Abstract:
:Type I IFN play a very important role in immunity against viral infections. Murine type I IFN belongs to a multigene family including 14 IFN-alpha subtypes but the biological functions of IFN-alpha subtypes in retroviral infections are unknown. We have used the Friend retrovirus model to determine the anti-viral effects of IFN-alpha subtypes in vitro and in vivo. IFN-alpha subtypes alpha1, alpha4, alpha6 or alpha9 suppressed Friend virus (FV) replication in vitro, but differed greatly in their anti-viral efficacy in vivo. Treatment of FV-infected mice with the IFN-alpha subtypes alpha1, alpha4 or alpha9, but not alpha6 led to a significant reduction in viral loads. Decreased splenic viral load after IFN-alpha1 treatment correlated with an expansion of activated FV-specific CD8(+) T cells and NK cells into the spleen, whereas in IFN-alpha4- and -alpha9-treated mice it exclusively correlated with the activation of NK cells. The results demonstrate the distinct anti-retroviral effects of different IFN-alpha subtypes, which may be relevant for new therapeutic approaches.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Gerlach N,Gibbert K,Alter C,Nair S,Zelinskyy G,James CM,Dittmer Udoi
10.1002/eji.200838311subject
Has Abstractpub_date
2009-01-01 00:00:00pages
136-46issue
1eissn
0014-2980issn
1521-4141journal_volume
39pub_type
杂志文章abstract::F protein is found predominantly in the liver and is of unknown function. The protein has been of interest to immunologists in the areas of self tolerance and the immunogenetics of the anti-F protein response. In the mouse there are two alleles (F1 and F2), and although mice are completely tolerant to the self form of...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210521
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270828
更新日期:1997-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830130810
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abstract::Dendritic cells expanded from mouse bone marrow (BMDC) with granulocyte/macrophage-colony-stimulating factor have potent T cell-stimulatory properties both in vitro and in vivo. This has been well documented for major histocompatibility complex (MHC) class II-restricted responses, and more recently using peptide-loade...
journal_title:European journal of immunology
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doi:10.1002/eji.1830270141
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830140516
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journal_title:European journal of immunology
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doi:10.1002/eji.200526323
更新日期:2005-09-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1981-11-01 00:00:00
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更新日期:2011-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230948
更新日期:1993-09-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199911)29:11<3643::AID-IMM
更新日期:1999-11-01 00:00:00
abstract::Cross-linking of surface immunoglobulin (sIg) by antibodies against IgM, IgG and IgD activates B cells and in some circumstances can induce cell proliferation. We studied the potential link between anti-Ig-induced changes in the cytosolic free Ca2+ concentration ([Ca2+]i), inositol phosphate production and the ability...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830171209
更新日期:1987-12-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200108)31:8<2373::aid-immu2373>3
更新日期:2001-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180814
更新日期:1988-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221045
更新日期:1992-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636484
更新日期:2006-11-01 00:00:00
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journal_title:European journal of immunology
pub_type:
doi:10.1002/eji.201243022
更新日期:2013-01-01 00:00:00
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journal_title:European journal of immunology
pub_type: 临床试验,杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210816
更新日期:1991-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830120519
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830091213
更新日期:1979-12-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201344270
更新日期:2014-04-01 00:00:00
abstract::Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from t...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200323730
更新日期:2003-05-01 00:00:00
abstract::Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox-PL) on T cell activation and function. We could demonstrate that ox-PL strongly inhibit proliferation of purified human T cells induced with anti-CD3/CD28 or anti-CD3/CD63 mAb, whereas prolifera...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200737619
更新日期:2008-03-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142140
更新日期:2012-06-01 00:00:00
abstract::A multiparametric analysis of the resident immune populations in the parotid, submandibular and sublingual salivary glands was done in single-cell suspensions. The incidence of T and B cells and of macrophages was assessed using phenotypic markers in immunofluorescent staining and a functional assay was used to enumer...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160313
更新日期:1986-03-01 00:00:00
abstract::The involvement of rheumatoid factor (RF)-secreting cells in normal immune responses was examined by screening hybridomas derived from 129/Sv mice during primary and secondary immune responses against foreign proteins. No RF-secreting cells were detected during primary responses, but up to 10% of the total number of c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830131106
更新日期:1983-11-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200737395
更新日期:2008-03-01 00:00:00
abstract::Cells from the monoclonal B cell lymphoma I.29 expressing surface IgM (mu +) are capable of differentiating in vitro to IgM secretion and of switching to IgA or IgE production in response to lipopolysaccharide (LPS) stimulation. To determine whether a single mu + B cell is capable of undertaking both differentiative p...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830170419
更新日期:1987-04-01 00:00:00
abstract::Using a culture system which supports primary T cell proliferative responses to various antigens we have detected mouse red blood cell (RBC)-reactive T cells in lymphoid tissues from untreated mice. The release of significant amounts of interleukin 2 (IL2) indicates that T helper (or helper/inducer) cells are activate...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830170610
更新日期:1987-06-01 00:00:00