CpG-enhanced CD8+ T-cell responses to peptide immunization are severely inhibited by B cells.

abstract：:The T cell receptor (TcR) on CD8+ T lymphocytes recognizes a complex which consists of a major histocompatibility complex (MHC) heavy chain, beta 2-microglobulin (beta 2M), and peptide on the surface of antigen-presenting cells. Mutational analyses have suggested that the TcR recognizes both the alpha 1 and alpha 2 do...

journal_title：European journal of immunology

authors： Hogquist KA,Grandea AG 3rd,Bevan MJ

更新日期：1993-11-01 00:00:00

abstract：:The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal, emergency hematopoiesis, and acute myeloid leukemia initiation and maintenan...

journal_title：European journal of immunology

authors： Jackson JT,O'Donnell K,Light A,Goh W,Huntington ND,Tarlinton DM,McCormack MP

更新日期：2020-07-01 00:00:00

abstract：:The desire to induce HIV-1-specific responses soon after birth to prevent breast milk transmission of HIV-1 led us to propose a vaccine regimen which primes HIV-1-specific T cells using a recombinant Mycobacterium bovis bacillus Calmette-Guérin (rBCG) vaccine. Because attenuated live bacterial vaccines are typically n...

journal_title：European journal of immunology

authors： Hopkins R,Bridgeman A,Bourne C,Mbewe-Mvula A,Sadoff JC,Both GW,Joseph J,Fulkerson J,Hanke T

更新日期：2011-12-01 00:00:00

abstract：:In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional cytokeleton. We show that CD82 signaling induces long-lasting adhesion, spreading and development of membrane extensions, involving actin polymerization. Addition of various co-stimuli (phorbol ...

journal_title：European journal of immunology

authors： Lagaudrière-Gesbert C,Lebel-Binay S,Hubeau C,Fradelizi D,Conjeaud H

更新日期：1998-12-01 00:00:00

abstract：:Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, ...

journal_title：European journal of immunology

authors： Ichikawa T,Negishi Y,Shimizu M,Takeshita T,Takahashi H

更新日期：2016-08-01 00:00:00

abstract：:The fate of the T cell receptor (TcR)/CD3 complex was examined on a cytotoxic T lymphocyte (CTL) clone (KB5.C20) activated either via binding of an anti-TcR monoclonal antibody (mAb) or by a Ca2+ ionophore and phorbol 12-myristate 13-acetate (PMA). After binding of the anti-TcR mAb, electron microscopy revealed intern...

journal_title：European journal of immunology

authors： Boyer C,Auphan N,Luton F,Malburet JM,Barad M,Bizozzero JP,Reggio H,Schmitt-Verhulst AM

更新日期：1991-07-01 00:00:00

abstract：:The inducible B cell lymphoma, CH12, and its in vitro adapted subclone, CH12-LBK, produce immunoglobulins of identical sequence, specificity and isotype, with equivalent affinities for the hapten trimethyl ammonium. However, the hemolytic efficiencies of the antibody secreted by the two cell lines are quite different....

journal_title：European journal of immunology

authors： Randall TD,King LB,Corley RB

更新日期：1990-09-01 00:00:00

abstract：:Intrathymic deletion of immature thymocytes that express self-reactive TCR specificities is essential in the generation of self tolerance. Medullary thymic epithelial cells (mTEC) expressing the transcriptional regulator Aire play a key role in this process by regulating expression of tissue-restricted antigens to ens...

journal_title：European journal of immunology

authors： White AJ,Withers DR,Parnell SM,Scott HS,Finke D,Lane PJ,Jenkinson EJ,Anderson G

更新日期：2008-04-01 00:00:00

abstract：:In vivo, T cells expressing low-affinity TCR predominate in primary, but not in secondary responses, a process referred to as T cell affinity maturation. Using CD4 dependence as a measure of the avidity of the interaction between the allospecific TCR and the alloantigen, we show that a similar process occurs in mixed ...

journal_title：European journal of immunology

authors： van Bergen J,Kooy Y,Koning F

更新日期：2001-02-01 00:00:00

abstract：:Human peripheral blood mononuclear leukocytes (PBL) cocultured with WISH human amnion cells rapidly produced alpha-type interferon (IFN-alpha) and in an IFN-dependent manner protected the WISH cells against the cytopathic effects caused by vesicular stomatitis virus. When the number of PBL per WISH cell monolayer cult...

