Oxidized phospholipids induce anergy in human peripheral blood T cells.

abstract：:Cross-linking of surface Ig receptors (sIg) by mitogenic forms of anti-Ig antibodies (e.g. F(ab')2 fragments of rabbit anti-Ig) causes the rapid, and prolonged breakdown of phosphatidylinositol 4,5-bisphosphate. This response involves an unidentified guanine nucleotide regulatory protein (termed Gp), which couples sIg...

journal_title：European journal of immunology

authors： Rigley KP,Harnett MM,Klaus GG

更新日期：1989-03-01 00:00:00

abstract：:We recently constructed IL-15 transgenic (Tg) mice using cDNA encoding a secretable isoform of the IL-15 precursor protein under the control of an MHC class I promoter. The IL-15 Tg mice exhibited resistance against a primary infection with Listeria monocytogenes. The numbers of memory CD8(+) T cells were markedly inc...

journal_title：European journal of immunology

authors： Yajima T,Nishimura H,Ishimitsu R,Yamamura K,Watase T,Busch DH,Pamer EG,Kuwano H,Yoshikai Y

更新日期：2001-03-01 00:00:00

abstract：:The MRC OX-47 monoclonal antibody recognizes a membrane antigen present at low levels on many lymphocytes but whose expression is markedly increased on activation with mitogens. cDNA clones for the OX-47 antigen were isolated from an expression library and the protein sequence deduced. It contains a leader sequence gi...

journal_title：European journal of immunology

authors： Fossum S,Mallett S,Barclay AN

更新日期：1991-03-01 00:00:00

abstract：:One of the clear paradoxes in tumor immunology is the fact that cross-presentation of cell-associated tumor antigens to CD8(+) T cells is efficient, yet CTL generation is weak, and tumors continue to grow. We examined, for the first time whether this may be due to alterations in the phenotype or function of cross-pres...

journal_title：European journal of immunology

authors： McDonnell AM,Prosser AC,van Bruggen I,Robinson BW,Currie AJ

更新日期：2010-06-01 00:00:00

abstract：:Natural resistance to hemopoietic allograft results in functional elimination of the graft from the host within 24 to 48 h. The resistance is specific and is directed to the cell surface target structures of an unidentified nature. These determinants are controlled by the major histocompatibility complex-linked hemopo...

journal_title：European journal of immunology

authors： Shimamura K,Kaminsky SG,Nakamura I

更新日期：1989-07-01 00:00:00

abstract：:The CD4 T cell surface molecule binds MHC class II determinants expressed on antigen-presenting cells. CD4 is thought to enhance T cell activation by serving as an adhesion molecule as well as possibly by transducing an independent intracellular signal during the process of antigen stimulation. The recent observation ...

journal_title：European journal of immunology

authors： Veillette A,Sleckman BP,Ratnofsky S,Bolen JB,Burakoff SJ

更新日期：1990-06-01 00:00:00

abstract：:Upon transplantation of T cells from a CD28 superagonist (CD28-SA) treated donor into an irradiated allogeneic host, the CD28-SA-induced activation and expansion of Treg cells inhibits acute graft versus host disease (aGvHD), while not abrogating the desired graft versus tumor effect. Human peripheral blood CD4(+) T c...

journal_title：European journal of immunology

authors： Beyersdorf N,Werner S,Wolf N,Hünig T,Kerkau T

更新日期：2015-07-01 00:00:00

abstract：:In this study, we have analyzed the in vivo dynamics of the interaction between polyclonal Foxp3(+) Treg cells, effector T (Teff) cells, and DCs in order to further our understanding of the mechanisms of Treg cell-mediated suppression. Cotransfer of polyclonal activated Treg cells into healthy mice attenuated the ind...

journal_title：European journal of immunology

authors： Davidson TS,Shevach EM

更新日期：2011-10-01 00:00:00

abstract：:A gene-encoding ligand for deletion of T cells bearing TcRV beta 6 and V beta 8.1 cosegregates a new mammary tumor provirus locus, Mtv-50 in NC mice. The sequence of the open reading frame (ORF) in the 3' long terminal repeat (LTR) of Mtv-50 was strikingly similar to those of Mtv-7, Mtv-43 and exogenous mouse mammary ...

journal_title：European journal of immunology

authors： Niimi N,Wajjwalku W,Ando Y,Tomida S,Takeuchi M,Ueda M,Kaneda T,Yoshikai Y

更新日期：1994-02-01 00:00:00

abstract：:Two cloned murine helper T lymphocyte (HTL) lines were used to investigate the immunoregulatory properties of highly purified interleukin 2 (IL2). The clone, designated J6.19, secretes lymphokines, including IL2, and proliferates when stimulated with ovalbumin in the presence of I-Ak-bearing spleen cells, while the al...

