GL7 defines the cycling stage of pre-B cells in murine bone marrow.

Abstract:

:We have identified a novel subset of early B lineage cells in the mouse bone marrow (BM) by GL7 expression on cell surface. GL7(+)B220(low) BM cells have a large cell size and are CD43(-to low), CD95(-), Sca-1(-), I-A(low), IgM(-) and IgD(-), suggesting that they are large pre-B cells. These BM cells express lambda5 and VpreB but not terminal deoxytransferase (TdT) and Bcl-2, and approximately 50 % of them are in cell cycle. This fraction was not detected in BM cells of Rag-1-deficient and Scid mice, supporting that GL7(+)B220(low) BM cells belong to fraction C' and D according to Hardy's criteria or to an early large pre-B-II fraction according to Melchers-Rolink's criteria. Furthermore, GL7(+)B220(low) BM cells can differentiate into IgM(+) immature B cells in co-culture with stromal cells. These results suggest that B lymphocytes pass through the GL7(+) pre-B cell stage during differentiation in the BM. Thus, GL7 is the critical marker to define the proliferation stage of large pre-B cells.

journal_name

Eur J Immunol

authors

Murasawa M,Okada S,Obata S,Hatano M,Moriya H,Tokuhisa T

doi

10.1002/1521-4141(200201)32:1<291::AID-IMMU291>3.0

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

291-8

issue

1

eissn

0014-2980

issn

1521-4141

journal_volume

32

pub_type

杂志文章
  • Immunosuppression by cell-free translation products from monoclonal antigen-specific suppressor T cell mRNA.

    abstract::Polypeptides synthesized in a rabbit reticulocyte lysate system directed by mRNA from the T cell line LH8-105, obtained by radiation leukemia virus-induced transformation of hen egg-white lysozyme (HEL)-specific suppressor T lymphocytes, are able, when injected into mice, to specifically suppress the antibody response...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830150409

    authors: Ricciardi-Castagnoli P,Robbiati F,Barbanti E,Colizzi V,Pini C,De Santis R,Doria G,Adorini L

    更新日期:1985-04-01 00:00:00

  • Functional analysis of avian class I (BFIV) glycoproteins by epitope tagging and mutagenesis in vitro.

    abstract::Similarities between the physical structures of avian and mammalian major histocompatibility complex (MHC) class I glycoproteins have been proposed based on comparative alignment of their amino acid sequences. To investigate the physical structure of the chicken class I glycoprotein, we cloned the cDNA representing th...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830250740

    authors: Fulton JE,Thacker EL,Bacon LD,Hunt HD

    更新日期:1995-07-01 00:00:00

  • Complement alternative pathway activation and control on membranes of human lymphoid B cell lines.

    abstract::Membrane regulatory molecules normally prevent complement activation by autologous cells, therefore we compared the membrane control system of human lymphoid cell lines which activate or not human complement through the alternative pathway (AP). Membrane expression of decay-accelerating factor (DAF), membrane cofactor...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830201218

    authors: Caudwell V,Porteu F,Calender A,Pangburn MK,Halbwachs-Mecarelli L

    更新日期:1990-12-01 00:00:00

  • The effect of carrier and carrier priming on the kinetics and pattern of somatic mutation in the V chi Ox1 gene.

    abstract::Priming mice with a chicken gamma globulin (CGG) carrier protein significantly accelerated the onset of somatic mutation in the V chi Ox1 gene when the mice were subsequently immunized with 2-phenyl-5-oxazolone (phOx) coupled to CGG. The first mutations were already detected 7 days after immunization, while in the tru...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830250834

    authors: Källberg E,Gray D,Leanderson T

    更新日期:1995-08-01 00:00:00

  • Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiation.

    abstract::Delivery of foreign antigens to mucosal surfaces, such as the pulmonary airways, has been shown to preferentially induce Th2-mediated responses in humans and in mice. What is not clear from these studies is whether this preferential skewing in responses is the result of the limited types of antigen being administered ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/1521-4141(200003)30:3<840::AID-IMMU840>3.0

    authors: Constant SL,Lee KS,Bottomly K

    更新日期:2000-03-01 00:00:00

  • Processing requirements for T cell activation by Mycoplasma arthritidis-derived mitogen.

    abstract::Mycoplasma arthritidis produces in culture a polyclonal mitogen which is active for murine and human T lymphocytes in the presence of accessory cells (AC). We studied the requirements for processing and presentation by AC of Mycoplasma arthritidis supernatant (MAS) mitogen to human T cells. As inhibitors of AC process...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830181239

    authors: Bauer A,Rutenfranz I,Kirchner H

    更新日期:1988-12-01 00:00:00

  • The nature of active and passive thyroglobulin binding lymphoid cells in Obese strain (OS) chickens.

