Targeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapy.

abstract：:Mercury-induced autoimmune glomerulonephritis in the Brown-Norway (BN) rat is characterized by the successive appearance of linear and granular glomerular IgG deposits. Anti-laminin autoantibodies represent the major part of the anti-glomerular basement membrane (GBM) antibodies produced in this model. Fusions were pe...

journal_title：European journal of immunology

authors： Guéry JC,Druet E,Glotz D,Hirsch F,Mandet C,De Heer E,Druet P

更新日期：1990-01-01 00:00:00

abstract：:Macrophages can be stimulated to produce a relatively large amount of nitric oxide, which is an important component in macrophage-mediated defense mechanisms and regulation of T cell activities. It has been known that T helper (Th) cell activation requires intimate physical interaction between T helper cells and macro...

journal_title：European journal of immunology

authors： Tian L,Noelle RJ,Lawrence DA

更新日期：1995-01-01 00:00:00

abstract：:A commonly held postulate regarding the etiology of rheumatoid arthritis (RA) is that of antigenic mimicry. Recent interest has focused on the mycobacterial 65-kDa heat-shock protein (hsp) as a putative causal agent. The 65-kDa hsp has over 40% sequence homology with the human hsp 60, and elevated synovial T cell resp...

journal_title：European journal of immunology

authors： Quayle AJ,Wilson KB,Li SG,Kjeldsen-Kragh J,Oftung F,Shinnick T,Sioud M,Førre O,Capra JD,Natvig JB

更新日期：1992-05-01 00:00:00

abstract：:Heat-stable antigen (HSA)/mouse CD24 (formerly termed Nectadrin) is a membrane glycoprotein with an unusual structure consisting of a small protein core and extensive glycosylation. It is expressed by hematopoietic cells but not by mature T lymphocytes. HSA on accessory cells is an important costimulatory molecule req...

journal_title：European journal of immunology

authors： Hubbe M,Altevogt P

更新日期：1994-03-01 00:00:00

abstract：:In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF-β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote the generation and maintenance of mucosal IgA-expressing plasma cells. Here, we demonst...

journal_title：European journal of immunology

authors： Beller A,Kruglov A,Durek P,von Goetze V,Werner K,Heinz GA,Ninnemann J,Lehmann K,Maier R,Hoffmann U,Riedel R,Heiking K,Zimmermann J,Siegmund B,Mashreghi MF,Radbruch A,Chang HD

更新日期：2020-06-01 00:00:00

abstract：:Similarities between the physical structures of avian and mammalian major histocompatibility complex (MHC) class I glycoproteins have been proposed based on comparative alignment of their amino acid sequences. To investigate the physical structure of the chicken class I glycoprotein, we cloned the cDNA representing th...

journal_title：European journal of immunology

authors： Fulton JE,Thacker EL,Bacon LD,Hunt HD

更新日期：1995-07-01 00:00:00

abstract：:One of the clear paradoxes in tumor immunology is the fact that cross-presentation of cell-associated tumor antigens to CD8(+) T cells is efficient, yet CTL generation is weak, and tumors continue to grow. We examined, for the first time whether this may be due to alterations in the phenotype or function of cross-pres...

journal_title：European journal of immunology

authors： McDonnell AM,Prosser AC,van Bruggen I,Robinson BW,Currie AJ

更新日期：2010-06-01 00:00:00

abstract：:An anti-T cell receptor (TcR) monoclonal antibody (mAb), LC4, directed against a human leukemic T cell line, SUP-T13, caused DNA fragmentation ("apoptosis") and cell death upon binding to this cell line. Cross-linking of receptor molecules was necessary for this effect since F(ab')2, but not Fab', fragments of LC4 cou...

journal_title：European journal of immunology

authors： Takahashi S,Maecker HT,Levy R

更新日期：1989-10-01 00:00:00

abstract：:The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expres...

journal_title：European journal of immunology

authors： Hong R,Lai N,Ouchida R,Xiong E,Zhou Y,Min Q,Liu J,Tang Y,Hikida M,Tsubata T,Wang Y,Wang JY

更新日期：2019-06-01 00:00:00

abstract：:We have investigated perforin and granzyme B expression in graft-infiltrating lymphocytes of patients who underwent heart transplantation. Those proteins are commonly present in the cytoplasmic granules of cytotoxic T lymphocytes and are released upon effector-target cell interaction. From 28 patients 103 endomyocardi...

journal_title：European journal of immunology

authors： Legros-Maïda S,Soulié A,Benvenuti C,Wargnier A,Vallée N,Berthou C,Guillet J,Sasportes M,Sigaux N

