The "natural resistance" to bone marrow allografts in normal and athymic nude rats. Rapid cytotoxic reactions both in vivo and in vitro.

abstract：:The responses of resting human B lymphocytes to a variety of activation signals were studied. Human tonsillar B lymphocytes were separated according to size by countercurrent elutriation. The small B lymphocytes were then stimulated in vitro with various concentrations of anti-mu antibody in the presence or absence of...

journal_title：European journal of immunology

authors： Kehrl JH,Muraguchi A,Fauci AS

更新日期：1984-02-01 00:00:00

abstract：:The thymus is a primary lymphoid organ supporting the development of self-tolerant T cells. Key events in T-cell development in the thymus include lineage commitment, selection events, and thymic emigration. This review discusses the proposed role of sphingosine-1-phosphate and its receptors in the emigration of both ...

journal_title：European journal of immunology

authors： Drennan MB,Elewaut D,Hogquist KA

更新日期：2009-04-01 00:00:00

abstract：:To study allelic exclusion of TcR genes we analyzed two types (I and II) of TcR beta transgenic mice. T cells derived from both types of mice contained similar amounts of transgenic RNA transcripts; however, surface expression of the transgenic beta chain was drastically reduced in type II compared to type I. In type ...

journal_title：European journal of immunology

authors： Pircher H,Ohashi P,Miescher G,Lang R,Zikopoulos A,Bürki K,Mak TW,MacDonald HR,Hengartner H

更新日期：1990-02-01 00:00:00

abstract：:Pairs of monoclonal antibodies (mAb) defining epitopes T 11.1 and T 11.2 on the CD 2 molecule are mitogenic for purified human T cells in the presence of a submitogenic dose of 12-O-tetradecanoylphorbol 13-acetate (TPA). Anti-CD 28 mAb can substitute for the action of TPA in the anti-CD 2-induced proliferative respons...

journal_title：European journal of immunology

authors： Pierrès A,Lopez M,Cerdan C,Nunes J,Olive D,Mawas C

更新日期：1988-05-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is characterized by a dysregulated intestinal immune response with elevated levels of the Th1 cytokines TNF, IL-12 and IFN-gamma. The luminal flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic intestinal inflammation by as yet unknown...

journal_title：European journal of immunology

authors： Obermeier F,Dunger N,Deml L,Herfarth H,Schölmerich J,Falk W

更新日期：2002-07-01 00:00:00

abstract：:Site-directed mutagenesis of a recombinant Fc hinge fragment has recently been used to localize the site of the mouse IgG1 (mIgG1) molecule that is involved in the intestinal transfer of recombinant Fc hinge fragments in neonatal mice. This site encompasses Ile-253, His-310, Gln-311, His-433 and Asn-434, localized at ...

journal_title：European journal of immunology

authors： Medesan C,Radu C,Kim JK,Ghetie V,Ward ES

更新日期：1996-10-01 00:00:00

abstract：:Incorporation of an 11 amino acid region of the HIV TAT protein transduction domain (TAT PTD) into proteins facilitates rapid, efficient entry into cells. We previously showed that rTAT-PTD-OVA-transduced dendritic cells (DC) stimulated antigen (Ag)-specific CTL and Th cells, and vaccinated against OVA-expressing tumo...

journal_title：European journal of immunology

authors： Shibagaki N,Udey MC

更新日期：2003-04-01 00:00:00

abstract：:Activation of mature CD8+ T cells requires recognition, via the T cell receptor (TCR), of peptide + MHC (pMHC) complexes with an avidity that exceeds a designated threshold. Multiple indicators of T cell avidity have been described that provide unique information on the characteristics of T cell interactions. However,...

journal_title：European journal of immunology

authors： La Gruta NL,Doherty PC,Turner SJ

更新日期：2006-11-01 00:00:00

abstract：:In mice infected with the non-lethal malaria parasite Plasmodium chabaudi chabaudi AS, a prominent switch from a Th1 to a Th2 type of response occurs in CD4+ T cells at the time of peak parasitemia or shortly thereafter (9-15 days after infection). This is accompanied by a major increase in IL-4, and a similar decreas...

journal_title：European journal of immunology

authors： Poorafshar M,Helmby H,Troye-Blomberg M,Hellman L

更新日期：2000-09-01 00:00:00

abstract：:F protein is found predominantly in the liver and is of unknown function. The protein has been of interest to immunologists in the areas of self tolerance and the immunogenetics of the anti-F protein response. In the mouse there are two alleles (F1 and F2), and although mice are completely tolerant to the self form of...