    abstract::Thyroglobulin-binding lymphoid cells were identified in the spleen of Obese strain (DS) chickens by their capacity to form rosettes with thyroglobulin-coated chicken red blood cells. The nature of these cells was studied in inhibition experiments using turkey anti-chicken bursa or thymus cell sera and rabbit antisera ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830050810

    authors: Richter E,Wick G,Schauenstein K

    更新日期:1975-08-01 00:00:00

  • Increased Fas antigen expression in murine retrovirus-induced immunodeficiency syndrome, MAIDS.

    abstract::The Fas antigen (Fas), which is a cell surface protein belonging to the tumor necrosis factor receptor family, mediates apoptosis. To assess the contribution of Fas to the pathogenesis of retrovirus-induced immunodeficiency, we examined the kinetics of Fas expression on the lymphocytes during the course of murine acqu...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830241028

    authors: Hiromatsu K,Aoki Y,Makino M,Matsumoto Y,Mizuochi T,Gotoh Y,Nomoto K,Ogasawara J,Nagata S,Yoshikai Y

    更新日期:1994-10-01 00:00:00

  • Rheumatoid factor autoantibody-binding site: a molecular analysis using monoclonal antibodies with dual anti-TNP and anti-IgG activities.

    abstract::Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830191123

    authors: Reininger L,Spertini F,Shibata T,Jaton JC,Izui S

    更新日期:1989-11-01 00:00:00

  • Liposomes as immunological adjuvants in eliciting antibodies specific to the synthetic polypeptide poly(LTyr, LGlu)-poly(DLAla)--(LLys) with high frequency of site-associated idiotypic determinants.

    abstract::The antibody response to the synthetic polypeptide, poly(LTyr, LGlu)-poly(DLAla)--poly(LLys), [(T,G)-A--L], injected entrapped in liposomes which served as adjuvant has been analyzed. The liposomes used were composed of phosphatidylcholine, cholesterol, dicetylphosphate and DL alpha-tocopherol (molar ratios as 4:3:0.1...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830110510

    authors: Lifshitz R,Gitler C,Mozes E

    更新日期:1981-05-01 00:00:00

  • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.

    abstract::IL-22 is an IFN-IL-10 cytokine family member, which is produced by activated Th1 and NK cells and acts primarily on epithelial cells. Here we demonstrate that IL-22, in contrast to its relative IFN-gamma, regulates the expression of only a few genes in keratinocytes. This is due to varied signal transduction. Gene exp...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200535503

    authors: Wolk K,Witte E,Wallace E,Döcke WD,Kunz S,Asadullah K,Volk HD,Sterry W,Sabat R

    更新日期:2006-05-01 00:00:00

  • Homotypic aggregation of human cell lines by HLA class II-, class Ia- and HLA-G-specific monoclonal antibodies.

    abstract::Major histocompatibility complex (MHC) class II molecules have been implicated in cell adhesion in two ways. In addition to the well-established role of class II antigens in low-affinity adhesion provided by interactions between class II and CD4, recent data indicated that class II may also induce adhesion between T a...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830210921

    authors: Odum N,Ledbetter JA,Martin P,Geraghty D,Tsu T,Hansen JA,Gladstone P

    更新日期:1991-09-01 00:00:00

  • DTR-mediated conditional cell ablation-Progress and challenges.

    abstract::Cell ablation is a valuable complement to mutagenesis for experimentally defining specific cell functions in physiology and pathophysiology in small animal models. One of the most popular ablation strategies involves transgenic expression of a primate diphtheria toxin receptor (DTR) on murine cells that are otherwise ...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章

    doi:10.1002/eji.201847527

    authors: Ruedl C,Jung S

    更新日期:2018-07-01 00:00:00

  • Human cytotoxic T cell structures associated with expression of cytolysis. I. Analysis at the clonal cell level of the cytolysis-inhibiting effect of 7 monoclonal antibodies.

    abstract::Monoclonal antibodies (mAb) derived from BALB/c mice immunized with human anti-HLA-A2 cloned cytotoxic T lymphocytes (CTL) were screened for their ability to block, in the absence of complement, the cytolytic activity of the immunizing CTL clone. Eight cytolysis-inhibiting mAb have been derived. One of these was direc...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830120908

    authors: Malissen B,Rebai N,Liabeuf A,Mawas C

    更新日期:1982-09-01 00:00:00

  • Histocompatibility antigens and genetic control of the immune response in guinea pigs. II. Specific inhibition of antigen-induced lymphocyte proliferation by anti-receptor alloantisera.

