Regulation of thymocyte proliferative response by macrophage-derived prostaglandin E2 and interleukin 1.

abstract：:To elucidate the rapid destruction of allogeneic bone marrow (BM) grafts in nonsensitized rats we have assessed: (a) the 21-h tissue localization of 51Cr-labeled allogeneic vs. syngeneic BM cells, (b) the ability of allogeneic BM cells to proliferate in the BM or irradiated recipients, (c) the survival of allogeneic v...

journal_title：European journal of immunology

authors： Rolstad B,Benestad HB

更新日期：1984-09-01 00:00:00

abstract：:Beta1 integrins can provide T cell co-stimulation, but little is known concerning their downstream signaling pathways. We found that Pyk2, a focal adhesion kinase-related tyrosine kinase, is regulated by beta1 integrin signaling in human T cells. Stimulation of Jurkat T cells with the alpha4beta1 integrin ligand VCAM-...

journal_title：European journal of immunology

authors： van Seventer GA,Mullen MM,van Seventer JM

更新日期：1998-11-01 00:00:00

abstract：:The mechanism of synergistic complement-mediated lysis of rat red cells was investigated using rat monoclonal antibodies against class I RT1Aa antigens. The increased lytic activity when using two antibodies simultaneously is due to the increase in the number of activated C1 molecules on the cell surface and this resu...

journal_title：European journal of immunology

authors： Hughes-Jones NC,Gorick BD,Howard JC

更新日期：1983-08-01 00:00:00

abstract：:Human adherent monocytes were incubated with interferon (IFN) preparations, then washed and stimulated with endotoxins. The interleukin (IL1) activity in the supernatants of IFN-treated monocyte cultures was found to be increased as compared to control (not pretreated) cultures. This phenomenon was observed whether al...

journal_title：European journal of immunology

authors： Arenzana-Seisdedos F,Virelizier JL

更新日期：1983-06-01 00:00:00

abstract：:The cytotoxic response of cell sorter-purified small Lyt-2+ splenic cytotoxic lymphocyte precursors from 10 individual C57BL/6 mice to mutant class I H-2Kbm1 or H-2Dbm14 allodeterminants was analyzed under limiting dilution conditions. The cytotoxic activity of anti-bm1-specific or anti-bm14-specific cytotoxic T lymph...

journal_title：European journal of immunology

authors： Reimann J,Bellan A

更新日期：1986-12-01 00:00:00

abstract：:The F1 progeny of autoimmune NZB and normal SWR mice uniformly develop severe and accelerated lupus nephritis. The (SWR x NZB)F1 mice produce an oligoclonally expanded population of nephritogenic anti-DNA autoantibodies that share a recurrent cross-reactive idiotype (Id564), use highly homologous VH genes and surprisi...

journal_title：European journal of immunology

authors： O'Keefe TL,Datta SK,Imanishi-Kari T

更新日期：1992-03-01 00:00:00

abstract：:Although the role of interleukin 2 (IL 2) in mature T lymphocyte function is well documented, its effect on hematopoietic progenitor cells is less well characterized. Here we have used recombinant retroviruses to transduce and express a cDNA clone encoding the p55 component of the human IL 2 receptor (h-p55), in a mur...

journal_title：European journal of immunology

authors： Collins MK,Malde P,Miyajima A,Arai K,Smith KA,Mulligan RC

更新日期：1990-03-01 00:00:00

abstract：:We have previously reported that a subset of T cells in T cell receptor (TCR)-transgenic mice may express two different alpha chains on their surface. The expression of two functional alpha chains has also been demonstrated for human peripheral blood T cells. In this report, we show that a proportion of normal murine ...

journal_title：European journal of immunology

authors： Heath WR,Carbone FR,Bertolino P,Kelly J,Cose S,Miller JF

更新日期：1995-06-01 00:00:00

abstract：:The scavenger receptor-A I/II (SR-A) and macrophage receptor with collagenous domain (MARCO) share a common domain organisation and ligand repertoire, including selected polyanions and gram-positive and -negative organisms, but differ in fine specificity of ligand binding, tissue distribution and regulation. Neisseria...

journal_title：European journal of immunology

authors： Mukhopadhyay S,Chen Y,Sankala M,Peiser L,Pikkarainen T,Kraal G,Tryggvason K,Gordon S

更新日期：2006-04-01 00:00:00

abstract：:Antimicrobial peptides human beta-defensins (hBD) are mainly produced by epithelia of several organs including skin, and participate in innate immunity by killing invading pathogens. Besides their microbicidal activities, hBD activate several inflammatory and immune cells. Since hBD are generated by tissues where mast...

