journal_title：European journal of immunology

authors： Belkaid Y

更新日期：2008-04-01 00:00:00

abstract：:The influence of muramyl dipeptide (N-acetylmuramyl-L-alanyl-D-isoglutamine) on the rejection of mouse skin allografts was investigated. While the 0.1-mg dose administered on days 7, 6, 5 prior to transplantation caused significant prolongation of the graft survival, the 0.5-mg dose administered on days 3, 2, 1 prior ...

journal_title：European journal of immunology

authors： Zídek Z,Capková J,Boubelík M,Masek K

更新日期：1983-10-01 00:00:00

abstract：:Mature T cells first appear in the thymus of the mouse a few days before birth, about 7-8 days after the thymus was colonized by stem cells. These mature cells are exported to the peripheral lymphoid organs beginning at about the time of birth, but because the number is very small at this stage, little is known about ...

journal_title：European journal of immunology

authors： Kelly KA,Scollay R

更新日期：1992-02-01 00:00:00

abstract：:Priming mice with a chicken gamma globulin (CGG) carrier protein significantly accelerated the onset of somatic mutation in the V chi Ox1 gene when the mice were subsequently immunized with 2-phenyl-5-oxazolone (phOx) coupled to CGG. The first mutations were already detected 7 days after immunization, while in the tru...

journal_title：European journal of immunology

authors： Källberg E,Gray D,Leanderson T

更新日期：1995-08-01 00:00:00

abstract：:Interferon-gamma inducing factor (IGIF) is a recently identified cytokine which stimulates the production of interferon-gamma (IFN-gamma) by T cells and enhances natural killer (NK) cell cytolytic activity. Protein fold recognition, structure prediction and comparative modeling have revealed that IGIF is a member of t...

journal_title：European journal of immunology

authors： Hunter CA,Timans J,Pisacane P,Menon S,Cai G,Walker W,Aste-Amezaga M,Chizzonite R,Bazan JF,Kastelein RA

更新日期：1997-11-01 00:00:00

abstract：:The cell surface molecule CD44, thought to be a cell surface receptor for hyaluronic acid, is expressed by thymocytes and peripheral T cells. Following T cell activation with mitogens or antigens, surface expression of CD44 increases. This increase in CD44 cell surface expression has been used as a means of identifyin...

journal_title：European journal of immunology

authors： Haegel H,Ceredig R

更新日期：1991-06-01 00:00:00

abstract：:Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the sec...

journal_title：European journal of immunology

authors： Müller N,Fischer JC,Yabal M,Haas T,Poeck H,Jost PJ

更新日期：2019-03-01 00:00:00

abstract：:Ligand binding to beta1-integrins exerts multiple effects on cells of the immune system including adhesion, spreading, haptotaxis and costimulation of T cells activated by anti-CD3. Here we show that a high-affinity ligand for beta1-integrins, the invasin (Inv) protein of Yersinia pseudotuberculosis, can induce cell d...

journal_title：European journal of immunology

authors： Arencibia I,Frankel G,Sundqvist KG

更新日期：2002-04-01 00:00:00

abstract：:The lymph node cells (LNC) activated in vivo by liver regeneration following partial hepatectomy of mice (primed lymph node cells) respond to regenerating liver cells in vitro with typical secondary immune response characteristics (Miyahara, S. et al., Eur. J. Immunol. 1983. 13: 878). These LNC activated in vivo suppr...

journal_title：European journal of immunology

authors： Yokomuro K,Miyahara S,Takahashi H,Kimura Y

更新日期：1983-11-01 00:00:00