Delay in expression of a mammary tumor provirus is responsible for defective clonal deletion during postnatal period.

abstract：:We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the alternative pathway (AP) of complement activation might play a role in retinal inflamma...

journal_title：European journal of immunology

authors： Chen M,Muckersie E,Luo C,Forrester JV,Xu H

更新日期：2010-10-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent inducer of interleukin 1 (IL 1) synthesis and release, and of tumor necrosis factor (TNF) secretion. Many signals can enhance the LPS-induced production of these cytokines. We have previously observed that addition of low amounts of normal human serum to the culture medium enhances...

journal_title：European journal of immunology

authors： Cavaillon JM,Fitting C,Haeffner-Cavaillon N

更新日期：1990-02-01 00:00:00

abstract：:We have demonstrated that analogues of alpha-mannosyl ceramide (alpha-ManCer) consisting of a series of immunosuppressive 2-aminoalcohol derivatives in place of sphingosine promote a greater immune response from mouse invariant Valpha19-Jalpha26 (AV19-AJ33) TCR-bearing NKT (Valpha19 NKT) cells than alpha-ManCer itself...

journal_title：European journal of immunology

authors： Shimamura M,Huang YY,Okamoto N,Suzuki N,Yasuoka J,Morita K,Nishiyama A,Amano Y,Mishina T

更新日期：2007-07-01 00:00:00

abstract：:Recombinant vaccinia viruses (VV)-encoding murine interferon-gamma (IFN-gamma) were constructed and the effect of virus-encoded IFN-gamma on the immune response towards VV in vivo investigated. In athymic nude mice and sublethally irradiated euthymic mice, IFN-gamma expression by VV enabled the mice to recover from th...

journal_title：European journal of immunology

authors： Kohonen-Corish MR,King NJ,Woodhams CE,Ramshaw IA

更新日期：1990-01-01 00:00:00

abstract：:The cytotoxic response of cell sorter-purified small Lyt-2+ splenic cytotoxic lymphocyte precursors from 10 individual C57BL/6 mice to mutant class I H-2Kbm1 or H-2Dbm14 allodeterminants was analyzed under limiting dilution conditions. The cytotoxic activity of anti-bm1-specific or anti-bm14-specific cytotoxic T lymph...

journal_title：European journal of immunology

authors： Reimann J,Bellan A

更新日期：1986-12-01 00:00:00

abstract：:PKCε is implicated in T cell activation and proliferation and is overexpressed in CD4+ -T cells from patients with autoimmune Hashimoto's thyroiditis. Although this might induce the suspicion that PKCε takes part in autoimmunity, its role in the molecular pathophysiology of immune-mediated disorders is still largely u...

journal_title：European journal of immunology

authors： Martini S,Pozzi G,Carubbi C,Masselli E,Galli D,Di Nuzzo S,Banchini A,Gobbi G,Vitale M,Mirandola P

更新日期：2018-04-01 00:00:00

abstract：:Despite accounting for only a minor fraction of all cells in Hodgkin's lymphoma tissue, the Hodgkin and Reed-Sternberg (HRS) cells represent the malignant tumor cell clone in Hodgkin's disease (HD). By far the most abundant cell type in the tumor tissue are CD4+ T cells. Some of them intimately associate with HRS cell...

journal_title：European journal of immunology

authors： Roers A,Montesinos-Rongen M,Hansmann ML,Rajewsky K,Küppers R

更新日期：1998-08-01 00:00:00

abstract：:Transcription of the gene encoding the transcriptional coactivator Oct-binding factor 1 (OBF-1)/OCA-B/Bob.1 is largely restricted to B cells. During B cell development OBF-1 expression shows two peaks, one in immature B cells in the bone marrow and the other in germinal center B cells. Promoter analysis has identified...

journal_title：European journal of immunology

authors： Massa S,Junker S,Schubart K,Matthias G,Matthias P

更新日期：2003-10-01 00:00:00

abstract：:Vitamin A deficiency is known to be accompanied with immune deficiency and susceptibility to a wide range of infectious diseases. Experimental evidence suggests that the active metabolites of vitamin A that mediate its effects on the immune system are the retinoic acids (RA), which are ligands for the nuclear RA recep...

journal_title：European journal of immunology

authors： Kiss I,Rühl R,Szegezdi E,Fritzsche B,Tóth B,Pongrácz J,Perlmann T,Fésüs L,Szondy Z

更新日期：2008-01-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic conditions that result from uncontrolled intestinal inflammation. Pathogenic Th17 cells, characterized by production of IL-17A in the absence of IL-10, are thought to contribute to this inflammation, but in humans, antibody-mediated blockade of IL-17A is an ineffective IBD...

