Abstract:
:The cytokine IL-7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL-7 receptor alpha-deficient mice. We demonstrate that the IL-7 receptor becomes progressively more important with age. B lymphopoiesis takes place, albeit at reduced levels, in fetal liver and bone marrow of young mice, but is arrested in adults. The outcome is a severe reduction, from an early age, in peripheral B cells including follicular, marginal zone and B-1 B cells as well as perturbed splenic B cell structures, which are restored after adoptive transfer of normal spleen cells. We conclude that in the absence of the IL-7 receptor, the residual B lymphopoiesis occurring early in ontogeny must be facilitated by another component, whereas the IL-7 receptor is the key factor in adults. The impairment of marginal zone and B-1 B cells in IL-7 receptor- but not IL-7-deficient mice suggests non-redundant functions for the IL-7 receptor ligands, IL-7 and thymic stromal lymphopoietin.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Erlandsson L,Licence S,Gaspal F,Bell S,Lane P,Corcoran AE,Mårtensson ILdoi
10.1002/eji.200425217keywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
3595-603issue
12eissn
0014-2980issn
1521-4141journal_volume
34pub_type
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