IFN-beta protects from vascular leakage via up-regulation of CD73.

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by congenital thrombocytopenia and progressive deterioration of the immune function. Dendritic cells (DC) are key effectors in the induction of specific immunity and are highly specialized in antigen uptake and subsequent migration to draining lymph ...

journal_title：European journal of immunology

authors： Allavena P,Badolato R,Facchetti F,Vermi W,Paganin C,Luini W,Giliani S,Mazza C,Bolzern U,Chiesa I,Notarangelo L,Mantovani A,Sozzani S

更新日期：2001-12-01 00:00:00

abstract：:Naïve phenotype (NP) T cells spontaneously initiate homeostatic proliferation (HP) as T-cell output is reduced because of physiologic thymic involution with age. However, the effects of sustained HP on overall immune function are poorly understood. We demonstrated that the NP CD8+ T cell population in adult thymectomi...

journal_title：European journal of immunology

authors： Kato A,Takaori-Kondo A,Minato N,Hamazaki Y

更新日期：2018-10-01 00:00:00

abstract：:T cells from human peripheral blood were enriched in T4+ cells by lysis of T8+ cells with the monoclonal antibody OKT8 plus complement. The T4+ subset was separated into 4 fractions differing in avidity for the lectin Helix pomatia A hemagglutinin (HP). The fractions were studied for their capacity to help autologous ...

journal_title：European journal of immunology

authors： Wikén M,Hellström U,Perlmann P

更新日期：1984-11-01 00:00:00

abstract：:The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model. We found that both the endothelium and epithelium of murine cor...

journal_title：European journal of immunology

authors： Fu H,Khan A,Coe D,Zaher S,Chai JG,Kropf P,Müller I,Larkin DF,George AJ

更新日期：2011-10-01 00:00:00

abstract：:We have identified a novel subset of early B lineage cells in the mouse bone marrow (BM) by GL7 expression on cell surface. GL7(+)B220(low) BM cells have a large cell size and are CD43(-to low), CD95(-), Sca-1(-), I-A(low), IgM(-) and IgD(-), suggesting that they are large pre-B cells. These BM cells express lambda5 a...

journal_title：European journal of immunology

authors： Murasawa M,Okada S,Obata S,Hatano M,Moriya H,Tokuhisa T

更新日期：2002-01-01 00:00:00

abstract：:Global transcriptional technologies have revolutionised the study of lymphoid cell populations, but human γδ T lymphocytes specific for phosphoantigens remain far less deeply characterised by these methods despite the great therapeutic potential of these cells. Here we analyse the transcriptome of circulating TCRVγ(+)...

journal_title：European journal of immunology

authors： Pont F,Familiades J,Déjean S,Fruchon S,Cendron D,Poupot M,Poupot R,L'faqihi-Olive F,Prade N,Ycart B,Fournié JJ

更新日期：2012-01-01 00:00:00

abstract：:The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). We previously showed that binding of A39R to Plexin C1 induces local rearrangement of the actin cytoskeleton and inhibits integrin-mediated adhesion, leading to cell ret...

journal_title：European journal of immunology

authors： Walzer T,Galibert L,De Smedt T

更新日期：2005-02-01 00:00:00

abstract：:Previously we implicated c-Jun N-terminal kinase (JNK) as an element that is involved in signal integration during co-stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR and CD28. A large portio...

journal_title：European journal of immunology

authors： Avraham A,Jung S,Samuels Y,Seger R,Ben-Neriah Y

更新日期：1998-08-01 00:00:00

abstract：:A specialized subpopulation of T lymphocytes is reactive to the MHC class I-like molecule CD1d. It is not clear which cells are the major antigen-presenting cells in vivo in the activation of CD1-restricted immune responses. We have characterized a subset of B lymphocytes expressing six- to eightfold higher levels of ...

journal_title：European journal of immunology

authors： Makowska A,Faizunnessa NN,Anderson P,Midtvedt T,Cardell S

更新日期：1999-10-01 00:00:00

abstract：:Even if omalizumab is broadly used in the treatment of severe, allergic asthma, the immunological effects in long-term treated patients have not been fully elucidated. To this aim, a cohort of 15 allergic asthmatic patients treated with omalizumab for at least three years was compared with 12 allergic asthma patients ...

journal_title：European journal of immunology

authors： Maggi L,Rossettini B,Montaini G,Matucci A,Vultaggio A,Mazzoni A,Palterer B,Parronchi P,Maggi E,Liotta F,Annunziato F,Cosmi L

