Effect of CD80 and CD86 blockade and anti-interleukin-12 treatment on mouse acute graft-versus-host disease.

abstract：:We have characterized the peripheral B cell repertoire in T cell-mediated insulin-dependent diabetes mellitus (IDMM) and in B cell-mediated autoimmune idiopathic thrombocytopenic purpura (AITP). The VH6-containing repertoire in adult patients with IDDM or AITP and healthy control subjects was investigated by PCR ampli...

journal_title：European journal of immunology

authors： Söderström I,van Dijk-Härd I,Feld S,Hillörn V,Holmberg D,Lundkvist I

更新日期：1999-09-01 00:00:00

abstract：:CD40-CD40 ligand (CD40L) signaling plays multiple indispensable roles in cellular and humoral immunity. Impaired memory T-cell responses in the absence of CD40L have been well documented, but the requirement of this interaction for efficient priming of CD8+ T cells especially under inflammatory conditions has been und...

journal_title：European journal of immunology

authors： Durlanik S,Loyal L,Stark R,Sercan Alp Ö,Hartung A,Radbruch A,von Herrath M,Matzmohr N,Frentsch M,Thiel A

更新日期：2016-11-01 00:00:00

abstract：:Vgamma9/Vdelta2+ T cells specifically recognize Mycobacterium tuberculosis in vitro and are precociously recruited in early mycobacterial lesions. Even if gammadelta T cells are only fortuitously detected in granulomas or bronchoalveolar lavages of patients with active pulmonary tuberculosis, a role in shaping the mat...

journal_title：European journal of immunology

authors： Manfredi AA,Heltai S,Rovere P,Sciorati C,Paolucci C,Galati G,Rugarli C,Vaiani R,Clementi E,Ferrarini M

更新日期：1998-06-01 00:00:00

abstract：:Endogenous superantigens (SAg) presented by MHC class II IA molecules induce slow-evolving negative selection of alpha beta T cells. The role of both B and gamma delta T cells on the regulation of these SAg-specific alpha beta T cell responses was addressed in IA(b+)IE(b-) C57BL/6 mice bearing genetically induced B ce...

journal_title：European journal of immunology

authors： Izcue A,Morales G,Minguet S,Sánchez-Movilla A,Morales P,Martínez-M JA,Gaspar ML,Marcos MA

更新日期：2001-09-01 00:00:00

abstract：:After incorporation of 14C-labeled amino acids and/or of [3H]fucose during in vitro culture of the Thy-1.1-bearing, Fc receptor-positive T lymphoma, L-5187-Y, attempts were made to purify the Fc binding structure(s). Following solubilization of a crude membrane pellet using sodium deoxycholate, the 110 000 x g superna...

journal_title：European journal of immunology

authors： Frade R,Kourilsky FM

更新日期：1977-09-01 00:00:00

abstract：:The monoclonal antibody OKT3 can induce T suppressor cells of the in vitro antibody response when used at concentrations as low as 10 ng/ml and in cultures containing as few as 4% OKT3-pretreated T cells. These suppressor cells are radioresistant, cyclosporin sensitive and belong to the T4 as well as the T8 subpopulat...

journal_title：European journal of immunology

authors： Delfraissy JF,Wallon C,Boué F,Vazquez A,Galanaud P

更新日期：1985-05-01 00:00:00

abstract：:Mast cells are widely distributed in tissues, particularly near surfaces exposed to the environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE and specific Ag and many other stimuli, including products derived from either pathogens or the host during innate immune responses. Althoug...

journal_title：European journal of immunology

authors： Galli SJ,Tsai M

更新日期：2010-07-01 00:00:00

abstract：:The viral CC chemokine macrophage inhibitory protein-II (vMIP-II) encoded by human herpes virus 8 (HHV-8) binds to multiple chemokine receptors, however, its ability to control the initial recruitment of specific leukocyte subtypes from the peripheral circulation has not been fully clarified. Here we show that vMIP-II...

journal_title：European journal of immunology

authors： Weber KS,Gröne HJ,Röcken M,Klier C,Gu S,Wank R,Proudfoot AE,Nelson PJ,Weber C

更新日期：2001-08-01 00:00:00

abstract：:To detect possible differences in immunogenicity between tumors induced in T cell-deficient mice and phenotypically normal congenic mice, 16 sarcomas, 8 having developed in nude BALB/c mice and 8 having developed in congenic normal (nu/+) mice, were transplanted to normal BALB/c recipients and the rates of rejection o...

