Abstract:
:The CD38 antigen displays restricted functional associations with surface molecules involved in immune system and complement. Capping of the CD38 molecule in normal or neoplastic T cells is followed by rapid and specific co-modulation of the CD3-T cell receptor (TcR) complex. In normal and tumor cells of B lineage, CD38 was found to be also associated with surface Ig (sIg) and with the complement receptor 2 (CR2)/CD19 complex. The CD38 molecule expressed by purified natural killer cells displayed an association with the low affinity IgG Fc receptor (Fc gamma RIII) CD16. These observations suggest that specialized areas in the plasma membrane contain co-modulating structures, including different receptors involved in the transduction of extracellular signals. We propose a model whereby TcR, CR2 and CD16 are ligand binding structures in their respective lineages, while CD38 is a molecule involved in the intracellular transduction of the signals.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Funaro A,De Monte LB,Dianzani U,Forni M,Malavasi Fdoi
10.1002/eji.1830231005subject
Has Abstractpub_date
1993-10-01 00:00:00pages
2407-11issue
10eissn
0014-2980issn
1521-4141journal_volume
23pub_type
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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更新日期:1984-02-01 00:00:00
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journal_title:European journal of immunology
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更新日期:1995-03-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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更新日期:1990-01-01 00:00:00
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