更新日期：2018-12-01 00:00:00

abstract：:In humans infected with lymphatic filariasis, microfilaraemia [the presence of microfilariae (Mf) in the blood] is generally associated with both poor antigen (Ag)-specific proliferative responses and with protection from severe disease. Clonal deletion has been suggested as one possible mechanism by which parasite-re...

journal_title：European journal of immunology

authors： Jenson JS,O'Connor R,Osborne J,Devaney E

更新日期：2002-03-01 00:00:00

abstract：:When cytotoxic titrations were made of rabbit anti-mouse brain and anti-Thy-1.2 sera against mouse lymphoid cells in the presence of sodium barbital or xylocaine, it was observed that a proportion of T cells were much more sensitive (50 x) than the remainder. This effect could be detected with ethidium or fluorescein ...

journal_title：European journal of immunology

authors： Lee SK,Singh J,Taylor RB

更新日期：1975-04-01 00:00:00

abstract：:Blockade of the immune response, caused by a high dose of Salmonella typhi Vi antigen (200 microgram i.v.) and cyclophosphamide (CY)-induced tolerance to Vi antigen, were analyzed. The results of the study show that blockade of the immune response cannot be attributed to masking of the response resulting from neutrali...

journal_title：European journal of immunology

authors： Prigozhina TB,Fontalin LN

更新日期：1980-08-01 00:00:00

abstract：:IL-15 induces proliferation, inhibits apoptosis and increases IL-4 production in murine mast cells. There is evidence that these activities are mediated via the uncharacterised receptor, IL-15R-X, rather than the classical three-chain IL-15 receptor. Effects of IL-15 on important aspects of mast cell biology, such as ...

journal_title：European journal of immunology

authors： Jackson NE,Wang HW,Tedla N,McNeil HP,Geczy CL,Collins A,Grimm MC,Hampartzoumian T,Hunt JE

更新日期：2005-08-01 00:00:00

abstract：:Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process. However, Tfr-cell function in the GC is not well understood. Here, we define Tfr cells as a C...

journal_title：European journal of immunology

authors： Wu H,Chen Y,Liu H,Xu LL,Teuscher P,Wang S,Lu S,Dent AL

更新日期：2016-05-01 00:00:00

abstract：:There is a current need for safe, cheap, and effective vaccine adjuvants, to combine with sub-unit antigens to enhance their immunogenicity. In this study we have used probiotic Bacillus subtilis spores, known to be safe and fully tolerated by ingestion in man, and explored their ability to influence the magnitude and...

journal_title：European journal of immunology

authors： Barnes AG,Cerovic V,Hobson PS,Klavinskis LS

更新日期：2007-06-01 00:00:00

abstract：:Brain invasion by Borrelia burgdorferi, the agent of Lyme disease, results in an inflammatory and neurodegenerative disorder called neuroborreliosis. In humans, neuroborreliosis has been correlated with enhanced concentration of glial fibrillary acidic protein in the cerebrospinal fluid, a sign of astrogliosis. Rhesus...

journal_title：European journal of immunology

authors： Ramesh G,Alvarez AL,Roberts ED,Dennis VA,Lasater BL,Alvarez X,Philipp MT

更新日期：2003-09-01 00:00:00

abstract：:There is limited insight into the mechanisms involved in the counterregulation of TLR. Given the important role of TLR3/TIR domain-containing adaptor-inducing IFN-β (TRIF)-dependent signalling in innate immunity, novel insights into its modulation is of significance in the context of many physiological and pathologica...

journal_title：European journal of immunology

authors： Siednienko J,Halle A,Nagpal K,Golenbock DT,Miggin SM

更新日期：2010-11-01 00:00:00

abstract：:The germ-line V gene segments encoding the subgroups A and G of the BALB/c V kappa 21 family were cloned and assigned to the previously described 30-kb cluster of the V kappa 21 family. Sequence comparison revealed close homology between the two gene segments at the DNA and the predicted amino acid sequence level, ind...

journal_title：European journal of immunology

authors： Alanen A,Weiss S

更新日期：1989-10-01 00:00:00

abstract：:Previously, we found that co-expression of CD25 and TNFR2 identified the most suppressive subset of mouse Treg. In this study, we report that human peripheral blood (PB) FOXP3(+) cells present in CD25(high), CD25(low) and even CD25(-) subsets of CD4(+) cells expressed high levels of TNFR2. Consequently, TNFR2-expressi...