journal_title：European journal of immunology

authors： Otten G,Wilde DB,Prystowsky MB,Olshan JS,Rabin H,Henderson LE,Fitch FW

更新日期：1986-03-01 00:00:00

abstract：:Pre-B cells which show a delayed development of responsiveness to the B cell mitogen lipopolysaccharide (LPS) are found in murine embryonic blood between day 10 and 14 of gestation. The highest frequency of pre-B cells in embryonic blood is found at day 12 of gestation. All pre-B cells of embryonic blood, isolated at ...

journal_title：European journal of immunology

authors： Melchers F,Abramczuk J

更新日期：1980-10-01 00:00:00

abstract：:The mer receptor tyrosine kinase mediates phagocytosis of apoptotic cells and modulates cytokine production; it is also required for prevention of systemic autoimmune disease. Using a mer-specific antibody, we have confirmed the presence of mer on macrophages and now report its expression on NK cells, NKT cells, and d...

journal_title：European journal of immunology

authors： Behrens EM,Gadue P,Gong SY,Garrett S,Stein PL,Cohen PL

更新日期：2003-08-01 00:00:00

abstract：:The phosphodiesterase inhibitor oxpentifylline (OXP) has a number of potentially important immunomodulatory actions which include a selective inhibition of the Th1 subset of CD4+ cells in vitro and inhibition of tumor necrosis factor (TNF)-alpha mRNA transcription. In vivo, it has a dramatic protective effect against ...

journal_title：European journal of immunology

authors： Kiely PD,Gillespie KM,Oliveira DB

更新日期：1995-10-01 00:00:00

abstract：:A human IgE-producing myeloma has been cultivated in vitro as a continuous cell line (U-266) since 1968. Analysis of immunoglobulin production during early passages of the cell line demonstrated a high synthesis rate of monoclonal IgE. Analysis of late passages, cultivated after 1980, revealed a 3-6-fold lower rate of...

journal_title：European journal of immunology

authors： Hellman L,Josephson S,Jernberg H,Nilsson K,Pettersson U

更新日期：1988-06-01 00:00:00

abstract：:The pathogenesis of immune-mediated drug-induced liver injury (DILI) following halogenated anesthetics, carbamazepine or alcohol has not been fully elucidated. Detecting cytochrome P450 2E1 (CYP2E1) IgG4 auto-antibodies in anesthetic DILI patients suggests a role for IL-4 in this hapten-mediated process. We investigat...

journal_title：European journal of immunology

authors： Njoku DB,Li Z,Washington ND,Mellerson JL,Talor MV,Sharma R,Rose NR

更新日期：2009-06-01 00:00:00

abstract：:We have proposed earlier that the poor capacity of the lipocalin allergen Bos d 2 to stimulate highly allergic subjects' peripheral blood mononuclear cells could be ascribed to endogenous lipocalins and could be related to the allergenic potential of the molecule. Here, we have characterized the proliferative and cyto...

journal_title：European journal of immunology

authors： Kinnunen T,Buhot C,Närvänen A,Rytkönen-Nissinen M,Saarelainen S,Pouvelle-Moratille S,Rautiainen J,Taivainen A,Maillère B,Mäntyjärvi R,Virtanen T

更新日期：2003-06-01 00:00:00

abstract：:B cells have multiple functions in adaptive immunity, including antibody production, antigen presentation and regulation of T-cell responses. Recent evidences indicate that B cells have more subsets than previously thought and may have non-classical functions, such as involvement in innate immunity and immune regulati...

journal_title：European journal of immunology

authors： Bao Y,Han Y,Chen Z,Xu S,Cao X

更新日期：2011-03-01 00:00:00

abstract：:Mitogens such as pokeweed mitogen, Staphylococcus aureus Cowan I, concanavalin A and phytohemagglutinin and monoclonal anti-CD antibodies were examined for their capacity to induce IgE synthesis by peripheral blood leukocytes obtained from both atopic and nonatopic individuals. While lectins failed to induce IgE synth...

journal_title：European journal of immunology

authors： Yang XD,De Weck AL,Stadler BM

更新日期：1988-03-01 00:00:00

abstract：:Gene targeting in hybridoma cells provides a tool for generating chimeric antibodies with great ease and at high yield. We present an evaluation of integration vectors for the chimerization of the immunoglobulin heavy chain locus which are universally applicable to hybridomas of different isotypes and mouse strains. T...

journal_title：European journal of immunology

authors： Kardinal C,Hooijberg E,Lang P,Zeidler R,Mocikat R

更新日期：1995-03-01 00:00:00

abstract：:The cytokine IL-7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL-7 receptor alpha-deficient mice. We demonstrate that the IL-7 receptor becomes progressively more important with age. B lymphopoiesis takes place...