更新日期：1994-01-01 00:00:00

abstract：:The presentation of islet antigens in the pancreatic LNs (PLNs) of mice is a developmentally regulated process. It has been hypothesized that, during physiological tissue remodeling, a wave of neonatal β-cell apoptosis may initiate diabetes in autoimmune-prone strains of mice. If true, increasing or decreasing physiol...

journal_title：European journal of immunology

authors： Carrington EM,Kos C,Zhan Y,Krishnamurthy B,Allison J

更新日期：2011-08-01 00:00:00

abstract：:CSF1R (colony stimulating factor 1 receptor) is the main receptor for CSF1 and has crucial roles in regulating myelopoeisis. CSF1R can be proteolytically released from the cell surface by ADAM17 (A disintegrin and metalloprotease 17). Here, we identified CSF1R as a major substrate of ADAM17 in an unbiased degradomics ...

journal_title：European journal of immunology

authors： Qing X,Rogers L,Mortha A,Lavin Y,Redecha P,Issuree PD,Maretzky T,Merad M,McIlwain D,Mak TW,Overall CM,Blobel CP,Salmon JE

更新日期：2016-12-01 00:00:00

abstract：:Exosomes are nanovesicles produced constitutively and inducibly by several types of cells. They are generated as intraluminal vesicles of multivesicular bodies and express MHC and several endosomal/lysosomal proteins. In spite of their potential role in cellular immunity, the regulatory mechanisms of exosome productio...

journal_title：European journal of immunology

authors： Arita S,Baba E,Shibata Y,Niiro H,Shimoda S,Isobe T,Kusaba H,Nakano S,Harada M

更新日期：2008-05-01 00:00:00

abstract：:In rheumatoid arthritis (RA), T cells in the inflamed joint are considered to play a crucial role in the pathogenesis. However, despite the fact that synovial T cells have an activated memory phenotype, they are functionally suppressed upon combined CD3 and CD28 stimulation. Here, we analyzed the contribution of both ...

journal_title：European journal of immunology

authors： Maurice MM,van der Voort EA,Leow A,Levarht N,Breedveld FC,Verweij CL

更新日期：1998-05-01 00:00:00

abstract：:Inhibition of growth or eradication of experimentally induced tumors has been shown to be accompanied by infiltration of eosinophils and macrophages into the tumor mass. Since macrophages are important mediators of host antitumor activity, the possibility arises that a collaboration may exist between these two cell ty...

journal_title：European journal of immunology

authors： Spessotto P,Dri P,Bulla R,Zabucchi G,Patriarca P

更新日期：1995-05-01 00:00:00

abstract：:Membrane regulatory molecules normally prevent complement activation by autologous cells, therefore we compared the membrane control system of human lymphoid cell lines which activate or not human complement through the alternative pathway (AP). Membrane expression of decay-accelerating factor (DAF), membrane cofactor...

journal_title：European journal of immunology

authors： Caudwell V,Porteu F,Calender A,Pangburn MK,Halbwachs-Mecarelli L

更新日期：1990-12-01 00:00:00

abstract：:Our understanding of the biology of human natural killer (NK) cells has significantly advanced in recent years upon identification of a family of NK cell-expressed genes that encode killer cell inhibitory receptors (KIR). Individual KIR can selectively bind various HLA class I allotypes and consequently transduce inhi...

journal_title：European journal of immunology

authors： Campbell KS,Cella M,Carretero M,López-Botet M,Colonna M

更新日期：1998-02-01 00:00:00

abstract：:Natural killer (NK) cells play an important role in early defense against viral infection. The cytotoxic activity of NK cells is increased by interferon-alpha/beta (IFN-alpha/beta), produced en masse in virally infected cells. However, the mechanism(s) by which IFN-alpha/beta contribute to the NK-cell-mediated antivir...

journal_title：European journal of immunology

authors： Sato K,Hida S,Takayanagi H,Yokochi T,Kayagaki N,Takeda K,Yagita H,Okumura K,Tanaka N,Taniguchi T,Ogasawara K

更新日期：2001-11-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and II products are specialized to present antigens via different intracellular processing routes. Peptides originating from proteins in the cytoplasm can gain access to class I peptide-binding grooves, most likely in the rough endoplasmic reticulum. Peptides from protein...

journal_title：European journal of immunology

authors： Zaghouani H,Kuzu Y,Kuzu H,Brumeanu TD,Swiggard WJ,Steinman RM,Bona CA

更新日期：1993-11-01 00:00:00

abstract：:Fc gamma receptor I-positive (CD64+) and Fc gamma receptor I-negative (CD64-) monocytes were prepared from highly purified (elutriation-derived) human monocytes by cytofluorograph cell sorting, and a phenotypical and functional dissociation of the isolated CD64+ and CD64- monocyte subsets is demonstrated. Surface anal...