journal_title：European journal of immunology

authors： Rönnblom L,Alm GV

更新日期：1982-05-01 00:00:00

abstract：:Activated human monocytes are a source of numerous beta-chemokines. The present study was conducted to determine whether these cells produce the human beta-chemokine I-309 and to compare the induction requirements of I-309 to those of other beta-chemokines. We demonstrate that appropriately stimulated adherence-purifi...

journal_title：European journal of immunology

authors： Selvan RS,Zhou LJ,Krangel MS

更新日期：1997-03-01 00:00:00

abstract：:Development of Th1 and Th2 effector lymphocytes is driven primarily by IL-12 or IL-4, but is also influenced by the strength of antigenic stimulation. However, the mechanism by which TCR signaling contributes to T cell polarization remains elusive. We show that in the presence of IL-12 a short TCR stimulation can lead...

journal_title：European journal of immunology

authors： Iezzi G,Scotet E,Scheidegger D,Lanzavecchia A

更新日期：1999-12-01 00:00:00

abstract：:The analysis of an Ia specificity was performed in several H-2 haplotypes by evaluating the affinity of the binding to mouse spleen cells of a monoclonal anti-Ia alloantibody. We used the monoclonal antibody 10-2.16 (Oi et al., Curr. Top. Microbiol. Immunol. 1978. 81: 115.) which recognizes on I-A gene products a publ...

journal_title：European journal of immunology

authors： Birnbaum D,Kourilsky FM

更新日期：1981-09-01 00:00:00

abstract：:NK cells are innate lymphocytes crucial for surveillance against pathogens and tumors. Although the basic mechanisms through which NK cells operate have been established, many questions are still unresolved. Are all NK cells equal or can we identify subsets with distinct developmental origin and function? How do NK ce...

journal_title：European journal of immunology

authors： Colonna M

更新日期：2008-11-01 00:00:00

abstract：:Physical exercise, mental stress, or infusion of beta-adrenergic agonists result in an increase in the number of natural killer (NK) cells in the peripheral circulation. In view of the specific migration pattern of NK cells in vivo, it has been suggested that these cells may be released from the marginating pool in bl...

journal_title：European journal of immunology

authors： Benschop RJ,Oostveen FG,Heijnen CJ,Ballieux RE

更新日期：1993-12-01 00:00:00

abstract：:In vitro prepared antigen-specific helper factors reactive to the synthetic polypeptide antigens poly-L(Tyr, Glu)-poly-DLAla--poly-LLys [(T, G)-A--L] or LGlu60-LAla30-LTyr10 (GAT) and bearing Ia determinants were analyzed serologically to determine the nature of the Ia determinants they expressed. I subregion-specific...

journal_title：European journal of immunology

authors： Howie S,Parish CR,David CS,McKenzie IF,Maurer PH,Feldmann M

更新日期：1979-07-01 00:00:00

abstract：:IL-18 was originally described as a cytokine which induced IFN-gamma production by established Th1 cells in an IL-12-independent manner. However, subsequent studies demonstrated that exogenous IL-18 in the absence of IL-12 failed to drive Th1 differentiation of naive cells and induced IFN-gamma from established Th1 ce...

journal_title：European journal of immunology

authors： Chang JT,Segal BM,Nakanishi K,Okamura H,Shevach EM

更新日期：2000-04-01 00:00:00

abstract：:The T cell receptor is a molecular complex compriSed of a clonally-restricted heterodimer (Ti) responsible for specific antigen recognition and a set of invariant CD3 peptides termed gamma, delta, epsilon, zeta and eta. The latter are believed to be involved in transmembrane signaling events given that monoclonal anti...

journal_title：European journal of immunology

authors： Transy C,Moingeon PE,Marshall B,Stebbins C,Reinherz EL

更新日期：1989-05-01 00:00:00

abstract：:The antigen receptor of the T lymphocytes is one of the most complex eukaryotic membrane structures studied to date. The T cell receptor (TcR) consists of two disulfide-linked glycoprotein chains (alpha/beta or gamma/delta) and is noncovalently associated with a group of small and invariable CD 3 proteins. Four CD 3 c...

journal_title：European journal of immunology

authors： Clevers H,Dunlap S,Terhorst C

更新日期：1988-05-01 00:00:00

abstract：:This study describes a general strategy to produce hybrid monoclonal antibodies that are capable of targeting human cytotoxic T lymphocytes (CTL) against any cell carrying the appropriate target antigen. This is done by fusing a HAT-sensitive, G418-resistant anti-T3 hybridoma with immune spleen cells (or with other hy...

journal_title：European journal of immunology

authors： Lanzavecchia A,Scheidegger D

更新日期：1987-01-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF-κB) signaling through both its adaptor and proteolytic function. Malt1 is also a target of its own protease activity and this self-cleavage further contributes to NF-κB activity. Until now, t...