    abstract::The in vitro recognition of acetylsalicilyl ovalbumin, penicilloylated bovine IgG (BPO-BGG) and the multichain copolymer poly-L-(Tyr, Glu)-poly-D L-Alapoly-L-Lys [(T, G)-A-L] by primed (2 x 13) F1 cells could be markedly and specifically blocked by alloantisera directed against "receptors" (R) or recognition structure...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830051012

    authors: Geczy AF,Geczy CL,de Weck AL

    更新日期:1975-10-01 00:00:00

  • Induction of human in vitro IgE synthesis via stimulation by anti-CD3 antibody.

    abstract::Mitogens such as pokeweed mitogen, Staphylococcus aureus Cowan I, concanavalin A and phytohemagglutinin and monoclonal anti-CD antibodies were examined for their capacity to induce IgE synthesis by peripheral blood leukocytes obtained from both atopic and nonatopic individuals. While lectins failed to induce IgE synth...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830180322

    authors: Yang XD,De Weck AL,Stadler BM

    更新日期:1988-03-01 00:00:00

  • Complementarity and redundancy of the binding specificity of HLA-DRB1, -DRB3, -DRB4 and -DRB5 molecules.

    abstract::The second HLA-DR molecules, which are encoded by loci different from HLA-DRB1 are weakly polymorphic. Predominant alleles such as HLA-DRB3*0101, HLA-DRB4*0101 and HLA-DRB5*0101 are therefore interesting targets to define antigenic peptides with major impact for the entire population. Strikingly, they have been poorly...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/1521-4141(200106)31:6<1837::aid-immu1837>3

    authors: Texier C,Pouvelle-Moratille S,Busson M,Charron D,Ménez A,Maillère B

    更新日期:2001-06-01 00:00:00

  • Alteration of the T cell self-specificity repertoire by treatment with anti-Ia antibody during embryonic life.

    abstract::The effect of anti-Ia antibody on the development of murine neonatal self-Ia-reactive T lymphocytes in the thymus was studied. A C57BL/6 (B6) mouse pregnant with (B6 X C3H/He)F1 (B6C3F1) embryos was injected with monoclonal anti-I-Ek (m alpha I-Ek) antibody every other day starting from the 12th day of gestation. The ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830160719

    authors: Kimoto M,Kishimoto S

    更新日期:1986-07-01 00:00:00

  • Delayed-type hypersensitivity induced in immunodeficient mice with syngeneic modified self antigens: a suggestive model of autoimmune response.

    abstract::Previous studies suggested that trinitrophenyl (TNP)-modified syngeneic red cells induced humoral autoimmune response in mice with defective T cell function but not in normal mice. The ability of modified self antigen to induce autoimmune response in immunodeficient mice was further explored using the delayed-type hyp...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830121112

    authors: Tarcic N,Naor D

    更新日期:1982-11-01 00:00:00

  • Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptor.

    abstract::Adenosine triphosphate has previously been shown to induce semi-mature human monocyte-derived dendritic cells (DC). These are characterized by the up-regulation of co-stimulatory molecules, the inhibition of IL-12 and the up-regulation of some genes involved in immune tolerance, such as thrombospondin-1 and indoleamin...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200737781

    authors: Ben Addi A,Lefort A,Hua X,Libert F,Communi D,Ledent C,Macours P,Tilley SL,Boeynaems JM,Robaye B

    更新日期:2008-06-01 00:00:00

  • Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice.

    abstract::T cells are known to play an important role in beta cell destruction in the nonobese diabetic (NOD) mouse model of Type I diabetes and islet-specific T cell clones have been demonstrated to be capable of adoptive transfer of diabetes. One important issue involves the identity of beta cell antigens that are recognized ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830250430

    authors: Daniel D,Gill RG,Schloot N,Wegmann D

    更新日期:1995-04-01 00:00:00

  • Fc gamma RII-dependent sensitisation of natural interferon-producing cells for viral infection and interferon-alpha responses.

    abstract::Natural interferon-producing cells (NIPC), also called plasmacytoid dendritic cells, are the most potent producers of IFN-alpha in response to viral and bacterial components, serving an important function in innate immune defences. The present work demonstrates that NIPC responsiveness can be primed by immunisation, i...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200525998

    authors: Balmelli C,Vincent IE,Rau H,Guzylack-Piriou L,McCullough K,Summerfield A

    更新日期:2005-08-01 00:00:00

  • Lack of somatic mutation in a kappa light chain transgene.