journal_title：European journal of immunology

authors： Schofield JP,Vijayakumar RK,Oliveira DB

更新日期：1991-05-01 00:00:00

abstract：:Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that diff...

journal_title：European journal of immunology

authors： Redpath SA,Heieis GA,Reynolds LA,Fonseca NM,Kim SS,Perona-Wright G

更新日期：2018-01-01 00:00:00

abstract：:We have previously identified a molecule on the T cell surface, which, in addition to CD2 is involved in the rosette phenomenon. This is a 32-kDa single polypeptide chain which we have termed E2. The studies reported here show striking patterns on the glycosylation status of E2. It is a heavily sialylated and glycosyl...

journal_title：European journal of immunology

authors： Aubrit F,Gelin C,Pham D,Raynal B,Bernard A

更新日期：1989-08-01 00:00:00

abstract：:Human T cell clones expressing the T cell receptor (TcR) gamma/delta were isolated from peripheral blood lymphocytes of two unrelated donors. The TcR gamma/delta+ clones derived from one of these donors were all of the Ti gamma A+, delta-TCS1-, BB3+ phenotype indicating the exclusive use of the V gamma 9 and V delta 3...

journal_title：European journal of immunology

authors： Koning F,Knot M,Wassenaar F,Van den Elsen P

更新日期：1989-11-01 00:00:00

abstract：:Cyclosporin A (CSA), an immunosuppressive agent used in organ transplantation and to treat some autoimmune diseases, blocks the Ca2+-dependent steps involved in T cell receptor triggering leading to interleukin (IL)-2 production. Considering that the early steps of T cell activation are insensitive to CSA, we asked wh...

journal_title：European journal of immunology

authors： Bemer V,Truffa-Bachi P

更新日期：1996-07-01 00:00:00

abstract：:A rapidly-growing, HAT-sensitive cell line LICR-LON-HMy2 has been derived from the ARH-77 human plasma cell leukemia-derived line. It lacks the enzyme hypoxanthine phosphoribosyltransferase (EC 2.4.2.8). Hybrids have been reproducibly made for more than a year and in independent laboratories with lymphocytes from tons...

journal_title：European journal of immunology

authors： Edwards PA,Smith CM,Neville AM,O'Hare MJ

更新日期：1982-08-01 00:00:00

abstract：:APO-1/Fas (CD95) is a transmembrane receptor that transduces apoptotic signals within various cells including T and B cells. The APO-1 gene was found to be defective in lpr mice. In these mice insertion of a retrotransposon gives rise to transcription of an abnormal mRNA and only a fraction of wild-type APO-1 mRNA. It...

journal_title：European journal of immunology

authors： Mariani SM,Matiba B,Armandola EA,Krammer PH

更新日期：1994-12-01 00:00:00

abstract：:We have identified a novel subset of early B lineage cells in the mouse bone marrow (BM) by GL7 expression on cell surface. GL7(+)B220(low) BM cells have a large cell size and are CD43(-to low), CD95(-), Sca-1(-), I-A(low), IgM(-) and IgD(-), suggesting that they are large pre-B cells. These BM cells express lambda5 a...

journal_title：European journal of immunology

authors： Murasawa M,Okada S,Obata S,Hatano M,Moriya H,Tokuhisa T

更新日期：2002-01-01 00:00:00

abstract：:The present report describes functional characteristics of a monoclonal antibody (mAb), TA/211, which is reactive with a common determinant of the human CD45 molecules. When added to purified testing human T cells, TA/211, which is itself not mitogenic, leads to a strong proliferative response in combination with subm...

journal_title：European journal of immunology

authors： Schraven B,Roux M,Hutmacher B,Meuer SC

更新日期：1989-02-01 00:00:00

abstract：:Ligation of interleukin 2 (IL2) is known to regulate both protein tyrosine and serine/threonine phosphorylation. A family of leukocyte transmembrane proteins whose cytoplasmic domain exhibits intrinsic protein tyrosine phosphatase activity is collectively called CD45 and is identified by a set of common cell surface e...

journal_title：European journal of immunology

authors： Valentine MA,Widmer MB,Ledbetter JA,Pinault F,Voice R,Clark EA,Gallis B,Brautigan DL

更新日期：1991-04-01 00:00:00

abstract：:Stimulation of mixed lymphocyte cultures with ultraviolet (UV)-irradiated stimulator cells leads to selective activation of Lyt-2+ cytotoxic T lymphocyte precursors (CTL-P) to acquire interleukin 2 (IL2) reactivity: (a) no proliferative response, nor IL2 production was observed in these cultures; (b) upon addition of ...