journal_title：European journal of immunology

authors： Erlandsson L,Licence S,Gaspal F,Bell S,Lane P,Corcoran AE,Mårtensson IL

更新日期：2004-12-01 00:00:00

abstract：:In man, B cell maturation factors obtained from T cells or T cell lines have been shown to induce antibody formation in mitogen or anti-immunoglobulin activated B cells, and in some continuous B cell lines, but the relationships between these factors and B cell differentiation factors in antigen-specific antibody resp...

journal_title：European journal of immunology

authors： Callard RE,Booth RJ,Brown MH,McCaughan GW

更新日期：1985-01-01 00:00:00

abstract：:Peritoneal macrophages from C57BL/6 mice process antigens from bacteria or coated on polystyrene beads for presentation by major histocompatibility complex (MHC) class I molecules. To investigate this antigen processing pathway, peritoneal macrophages from homozygous TAP1-/- mice, which lack the transporter associated...

journal_title：European journal of immunology

authors： Wick MJ,Pfeifer JD

更新日期：1996-11-01 00:00:00

abstract：:A majority of immunodominant epitopes of mycobacterial antigens are known to be recognized by murine T cells in the context of several H-2 haplotypes. In this study, we established the frequency of T cells able to recognize these peptides promiscuously, i.e. in the context of allogeneic antigen-presenting cells, using...

journal_title：European journal of immunology

authors： Vordermeier HM,Arya A,Harris DP,Moreno C,Ivanyi J

更新日期：1995-10-01 00:00:00

abstract：:Upon activation in vitro, only a fraction of the bulk human T helper cell cultures secret the hallmark Th1/2 cytokines (IFN-gamma for Th1 and IL-4 for Th2, respectively). It is uncertain whether these IFN-gamma-/IL-4- cells are differentiated Th1 or Th2 cells. Here, we have characterized live IFN-gamma+, IL-4+ and IFN...

journal_title：European journal of immunology

authors： Cao W,Chen Y,Alkan S,Subramaniam A,Long F,Liu H,Diao R,Delohery T,McCormick J,Chen R,Ni D,Wright PS,Zhang X,Busch S,Zilberstein A

更新日期：2005-09-01 00:00:00

abstract：:Previously we implicated c-Jun N-terminal kinase (JNK) as an element that is involved in signal integration during co-stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR and CD28. A large portio...

journal_title：European journal of immunology

authors： Avraham A,Jung S,Samuels Y,Seger R,Ben-Neriah Y

更新日期：1998-08-01 00:00:00

abstract：:Tetanus toxin has been a valuable model antigen to study the MHC class II-restricted antigen processing pathway and is also frequently used to provide T helper determinants in vaccine formulations. To date most basic studies on the processing of this antigen have utilized human T and B cell clones. As a first step tow...

journal_title：European journal of immunology

authors： Antoniou AN,Watts C

更新日期：2002-02-01 00:00:00

abstract：:The CBA/N mouse carries the X-linked immunodeficiency xid, resulting in defective B cell development. B cells from these animals cannot mount antibody responses to type 2 T-independent antigens, and do not synthesize DNA when stimulated with anti-immunoglobulin (Ig) antibodies which are mitogenic for normal B cells. T...

journal_title：European journal of immunology

authors： Hasbold J,Klaus GG

更新日期：1994-01-01 00:00:00

abstract：:Retinoic acid (RA), which is the biologically active form of vitamin A, acts through the nuclear hormone receptor RAR (RA receptor) to induce either gene activation or repression. RA production and its effects have been linked to macrophages, dendritic cells, T and B cells, and iNKT cells in the immune system and play...

journal_title：European journal of immunology

authors： Nagy L

更新日期：2012-07-01 00:00:00

abstract：:The contribution of direct and indirect alloresponses by CD4(+) Th1 and Th2 cells in acute and chronic rejection of allogeneic transplants remains unclear. In the present study, we addressed this question using a transplant model in a single MHC class I-disparate donor-recipient mouse combination. BALB/c-dm2 (dm2) mut...

journal_title：European journal of immunology

authors： Illigens BM,Yamada A,Anosova N,Dong VM,Sayegh MH,Benichou G

更新日期：2009-11-01 00:00:00

abstract：:A human lymphoid cell ine (S95) with surface-located IgG is described. The line was derived from a patient with Hodgkin's disease and is aneuploid. Its characteristics are suggestive of a malignant B lymphocyte derivation, but no ultimate proof of malignancy can be forwarded. The line produces immunoglobulin (IgG) whi...

journal_title：European journal of immunology

authors： Nilsson K,Ghetie V,Sjöquist J

更新日期：1975-08-01 00:00:00