A human lymphoid cell line with an IgG-like membrane component.

abstract：:Responding B cells in specific immune responses diversify their immunoglobulin genes and are selected on their variant antigen receptors in the microenvironment of the germinal center. The patterns of mutations previously reported for immunglobulin (Ig) genes have supported mechanistic hypotheses of either error-prone...

journal_title：European journal of immunology

authors： Ford JE,McHeyzer-Williams MG,Lieber MR

更新日期：1994-08-01 00:00:00

abstract：:The successful implementation of immunotherapies has provided new impetus in the fight against cancer. Antibody-mediated blockade of immune checkpoint molecules PD-1/PD-L1 and CTLA-4 has had a dramatic impact upon the treatment of previously intractable cancers such as malignant melanoma, while adoptive cell therapies...

journal_title：European journal of immunology

authors： Hope HC,Salmond RJ

更新日期：2019-08-01 00:00:00

abstract：:The studies described in this report were designed to investigate factors that could influence the behavior of erythrocytes following their interaction with monoclonal antibodies (mAb) in a fully homologous experimental opsonization system in vivo. The clearance profiles and tissue distribution of target erythrocytes ...

journal_title：European journal of immunology

authors： Yousaf N,Howard JC,Williams BD

更新日期：1991-04-01 00:00:00

abstract：:NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...

journal_title：European journal of immunology

authors： Campos PC,Gomes MTR,Marinho FAV,Guimarães ES,de Moura Lodi Cruz MGF,Oliveira SC

更新日期：2019-07-01 00:00:00

abstract：:Murine spleen and lymph node L3T4+ T cells were found to spontaneously produce high levels of interleukin 3 (IL3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in cultures containing 10% fetal calf serum (FCS) in the absence of other stimulation. The IL3 and GM-CSF activities in culture supernatants pe...

journal_title：European journal of immunology

authors： Davignon JL,Kimoto M,Kindler V,De Kossodo S,Vassalli P,Izui S

更新日期：1988-09-01 00:00:00

abstract：:In mice infected with the non-lethal malaria parasite Plasmodium chabaudi chabaudi AS, a prominent switch from a Th1 to a Th2 type of response occurs in CD4+ T cells at the time of peak parasitemia or shortly thereafter (9-15 days after infection). This is accompanied by a major increase in IL-4, and a similar decreas...

journal_title：European journal of immunology

authors： Poorafshar M,Helmby H,Troye-Blomberg M,Hellman L

更新日期：2000-09-01 00:00:00

abstract：:For homeostasis, T cells integrate non-cognate TCR-dependent and -independent signals to survive and weakly proliferate. In contrast to antigen-specific, stable, and long-lived contacts, signaling in short-lived homeostatic interactions depends upon the coordination of ongoing T-cell migration on the surface of DC and...

journal_title：European journal of immunology

authors： Storim J,Bröcker EB,Friedl P

更新日期：2010-10-01 00:00:00

abstract：:Secretion of type I interferon (IFN) is the first cellular reaction to invading pathogens. Despite the protective function of these cytokines, an excessive response to their action can contribute to serious pathologies, such as autoimmune diseases. Transcripts of most cytokines contain adenylate-uridylate (A/U)-rich e...

journal_title：European journal of immunology

authors： Herdy B,Karonitsch T,Vladimer GI,Tan CS,Stukalov A,Trefzer C,Bigenzahn JW,Theil T,Holinka J,Kiener HP,Colinge J,Bennett KL,Superti-Furga G

更新日期：2015-05-01 00:00:00

abstract：:Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...

journal_title：European journal of immunology

authors： Reininger L,Spertini F,Shibata T,Jaton JC,Izui S

更新日期：1989-11-01 00:00:00

abstract：:Accumulating evidence suggests that Th17 cells and Tregs may exhibit development plasticity and that CD4(+) Tregs can differentiate into IL-17-producing T cells; however, whether Th17 cells can reciprocally convert into Tregs has not been described. In this study, we generated Th17 clones from tumor-infiltrating T lym...

journal_title：European journal of immunology

authors： Ye J,Su X,Hsueh EC,Zhang Y,Koenig JM,Hoft DF,Peng G

更新日期：2011-04-01 00:00:00

abstract：:Natural killer (NK) cells in normal mouse spleen have so far been found to lack conventional cell surface markers. Recently, neuraminidase treatment has been shown to uncover receptors for the A hemagglutinin of the snail Helix pomatia (HP) on populations (preferentially T cells) of human blood lymphocytes. We have us...