journal_title：European journal of immunology

authors： Chen X,Niyonsaba F,Ushio H,Hara M,Yokoi H,Matsumoto K,Saito H,Nagaoka I,Ikeda S,Okumura K,Ogawa H

更新日期：2007-02-01 00:00:00

abstract：:Lymphocyte infiltration to pancreatic islets is associated to chemoattraction, as are other inflammatory autoimmune processes. We examined whether development of insulitis and diabetes depends on chemoattraction of lymphocytes via the CCR5 chemokine receptor. In non-obese diabetic (NOD) mice, a substantial fraction of...

journal_title：European journal of immunology

authors： Carvalho-Pinto C,García MI,Gómez L,Ballesteros A,Zaballos A,Flores JM,Mellado M,Rodríguez-Frade JM,Balomenos D,Martínez-A C

更新日期：2004-02-01 00:00:00

abstract：:Mast cells are widely distributed in tissues, particularly near surfaces exposed to the environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE and specific Ag and many other stimuli, including products derived from either pathogens or the host during innate immune responses. Althoug...

journal_title：European journal of immunology

authors： Galli SJ,Tsai M

更新日期：2010-07-01 00:00:00

abstract：:Activation of naive T cells is tightly controlled and depends on cognate interactions with professional antigen-presenting cells. We analyzed dependency on secondary lymphoid tissues for the activation of naive and memory CD4(+) and CD8(+) T cells following primary and secondary Listeria monocytogenes infection, respe...

journal_title：European journal of immunology

authors： Kursar M,Jänner N,Pfeffer K,Brinkmann V,Kaufmann SH,Mittrücker HW

更新日期：2008-01-01 00:00:00

abstract：:Bispecific antibodies binding to the TCR/CD3 complex and to a tumor-associated surface molecule can be used to target cytotoxic T lymphocytes against tumor cells. We reasoned that high-affinity binding to CD3 may reduce the efficiency of T cell stimulation and target the bispecific reagent to T cells rather than to tu...

journal_title：European journal of immunology

authors： Bortoletto N,Scotet E,Myamoto Y,D'Oro U,Lanzavecchia A

更新日期：2002-11-01 00:00:00

abstract：:High-dose infusion of IgG (IVIG) is used to treat autoimmune and inflammatory diseases, including Kawasaki disease (KD). Although the immunomodulatory effects of IVIG on blood cells such as macrophages have been well studied, its effects on tissue cells remain unclear. Here, we show that high-dose IgG specifically and...

journal_title：European journal of immunology

authors： Matsuda A,Morita H,Unno H,Saito H,Matsumoto K,Hirao Y,Munechika K,Abe J

更新日期：2012-08-01 00:00:00

abstract：:The role of the invariant chain (Ii), an MHC class II-associated chaperone, in B cell development is controversial. Ii deficient mice (Ii(-/-) mice) show a defect in B cell development. This defect has been attributed to the absence of a fragment liberated from the Ii by intramembranous proteolysis. It was proposed th...

journal_title：European journal of immunology

authors： Maehr R,Kraus M,Ploegh HL

更新日期：2004-08-01 00:00:00

abstract：:Under physiological conditions, activation of CD4+ T cells by major histocompatibility complex (MHC)antigen complexes requires engagement of both the T cell receptor and the CD4 molecule. However, CD4 ligands binding to the CD4 molecule has also been shown to inhibit T cell proliferation and interleukin (IL)-2 product...

journal_title：European journal of immunology

authors： Jabado N,Pallier A,Jauliac S,Fischer A,Hivroz C

更新日期：1997-02-01 00:00:00

abstract：:Polyclonal differentiation of unprimed B cells into IgM-producing cells induced by lipopolysaccharide (LPS) or T cell-derived lymphokine B151-TRF2 has been shown to contain a process of I-A-restricted B-B cell interaction, so that the B cell responses are inhibited by monoclonal antibodies (mAb) specific for I-A molec...

journal_title：European journal of immunology

authors： Takahama Y,Ono S,Ishihara K,Muramatsu M,Hamaoka T

更新日期：1989-12-01 00:00:00

abstract：:Previously, we have shown that the intravenous (i.v.) injection of allogeneic lymphocytes across an H-2 class I-mutant disparity leads to specific skin allograft tolerance caused by irradiation-sensitive donor T cells, which function as veto cells. In the present study, we show that the i.v. injection of H-2 class II-...

journal_title：European journal of immunology

authors： van Twuyver E,Kast WM,Mooijaart RJ,Melief CJ,De Waal LP

更新日期：1990-02-01 00:00:00

abstract：:Plasma cells secreting IgG, M, and A abound in the synovium of patients with rheumatoid arthritis, yet their immunoglobulin repertoire and clonal relationship remain to be elucidated. Locally synthesized immunoglobulins probably contribute to the chronic joint inflammatory processes which are characteristic of these p...