journal_title：European journal of immunology

authors： Baens M,Stirparo R,Lampi Y,Verbeke D,Vandepoel R,Cools J,Marynen P,de Bock CE,Bornschein S

更新日期：2018-10-01 00:00:00

abstract：:The structure of immunological synapses formed between murine naive T cells and mature dendritic cells has been subjected to a quantitative analysis. Immunofluorescence images of synapses formed in the absence of antigen show a diffuse synaptic accumulation of CD3 and LFA-1. In electron microscopy, these antigen-free ...

journal_title：European journal of immunology

authors： Brossard C,Feuillet V,Schmitt A,Randriamampita C,Romao M,Raposo G,Trautmann A

更新日期：2005-06-01 00:00:00

abstract：:IL-33 is a novel cytokine of the IL-1 family and mediates its biological effect via the receptor ST2, which is selectively expressed on Th2 cells but not Th1 cells. IL-33 drives production of Th2-associated cytokines including IL-5 and IL-13 and thereby promotes defense and pathology in mucosal organs. Cell locomotion...

journal_title：European journal of immunology

authors： Komai-Koma M,Xu D,Li Y,McKenzie AN,McInnes IB,Liew FY

更新日期：2007-10-01 00:00:00

abstract：:Heat-stable antigen (HSA)/mouse CD24 (formerly termed Nectadrin) is a membrane glycoprotein with an unusual structure consisting of a small protein core and extensive glycosylation. It is expressed by hematopoietic cells but not by mature T lymphocytes. HSA on accessory cells is an important costimulatory molecule req...

journal_title：European journal of immunology

authors： Hubbe M,Altevogt P

更新日期：1994-03-01 00:00:00

abstract：:Dendritic cells (DC) are extremely proficient inducers of naïve CD4+ T cell activation due to their high expression level of peptide-MHC and an array of accessory molecules involved in cell migration, adhesion and co-signaling, including PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). Whether PD-L1 and PD-L2 have a s...

journal_title：European journal of immunology

authors： Kuipers H,Muskens F,Willart M,Hijdra D,van Assema FB,Coyle AJ,Hoogsteden HC,Lambrecht BN

更新日期：2006-09-01 00:00:00

abstract：:At the surface of the murine T lymphoma cell line RMA-S, the expression of "empty" class I molecules can be dramatically enhanced by culture at 26 degrees C. These class I molecules are unstable following transfer to 37 degrees C unless they are loaded with exogenously added peptides. Class I heterodimers that have fa...

journal_title：European journal of immunology

authors： Neefjes JJ,Smit L,Gehrmann M,Ploegh HL

更新日期：1992-06-01 00:00:00

abstract：:Elucidating the signaling events that promote T-cell tolerance versus activation provides important insights for manipulating immunity in vivo. Previous studies have suggested that the absence of PKCtheta results in the induction of anergy and that the balance between the induction of the transcription factors NFAT, A...

journal_title：European journal of immunology

authors： Deenick EK,Po L,Chapatte L,Murakami K,Lu YC,Elford AR,Saibil SD,Ruland J,Gerondakis S,Mak TW,Ohashi PS

更新日期：2010-03-01 00:00:00

abstract：:A considerable fraction of T cells express two distinct T cell receptors (TCR), mainly due to expression of two TCR alpha chains. It has been suggested that such dual-TCR cells could have a role in autoimmunity. However, as such cells express less of each TCR, they could be less sensitive to their physiological ligand...

journal_title：European journal of immunology

authors： Blichfeldt E,Munthe LA,Røtnes JS,Bogen B

更新日期：1996-12-01 00:00:00

abstract：:Majority of HIV-2-infected individuals meet the criteria of long-term non-progressors. This has been linked to superior qualitative HIV-2-specific cellular immune responses that correlate with viral control. However, it is unknown whether this is due to frequent targeting of immunodominant Gag epitopes in HIV-2 than H...

journal_title：European journal of immunology

authors： Ondondo BO,Rowland-Jones SL,Dorrell L,Peterson K,Cotten M,Whittle H,Jaye A

更新日期：2008-12-01 00:00:00

abstract：:Natural resistance to hemopoietic allograft results in functional elimination of the graft from the host within 24 to 48 h. The resistance is specific and is directed to the cell surface target structures of an unidentified nature. These determinants are controlled by the major histocompatibility complex-linked hemopo...

journal_title：European journal of immunology

authors： Shimamura K,Kaminsky SG,Nakamura I

更新日期：1989-07-01 00:00:00