journal_title：European journal of immunology

authors： Boardman DA,Garcia RV,Ivison SM,Bressler B,Dhar TM,Zhao Q,Levings MK

更新日期：2020-09-01 00:00:00

abstract：:T-cell homeostasis preserves the numbers, the diversity and functional competence of different T-cell subsets that are required for adaptive immunity. Naïve CD4(+) T (TN ) cells are maintained in the periphery via the common γ-chain family cytokine IL-7 and weak antigenic signals. However, it is not clear how memory C...

journal_title：European journal of immunology

authors： Yamaki S,Ine S,Kawabe T,Okuyama Y,Suzuki N,Soroosh P,Mousavi SF,Nagashima H,Sun SL,So T,Sasaki T,Harigae H,Sugamura K,Kudo H,Wada M,Nio M,Ishii N

更新日期：2014-10-01 00:00:00

abstract：:Murine spleen and lymph node L3T4+ T cells were found to spontaneously produce high levels of interleukin 3 (IL3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in cultures containing 10% fetal calf serum (FCS) in the absence of other stimulation. The IL3 and GM-CSF activities in culture supernatants pe...

journal_title：European journal of immunology

authors： Davignon JL,Kimoto M,Kindler V,De Kossodo S,Vassalli P,Izui S

更新日期：1988-09-01 00:00:00

abstract：:The proteins p40 (Mr = 40 000), p32 (Mr = 32 000), p28 (Mr = 28 000), p20 (Mr = 20 000) and p10 (Mr = 10 000) are described which occur in noncovalent association with the polymorphic alpha, beta heterodimer of class II antigens. They were investigated with respect to their molecular characteristics and their mutual s...

journal_title：European journal of immunology

authors： Zecher R,Ballhausen W,Reske K,Linder D,Schlüter M,Stirm S

更新日期：1984-06-01 00:00:00

abstract：:The genetic control of in vitro primary syngeneic sensitization on monolayers of thyroid epithelial cells was investigated both at the level of the responder lymphocytes and that of stimulator thyroid epithelial cells using congenic resistant strains of mice. It clearly appears that similar to the in vivo model of exp...

journal_title：European journal of immunology

authors： Salamero J,Charreire J

更新日期：1983-11-01 00:00:00

abstract：:Mycoplasma arthritidis produces in culture a polyclonal mitogen which is active for murine and human T lymphocytes in the presence of accessory cells (AC). We studied the requirements for processing and presentation by AC of Mycoplasma arthritidis supernatant (MAS) mitogen to human T cells. As inhibitors of AC process...

journal_title：European journal of immunology

authors： Bauer A,Rutenfranz I,Kirchner H

更新日期：1988-12-01 00:00:00

abstract：:Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimul...

journal_title：European journal of immunology

authors： Sander B,Cardell S,Möller G,Möller E

更新日期：1991-08-01 00:00:00

abstract：:Interferon regulatory factor-1 (IRF-1) is a transcription factor regulating the expression of several cytokines. Using IRF-1 knockout (KO) mice, the role of IRF-1 in the production and activity of IL-18 was evaluated. Administration of IL-12 or concanavalin A significantly increased levels of circulating IL-18 in wild...

journal_title：European journal of immunology

authors： Fantuzzi G,Reed D,Qi M,Scully S,Dinarello CA,Senaldi G

更新日期：2001-02-01 00:00:00

abstract：:The problem of the structural relationship between suppressive IgG-binding factor and low-affinity receptors for the Fc portion of IgG (Fc gamma RII) has not yet been solved. In the present work we have isolated a recombinant soluble Fc gamma RII containing only the two external domains of Fc gamma RII, and analyzed i...

journal_title：European journal of immunology

authors： Varin N,Sautès C,Galinha A,Even J,Hogarth PM,Fridman WH

更新日期：1989-12-01 00:00:00

abstract：:In order to characterize the murine anti-human xenogeneic mixed lymphocyte reactions (MLR), we studied T cell proliferative responses against various human lymphoid cells by immunization of mice either with cellular or purified HLA-DR antigens. Data presented here indicated that small amounts of soluble HLA-DR antigen...

journal_title：European journal of immunology

authors： Viguier M,Lotteau V,Charron D,Debré P

更新日期：1987-11-01 00:00:00

abstract：:We have identified a novel subset of early B lineage cells in the mouse bone marrow (BM) by GL7 expression on cell surface. GL7(+)B220(low) BM cells have a large cell size and are CD43(-to low), CD95(-), Sca-1(-), I-A(low), IgM(-) and IgD(-), suggesting that they are large pre-B cells. These BM cells express lambda5 a...