journal_title：European journal of immunology

authors： Haller O,Gidlund M,Hellström U,Hammarström S,Wigzell H

更新日期：1978-11-01 00:00:00

abstract：:The aim of this study was to investigate malignant lymphomas of donor origin induced in F1 mice undergoing a chronic graft-versus-host reaction (GVHR) after injection of parental strain spleen cells. A total of 3 X 10(8) or 4 X 10(8) C57BL/10 spleen cells were administered to 7-8-week-old H-2 incompatible (C57BL/10 X ...

journal_title：European journal of immunology

authors： Gleichmann E,Peters K,Lattmann E,Gleichmann H

更新日期：1976-06-01 00:00:00

abstract：:Although the role of interleukin 2 (IL 2) in mature T lymphocyte function is well documented, its effect on hematopoietic progenitor cells is less well characterized. Here we have used recombinant retroviruses to transduce and express a cDNA clone encoding the p55 component of the human IL 2 receptor (h-p55), in a mur...

journal_title：European journal of immunology

authors： Collins MK,Malde P,Miyajima A,Arai K,Smith KA,Mulligan RC

更新日期：1990-03-01 00:00:00

abstract：:Recent evidence suggests a role for phosphatidylinositol (PI) 3-kinase in various inflammatory responses. In this study, the consequences of LPS-induced PI 3-kinase activation on cytokine and chemokine expression and the intracellular mechanisms of inflammatory activation were examined in mouse macrophages. LPS stimul...

journal_title：European journal of immunology

authors： Ojaniemi M,Glumoff V,Harju K,Liljeroos M,Vuori K,Hallman M

更新日期：2003-03-01 00:00:00

abstract：:In a search for proteins involved in signal transduction through the T cell receptor (TcR/CD3 complex), a recently developed highly efficient method for labeling of nucleotide binding proteins in permeabilized cells was applied. Here, we report that human CD3-gamma could be labeled by periodate-oxidized [alpha-32P] GT...

journal_title：European journal of immunology

authors： Peter ME,Wileman T,Terhorst C

更新日期：1993-02-01 00:00:00

abstract：:Previous reports suggested that lethal toxin (LT)-induced caspase-1 activity and/or IL-1beta accounted for Bacillus anthracis (BA) infection lethality. In contrast, we now report that caspase-1-mediated IL-1beta expression in response to BA spores is required for anti-BA host defenses. Caspase-1(-/-) and IL-1beta(-/-)...

journal_title：European journal of immunology

authors： Kang TJ,Basu S,Zhang L,Thomas KE,Vogel SN,Baillie L,Cross AS

更新日期：2008-06-01 00:00:00

abstract：:Beside diabetes, non-obese diabetic (NOD) mice develop sporadic lymphoid infiltration of the thyroid gland, mimicking Hashimoto's thyroiditis. We have examined the prevalence of those manifestations in NOD mice, the influence of the major histocompatibility complex (MHC) and the association with autoantibodies. The in...

journal_title：European journal of immunology

authors： Damotte D,Colomb E,Cailleau C,Brousse N,Charreire J,Carnaud C

更新日期：1997-11-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by congenital thrombocytopenia and progressive deterioration of the immune function. Dendritic cells (DC) are key effectors in the induction of specific immunity and are highly specialized in antigen uptake and subsequent migration to draining lymph ...

journal_title：European journal of immunology

authors： Allavena P,Badolato R,Facchetti F,Vermi W,Paganin C,Luini W,Giliani S,Mazza C,Bolzern U,Chiesa I,Notarangelo L,Mantovani A,Sozzani S

更新日期：2001-12-01 00:00:00

abstract：:In order to characterize the murine anti-human xenogeneic mixed lymphocyte reactions (MLR), we studied T cell proliferative responses against various human lymphoid cells by immunization of mice either with cellular or purified HLA-DR antigens. Data presented here indicated that small amounts of soluble HLA-DR antigen...

journal_title：European journal of immunology

authors： Viguier M,Lotteau V,Charron D,Debré P

更新日期：1987-11-01 00:00:00

abstract：:Thyroglobulin-binding lymphoid cells were identified in the spleen of Obese strain (DS) chickens by their capacity to form rosettes with thyroglobulin-coated chicken red blood cells. The nature of these cells was studied in inhibition experiments using turkey anti-chicken bursa or thymus cell sera and rabbit antisera ...