journal_title：European journal of immunology

authors： Svane IM,Engel AM,Nielsen MB,Ljunggren HG,Rygaard J,Werdelin O

更新日期：1996-08-01 00:00:00

abstract：:Oxidant stress can initiate or enhance inflammatory responses during tissue injury, possibly through activation of redox-sensitive chemokines. Because the transcription factor Nrf2 (NF-E2-related factor 2) is responsive to oxidative stress, and induces expression of cytoprotective and antioxidant genes that attenuate ...

journal_title：European journal of immunology

authors： Zhang X,Chen X,Song H,Chen HZ,Rovin BH

更新日期：2005-11-01 00:00:00

abstract：:Bone marrow mesenchymal progenitor cells (BMSC) are used for regenerating tissues of mesodermal origin, as well as tissues of different embryological derivation. Experimental evidence shows that BMSC are able to suppress the activation of the immune response by mechanisms that are still not completely understood. Thus...

journal_title：European journal of immunology

authors： Augello A,Tasso R,Negrini SM,Amateis A,Indiveri F,Cancedda R,Pennesi G

更新日期：2005-05-01 00:00:00

abstract：:The specificity and efficiency of endogenous peptides in the HLA class I binding have been investigated by the use of a simple procedure that is based on the serological detection of the folding of HLA class I alpha chains that is induced by the binding to specific peptides in the presence of beta 2 microglobulin. HLA...

journal_title：European journal of immunology

authors： Tanigaki N

更新日期：1992-08-01 00:00:00

abstract：:The atypical chemokine receptor CXCR7 binds the chemokines CXCL12 and CXCL11. The receptor is widely expressed and was shown to tune CXCR12-induced responses of CXCR4. Here, the function of CXCR7 was examined at late stages of human B-cell maturation, when B cells differentiate into Ab-secreting plasmablasts. We ident...

journal_title：European journal of immunology

authors： Humpert ML,Pinto D,Jarrossay D,Thelen M

更新日期：2014-03-01 00:00:00

abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

journal_title：European journal of immunology

authors： Yamada T,Hitomi Y,Satake M,Oikawa T

更新日期：1995-09-01 00:00:00

abstract：:Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and p...

journal_title：European journal of immunology

authors： Webb LM,Walmsley MJ,Feldmann M

更新日期：1996-10-01 00:00:00

abstract：:In an effort to derive monoclonal antibodies (mAb) which can induce production of macrophage-activating factor (MAF) by cloned murine cytolytic T lymphocyte (CTL) lines, we have fused spleen cells from a rat immunized with a CTL clone with the nonsecreting mouse myeloma X63-Ag8.653. Three mAb (designated I-22, III-5 a...

journal_title：European journal of immunology

authors： MacDonald HR,Bron C,Rousseaux M,Horvath C,Cerottini JC

更新日期：1985-05-01 00:00:00

abstract：:Gammadelta T cells are expanded in human IgA nephropathy and in a rat model of adriamycin (ADR)-induced nephropathy. Despite different diseases and species, these renal gammadelta T cells use a restricted set of gammadelta T cell receptor (TCR) genes. To explore whether this phenomenon of post injury expansion of gamm...

journal_title：European journal of immunology

authors： Wu H,Knight JF,Alexander SI

更新日期：2004-08-01 00:00:00

abstract：:In humans and in BALB/c mice, immune responses to the hormone insulin use evolutionarily related VHV (human) and VHIX (murine) gene families. To determine if these structural relationships include regulatory elements, BALB/c mice were pretreated with autologous immunoglobulin G (IgG) monoclonal antibodies (mAb) that r...

journal_title：European journal of immunology

authors： Thomas JW

更新日期：1992-09-01 00:00:00

abstract：:It has been reported that, following the initial expression of the T cell receptor (TcR) alpha/beta, newly generated thymocytes pass through a developmental window characterized by ineffective coupling between the alpha/beta and CD3 components resulting in resistance to deletion (negative selection). However, we now p...

journal_title：European journal of immunology

authors： Jenkinson EJ,Kingston R,Owen JJ

更新日期：1990-11-01 00:00:00

abstract：:The inducible B cell lymphoma, CH12, and its in vitro adapted subclone, CH12-LBK, produce immunoglobulins of identical sequence, specificity and isotype, with equivalent affinities for the hapten trimethyl ammonium. However, the hemolytic efficiencies of the antibody secreted by the two cell lines are quite different....

journal_title：European journal of immunology

authors： Randall TD,King LB,Corley RB

更新日期：1990-09-01 00:00:00

abstract：:Cellular immune responses are likely to play a key role in determining the clinical outcome in acute infection with hepatitis C virus (HCV), but the dynamics of such responses and their relationship to viral clearance are poorly understood. In a previous study we have shown highly activated, multispecific cytotoxic T ...

