Abstract:
:Endogenous superantigens (SAg) presented by MHC class II IA molecules induce slow-evolving negative selection of alpha beta T cells. The role of both B and gamma delta T cells on the regulation of these SAg-specific alpha beta T cell responses was addressed in IA(b+)IE(b-) C57BL/6 mice bearing genetically induced B cell and gamma delta T cell deficiencies. B lymphocytes were required in the negative selection of Vbeta5(+)/Vbeta12(+) CD4(+) T cells. In contrast, gamma delta T cells positively stimulated the utilization of the same SAg-responsive alpha beta T cell subsets. These differences started in mature CD4(+) thymocytes and extended to naive T cell pools for B cell negative selection, and up to memory T cells for gamma deltaT cell influences. The levels of SAg-responsive T cells did not vary between C57BL/6 and double deficient (B cell and gamma delta T cell-deficient) congenic mice, implying that both B and gamma delta T cells acted through independent mechanisms.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Izcue A,Morales G,Minguet S,Sánchez-Movilla A,Morales P,Martínez-M JA,Gaspar ML,Marcos MAdoi
10.1002/1521-4141(200109)31:9<2811::aid-immu2811>3keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
2811-7issue
9eissn
0014-2980issn
1521-4141pii
10.1002/1521-4141(200109)31:9<2811::AID-IMMU2811>3journal_volume
31pub_type
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