journal_title：European journal of immunology

authors： Grage-Griebenow E,Lorenzen D,Fetting R,Flad HD,Ernst M

更新日期：1993-12-01 00:00:00

abstract：:The active role of chemokines in the central nervous system (CNS) during the pathogenesis of experimental autoimmune encephalomyelitis (EAE) has been clearly established. In this study the expression pattern of several chemokines and cytokines was elucidated using reverse transcription-PCR and immunohistochemistry in ...

journal_title：European journal of immunology

authors： Nygårdas PT,Määttä JA,Hinkkanen AE

更新日期：2000-07-01 00:00:00

abstract：:In man, B cell maturation factors obtained from T cells or T cell lines have been shown to induce antibody formation in mitogen or anti-immunoglobulin activated B cells, and in some continuous B cell lines, but the relationships between these factors and B cell differentiation factors in antigen-specific antibody resp...

journal_title：European journal of immunology

authors： Callard RE,Booth RJ,Brown MH,McCaughan GW

更新日期：1985-01-01 00:00:00

abstract：:Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a familial hemophagocytic lymphohistio-cytosis, we wanted to clarify whether STX11 is functionally important for key immune cell populations. This was studied in primary cells obtain...

journal_title：European journal of immunology

authors： D'Orlando O,Zhao F,Kasper B,Orinska Z,Müller J,Hermans-Borgmeyer I,Griffiths GM,Zur Stadt U,Bulfone-Paus S

更新日期：2013-01-01 00:00:00

abstract：:TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce apoptosis in Kym-1 cells within 18 h. TWEAK-induced apoptosis is indirect and is mediated by the interaction of endogenous TNF and TNF receptor (TNFR)1, as each TNFR1-Fc, neutralizing TNF-specific ...

journal_title：European journal of immunology

authors： Schneider P,Schwenzer R,Haas E,Mühlenbeck F,Schubert G,Scheurich P,Tschopp J,Wajant H

更新日期：1999-06-01 00:00:00

abstract：:The CD4 T cell surface molecule binds MHC class II determinants expressed on antigen-presenting cells. CD4 is thought to enhance T cell activation by serving as an adhesion molecule as well as possibly by transducing an independent intracellular signal during the process of antigen stimulation. The recent observation ...

journal_title：European journal of immunology

authors： Veillette A,Sleckman BP,Ratnofsky S,Bolen JB,Burakoff SJ

更新日期：1990-06-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are innate effectors playing an important role in the defense against helminthic infections and in the pathogenesis of allergic inflammation. Cytokines have been identified as the major stimuli driving ILC2 activation and expansion. Conversely, it is unclear whether costimulatory ...

journal_title：European journal of immunology

authors： Paclik D,Stehle C,Lahmann A,Hutloff A,Romagnani C

更新日期：2015-10-01 00:00:00

abstract：:Cytokines are the main agents known to regulate Th1 / Th2 commitment, where they may operate through paracrine activity within clusters of T cells gathered around dendritic cells (DC). An in vitro system is used here to test this possibility, using clusters around DC composed of naive TCR-transgenic ovalbumin peptide ...

journal_title：European journal of immunology

authors： Schuhbauer DM,Mitchison NA,Mueller B

更新日期：2000-05-01 00:00:00

abstract：:The progression of experimental allergic encephalomyelitis (EAE) in certain mouse strains has been reported to involve a broadening of the response to myelin antigens, apparently resulting from priming to endogenous determinants of the myelin sheath. The phenomenon has been termed determinant spread. Interest in this ...

journal_title：European journal of immunology

authors： Takács K,Chandler P,Altmann DM

更新日期：1997-11-01 00:00:00

abstract：:From human precursor B cells which had both immunoglobulin (Ig) heavy (H) chain loci in germ-line configuration, various IgH chain germ-line transcripts were isolated and sequenced. These transcripts were shown to contain sequences derived from the JH region, the IgH chain enhancer element or the Ig switch region. A n...

journal_title：European journal of immunology

authors： Thompson A,Timmers E,Schuurman RK,Hendriks RW

更新日期：1995-01-01 00:00:00

abstract：:The death of individual cells is a frequent and physiological event in the mammalian immune system and most often occurs by apoptosis. It is becoming increasingly clear that cell death is also induced during bacterial infections. Here we report that, in addition to the apoptotic form already established, a necrosis-li...

journal_title：European journal of immunology

authors： Kirschnek S,Scheffel J,Heinzmann U,Häcker G

更新日期：2004-05-01 00:00:00