journal_title：European journal of immunology

authors： Williams DG,Taylor PC

更新日期：1997-02-01 00:00:00

abstract：:Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might...

journal_title：European journal of immunology

authors： Zurn AD,Fulpius BW

更新日期：1977-08-01 00:00:00

abstract：:In this study, we investigated whether the phenotype-related differentiation of human 2H4+ (CD45R) naive cells to 2H4- (CDw29) memory CD4 cells corresponded to modulation of interleukin (IL) 2, IL 4, interferon (IFN)-gamma and granulocyte-monocyte colony-stimulating factor (GM-CSF) gene expression, a phenomenon which ...

journal_title：European journal of immunology

authors： Bettens F,Walker C,Gauchat JF,Gauchat D,Wyss T,Pichler WJ

更新日期：1989-09-01 00:00:00

abstract：:Fourteen noncytotoxic human helper T cell clones were examined for autocrine proliferative responses and cytotoxicity to tumor cells after stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and ionomycin (Io). Although all clones responded to alloantigen, they could be divided into two groups based on their p...

journal_title：European journal of immunology

authors： Pawelec G,Busch F,Reinhold U,Rehbein A,Balko I,Bühring HJ

更新日期：1988-07-01 00:00:00

abstract：:C57BL/10ScCr (Cr) mice carry a deletion of the Toll-like receptor 4 (tlr4) gene (i.e. they are tlr4(0/0)) and are thus refractory to LPS effects. Insertion of wild-type tlr4 transgene into the tlr4(0/0) Cr germ line endowed LPS susceptibility in the two transgenic lines created, indicating that TLR4 is the only limiti...

journal_title：European journal of immunology

authors： Kalis C,Kanzler B,Lembo A,Poltorak A,Galanos C,Freudenberg MA

更新日期：2003-03-01 00:00:00

abstract：:The progression of experimental allergic encephalomyelitis (EAE) in certain mouse strains has been reported to involve a broadening of the response to myelin antigens, apparently resulting from priming to endogenous determinants of the myelin sheath. The phenomenon has been termed determinant spread. Interest in this ...

journal_title：European journal of immunology

authors： Takács K,Chandler P,Altmann DM

更新日期：1997-11-01 00:00:00

abstract：:We have analyzed the relationship between the signaling pathways coupled to surface immunoglobulin and interleukin (IL)-4 receptors in human B cells from the patterns of expression of a panel of phorbol ester-inducible early response genes (ERG) activated by anti-IgM and IL-4 stimulation in vitro. Anti-IgM stimulation...

journal_title：European journal of immunology

authors： Murphy JJ,Norton JD

更新日期：1993-11-01 00:00:00

abstract：:Dendritic cells expanded from mouse bone marrow (BMDC) with granulocyte/macrophage-colony-stimulating factor have potent T cell-stimulatory properties both in vitro and in vivo. This has been well documented for major histocompatibility complex (MHC) class II-restricted responses, and more recently using peptide-loade...

journal_title：European journal of immunology

authors： Norbury CC,Chambers BJ,Prescott AR,Ljunggren HG,Watts C

更新日期：1997-01-01 00:00:00

abstract：:Mutations in PTEN-induced kinase 1 (PINK1), a serine/threonine kinase linked to familial early-onset Parkinsonism, compromise mitochondrial integrity and metabolism and impair AKT signaling. As the activation of a naïve T cell requires an AKT-dependent reorganization of a cell's metabolic machinery, we sought to deter...

journal_title：European journal of immunology

authors： Ellis GI,Zhi L,Akundi R,Büeler H,Marti F

更新日期：2013-12-01 00:00:00

abstract：:The effect of Trypanosoma brucei infections on parasite-specific antibody responses was examined by immunization of infected mice with radio-attenuated trypanosomes of a noncross-reacting clone. Antibody titers (total Ig) against variant surface antigen were determined by indirect immunofluorescence. The suppression r...

journal_title：European journal of immunology

authors： Sacks DL,Askonas BA

更新日期：1980-12-01 00:00:00

abstract：:The potential of synthetic peptides as vaccines is restricted by their frequent lack of immunogenicity. As with haptens, coupling to a carrier protein is usually required to provide T cell help to anti-peptide antibody-producing B cells. In spite of their short length, a few natural or synthetic peptides are immunogen...

journal_title：European journal of immunology

authors： Borras-Cuesta F,Petit-Camurdan A,Fedon Y

更新日期：1987-08-01 00:00:00