journal_title：European journal of immunology

authors： Chen X,Subleski JJ,Hamano R,Howard OM,Wiltrout RH,Oppenheim JJ

更新日期：2010-04-01 00:00:00

abstract：:Heat-stable antigen (HSA)/mouse CD24 (formerly termed Nectadrin) is a membrane glycoprotein with an unusual structure consisting of a small protein core and extensive glycosylation. It is expressed by hematopoietic cells but not by mature T lymphocytes. HSA on accessory cells is an important costimulatory molecule req...

journal_title：European journal of immunology

authors： Hubbe M,Altevogt P

更新日期：1994-03-01 00:00:00

abstract：:A significant proportion of memory B cells home to bone marrow (BM) which is a major site of anamnestic antibody responses in mice. We hypothesized that memory T cells likewise accumulate in BM perhaps to provide help for antibody production, and that the compartment of CD4+ T cells in BM of unimmunized mice would be ...

journal_title：European journal of immunology

authors： Price PW,Cerny J

更新日期：1999-03-01 00:00:00

abstract：:The variable region nucleotide sequences of seven (five IgM and two IgG) anti-histone monoclonal antibodies from a single MRL/Mp-lpr/lpr mouse have been determined. These antibodies are not clonally related and used diverse V, D and J genes. However, six of the seven antibodies have VH segments encoded by genes from t...

journal_title：European journal of immunology

authors： Monestier M

更新日期：1991-07-01 00:00:00

abstract：:Human immunodeficiency virus binds to CD4 T lymphocytes by interaction between its envelope glycoprotein gp120 and the CD4 molecule. The latter is non-covalently associated with a src-related tyrosine kinase, p56lck. CD4 cross-linking increases the activity of p56lck, leading to phosphorylation of several cellular sub...

journal_title：European journal of immunology

authors： Hivroz C,Mazerolles F,Soula M,Fagard R,Graton S,Meloche S,Sekaly RP,Fischer A

更新日期：1993-03-01 00:00:00

abstract：:Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic repr...

journal_title：European journal of immunology

authors： Muri J,Thut H,Heer S,Krueger CC,Bornkamm GW,Bachmann MF,Kopf M

更新日期：2019-05-01 00:00:00

abstract：:Targeting exogenous antigen into the MHC class I-restricted presentation pathway is a prerequisite for the induction of cytotoxic T lymphocytes (CTL) which have been shown to represent an important component of the protective and therapeutic immune response to viral infections and tumors. In this study, we produced re...

journal_title：European journal of immunology

authors： Lee RS,Tartour E,van der Bruggen P,Vantomme V,Joyeux I,Goud B,Fridman WH,Johannes L

更新日期：1998-09-01 00:00:00

abstract：:Studies of chronic viral infections have highlighted the phenotypic and functional heterogeneity of antigen-specific T cells and suggested that polyfunctional T cells that secrete multiple cytokines and are able to proliferate on encounter with antigen are more likely than single cytokine secretors to represent correl...

journal_title：European journal of immunology

authors： Wilkinson KA,Wilkinson RJ

更新日期：2010-08-01 00:00:00

abstract：:We have previously reported that a subset of T cells in T cell receptor (TCR)-transgenic mice may express two different alpha chains on their surface. The expression of two functional alpha chains has also been demonstrated for human peripheral blood T cells. In this report, we show that a proportion of normal murine ...

journal_title：European journal of immunology

authors： Heath WR,Carbone FR,Bertolino P,Kelly J,Cose S,Miller JF

更新日期：1995-06-01 00:00:00

abstract：:CSF1R (colony stimulating factor 1 receptor) is the main receptor for CSF1 and has crucial roles in regulating myelopoeisis. CSF1R can be proteolytically released from the cell surface by ADAM17 (A disintegrin and metalloprotease 17). Here, we identified CSF1R as a major substrate of ADAM17 in an unbiased degradomics ...

journal_title：European journal of immunology

authors： Qing X,Rogers L,Mortha A,Lavin Y,Redecha P,Issuree PD,Maretzky T,Merad M,McIlwain D,Mak TW,Overall CM,Blobel CP,Salmon JE

更新日期：2016-12-01 00:00:00

abstract：:We investigated the efficacy of a combination of anti-CD80 and CD86 (CD80 + 86) monoclonal antibodies (mAb), anti-interleukin (IL)-12 mAb, or both, for prophylaxis in a mouse acute graft-versus-host-disease (GVHD) model. The treatment with a combination of anti-CD80 + 86 mAb efficiently reduced the lethality of GVHD, ...

journal_title：European journal of immunology

authors： Saito K,Yagita H,Hashimoto H,Okumura K,Azuma M

更新日期：1996-12-01 00:00:00