journal_title：European journal of immunology

authors： Richter E,Wick G,Schauenstein K

更新日期：1975-08-01 00:00:00

abstract：:Human peripheral blood natural killer (NK) cells (CD56+, CD16+, CD3 epsilon- lymphocytes) express CD69 after their stimulation by interleukin-2 (IL-2) or interferon-alpha (IFN-alpha). This activation antigen represents a triggering surface molecule in NK cell clones as its stimulation triggers the cytolytic machinery ...

journal_title：European journal of immunology

authors： Borrego F,Peña J,Solana R

更新日期：1993-05-01 00:00:00

abstract：:Low zone tolerance (LZT) to contact allergens is induced by epicutaneous exposure to haptens in subsensitizing doses resulting in an inhibition of contact hypersensitivity (CHS), which, in contrast, occurs after sensitization with immunogenic doses of allergens. Performing the protocol of tolerance induction resulted ...

journal_title：European journal of immunology

authors： Seidel-Guyenot W,Alt R,Perschon S,Knop J,Steinbrink K

更新日期：2004-11-01 00:00:00

abstract：:The interaction between TCR and peptide-MHC is well described in terms of the recognition of the peptide, but the recognition of the MHC is less well understood. At issue is whether particular V gene products may have higher affinity for some MHC over others and to what extent the bound peptide influences V gene selec...

journal_title：European journal of immunology

authors： Battaglia M,Gorski J

更新日期：2002-08-01 00:00:00

abstract：:By immunizing Lewis rats with myelin basic protein (MBP) peptide variants derived from the major encephalitogenic epitope of guinea pig (MBP(68-88) and then isolating encephalitogenic T cells from these animals, we demonstrated that the variant peptides do not elicit the same encephalitogenic T cell subsets as those i...

journal_title：European journal of immunology

authors： Sun D,Coleclough C,Hu XZ

更新日期：1995-06-01 00:00:00

abstract：:Tetanus toxin has been a valuable model antigen to study the MHC class II-restricted antigen processing pathway and is also frequently used to provide T helper determinants in vaccine formulations. To date most basic studies on the processing of this antigen have utilized human T and B cell clones. As a first step tow...

journal_title：European journal of immunology

authors： Antoniou AN,Watts C

更新日期：2002-02-01 00:00:00

abstract：:The inbred strain 13 guinea pig expresses at least three isotypes of immunoglobulin (Ig) lambda chain. The proportion of these isotypes in normal Ig can be estimated by isolating a constant (C) region cyanogen bromide peptide from lambda chains and quantitatively analyzing its component tryptic peptides. Anti-phenyltr...

journal_title：European journal of immunology

authors： Brunhouse RF,Cebra JJ

更新日期：1978-12-01 00:00:00

abstract：:While the nasal mucosa is a potentially useful site for human immunization, toxin-based nasal adjuvants are generally unsafe and less effective in humans. Safe mucosal adjuvants that activate protective immunity via mucosal administration are highly dependent on barrier antigen sampling by epithelial and DCs. Here, we...

journal_title：European journal of immunology

authors： Makidon PE,Belyakov IM,Blanco LP,Janczak KW,Landers J,Bielinska AU,Groom JV 2nd,Baker JR Jr

更新日期：2012-08-01 00:00:00

abstract：:Several groups have described that a low percentage of in vitro cultured T cell receptor (TcR) gamma/delta cells express CD8. Contrary to TcR alpha/beta cells, however, CD8 on these TcR gamma/delta cells was shown to be a CD8 alpha homodimer. We describe here that addition of interleukin-7 (IL-7) to a short-term in vi...

journal_title：European journal of immunology

authors： Leclercq G,De Smedt M,Plum J

更新日期：1992-09-01 00:00:00

abstract：:The phosphodiesterase inhibitor oxpentifylline (OXP) has a number of potentially important immunomodulatory actions which include a selective inhibition of the Th1 subset of CD4+ cells in vitro and inhibition of tumor necrosis factor (TNF)-alpha mRNA transcription. In vivo, it has a dramatic protective effect against ...

journal_title：European journal of immunology

authors： Kiely PD,Gillespie KM,Oliveira DB

更新日期：1995-10-01 00:00:00

abstract：:This Viewpoint series provides authoritative and detailed outlines of exciting areas of DC research. Some of the subjects that frequently come up include development of DC; distribution of DC in lymphoid and non-lymphoid tissues such as skin, intestine and lung; different forms or subsets of DC; and the role of DC in ...

journal_title：European journal of immunology

authors： Steinman RM

更新日期：2010-08-01 00:00:00