Abstract:
:Murine splenic T lymphocytes display maximal cellular myc gene (c-myc) expression already 3 h after concanavalin A stimulation and subsequent down-regulation before the onset of DNA synthesis. Stimulation by leucoagglutinin in the presence or absence of interleukin 2 leads to only low initial levels of c-myc-specific RNA which, however, increase later on. A similar pattern of c-myc expression is shown by the Lyt-2+ T cell subpopulation stimulated with either concanavalin A or leucoagglutinin in the presence of interleukin 2. Although [3H]thymidine incorporation was identical, the leucoagglutinin-stimulated Lyt-2+ T cells were void of any demonstrable c-myc-specific RNA at 3 h post-stimulation. Thus, the kinetics of c-myc expression in mouse T lymphocytes are not at all uniform, but depend on the mitogen and the subpopulation. In contrast, levels of c-ras-Ha-specific RNA were always low at early times, always increased towards the onset of DNA synthesis and down-regulation was not observed.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Schneider-Schaulies J,Hünig T,Schimpl A,Wecker Edoi
10.1002/eji.1830160319subject
Has Abstractpub_date
1986-03-01 00:00:00pages
312-6issue
3eissn
0014-2980issn
1521-4141journal_volume
16pub_type
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journal_title:European journal of immunology
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