journal_title：European journal of immunology

authors： Murasawa M,Okada S,Obata S,Hatano M,Moriya H,Tokuhisa T

更新日期：2002-01-01 00:00:00

abstract：:The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expres...

journal_title：European journal of immunology

authors： Hong R,Lai N,Ouchida R,Xiong E,Zhou Y,Min Q,Liu J,Tang Y,Hikida M,Tsubata T,Wang Y,Wang JY

更新日期：2019-06-01 00:00:00

abstract：:MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88(-/-) mice. We found an increased susceptibility to VSV in myd88(-/...

journal_title：European journal of immunology

authors： Lang KS,Navarini AA,Recher M,Lang PA,Heikenwalder M,Stecher B,Bergthaler A,Odermatt B,Akira S,Honda K,Hengartner H,Zinkernagel RM

更新日期：2007-09-01 00:00:00

abstract：:To detect possible differences in immunogenicity between tumors induced in T cell-deficient mice and phenotypically normal congenic mice, 16 sarcomas, 8 having developed in nude BALB/c mice and 8 having developed in congenic normal (nu/+) mice, were transplanted to normal BALB/c recipients and the rates of rejection o...

journal_title：European journal of immunology

authors： Svane IM,Engel AM,Nielsen MB,Ljunggren HG,Rygaard J,Werdelin O

更新日期：1996-08-01 00:00:00

abstract：:RNA from 170 different Ig-secreting hybridomas was hybridized with VH gene probes 7183, QUPC52, S107, J558, J606, 36-60, V31, X-24 and V-GAM 3.8, with the aim of comparing xid to non-xid mice, neonatal NZB to adult NZB, and the peritoneal cavity with the splenic compartments for VH gene family expression. Our results ...

journal_title：European journal of immunology

authors： Dighiero G,Lim A,Lembezat MP,Kaushik A,Andrade L,Freitas A

更新日期：1988-12-01 00:00:00

abstract：:We have previously demonstrated that mycobacterial lipoproteins engage TLR2 on human CD4(+) T cells and upregulate TCR-triggered IFN-γ secretion and cell proliferation in vitro. Here we examined the role of CD4(+) T-cell-expressed TLR2 in Mycobacterium tuberculosis (MTB) Ag-specific T-cell priming and in protection ag...

journal_title：European journal of immunology

authors： Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE

更新日期：2014-05-01 00:00:00

abstract：:Current concepts on the pathogenesis of chronic asthma emphasize the role of several inflammatory cell populations and their respective mediators that interact in a complex network. However, beside inflammatory cells, lymphocytes are also present in asthmatic airways. Although little is known about their involvement i...

journal_title：European journal of immunology

authors： Lassalle P,Delneste Y,Gosset P,Gras-Masse H,Wallaert B,Tonnel AB

更新日期：1993-04-01 00:00:00

abstract：:The structure of immunological synapses formed between murine naive T cells and mature dendritic cells has been subjected to a quantitative analysis. Immunofluorescence images of synapses formed in the absence of antigen show a diffuse synaptic accumulation of CD3 and LFA-1. In electron microscopy, these antigen-free ...

journal_title：European journal of immunology

authors： Brossard C,Feuillet V,Schmitt A,Randriamampita C,Romao M,Raposo G,Trautmann A

更新日期：2005-06-01 00:00:00

abstract：:Activation pathways inducing the expression of the interferon (IFN)-gamma gene in a cytotoxic T lymphocyte (CTL) clone were studied for their effects on transcription and on mRNA stability. IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein ...

journal_title：European journal of immunology

authors： Kaldy P,Schmitt-Verhulst AM

更新日期：1995-04-01 00:00:00

abstract：:Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...

journal_title：European journal of immunology

authors： Werner-Favre C,Bovia F,Schneider P,Holler N,Barnet M,Kindler V,Tschopp J,Zubler RH

更新日期：2001-01-01 00:00:00

abstract：:Paxillin is an adaptor protein associated with focal adhesion complex, and is activated by tyrosine phosphorylation through focal adhesion kinase (FAK) and Src kinase. Recent studies reveal that serine phosphorylation of paxillin by JNK and p38 MAPK is essential for cell migration or neurite extension, but their cellu...

journal_title：European journal of immunology

authors： Lee YC,Chang AY,Lin-Feng MH,Tsou WI,Chiang IH,Lai MZ

更新日期：2012-08-01 00:00:00