journal_title：European journal of immunology

authors： Lechner F,Gruener NH,Urbani S,Uggeri J,Santantonio T,Kammer AR,Cerny A,Phillips R,Ferrari C,Pape GR,Klenerman P

更新日期：2000-09-01 00:00:00

abstract：:We have produced a chimeric single-chain T cell receptor (TcR) that combines the specific antibody recognition function and TcR/CD3 signaling properties within the same polypeptide chain. This hybrid molecule consisted of a single-chain antibody combining site that was connected over a short spacer to the transmembran...

journal_title：European journal of immunology

authors： Brocker T,Peter A,Traunecker A,Karjalainen K

更新日期：1993-07-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a major part in providing innate immunity against pathogenic microorganisms. Recent studies show that these receptors are also expressed on T cells, which are the sentinels of adaptive immunity. Here, we have investigated the regulatory role of the T-cell receptor in the functioning of ...

journal_title：European journal of immunology

authors： Akhade AS,Qadri A

更新日期：2015-09-01 00:00:00

abstract：:We have analyzed the relationship between the signaling pathways coupled to surface immunoglobulin and interleukin (IL)-4 receptors in human B cells from the patterns of expression of a panel of phorbol ester-inducible early response genes (ERG) activated by anti-IgM and IL-4 stimulation in vitro. Anti-IgM stimulation...

journal_title：European journal of immunology

authors： Murphy JJ,Norton JD

更新日期：1993-11-01 00:00:00

abstract：:Continuous antigen stimulation of CD4(+)CD25(-) T cells leads to generation of adaptive CD4(+)CD25(+)FOXP3(+) regulatory T (T(R)) cells. Here, we show that highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) T cells can be generated in the same manner by continuous antigen stimulation in the presence of CD14(+) monocyte...

journal_title：European journal of immunology

authors： Mahic M,Henjum K,Yaqub S,Bjørnbeth BA,Torgersen KM,Taskén K,Aandahl EM

更新日期：2008-03-01 00:00:00

abstract：:Here we show that tumor cells (TC) from renal cancers regulate the migratory properties of autologous tumor-infiltrating lymphocytes (TIL), enhancing their ability to invade the extracellular matrix. A similar effect is exerted by human recombinant macrophage chemotactic protein 1 (MCP-1) and IL-8, chemokines known to...

journal_title：European journal of immunology

authors： Ferrero E,Fabbri M,Poggi A,Galati G,Bernasconi S,Zocchi MR

更新日期：1998-08-01 00:00:00

abstract：:Heterologous adenovirus-based vectors hold promise as preventative HIV vaccines but their capacity to induce effective T-cell immunity in established infection has not been explored. We vaccinated rhesus macaques chronically infected with SIVmac251 and undergoing antiretroviral therapy (ART) with human adenovirus sero...

journal_title：European journal of immunology

authors： Soloff AC,Liu X,Gao W,Day RD,Gambotto A,Barratt-Boyes SM

更新日期：2009-09-01 00:00:00

abstract：:A gene-encoding ligand for deletion of T cells bearing TcRV beta 6 and V beta 8.1 cosegregates a new mammary tumor provirus locus, Mtv-50 in NC mice. The sequence of the open reading frame (ORF) in the 3' long terminal repeat (LTR) of Mtv-50 was strikingly similar to those of Mtv-7, Mtv-43 and exogenous mouse mammary ...

journal_title：European journal of immunology

authors： Niimi N,Wajjwalku W,Ando Y,Tomida S,Takeuchi M,Ueda M,Kaneda T,Yoshikai Y

更新日期：1994-02-01 00:00:00

abstract：:Using a new mAb, 2F1, we characterize a mouse natural killer (NK) cell antigen termed 'killer cell lectin-like receptor G1' (KLRG1; formerly mouse MAFA or 2F1-Ag). KLRG1 is expressed on 30-60% of murine NK cells, and a small fraction of T cells, and is composed of a homodimer of glycosylated 30-38-kDa subunits. Striki...

journal_title：European journal of immunology

authors： Corral L,Hanke T,Vance RE,Cado D,Raulet DH

更新日期：2000-03-01 00:00:00

abstract：:Chemokines are chemotactic cytokines with a key role in the control of cell trafficking and positioning under homeostatic and inflammatory conditions. D6 is a promiscuous 7-transmembrane-domain receptor expressed on lymphatic vessels which recognizes most inflammatory, but not homeostatic, CC chemokines. In vitro expe...

journal_title：European journal of immunology

authors： Martinez de la Torre Y,Locati M,Buracchi C,Dupor J,Cook DN,Bonecchi R,Nebuloni M,Rukavina D,Vago L,Vecchi A,Lira SA,Mantovani A

更新日期：2005-05-01 00:00:00