    abstract::Analysis of mice transgenic for immunoglobulin genes should allow definition of the cis-acting DNA sequences required to target somatic mutation to antibody V genes. We have looked for mutations in a chimeric kappa transgene encoding a V region specific for the hapten 2-phenyloxazolone (phOx) linked to a rat C kappa g...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830200625

    authors: Sharpe MJ,Neuberger M,Pannell R,Surani MA,Milstein C

    更新日期:1990-06-01 00:00:00

  • Low-level infection with Trichuris muris significantly affects the polarization of the CD4 response.

    abstract::Resistance and susceptibility to the intestinal nematode Trichuris muris has been shown to be dependent upon the induction of T helper type 2 (Th2) or Th1 cells, respectively. This study demonstrates that in a normally resistant strain of mouse, i.e. BALB/K which mounts a dominant Th2 response, sub-threshold levels of...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830241230

    authors: Bancroft AJ,Else KJ,Grencis RK

    更新日期:1994-12-01 00:00:00

  • Selective stimulation of murine cytotoxic T cell and antibody responses by particulate or monomeric hepatitis B virus surface (S) antigen.

    abstract::In the murine system, we tested in vivo the immunogenicity of different preparations of the yeast-derived surface antigen (S-antigen or S-protein) of hepatitis B virus (HBV). Native S-protein molecules self-assemble into stable 22-nm particles. BALB/c mice immunized with low doses of native S-particles without adjuvan...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830240512

    authors: Schirmbeck R,Melber K,Mertens T,Reimann J

    更新日期:1994-05-01 00:00:00

  • Interferon-alpha can synergize with interleukin 2 for human in vitro antibody response.

    abstract::We tested the effect of interferon (IFN)-alpha on the specific anti-2,4,6-trinitrophenyl (TNP) response induced by TNP-conjugated polyacrylamide beads in cultures of purified human B cells. IFN-alpha alone had no effect. Interleukin 2 (IL2) alone had a restorative effect which could be considerably (10X) enhanced by I...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830180912

    authors: Delfraissy JF,Wallon C,Galanaud P

    更新日期:1988-09-01 00:00:00

  • Recognition by major histocompatibility complex class I-restricted cytolytic T lymphocytes of cells expressing vaccinia-encoded viral and class I proteins.

    abstract::Target cells expressing influenza virus hemagglutinin (HA) could be recognized by cytotoxic T lymphocytes (CTL) in conjunction with the murine major histocompatibility complex class I antigen, H-2Kd, when both antigens were encoded by recombinant vaccinia virus. This recognition occurred if HA and H-2Kd were encoded b...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830171021

    authors: Andrew ME,Coupar BE,Boyle DB,Blanden RV

    更新日期:1987-10-01 00:00:00

  • Linomide inhibits programmed cell death of peripheral T cells in vivo.

    abstract::Programmed cell death (PCD) is involved in the physiological regulation of lymphocyte turnover, as well in the antigen-driven selection of T and B cells. Here it is shown that the immunomodulator linomide (quinoline-3-carboxamide) inhibits the apoptotic decay of peripheral T lymphocytes in response to three different ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830240108

    authors: Gonzalo JA,González-García A,Kalland T,Hedlung G,Martínez C,Kroemer G

    更新日期:1994-01-01 00:00:00

  • Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans.

    abstract::The liver and activation-regulated chemokine (LARC), also termed MIP-3alpha and Exodus, is a novel human CC chemokine with a selective chemotactic activity for lymphocytes and dendritic cells. Here we describe genomic and cDNA clones encoding the murine orthologue of LARC (mLARC). The gene consists of four exons and t...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-4141(199902)29:02<633::AID-IMMU

    authors: Tanaka Y,Imai T,Baba M,Ishikawa I,Uehira M,Nomiyama H,Yoshie O

    更新日期:1999-02-01 00:00:00

  • Human CD4+ T cells stimulated by conserved adenovirus 5 hexon peptides recognize cells infected with different species of human adenovirus.

    abstract::The immune response against human adenovirus (HAdV) has gained interest because of the application of HAdV-based vectors in gene therapy and the high incidence of infections in pediatric recipients of allogeneic stem cell grafts. Because antiviral medication is frequently ineffective, the option of adoptive transfer o...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200535786

    authors: Veltrop-Duits LA,Heemskerk B,Sombroek CC,van Vreeswijk T,Gubbels S,Toes RE,Melief CJ,Franken KL,Havenga M,van Tol MJ,Schilham MW

    更新日期:2006-09-01 00:00:00