Abstract:
:IL-33 is a novel cytokine of the IL-1 family and mediates its biological effect via the receptor ST2, which is selectively expressed on Th2 cells but not Th1 cells. IL-33 drives production of Th2-associated cytokines including IL-5 and IL-13 and thereby promotes defense and pathology in mucosal organs. Cell locomotion is crucial to the induction of an effective immune response. We report here the chemoattraction of Th2 cells by IL-33. Recombinant IL-33 increased the proportion of human Th2 cells, but not Th1 cells, in polarized morphology in vitro and stimulated their subsequent invasion into collagen gels in an IL-33 concentration-dependent manner. Injection of recombinant IL-33 into the footpad of ST2(-/-) mice which had been adoptively transferred with polarized Th2 cells, led to local accumulation of the transferred Th2 cells. These data therefore demonstrate that IL-33 is a selective Th2 chemoattractant associated with the pro-inflammatory property of this novel cytokine.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Komai-Koma M,Xu D,Li Y,McKenzie AN,McInnes IB,Liew FYdoi
10.1002/eji.200737547subject
Has Abstractpub_date
2007-10-01 00:00:00pages
2779-86issue
10eissn
0014-2980issn
1521-4141journal_volume
37pub_type
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