journal_title：European journal of immunology

authors： Gullberg M,Larsson EL

更新日期：1982-12-01 00:00:00

abstract：:Age-associated thymic involution results in a diminished capacity to regenerate T cell populations, although the magnitude of this effect is unknown. In this report, thymic function was studied in aged vs. young adult mice after lethal irradiation and administration of T cell-depleted bone marrow (BM) from young mice....

journal_title：European journal of immunology

authors： Mackall CL,Punt JA,Morgan P,Farr AG,Gress RE

更新日期：1998-06-01 00:00:00

abstract：:CD4+ helper T lymphocytes and CD8+ killer T lymphocytes are both generated in the thymus from common precursor cells expressing CD4 and CD8. The development of immature CD4 CD8+ thymocytes into mature 'single-positive' T cells requires T cell antigen-receptor (TCR)-mediated positive selection signals. Although it is k...

journal_title：European journal of immunology

authors： Takahama Y,Tokoro Y,Sugawara T,Negishi I,Nakauchi H

更新日期：1997-12-01 00:00:00

abstract：:The physical association of CD5 and the T cell antigen receptor (TcR)/CD3 complex on the surface of intact human lymphocytes was investigated using co-capping experiments and fluorescence resonance energy transfer (FRET) analyses. Antibody-induced capping of CD5 or CD3 and double indirect immunofluorescence labeling r...

journal_title：European journal of immunology

authors： Osman N,Lazarovits AI,Crumpton MJ

更新日期：1993-05-01 00:00:00

abstract：:Changes in endothelial permeability are crucial in the pathogenesis of many diseases. Adenosine is one of the endogenous mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN-beta is a nove...

journal_title：European journal of immunology

authors： Kiss J,Yegutkin GG,Koskinen K,Savunen T,Jalkanen S,Salmi M

更新日期：2007-12-01 00:00:00

abstract：:A large panel of T cell clones (TCC) specific for the recombinant form of Poa pratensis allergen (rKBG7.2 or Poa p9) were established from the peripheral blood of grass pollen-sensitive donor in the absence or presence of recombinant interferon-alpha (IFN-alpha) in bulk culture and their pattern of cytokine secretion,...

journal_title：European journal of immunology

authors： Parronchi P,Mohapatra S,Sampognaro S,Giannarini L,Wahn U,Chong P,Mohapatra S,Maggi E,Renz H,Romagnani S

更新日期：1996-03-01 00:00:00

abstract：:Tissue factor (TF) is a transmembrane glycoprotein that plays an essential role in hemostasis by activating coagulation. TF is also expressed by monocytes/macrophages as part of the innate immune response to infections. In the current study, we determined the role of TF expressed by myeloid cells during Mycobacterium ...

journal_title：European journal of immunology

authors： Venkatasubramanian S,Tripathi D,Tucker T,Paidipally P,Cheekatla S,Welch E,Raghunath A,Jeffers A,Tvinnereim AR,Schechter ME,Andrade BB,Mackman N,Idell S,Vankayalapati R

更新日期：2016-02-01 00:00:00

abstract：:Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils. ...

journal_title：European journal of immunology

authors： Samadi N,Polak D,Kitzmüller C,Steinberger P,Zlabinger GJ,Jahn-Schmid B,Bohle B

更新日期：2019-09-01 00:00:00

abstract：:Cytokine-induced memory-like (CIML) NK cells are endowed with the capacity to mediate enhanced effector functions upon cytokine or activating receptor restimulation for several weeks following short-term preactivation with IL-12, IL-15, and IL-18. Promising results from a first-in-human clinical trial highlighted the ...

journal_title：European journal of immunology

authors： Ghofrani J,Lucar O,Dugan H,Reeves RK,Jost S

更新日期：2019-08-01 00:00:00

abstract：:Normal human peripheral blood lymphocytes were shown to activate complement in normal human serum (NHS). This activation led to C3 fixation on the cell membrane, which in turn was visualized by fluorescence. The reaction occurred in the absence of detectable amounts of antibodies, since an agammaglobulinemic patient's...

journal_title：European journal of immunology

authors： Gutiérrez C,Vega J,Kreisler M

更新日期：1979-01-01 00:00:00

abstract：:Gene targeting in hybridoma cells provides a tool for generating chimeric antibodies with great ease and at high yield. We present an evaluation of integration vectors for the chimerization of the immunoglobulin heavy chain locus which are universally applicable to hybridomas of different isotypes and mouse strains. T...

journal_title：European journal of immunology

authors： Kardinal C,Hooijberg E,Lang P,Zeidler R,Mocikat R

更新日期：1995-03-01 00:00:00